CN111097027A

CN111097027A - Traditional Chinese medicine composition capable of improving sleep quality and traditional Chinese medicine sachet

Info

Publication number: CN111097027A
Application number: CN202010079283.9A
Authority: CN
Inventors: 罗丽玲; 黄冰菁; 谢毅强; 苏运涛; 于星跃; 黄贤明; 许凤琴
Original assignee: Hainan Medical College
Current assignee: Hainan Medical College
Priority date: 2020-02-03
Filing date: 2020-02-03
Publication date: 2020-05-05

Abstract

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine sachet capable of improving sleep quality. The traditional Chinese medicine composition for improving sleep quality comprises the following components in parts by weight: 1-5 parts of albizia flower, 1-5 parts of fructus alpiniae oxyphyllae, 1-5 parts of polygala tenuifolia, 3-10 parts of lily, 1-5 parts of calendula, 1-6 parts of chrysanthemum morifolium and 1-5 parts of dry lemon. The traditional Chinese medicine composition and the traditional Chinese medicine sachet prepared from the traditional Chinese medicine composition have remarkable curative effect on improving the sleep quality of patients, and the difference of the scores of Pittsburgh sleep scores before and after the traditional Chinese medicine composition has statistical significance (P < 0.05).

Description

Traditional Chinese medicine composition capable of improving sleep quality and traditional Chinese medicine sachet

Technical Field

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine sachet capable of improving sleep quality.

Background

Sleep is an important way for balancing yin and yang of a human body, preponderance of yin qi leads to insomnia, preponderance of yang qi leads to the theory, insomnia is stubborn and difficult to treat, and long-term insomnia affects life, study and work of patients. Insomnia, which is called "insomnia", "lying down" or "ocular contemplations" in traditional Chinese medicine, refers to a subjective experience that the sleeping time and/or quality are not satisfied and affect the day-to-day social function. Insomnia is manifested by difficulty falling asleep (time to fall asleep exceeds 30min), sleep maintenance disorder (number of awakenings more than or equal to 2 throughout the night), early awakening, decreased sleep quality and decreased total sleep time (usually less than 6h), accompanied by daytime dysfunction. Under the influence of factors such as rapid pace of life and intense social competition, the number of patients with insomnia in different degrees is increasing, and great trouble is caused to normal work and life of people. Therefore, the research and development of the medicine capable of effectively improving the sleep disorder of people have very important significance.

Disclosure of Invention

The traditional Chinese medicine composition capable of improving sleep quality and the traditional Chinese medicine sachet prepared from the composition can effectively treat insomnia caused by various reasons, and have high application value.

The technical scheme of the invention is realized as follows:

a traditional Chinese medicine composition capable of improving sleep quality comprises the following components in parts by weight: 1-5 parts of albizia flower, 1-5 parts of fructus alpiniae oxyphyllae, 1-5 parts of polygala tenuifolia, 3-10 parts of lily, 1-5 parts of calendula, 1-6 parts of chrysanthemum morifolium and 1-5 parts of dry lemon.

Further, the traditional Chinese medicine composition comprises the following components in parts by weight: 2 parts of albizia flower, 2 parts of fructus alpiniae oxyphyllae, 2 parts of polygala tenuifolia, 5 parts of lily, 3 parts of calendula, 4 parts of chrysanthemum morifolium and 3 parts of dry lemon.

A preparation method of a traditional Chinese medicine composition capable of improving sleep quality comprises the following steps:

taking albizia flower, fructus alpiniae oxyphyllae, polygala tenuifolia, lily, calendula, chrysanthemum morifolium and dried lemon according to the formula amount respectively, removing impurities, drying and crushing to obtain the traditional Chinese medicine.

Further, the temperature is controlled to be 50-60 ℃ in the drying process.

Furthermore, the fructus alpiniae oxyphyllae is used after salt moxibustion.

The application of the traditional Chinese medicine composition capable of improving sleep quality in preparing a sleep improving preparation.

Furthermore, the traditional Chinese medicine composition capable of improving the sleep quality is administrated by a smelling mode and/or a skin mucous membrane.

A traditional Chinese medicine sachet comprises a shell and a content, wherein the content is the traditional Chinese medicine composition.

Further, the shell is made of a breathable material.

Furthermore, in the traditional Chinese medicine sachet, the weight of the traditional Chinese medicine composition is 20-25 g.

