CN110638945A - Nerve-soothing and sleep-aiding substitutional tea and preparation method thereof - Google Patents

Nerve-soothing and sleep-aiding substitutional tea and preparation method thereof Download PDF

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Publication number
CN110638945A
CN110638945A CN201910918885.6A CN201910918885A CN110638945A CN 110638945 A CN110638945 A CN 110638945A CN 201910918885 A CN201910918885 A CN 201910918885A CN 110638945 A CN110638945 A CN 110638945A
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raw materials
substitutional tea
liquorice
soothing
lily
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王明谦
纪东艺
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Ningbo Dekang Biological Products Co Ltd
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Ningbo Dekang Biological Products Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967Lilium, e.g. tiger lily or Easter lily
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/34Tea substitutes, e.g. matè; Extracts or infusions thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

Abstract

The invention belongs to the technical field of medicine-food homologous traditional Chinese medicines, relates to health-care substitutional tea, and particularly relates to substitutional tea consisting of medicine-food homologous traditional Chinese medicines for soothing nerves and assisting sleep and a preparation method thereof. The substitutional tea is prepared from the following traditional Chinese medicine raw materials in percentage by weight: 30-40% of lily, 10-30% of spina date seed, 5-15% of poria cocos, 5-15% of rhizoma polygonati, 5-10% of polygonatum odoratum, 5-10% of lophatherum gracile and 5-10% of liquorice. The preparation method comprises the following steps: weighing the raw materials according to the weight percentage; drying rhizoma Polygonati, rhizoma Polygonati Odorati, and folium Bambusae in oven; mixing semen Ziziphi Spinosae, Poria, and Bulbus Lilii, adding water, heating for extraction, adsorbing the extractive solution with Glycyrrhrizae radix, drying, and sieving; mixing the dried raw materials with the adsorption mixture, and packaging. The substitutional tea of the invention not only can effectively improve insomnia, but also can achieve the purposes of regulating yin and yang, tonifying middle-jiao and Qi and strengthening the foundation and cultivating vigor, has simple preparation process and is suitable for mass production.

Description

Nerve-soothing and sleep-aiding substitutional tea and preparation method thereof
Technical Field
The invention belongs to the technical field of medicine-food homologous traditional Chinese medicines, relates to health-care substitutional tea, and particularly relates to nerve-soothing and sleep-aiding substitutional tea consisting of medicine-food homologous traditional Chinese medicines and a preparation method thereof.
Background
Insomnia is one of the common clinical symptoms, although not a critical disease, it hinders the normal life, work, study and health of people, and even aggravates or induces symptoms such as palpitation, thoracic obstruction, vertigo, headache and apoplexy. Intractable insomnia brings long-term pain to patients, and western medicine mainly treats sedative hypnotic drugs such as barbiturates, benzodiazepines and non-benzodiazepines in treating insomnia, so that dependence on hypnotic drugs is easily formed after long-term administration, and iatrogenic diseases can also be caused.
The traditional Chinese medicine considers that the insomnia is characterized in that normal sleep often cannot be obtained due to malnutrition or uneasiness of the heart and the mind caused by emotional or dietary internal injury, or factors such as after illness and old age, insufficient innate endowment, heart deficiency and timidity. The sleep time is insufficient, fatigue cannot be eliminated, physical strength and energy are restored, and a light person is difficult to fall asleep, or sleeps soundly, sleeps wakefully, or cannot sleep after waking, and sleeps all over the night if the person is serious.
The traditional Chinese medicine summarizes the etiology and pathogenesis of insomnia into four aspects: 1) insufficient source of transformation, malnutrition of heart-mind; 2) hyperactivity of fire due to yin deficiency, yin failing to astringe yang; 3) timidity due to deficiency of the heart, restlessness; 4) phlegm-heat and excessive fire disturb the heart-mind. The traditional Chinese medicine has more methods for treating insomnia, good effect and less adverse reaction, generally treats the insomnia according to different pathogenesis differentiation, and comprehensively conditions various viscera of heart, liver, spleen and kidney by combining the whole idea, thereby fundamentally improving the physical condition of patients.
