CN116196352A - Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof - Google Patents
Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof Download PDFInfo
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- CN116196352A CN116196352A CN202211107153.7A CN202211107153A CN116196352A CN 116196352 A CN116196352 A CN 116196352A CN 202211107153 A CN202211107153 A CN 202211107153A CN 116196352 A CN116196352 A CN 116196352A
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Abstract
The invention provides compound essential oil for inducing resuscitation and refreshing mind, and a preparation method and application thereof. The preparation method comprises the following steps of: the preparation comprises storax essential oil, borneol, dried orange peel essential oil, patchouli essential oil, jasmine essential oil and citrus essential oil. The compound essential oil is prepared by utilizing the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicine, adopting threo essential oil as monarch drug, adopting borneol and dried orange peel essential oil as ministerial drug, adopting patchouli essential oil and jasmine essential oil as assistant and adopting citrus essential oil as guide, and preparing the compound essential oil capable of relieving symptoms such as dizziness, headache, nausea, vomiting, tinnitus, giddiness and the like caused by hypoxia. The preparation method comprises the step of uniformly mixing the preparation raw materials according to the proportion. The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, and has scientific formula proportion, safety and effectiveness. Experimental study shows that the anti-hypoxia effect is remarkable.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to compound essential oil for inducing resuscitation and refreshing mind, and a preparation method and application thereof.
Background
With the rapid development of socioeconomic performance, the working pressure and the learning pressure of people also increase dramatically. Long-time work or study can accelerate the consumption of oxygen by the brain and cause cerebral hypoxia symptoms. In addition, since the outbreak of new coronavirus pneumonia, masks have become a necessary protective tool for people. However, when the mask is worn for a long time, the gas exchange is affected, so that the organism is in an anoxic environment, the combination of hemoglobin and oxygen is reduced, and the deficiency of cerebral blood and oxygen supply is caused, thereby symptoms such as dizziness, nausea, tinnitus and the like appear. The traditional Chinese medicine considers that the spleen is the "acquired origin" and "the source of qi and blood biochemistry", the spleen is good in transport and strength, the vital energy is abundant, the mind is used mechanically, and if the spleen is damaged and the source is insufficient, the brain marrow is malnourished. The brain governs the mental mind and changes in mind and consciousness, and is externally applied to orifices such as the nose and ear, and is suitable for treating orifice diseases caused by stagnation of lung qi, depression of six fu organs, etc., which are commonly treated by syndrome differentiation and compatibility of aromatic resuscitation, and has wide treatment range. Ancient doctors considered that aromatic drugs are best good at entering spleen and stomach meridians, inducing resuscitation, and strengthening spleen and stomach to nourish five sense organs.
The aromatic essential oil is volatile matter obtained by processing and extracting aromatic plants, has small molecular weight and high lipophilicity, and is easy to penetrate through blood brain barrier, so as to achieve the effects of aromatic resuscitation, evil dispelling and mind reviving. For example, storax has a certain protection effect on acute cerebral ischemia and hypoxia of mice, and obviously prolongs the survival time of normal-pressure hypoxia mice; the pericarpium Citri Tangerinae essential oil has gastrointestinal tract stimulating effect, and can increase salivary amylase activity, promote gastric juice and bile secretion, and effectively enhance gastrointestinal digestion. The invention provides a compound essential oil with the effects of inducing resuscitation and refreshing mind, a preparation method and application thereof, and the compound essential oil is safe in source, obvious in effect and capable of meeting the requirements of users.
Disclosure of Invention
The invention aims to provide compound essential oil for inducing resuscitation and refreshing mind, and a preparation method and application thereof. The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, has scientific formula proportion and remarkable anti-hypoxia activity, and has the effects of inducing resuscitation and refreshing mind.
The first aspect of the invention discloses a compound essential oil for inducing resuscitation and refreshing, which comprises the following preparation raw materials: the preparation comprises storax essential oil, borneol, dried orange peel essential oil, patchouli essential oil, jasmine essential oil and citrus essential oil.
In some embodiments, the preparation materials include the following parts by weight: 1-10 parts of threo essential oil, 1-10 parts of borneol, 50-180 parts of dried orange peel essential oil, 1-50 parts of patchouli essential oil, 1-30 parts of jasmine essential oil and 50-150 parts of citrus essential oil.