Has the advantages that:

the traditional Chinese medicine composition takes albizia flower and fructus alpiniae oxyphyllae as monarch drugs, lily flower and polygala tenuifolia as ministerial drugs, calendula officinalis, chrysanthemum morifolium ramat as adjuvant drugs, and dry lemon as adjuvant drugs. The albizia flower is sweet in taste and neutral in nature, enters heart and liver meridians, can relieve depression and soothe nerves, is recorded in Shen nong Ben Cao Jing to mainly calm five internal organs, is good for heart, and is joyful; it is taken for a long time to lighten the body and improve the eyesight. Fructus Alpinae Oxyphyllae is pungent in flavor and warm in nature, and can enter spleen and kidney channels, and after salt moxibustion, can volatilize components for tranquilizing, hypnotizing and tonifying kidney essence; the two components can be combined to achieve the effect of communicating heart and kidney. Lily has pungent and sweet taste and slightly cold nature, and can enter lung, heart and stomach meridians to clear heart and tranquilize mind; polygala tenuifolia is bitter and pungent in flavor and warm in nature, and enters heart, kidney and lung meridians, and can soothe nerves and promote intelligence. The monarch, minister and guide can achieve the effects of nourishing heart, tranquilizing mind, clearing heart fire and improving intelligence. Calendula, chrysanthemum morifolium and dried lemon are added to enhance the effects of clearing away heart-fire and relieving restlessness. The whole formula is properly compatible, and the effects of restoring normal coordination between heart and kidney, clearing away heart-fire, relieving restlessness, calming the nerves and helping sleep are fully exerted. The aromatic medicine used by the traditional Chinese medicine sachet is inhaled by smelling, or absorbed into human body through channels and collaterals, skin of acupuncture points, mucous membrane and other ways, has the effects of balancing yin and yang, opening and relaxing striae, freeing lung and defensive qi, and regulating viscera functions, and is helpful for improving sleep.

The traditional Chinese medicines such as the albizia flower, the calendula, the polygala tenuifolia, the fructus alpiniae oxyphyllae and the like screened by the invention contain volatile oil components, can directly act on local skin mucous membranes, and has the effects of diminishing inflammation, sterilizing, tranquilizing, calming the nerves, expanding blood vessels and the like.

The traditional Chinese medicine sachet prepared by taking the composition as an effective component has a remarkable curative effect on improving the sleep quality of a patient, and the difference of Pittsburgh sleep score table values before and after the traditional Chinese medicine sachet is worn by the patient has statistical significance (P is less than 0.05).

Detailed Description

The invention will be better understood by reference to the following description taken in conjunction with the specific embodiments.

Example 1

A traditional Chinese medicine composition capable of improving sleep quality comprises the following components in parts by weight: 1g of albizia flower, 1g of fructus alpiniae oxyphyllae subjected to salt moxibustion, 1g of polygala tenuifolia, 3g of lily, 1g of calendula, 1g of chrysanthemum morifolium and 1g of dried lemon.

taking Albizzia julibrissin flower, salty moxibustion fructus Alpinae Oxyphyllae, cortex et radix Polygalae, flos Lilii Viriduli, calendula, flos Chrysanthemi and dried fructus Citri Limoniae according to formula amount, removing impurities, drying at 50-60 deg.C, and pulverizing.

The specific processing method of the salty moxibustion fructus alpiniae oxyphyllae comprises the following steps: adding 2g of salt into every 100g of fructus alpiniae oxyphyllae; dissolving salt 2g in 40ml water, mixing with fructus Alpinae Oxyphyllae, moistening for 30min, and parching at 250 deg.C for 8 min.

Example 2

A traditional Chinese medicine composition capable of improving sleep quality comprises the following components in parts by weight: 5g of albizia flower, 5g of fructus alpiniae oxyphyllae, 5g of polygala tenuifolia, 10g of lily, 5g of calendula, 6 g of chrysanthemum morifolium and 5g of dried lemon.

taking Albizzia julibrissin, fructus Alpinae Oxyphyllae, cortex et radix Polygalae, flos Lilii Viriduli, calendula, flos Chrysanthemi and dried fructus Citri Limoniae according to formula amount, removing impurities, drying at 50-60 deg.C, and pulverizing.