The substitute tea is a product prepared by processing leaves, flowers, fruits, rhizomes and the like of edible plants according to a certain proportion and adopting a drinking mode (drinking by soaking, boiling and the like) similar to tea leaves, and the commonly used raw materials are plants which can be used as both medicine and food or can be used as health-care food. The substitutional tea serving as a food therapy mode generally has the effects of prevention and health care, is low in concentration, small in irritation and good in taste, is more easily accepted by modern people compared with the traditional Chinese medicine with bitter taste, long treatment course and fussy decoction, has no toxic or side effect after being taken for a long time, and has wide development prospect. Therefore, the health-care substitutional tea aiming at the insomnia is developed by using the traditional Chinese medicine raw materials with homology of medicine and food on the basis of the traditional Chinese medicine theory, and has higher market value.
Disclosure of Invention
The invention aims to provide the substitutional tea for soothing the nerves and helping sleep, which takes the traditional Chinese medicines with homology of medicine and food as raw materials, and can quickly and effectively relieve insomnia symptoms by adding certain medicinal flavors of tonifying middle-jiao and Qi and strengthening the foundation and reinforcing vitality on the basis of the traditional Chinese medicine components for improving sleep through reasonable formula compatibility.
The above object of the present invention is achieved by the following technical solutions: the substitutional tea for soothing the nerves and insomnia is characterized by being prepared from the following traditional Chinese medicine raw materials in percentage by weight: 30-40% of lily, 10-30% of spina date seed, 5-15% of poria cocos, 5-15% of rhizoma polygonati, 5-10% of polygonatum odoratum, 5-10% of lophatherum gracile and 5-10% of liquorice.
The preferable raw materials in percentage by weight are: 32-38% of lily, 12-25% of spina date seed, 6-12% of poria cocos, 6-12% of rhizoma polygonati, 6-9% of polygonatum odoratum, 6-9% of lophatherum gracile and 6-9% of liquorice.
The further preferable raw materials comprise the following components in percentage by weight: 35% of lily, 20% of spina date seed, 12% of poria cocos, 9% of rhizoma polygonati, 9% of polygonatum odoratum, 8% of lophatherum gracile and 7% of liquorice.
Bulbus Lilii is sweet in taste and slightly cold in nature, and has effects of nourishing yin, moistening lung, clearing heart fire and tranquilizing mind, and can be used for treating diseases such as lung and stomach yin injury, chronic cough, hemoptysis, vexation, pavor, insomnia, dreaminess, absentmindedness, etc.
The spina date seed is sweet and sour in taste and neutral in nature, enters liver, gallbladder and heart channels, has the effects of nourishing heart and liver, calming heart and soothing nerves, arresting sweating and promoting fluid production, and is mainly used for treating dysphoria and insomnia, palpitation and dreaminess, asthenia and hyperhidrosis, body fluid deficiency and thirst.
Poria has sweet and light taste, neutral nature, and has effects of nourishing heart, lung, spleen, and kidney, promoting diuresis, invigorating spleen, and calming heart, and can be used for treating oliguria in water, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, restlessness, palpitation, and insomnia.
Rhizoma Polygonati is sweet in taste, neutral in nature, and can enter spleen, kidney and channels, and is a common medicine for invigorating qi, nourishing yin, invigorating spleen, moistening lung and invigorating kidney, and can be used for treating spleen and stomach qi deficiency, tiredness, debilitation, stomach yin deficiency, dry mouth, anorexia, lung deficiency, cough with excessive internal heat, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat.
Yuzhu is sweet in flavor and slightly cold in nature, enters lung and stomach meridians, has the effects of nourishing yin, moistening dryness, promoting the production of body fluid and quenching thirst, and is commonly used for treating yin injury of lung and stomach, dryness-heat cough, dry throat, thirst, internal heat and diabetes and other symptoms.
Lophatherum gracile is sweet and single in flavor and cold in nature, enters heart, lung, stomach and bladder channels, has the effects of clearing heat and purging fire, relieving restlessness and quenching thirst, and inducing diuresis for treating stranguria, and can be used for treating fever polydipsia, oliguria with reddish urine and painful urination, and aphtha of the mouth and tongue.