In some embodiments, the preparation materials include the following parts by weight: 1-5 parts of threo essential oil, 1-5 parts of borneol, 80-100 parts of dried orange peel essential oil, 10-30 parts of patchouli essential oil, 20-30 parts of jasmine essential oil and 60-100 parts of citrus essential oil.
In some embodiments, the preparation materials include the following parts by weight: 1 part of threo essential oil, 2 parts of borneol, 85 parts of dried orange peel essential oil, 20 parts of patchouli essential oil, 10 parts of jasmine essential oil and 70 parts of citrus essential oil.
The second aspect of the invention provides a preparation method of the compound essential oil, which is characterized in that the preparation raw materials are uniformly mixed.
The third aspect of the invention provides a compound essential oil, which is characterized by being prepared according to the preparation method.
The fourth aspect of the invention provides application of the compound essential oil, which is characterized in that the compound essential oil is used for inducing resuscitation and refreshing.
The fifth aspect of the invention provides the application of the compound essential oil in preparing anti-hypoxia drugs or sanitary products. The method is characterized in that: the antihypoxic is a spray composed of compound essential oil, or is a civil sanitary product prepared by taking the compound essential oil as an active ingredient and adding conventional auxiliary materials according to the conventional preparation process of traditional Chinese medicines, and comprises a mask, a sachet and the like.
The sixth aspect of the invention provides an anti-hypoxia drug, which is characterized by comprising the compound essential oil. The antihypoxic may also include pharmaceutically acceptable adjuvants.
The seventh aspect of the invention provides a refreshing efficacy evaluation of the compound essential oil on subjective feeling of human body.
Compared with the prior art, the invention has the following technical advantages:
(1) The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, and has scientific formula proportion, safety and effectiveness.
(2) Storax in the compound essential oil is a monarch drug, and the spicy flavor of the storax walks away and reaches orifices, so that the drug directly reaches focus. Borneol is strong in fragrance, especially good at reaching the head and face, and carries medicine upwards; dried orange peel regulates qi and harmonizes middle energizer, regulates qi movement, assists monarch drugs in inducing resuscitation and refreshing mind, and is used as ministerial drug. Herba Pogostemonis resolves dampness, arrest vomiting and assist monarch drugs in resolving turbidity; jasmine sooth liver, relieve depression, invigorate spleen, assist ministerial drugs and middle energizer. The citrus fruit can promote the production of body fluid, promote the appetite and harmonize the smell. The whole recipe can induce resuscitation and refresh mind, invigorate spleen and harmonize stomach, and play a role in refreshing mind together.
(3) Experimental study shows that the compound essential oil provided by the invention has remarkable anti-hypoxia activity.
(4) The preparation method is simple, does not need a complex preparation process, and is economical and environment-friendly.
(5) The compound essential oil of the invention is proved by experiments to ensure safe and reliable medication, quick absorption and remarkable effect, and can meet the requirements of users.
Drawings
FIG. 1 is a graph of data showing the effect of compound essential oil of example 1 on sodium dithionite-induced survival of PC12 nerve cells;
FIG. 2 is a graph of data showing the effect of storax on sodium dithionite-induced survival of PC12 neurons;
FIG. 3 is a graph of data showing the effect of patchouli on sodium dithionite-induced survival of PC12 neurons;
FIG. 4 is a graph of data showing the effect of jasmine on sodium dithionite-induced survival of PC12 neurons;
FIG. 5 is a graph showing the evaluation results of subjective feelings of the compound essential oil of example 1 on human bodies;
compared to the model group, (# # P < 0.001);
compared with the control group, the P is less than 0.1, P is less than 0.01 and P is less than 0.001.
Detailed Description
The invention is further illustrated by means of the following examples, which are not intended to limit the scope of the invention. The experimental methods, in which specific conditions are not noted in the following examples, were selected according to conventional methods and conditions, or according to the commercial specifications.
Su He and Xiang are warm in nature, and enter heart and spleen meridians to induce resuscitation, expel dirty and alleviate pain. The storax volatile oil can obviously prolong the sleep latency of mice caused by sodium pentobarbital, shorten the sleep duration and have a certain waking effect.