Example 3

A traditional Chinese medicine composition capable of improving sleep quality comprises the following components in parts by weight: 2g of albizia flower, 2g of fructus alpiniae oxyphyllae subjected to salt moxibustion, 2g of polygala tenuifolia, 5g of lily, 3g of calendula, 4g of chrysanthemum morifolium and 3g of dry lemon.

The specific treatment method of the salty moxibustion fructus alpiniae oxyphyllae is the same as that in example 1

The traditional Chinese medicine composition prepared by the embodiment can be prepared into corresponding products according to the preference of a patient, such as sachets, pouches, air fresheners, incensing agents and the like, and the effective components are volatilized into the air and directly act on local skin mucous membranes or are inhaled by the patient to play a therapeutic role.

Example 4

A traditional Chinese medicine sachet comprises a shell and a content, wherein the content is the traditional Chinese medicine composition in any one embodiment. The shell is made of air-permeable materials, such as non-woven fabrics, cotton and linen and the like.

The invention discloses a Chinese medicinal composition for investigating the medicinal effect

1 study object

50 cases of insomnia patients are randomly selected through questionnaire survey, and study objects accord with clinical symptoms of sleep disorder in the clinical research guideline of new traditional Chinese medicine, namely that sleep disorder occurs 3 times at least every week, the insomnia duration is more than 2 weeks, the Pittsburgh sleep score is more than 5 points, no serious physical and mental diseases exist, and the study objects have good understanding and communication capacity. Those with allergic constitution are excluded; eliminating acute attack stage of respiratory diseases; eliminate pregnant women, lying-in women, children, patients with serious mental diseases and disturbance of consciousness; eliminating secondary insomnia caused by pain, fever, trauma, operation and other factors; excluding patients with serious primary diseases of cardiovascular and cerebrovascular diseases, lung diseases, liver diseases, kidney diseases and hemopoietic system diseases; eliminating insomnia caused by alcoholism or psychotropic drug abuse and dependence. 50 patients, 11 men and 39 women, aged 19-52 years, mean (24.14 + -0.01) years, course 2 months to 3 years, mean (0.848 + -0.001) years. All study subjects signed informed consent and voluntarily participated in the study, and used self-former and later control experiments to explore curative effects, thus having research significance.

2 course of the study

① the inclusion questionnaire includes general information (patient's name, sex, occupation, medical history, etc.) and relevant information such as Pittsburgh sleep score table, ② the curative effect assessment questionnaire includes patient information, Pittsburgh sleep score table and curative effect judgment standard about insomnia in the Ministry of health & ltNew drug clinical research guidelines for traditional Chinese medicine & gt.

20 to 25g of the traditional Chinese medicine composition prepared in the embodiment 1 to 3 of the invention is randomly taken, and then is added with proper filler, sealed and added with a cotton-linen cloth bag with good air permeability to prepare the sachet for patients to use. The amounts used in the examples are as follows.

TABLE 1 sachet dosage statistics for the experiments

	Dosage (g)	Number of sachets
			Example 1	20	17
Example 2	25	17
			Example 3	21	16

3 research methods

3.1 Experimental population 50 experimental populations randomly administered the above prepared sachets, and worn with them, no time spent on other therapeutic drugs, no time spent in the experimental period. And carrying out periodic tracking recording; the medicine in the sachet is changed when the smell of the sachet becomes light every two weeks, and follow-up investigation is carried out, wherein 1 month is taken as the service cycle.

3.2 Observation indexes the Pittsburgh sleep scale (J. Zhonghua Neurology, page 534-540) provided by the Chinese medical society neurological Segren sleep disorder group in < Chinese Insomnia diagnosis and treatment guide > in 2012 was used to assess the sleep quality of the subject in about 1 month, including sleep quality, time to sleep, sleep time, sleep efficiency, sleep disorders, daytime dysfunctions, etc., and the comparison was performed. The total score of the scale is 21 points, and if the total score is more than 5 points, the insomnia patient can be judged, and the higher the score is, the worse the sleep quality is prompted.

3.3 evaluation of therapeutic effect adopts Pittsburgh sleep scale and therapeutic effect judgment standard (total effective rate ═ cure rate + significant efficiency rate + effective rate) of insomnia in the Ministry of health, clinical research and guidance of new Chinese medicine. The details are as follows.