The liquorice has sweet taste and neutral nature, enters heart, lung, spleen and stomach channels, has the effects of tonifying spleen and qi, clearing heat and detoxicating, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing other medicines, and is mainly used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and excessive phlegm, abdominal or limb spasm and acute pain, sore and carbuncle pyogenic infections, relieving medicine toxicity or fulminance and the like.
In the medicinal and edible raw materials adopted by the invention, the lily bulb, the spina date seed, the poria cocos, the lophatherum gracile and the liquorice are all inserted into the heart channel, wherein the spina date seed and the lily bulb have the effects of calming the heart and soothing the nerves, are commonly used for treating insomnia, are compatible with each other, and can effectively relieve symptoms such as dysphoria, insomnia, palpitation due to fright, dreaminess and the like. Meanwhile, the tuckahoe and the lophatherum gracile are added, so that the effects of calming the heart, purging fire and relieving restlessness can be achieved, and the insomnia symptoms caused by unsteadiness of heart-mind and heart disturbance due to excessive fire can be further relieved.
In addition, Poria cocos and rhizoma Polygonati both enter spleen and kidney meridians and can invigorate spleen and tonify kidney; yu Zhu enters lung and stomach meridians to nourish yin and moisten dryness; and rhizoma Polygonati Odorati are the common pair of yin-tonifying herbs, and are mainly used for treating spleen and stomach qi deficiency, stomach yin deficiency, lung and stomach yin injury, lung deficiency dry cough, essence and blood deficiency, and insomnia caused by yin deficiency and fire excess. Meanwhile, the liquorice is added to achieve the purposes of tonifying middle-jiao and Qi and strengthening the body resistance and cultivating vigor.
The substitutional tea of the invention not only aims at the disease of insomnia, but also improves and regulates the physical condition of patients, and regulates yin and yang, tonifies middle-jiao and Qi, strengthens foundation and strengthens primordial qi by the dialectical thought of the traditional Chinese medicine. According to the clinical test of the predecessor, the single-component traditional Chinese medicine has good curative effect on insomnia, but has dependence and tolerance, and the substitutional tea takes medicinal and edible plants as raw materials, and reduces the dependence and tolerance as much as possible by reasonable compatibility and formulation.
The invention also aims to provide a preparation method of the substitutional tea for soothing the nerves and helping sleep, which adopts the technical scheme that the preparation method comprises the following steps:
A. weighing the following raw materials in percentage by weight: 30-40% of lily, 10-30% of spina date seed, 5-15% of poria cocos, 5-15% of rhizoma polygonati, 5-10% of polygonatum odoratum, 5-10% of lophatherum gracile and 5-10% of liquorice;
B. placing the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A into an oven for drying;
C. mixing the spina date seed, the poria cocos and the lily in the step A, adding water, heating and extracting, adsorbing an extracting solution by using liquorice, drying and sieving;
D. and C, mixing the dried raw materials in the step B and the adsorption mixture in the step C, and packaging.
Preferably, the drying temperature in the step B of the preparation method is 50-70 ℃, and the drying time is 30-60 min.
Preferably, the extraction process in the step C of the preparation method is that the added water amount is 1-4 times of the mass of the raw materials, the extraction time is 1-2 hours, and the sieve aperture is 10-40 meshes.
The packaged dose of the substitutional tea of the invention comprises but is not limited to 1 g/bag, 3 g/bag, 5 g/bag and 6 g/bag. The dosage can be increased or decreased according to body constitution and individual symptoms.
The drinking method of the substitutional tea of the invention comprises the following steps: each bag is brewed with about 300mL of boiled water for 3-5 minutes and can be drunk.
Among the raw materials, lily is a rhizome traditional Chinese medicine, spina date seed is a seed medicinal material, poria cocos is a fungus, the three medicinal materials are uniform and compact in texture, effective ingredients are not easy to dissolve out, most of the effective ingredients can be boiled out by heating and boiling extraction, and licorice is loose in texture, rich in fiber and strong in adsorbability, can adsorb the effective ingredients in a boiled water solution on the surface, and can be dissolved in water again when drinking, so that the medicinal materials can be used by patients more conveniently while fully playing a role.