Bing pian is pungent and bitter in nature and slightly cold in nature, and enters heart, spleen and lung meridians, it can induce resuscitation and refresh mind, clear heat and alleviate pain. The borneol can obviously inhibit ischemia and hypoxia injury caused by sodium dithionite to PC12 cells, plays a role in protecting nerve cells, and preliminarily proves that volatile components are the material basis for playing the role of neuroprotection and resisting ischemia and hypoxia.
Chen Pi is bitter and pungent in flavor, warm in nature, enters lung and spleen meridians, and can regulate qi and invigorate spleen, dry dampness and resolve phlegm. The pericarpium Citri Tangerinae has dose-dependent effect in enhancing pepsin activity, increasing gastric acid secretion and motilin content, gastrin content, and beta-endorphin content in blood plasma, promoting gastric emptying, and improving and regulating anorexia of young rats.
Herba Pogostemonis, pungent and slightly warm in nature, enters spleen, stomach and lung meridians, and can be used for removing turbid pathogen by aromatics, regulating middle energizer and relieving vomiting, and relieving summer-heat. The patchouli volatile oil can inhibit spontaneous contraction of in vitro intestine and spasmodic contraction caused by acetylcholine and barium chloride, increase gastric acid secretion, improve pepsin activity, promote pancreas to secrete amylase, and improve serum amylase activity.
Jasmine is pungent and slightly sweet, has warm nature, enters spleen, stomach and liver meridians, and can regulate qi, resolve depression, and remove dirt and harmonize middle energizer. The jasmine extracting solution can obviously prolong the survival time of mice under normal pressure hypoxia-tolerant conditions, has an effect of improving cerebral hypoxia, and can obviously reduce the oxygen consumption of organisms.
Orange is sweet and sour, cool in nature, enters spleen, stomach and bladder meridians, and can promote the production of body fluid to relieve cough, moisten lung and resolve phlegm. The citrus peel can prolong the time required by the asphyxia death of the mice in the anoxic environment, has extremely remarkable anti-anoxic effect, prolongs the weight-bearing swimming death time of the mice, and has a certain anti-fatigue effect.
Example 1
Taking 1 part by weight of threo essential oil, 2 parts by weight of borneol, 85 parts by weight of tangerine peel essential oil, 20 parts by weight of patchouli essential oil, 10 parts by weight of jasmine essential oil and 70 parts by weight of citrus essential oil, and uniformly mixing to obtain the compound essential oil.
Example 2
Mixing 1.2 parts by weight of threo essential oil, 2.4 parts by weight of borneol, 102 parts by weight of tangerine peel essential oil, 24 parts by weight of patchouli essential oil, 12 parts by weight of jasmine essential oil and 84 parts by weight of citrus essential oil uniformly to obtain the compound essential oil.
Example 3
Taking 1.5 parts by weight of threo essential oil, 3 parts by weight of borneol, 128 parts by weight of tangerine peel essential oil, 30 parts by weight of patchouli essential oil, 15 parts by weight of jasmine essential oil and 105 parts by weight of citrus essential oil, and uniformly mixing to obtain the compound essential oil.
Example 4
Drug efficacy and safety experiment:
(1) Influence of the Compound essential oil of the invention on the survival rate of the sodium dithionite-induced PC12 cell injury model:
and detecting the refreshing activity of the essential oil based on the cytotoxicity concentration of the essential oil on PC 12. PC12 cells in logarithmic growth phase were collected at a cell density of about 2.5X10 4 Individual mL －1 The cell suspension was inoculated in 96-well plates for culture. 37 ℃,5% CO 2 Culturing for 24 hours under the condition. After the cells adhere to the wall, the original medium is discarded. Cells were divided into control, model and dosing groups. The control group and the model group are added with 100 mu L of 1640 culture medium for culture, the concentration of compound essential oil in the administration group is 1/4, 1/8, 1/16, 1/32, 1/64 and 1/128 of the original formula, and the concentration of single medicine storax and patchouli is 10, 5, 2.5, 1.25, 0.625 and 0.313 mu g.mL －1 The concentration of the dried orange peel of the single medicine is 100, 50, 25, 12.5, 6.25 and 3.13 mu g.mL －1 The concentration of single drug jasmine is 200, 100, 50, 25, 12.5 and 6.25 mug.mL －1 Each group was set with 5 parallel duplicate wells and incubated for 24h. After 24 hours of drug action, 100 mu L of the model group and the administration group are added simultaneously with 16 mmol.L of final concentration －1 Na 2 S 2 O 4 100 mu L of 1640 basal medium is added into the control group, and the model is built for 2h. Both modeling methods can enable the survival rate of the model group cells to be about 50%. After the molding was completed, the medium was discarded, and 100. Mu.L of 0.5 mg/mL of the medium was added to each well －1 Is a solution of MTT. After 4h incubation, the supernatant was discarded, 150. Mu.L of DMSO was added to each well and the crystals were dissolved well by shaking for 10 min. Measuring the absorbance of each hole by using an enzyme-labeled instrument, and calculating the cell activity according to the measured absorbance, wherein the detection wavelength is 490nm, so as to reflect the refreshing activity of the compound essential oil.