The judgment standard of insomnia in the clinical research guidelines of new traditional Chinese medicines of Ministry of health is as follows:

and (3) healing: the sleep time is recovered to be normal or the sleep time at night is deep sleep for more than 6h, and the people are energetic after waking up.

The effect is shown: the sleep is improved obviously, the sleep time is increased by more than 3h, and the sleep depth is increased.

The method has the following advantages: the symptoms are relieved, and the sleep time is increased by less than 3 hours compared with the prior art.

Statistical processing, processing each data by SPSS 11.0, measuring data line t test, and expressing in (x + -s). P <0.05 indicates that the difference is statistically significant.

4 results

4.1 comparison of Pittsburgh sleep scores of 50 Insomnia patients before and after experiment

The Pittsburgh sleep score of the patient before the experiment is (7.98 +/-0.01), the Pittsburgh sleep score of the patient after the experiment is (4.90 +/-0.01), the score is obviously lower than the score before the experiment, and the difference has statistical significance (P < 0.05). See table 2 for details.

TABLE 2 Pittsburgh sleep score comparison (X + -s) of 50 Insomnia patients before and after the experiment

Effective rate of treating insomnia of 4.250 study subjects

The total effective rate of insomnia treatment of patients in the experimental group is 94% (8 patients are cured, 18 patients are obviously effective, 21 patients are effective, and 3 patients are ineffective). See table 3 for details.

Table 350 subjects who studied insomnia treatment effective rate

Group of	Recovery method	Show effect	Is effective	Invalidation	Total effective
						Number of people (human)	8	18	21	3	47
Ratio (%)	16	36	42	6	94

To better explain the therapeutic effect, 10 of them were extracted and the effect before and after use thereof was described in detail.

(1) Name: a certain sex of king: age of the woman: age 49 years old

The main complaints are: intermittent insomnia is aggravated for 1 week after half a year.

And (3) diagnosis: insomnia (disharmony between heart and kidney)

The course of the disease is as follows: the insomnia of the patient is more than half a year, and is accompanied by the symptoms of amnesia, vexation, listlessness, and soreness and weakness of waist and knees. Convenient adjustment, good appetite, red tongue with little coating and wiry and thready pulse.

Treatment: the medicinal materials in the sachet are replaced when the smell of the sachet becomes light every 2 weeks without being distributed day and night or indoor and outdoor.

After the follow-up feedback of the re-diagnosis, the sleep quality is obviously improved after 4 weeks.

(2) Name: guo of a certain sex: age of the woman: complaints of 25 years: intermittent insomnia was aggravated for 1 week after 3 months.

And (3) diagnosis: insomnia (liver blood deficiency)

The course of the disease is as follows: the patient had insomnia for more than three months with symptoms of anxiety and restlessness. Diet, good stool and urine, pale tongue and wiry and thready pulse.

(3) Name: su a certain sex: age of the male: complaints at age 23: repeated insomnia is accompanied by anxiety and restlessness for 5 days.

And (3) diagnosis: insomnia (heart fire flaming up)

The course of the disease is as follows: the patient had insomnia for 5 days with anxiety. Diet, good stool and urine, red tongue with little coating and surging pulse.

(4) Name: sex of lysimachia foenum-graecum: age of the woman: complaints at age 22: intermittent insomnia lasts for 3 months and aggravation lasts for 3 days.

And (3) diagnosis: insomnia (phlegm-fire disturbing the heart)

The course of the disease is as follows: the patient has insomnia for more than 3 months, and is not easy to fall asleep and easy to awaken. Chest oppression, restlessness, nausea, belching, heavy head, blurred vision, bitter taste in the mouth, red tongue with yellow and greasy coating, and slippery and rapid pulse.

(5) Name: plum of a certain sex: age of the male: age 27

The main complaints are: intermittent insomnia is aggravated for 1 week after 1 year.

And (3) diagnosis: insomnia (dampness-heat of liver meridian)

The course of the disease is as follows: the patient has insomnia for more than one year, is not easy to fall asleep and is easy to awaken. Diet, good stool and urine, red tongue with thick and greasy coating, and surging pulse.

(6) Name: certain sex of luo: age of the woman: age 22

Complain about and repeat insomnia for 3 days.

And (3) diagnosis: 1. insomnia (deficiency of Qi and blood) 2, spleen deficiency

The course of the disease is as follows: the patient has insomnia for 3 days, and is not easy to fall asleep. Diet, good stool and urine, pale tongue with good coating, and thready pulse.