In addition, the boiled raw materials are comfortable to enter the mouth when being brewed for the first time after being adsorbed, the effective components in the medicinal materials can be continuously dissolved out, the drinking time is prolonged, and 2 g/bag can be repeatedly brewed for 3-4 times.
By adopting the technical scheme, the invention has the following beneficial effects:
1. the nerve-soothing and sleep-aiding substitutional tea takes the traditional Chinese medicines with homology of medicine and food as raw materials under the guidance of the dialectical thought of the traditional Chinese medicine, the spina date seed, the lily, the poria cocos and the lophatherum gracile play the roles of calming the heart, soothing the nerves and relieving restlessness together, and the rhizoma polygonati, the polygonatum odoratum and the liquorice are matched to achieve the purposes of regulating yin and yang, tonifying middle-jiao and Qi and strengthening the basis and cultivating vigor on the basis of improving insomnia.
2. The production of the nerve-soothing sleep-aiding substitutional tea utilizes the tissue structure characteristics of medicinal materials, water boiling and adsorption are carried out on partial raw materials, the characteristics of loose texture and rich fibers of the liquorice are utilized, active ingredients in a decoction solution are adsorbed on the surface, and the liquorice can be dissolved in water again when being drunk, so that the utilization rate of the active ingredients is improved, the mouthfeel is improved, the drinking time is prolonged, and the brewing times are increased.
3. The nerve-soothing and sleep-aiding substitutional tea is simple in preparation process, easy in raw material obtaining, economic and effective, and suitable for mass production.
Detailed Description
The technical solution of the present invention is further described and illustrated by the following specific examples. The raw materials used in the examples of the present invention are those commonly used in the art, and the methods used in the examples are those conventional in the art, unless otherwise specified.
Example 1
The nerve-soothing and sleep-aiding substitutional tea is prepared according to the following formula and process:
A. weighing the following raw materials in parts by weight: 35g of lily, 20g of spina date seed, 12g of poria cocos, 9g of rhizoma polygonati, 9g of polygonatum odoratum, 8g of lophatherum gracile and 7g of liquorice;
B. drying the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A for 30min in a 65 ℃ drying oven;
C. mixing the spina date seed, the poria cocos and the lily in the step A, adding 130mL of water, heating until the water is boiled and extracting for 2h, directly adding the liquorice into the extracting solution for adsorption until the extracting solution is completely adsorbed, drying the adsorption mixture in an oven at 55 ℃ for 120min, and sieving the dried mixture with a 10-mesh sieve;
D. and C, mixing the dried raw materials in the step B with the adsorption mixture in the step C, and packaging into 3g bags.
Example 2
The nerve-soothing and sleep-aiding substitutional tea is prepared according to the following formula and process:
A. weighing the following raw materials in parts by weight: 35g of lily, 20g of spina date seed, 12g of poria cocos, 9g of rhizoma polygonati, 9g of polygonatum odoratum, 8g of lophatherum gracile and 7g of liquorice;
B. drying the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A for 60min in a 50 ℃ oven;
C. mixing the spina date seed, the poria cocos and the lily in the step A, adding 200mL of water, heating until the water is boiled and extracting for 1h, directly adding the liquorice into the extracting solution for adsorption until the extracting solution is completely adsorbed, drying the adsorption mixture in an oven at 55 ℃ for 120min, and sieving the dried mixture with a 24-mesh sieve;
D. and C, mixing the dried raw materials in the step B with the adsorption mixture in the step C, and packaging into 2g of bags.
Example 3
The nerve-soothing and sleep-aiding substitutional tea is prepared according to the following formula and process:
A. weighing the following raw materials in parts by weight: 32g of lily, 25g of spina date seed, 10g of poria cocos, 9g of rhizoma polygonati, 9g of polygonatum odoratum, 8g of lophatherum gracile and 7g of liquorice;
B. drying the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A for 60min in a 50 ℃ oven;
C. mixing the spina date seed, the poria cocos and the lily in the step A, adding 130mL of water, heating until the water is boiled and extracting for 1.5h, directly adding the liquorice into the extracting solution for adsorption until the extracting solution is completely adsorbed, drying the adsorption mixture in an oven at 55 ℃ for 120min, and sieving the dried mixture with a 10-mesh sieve;
D. and C, mixing the dried raw materials in the step B with the adsorption mixture in the step C, and packaging into 2g of bags.