The experimental results are shown in fig. 1-4, and compared with single monosodium glutamate oil, the compound essential oil has the advantages that the storax, the patchouli and the jasmine of the single monosodium glutamate oil can obviously increase the survival rate of the PC12 cell damage model induced by sodium dithionite, and the anti-hypoxia activity of the compound essential oil is obvious.
(2) The refreshing efficacy of the compound essential oil in human body is evaluated by the subjective feeling scale of human body:
7 volunteers 20-30 years old are recruited, and a common mask and a mask with compound essential oil are worn for 1h respectively, so that fragrance is kept durable, and subjective feeling evaluation is performed. After wearing, subjective feeling evaluation is carried out on the refreshing efficacy of the compound essential oil, and adverse reactions which occur to the hypoxia symptom are selected as corresponding subjective indexes, wherein as shown in table 1, the higher the score is, the worse the refreshing efficacy is.
TABLE 1 subjective feeling evaluation index of refreshing efficacy
As shown in the experimental results in figure 5, compared with the blank group, the compound essential oil group has obvious improvement effects on indexes such as yawning, strength dizziness, head distention, suffocating, slight chest distress, hypodynamia and the like, and the compound essential oil has the effects of inducing resuscitation and refreshing mind.
The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, and yet fall within the scope of the invention.
Claims (10)
1. A compound essential oil for inducing resuscitation and refreshing mind, and a preparation method and application thereof are characterized by comprising the following preparation raw materials: the preparation comprises storax essential oil, borneol, dried orange peel essential oil, patchouli essential oil, jasmine essential oil and citrus essential oil.
2. The compound essential oil of claim 1, wherein the compound essential oil comprises the following preparation raw materials in parts by weight: 1-10 parts of threo essential oil, 1-10 parts of borneol, 50-180 parts of dried orange peel essential oil, 1-50 parts of patchouli essential oil, 1-30 parts of jasmine essential oil and 50-150 parts of citrus essential oil.
3. The compound essential oil of claim 1, wherein the compound essential oil comprises the following preparation raw materials in parts by weight: 1-5 parts of threo essential oil, 1-5 parts of borneol, 80-100 parts of dried orange peel essential oil, 10-30 parts of patchouli essential oil, 20-30 parts of jasmine essential oil and 60-100 parts of citrus essential oil.
4. The compound essential oil of claim 1, wherein the compound essential oil comprises the following preparation raw materials in parts by weight: 1 part of threo essential oil, 2 parts of borneol, 85 parts of dried orange peel essential oil, 20 parts of patchouli essential oil, 10 parts of jasmine essential oil and 70 parts of citrus essential oil.
5. A method for preparing the compound essential oil according to any one of claims 1 to 4, wherein the preparation raw materials are uniformly mixed.
6. A compound essential oil, characterized by being prepared according to the method of claim 5.
7. The use of a compound essential oil according to any one of claims 1-4 or 6, wherein the compound essential oil is used for inducing resuscitation and refreshing.
8. The use of a compound essential oil according to any one of claims 1-4 or 6 for the preparation of an anti-hypoxia drug or hygiene product, characterized in that: the antihypoxic is a spray composed of compound essential oil, or is a civil sanitary product prepared by taking the compound essential oil as an active ingredient and adding conventional auxiliary materials according to the conventional preparation process of traditional Chinese medicines, and comprises a mask and a sachet.
9. An antihypoxic comprising the compound essential oil according to any one of claims 1-4 or 6.
10. The antihypoxic according to claim 9, further comprising a pharmaceutically acceptable adjuvant.
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