(6) Name: certain sex of willow: age of the male: age 25

Complain about and insomnia is repeated for more than a month.

And (3) diagnosis: insomnia (fire excess from yin deficiency)

The course of the disease is as follows: the patient has insomnia for more than one month, and is often difficult to fall asleep, anxious and irritable. Accompanied by dry mouth, bitter taste, red tongue with little coating. Dry stool and yellow urine. The pulse is thready and rapid.

After the follow-up feedback of the re-diagnosis, the sleep quality is obviously improved after 3 weeks.

(7) Name: aging a certain sex: age of the woman: age 18

Chief complaints, repeated insomnia for more than three months.

And (3) diagnosis: insomnia (deficiency of both heart and spleen)

The course of the disease is as follows: the patient has insomnia for more than three months, dreaminess is frequent, the patient is easy to wake up, and the patient is difficult to fall asleep after waking up. Sometimes accompanied by palpitations and amnesia. Poor appetite, lusterless complexion, white coating and thready and weak pulse.

After the follow-up feedback of the re-diagnosis, the sleep quality is obviously improved after 2 weeks.

(8) Name: certain gender of Liu: age of the woman: age 45

Chief complaints, intermittent insomnia for more than half a year.

And (3) diagnosis: insomnia (yin-blood deficiency)

The course of the disease is as follows: the patient has insomnia more than half a year, often has dysphoria and is difficult to fall asleep. With dry mouth and thirst; sometimes, the patient suffers from dizziness, tinnitus, red tongue with little coating, and thready and rapid pulse.

(9) Name: a certain sex of king: age of the male: age 34 years old

Chief complaints, intermittent insomnia for more than one year.

And (3) diagnosis: insomnia (deficiency of middle-jiao)

The course of the disease is as follows: the insomnia of the patient is more than one year, and the patient often suffers from lassitude and lassitude. Poor appetite and loose stool; the tongue is pale with white coating and the pulse is thready.

(10) Name: certain sex of land: age of the woman: age 25

Complaining about insomnia for more than half a year.

And (3) diagnosis: insomnia (deficiency of both heart and spleen)

The course of the disease is as follows: the patient has insomnia for more than half a year, dreaminess is easy to wake up, and the patient is difficult to fall asleep after waking up. With palpitation and amnesia. Poor appetite and loose stool. A lusterless complexion, a white and greasy coating and a deep and weak pulse.

The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.

Claims

1. The traditional Chinese medicine composition capable of improving sleep quality is characterized by comprising the following components in parts by weight: 1-5 parts of albizia flower, 1-5 parts of fructus alpiniae oxyphyllae, 1-5 parts of polygala tenuifolia, 3-10 parts of lily, 1-5 parts of calendula, 1-6 parts of chrysanthemum morifolium and 1-5 parts of dried lemon.

2. The traditional Chinese medicine composition capable of improving sleep quality as claimed in claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 2 parts of albizia flower, 2 parts of fructus alpiniae oxyphyllae, 2 parts of polygala tenuifolia, 5 parts of lily, 3 parts of calendula, 4 parts of chrysanthemum morifolium and 3 parts of dried lemon.

3. The preparation method of the traditional Chinese medicine composition capable of improving sleep quality as claimed in claim 1 or 2, characterized by comprising the following steps:

4. The preparation method of the traditional Chinese medicine composition capable of improving sleep quality as claimed in claim 3, characterized in that: the temperature is controlled to be 50-60 ℃ in the drying process.

5. The preparation method of the traditional Chinese medicine composition capable of improving sleep quality as claimed in claim 3, characterized in that: the fructus alpiniae oxyphyllae is used after salt moxibustion.

6. Use of the Chinese medicinal composition for improving sleep quality as claimed in claim 1 or 2 in the preparation of a sleep improving preparation.

7. The use as claimed in claim 6, wherein the composition for improving sleep quality is administered by sniffing, transdermally and/or transmucosally.

8. A traditional Chinese medicine sachet comprises a shell and contents, and is characterized in that: the content is the traditional Chinese medicine composition.

9. The traditional Chinese medicine sachet of claim 6, wherein: the shell is made of a breathable material.

10. The traditional Chinese medicine sachet of claim 6, wherein: in each traditional Chinese medicine sachet, the weight of the traditional Chinese medicine composition is 20-25 g.