Example 4
The nerve-soothing and sleep-aiding substitutional tea is prepared according to the following formula and process:
A. weighing the following raw materials in parts by weight: 35g of lily, 15g of spina date seed, 12g of poria cocos, 12g of rhizoma polygonati, 9g of polygonatum odoratum, 9g of lophatherum gracile and 8g of liquorice;
B. drying the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A for 60min in a 50 ℃ oven;
C. mixing the spina date seed, the lily and the poria cocos in the step A, adding 180mL of water, heating until the water is boiled and extracting for 1.5h, directly adding the liquorice into the extracting solution for adsorption until the extracting solution is completely adsorbed, drying the adsorption mixture in an oven at 55 ℃ for 120min, and sieving the dried mixture with a 10-mesh sieve;
D. and C, mixing the dried raw materials in the step B with the adsorption mixture in the step C, and packaging into 5g of bags.
Example 5
The nerve-soothing and sleep-aiding substitutional tea is prepared according to the following formula and process:
A. weighing the following raw materials in parts by weight: 30g of lily, 25g of spina date seed, 8g of poria cocos, 12g of rhizoma polygonati, 10g of polygonatum odoratum, 9g of lophatherum gracile and 6g of liquorice;
B. drying the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A for 60min in a 50 ℃ oven;
C. mixing the spina date seed, the poria cocos and the lily in the step A, adding 240mL of water, heating until the water is boiled and extracting for 1h, directly adding the liquorice into the extracting solution for adsorption until the extracting solution is completely adsorbed, drying the adsorption mixture in an oven at 55 ℃ for 120min, and sieving the dried mixture with a 10-mesh sieve;
D. and C, mixing the dried raw materials in the step B with the adsorption mixture in the step C, and packaging into 1g of bags.
Comparative example 1
The nerve-soothing and sleep-aiding substitutional tea of the comparative example 1 is prepared by the following formula and process:
weighing the following raw materials in parts by weight: 75g of lily and 25g of liquorice; adding 225mL of water into Bulbus Lilii, heating to boil, extracting for 1h, directly adding Glycyrrhrizae radix into the extractive solution, adsorbing until the extractive solution is completely adsorbed, drying the adsorption mixture in a 55 deg.C oven for 120min, sieving with 24 mesh sieve, and packaging into substitute tea bag of 2g per bag.
Comparative example 2
The nerve-soothing and sleep-aiding substitutional tea of the comparative example 2 is prepared by the following formula and process:
weighing the following raw materials in parts by weight: 75g of spina date seed and 25g of liquorice; adding 225mL of water into semen Ziziphi Spinosae, boiling and extracting for 1h, directly adding Glycyrrhrizae radix into the extractive solution for adsorption until the extractive solution is completely adsorbed, drying the adsorption mixture in oven at 55 deg.C for 120min, sieving with 24 mesh sieve, and packaging into substitute tea bag of 2g per bag.
Comparative example 3
The composition of the raw materials of comparative example 3 was: 35g of lily, 20g of spina date seed, 12g of poria cocos, 8g of lophatherum gracile and 25g of liquorice; the preparation method is the same as that of example 2.
Comparative example 4
Comparative example 4 is different from example 2 in that the preparation process does not have the steps of water boiling and adsorption, and all the raw materials are directly placed in an oven with the temperature of 50 ℃ for drying for 60min and then packaged into 2g of substitutional tea in each bag.
Animal experiments
1. Animal grouping: the 40 experimental rats were randomly divided into 4 groups: blank control group, model control group, treatment group 1, treatment group 2, 10 each.
2. Establishing a model: preparing parachlorophenylalanine (PCPA) into suspension with the concentration of 30mg/mL by using weak alkaline physiological saline with the pH value of 7-8, respectively injecting 1mL/100g of PCPA suspension into the abdominal cavity of a model control group and a treatment group once a day for 2 days continuously; injecting the same volume of alkalescent normal saline into the abdominal cavity of a blank control group; after the first intraperitoneal injection is carried out for 28-30h, the circadian rhythm of the rat disappears, the activity is increased, the rat is difficult to fall asleep and is easy to be awakened by environmental interference, the overall observation is obviously different from that of a blank control group, and the model establishment is successful.
3. The test method comprises the following steps: the substitute tea prepared in example 2 and comparative example 2 was respectively brewed into 300mL solution for gastric perfusion. After the model is established, the rats in the treatment group are administrated by intragastric administration according to 1ml/100g, the tea is replaced in the intragastric administration example 2 in the treatment group 1, the tea is replaced in the intragastric administration comparative example 2 in the treatment group 2, 1 time per day, and the administration is continuously carried out for 8 days. The autonomic activity of the rats was measured 30 minutes before and after the administration on day 1 and day 7, respectively, and after the rats were placed in an autonomic activity apparatus to adapt for 2min, the autonomic activity frequency of the rats for 5min and the average value of each group were recorded. Pentobarbital sodium 30mg/kg is intraperitoneally injected 30min after the last administration, and the sleep latency (from pentobarbital sodium injection to disappearance of righting reflex) and the sleep time (from disappearance of righting reflex to restoration to normal) of each group of rats are observed and recorded.
4. As a result: compared with a blank control group, the PCPA induced rat insomnia model can increase rat autonomous activity, prolong sleep latency and shorten sleep time. Whereas the number of voluntary activities in the rats of treatment group 1 was significantly reduced after 7 days of administration. The sleep latency of treatment group 1 was significantly lower than that of the model control group and the blank control group, while the duration of sleep was the longest and significantly different from that of the model control group and the blank control group. Treatment group 1 had lower numbers of autonomic activity than treatment group 2 and had less sleep latency than treatment group 2 and longer sleep time than treatment group 2 after day 7 dosing. The results are shown in Table 1.
TABLE 1 autonomous Activity times, sleep latency and sleep time of rats in each group
Clinical observations
1. Clinical cases: the patients who have insomnia for more than one week are selected and randomly divided into 8 groups; the number of effective cases is 735, including 123 patients 15-24 years old, 382 patients 25-40 years old, 170 patients 41-60 years old, and 60 patients over 60 years old.
2. The treatment method comprises the following steps: the group A to the group D take the substitutional tea of the embodiment 1-4 of the invention respectively, the group E to the group I take the substitutional tea of the comparative example 1-4 respectively, each bag is brewed with about 300mL of boiled water for 3-5 minutes and can be drunk, each bag can be brewed for 3-4 times repeatedly, one bag is taken every day, and the tea is taken for 6 weeks continuously.
3. The therapeutic effect judgment standard is as follows: efficacy was assessed as Pittsburgh Sleep Quality Index (PSQI) and assessed before, 2 weeks, 4 weeks and 6 weeks of treatment, respectively. PSQI reduction rate was used as therapeutic efficacy criterion: and (3) healing: the PSQI reduction rate is more than 80%; the effect is shown: the PSQI reduction rate is 60-80%; the method has the following advantages: the PSQI reduction rate is 30-60%; and (4) invalidation: the PSQI reduction fraction is less than 30%.
4. Therapeutic effects
The PSQI comprehensive score results of each group showed that the PSQI score was significantly lower than that before treatment after 4 weeks of administration of the tea substitute of the present invention, and the total effective rate of examples 1 to 4 reached 80% or more after 6 weeks of administration (table 3). The effective rate of the comparative examples 1 to 3 is lower than that of the examples, because one or two traditional Chinese medicines are saved in the raw materials, the synergistic effect of the formula is weakened. And comparative example 4 is obtained by directly drying without water boiling and adsorption processes, so that the dissolution rate of the main components of the lily, the spina date seed and the tuckahoe is reduced, and the treatment effect is influenced. After the insomnia patients who participate in clinical observation are treated for 6 weeks, more than 7 patients gradually try to reduce the use amount while improving the sleep, and finally stop using the medicine, so that the insomnia symptoms do not rebound, which indicates that the product does not generate dependence and tolerance.
TABLE 2 statistic of PSQI composite scores for each group of clinical observations
Group of Examples 0 week 2 weeks 4 weeks 6 weeks
A Example 1 16.37 14.35 10.18 6.26
B Example 2 15.98 14.02 9.50 5.42
C Example 3 17.24 14.86 9.82 7.07
D Example 4 16.83 14.15 10.07 6.52
E Comparative example 1 17.03 16.89 14.73 11.32
F Comparative example 2 16.28 15.53 14.29 10.76
G Comparative example 3 15.66 15.03 13.85 9.86
I Comparative example 4 17.02 16.83 14.68 10.51
TABLE 3 statistics of the efficacy of each group of clinical observations
Examples Number of people Recovery method Show effect Is effective Invalidation Total effective rate
Example 1 89 5 26 52 6 93.26%
Example 2 93 9 30 49 5 94.62%
Example 3 94 7 24 53 10 89.36%
Example 4 92 6 22 56 8 91.30%
Comparative example 1 92 2 16 48 26 71.74%
Comparative example 2 88 1 20 39 28 68.18%
Comparative example 3 92 3 19 43 27 70.65%
Comparative example 4 95 1 15 50 29 69.47%
The specific embodiments described herein are merely illustrative of the spirit of the invention and do not limit the scope of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.

Claims (7)

1. The substitutional tea for soothing the nerves and helping sleep is characterized by being prepared from the following traditional Chinese medicine raw materials in percentage by weight: 30-40% of lily, 10-30% of spina date seed, 5-15% of poria cocos, 5-15% of rhizoma polygonati, 5-10% of polygonatum odoratum, 5-10% of lophatherum gracile and 5-10% of liquorice.
2. The substitutional tea for soothing nerves and helping sleep according to claim 1, which is prepared from the following traditional Chinese medicine raw materials in percentage by weight: 32-38% of lily, 12-25% of spina date seed, 6-12% of poria cocos, 6-12% of rhizoma polygonati, 6-9% of polygonatum odoratum, 6-9% of lophatherum gracile and 6-9% of liquorice.
3. The substitutional tea for soothing nerves and helping sleep according to claim 1, which is prepared from the following traditional Chinese medicine raw materials in percentage by weight: 35% of lily, 20% of spina date seed, 12% of poria cocos, 9% of rhizoma polygonati, 9% of polygonatum odoratum, 8% of lophatherum gracile and 7% of liquorice.
4. A method for preparing the nerve-soothing and sleep-aiding substitutional tea of any one of claims 1 to 3, which comprises the following steps:
A. weighing the following raw materials in percentage by weight: 30-40% of lily, 10-30% of spina date seed, 5-15% of poria cocos, 5-15% of rhizoma polygonati, 5-10% of polygonatum odoratum, 5-10% of lophatherum gracile and 5-10% of liquorice;
B. placing the sealwort, the polygonatum odoratum and the lophatherum gracile in the step A into an oven for drying;
C. mixing the spina date seed, the poria cocos and the lily in the step A, adding water, heating and extracting, adsorbing an extracting solution by using liquorice, drying and sieving;
D. and C, mixing the dried raw materials in the step B and the adsorption mixture in the step C, and packaging.
5. A preparation method of the tea substitute for soothing nerves and aiding sleep according to claim 4, wherein the drying temperature in the step B is 50-70 ℃, and the drying time is 30-60 min.
6. The preparation method of the substitutional tea for soothing nerves and helping sleep according to claim 4, wherein the extraction process in the step C is that the water addition amount is 1-4 times of the mass of the raw materials, and the extraction time is 1-2 h.
7. The method for preparing the substitutional tea for soothing nerves and aiding sleep according to claim 4, wherein the sieve in the step C has a pore size of 10-40 meshes.
CN201910918885.6A 2019-09-26 2019-09-26 Nerve-soothing and sleep-aiding substitutional tea and preparation method thereof Pending CN110638945A (en)

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