CN113230307A - Chinese medicinal refreshing compound essential oil and preparation method thereof - Google Patents

Chinese medicinal refreshing compound essential oil and preparation method thereof Download PDF

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CN113230307A
CN113230307A CN202110551329.7A CN202110551329A CN113230307A CN 113230307 A CN113230307 A CN 113230307A CN 202110551329 A CN202110551329 A CN 202110551329A CN 113230307 A CN113230307 A CN 113230307A
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essential oil
chinese medicine
traditional chinese
mint
refreshing compound
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沈霞
郗仕琼
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Shaanxi University of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

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Abstract

The invention provides a traditional Chinese medicine refreshing compound essential oil and a preparation method thereof, belonging to the technical field of traditional Chinese medicine product preparation, and the traditional Chinese medicine refreshing compound essential oil comprises borneol, peppermint essential oil, angelica essential oil and essential oil auxiliary materials, wherein the volume ratio of the peppermint essential oil to the angelica essential oil to the essential oil auxiliary materials is 100: 30-80:200 and 500, wherein 0.05g-0.2g of borneol is added into each 100ml of mint essential oil. The traditional Chinese medicine refreshing compound essential oil can radiate through the medicine properties of the mint, the angelica dahurica and the borneol when a person is in a state of drowsiness, fatigue and weakness and stimulate nerve centers through olfaction, thereby achieving the effects of improving and regulating body functions, relieving depression, removing fatigue and refreshing.

Description

Chinese medicinal refreshing compound essential oil and preparation method thereof
Technical Field
The invention belongs to the technical field of preparation of traditional Chinese medicine products, and relates to a product for improving eyesight and refreshing mind, in particular to traditional Chinese medicine refreshing compound essential oil and a preparation method thereof.
Background
With the rapid development of society, people gradually tend to fast-paced life, the working and learning time is long, and the method is particularly obvious in large and medium-sized cities. If the patient is subjected to long-term study or work and lacks rest, the patient is easy to be over-fatigued to cause sudden death. In this state, not only the efficiency of work and study is reduced, but also anxiety and tension are easily generated, and the health of the user is damaged. In most cases, people will choose coffee, tea, and even functional beverages to refresh and relieve fatigue. From the medical point of view, the long-term drinking of a large amount of tea, coffee, functional beverages and the like can cause symptoms of hand sweat, palpitation and tinnitus, stimulate gastric mucosa, stimulate vasodilatation, accelerate blood circulation, greatly increase the burden of cardiovascular vessels, cause blood pressure rise and arrhythmia, and interfere with the normal electrolyte balance of human bodies. The health care product has great harm to human bodies, and can influence normal sleep, nutrient absorption, growth hormone secretion and the like particularly for high and early school students in study. Products with certain refreshing effect in the current market comprise Liushen toilet water, essential balm, cooling oil and refreshing traditional Chinese medicine sachet. The main functions of the Liushen toilet water, the essential balm and the cooling oil are as follows: expelling parasites, relieving itching, refreshing brain, clearing away heat, and refreshing brain. The main use time is summer, and seasonal limitation is realized. Essential balm and cooling balm belong to medicines, have strong irritation and lack of comfort, and are not suitable for being used in some public places. Compared with the first three, the traditional Chinese medicine sachet can refresh, but the utilization degree is not complete, and the excessive waste of the medicinal materials is easily caused, so that the existing refreshing product in the market cannot completely meet the requirements of users. No matter the office workers, the students or the drivers, how to change the fatigue work becomes a big problem.
Disclosure of Invention
Aiming at the problems that the refreshing product in the current market is poor in comfort level and strong in irritation and is not suitable for being used in public places, the invention provides the traditional Chinese medicine refreshing compound essential oil and the preparation method thereof. The specific technical scheme is as follows:
the traditional Chinese medicine refreshing compound essential oil comprises borneol, mint essential oil, angelica essential oil and essential oil auxiliary materials, wherein the volume ratio of the mint essential oil to the angelica essential oil to the essential oil auxiliary materials is 100: 30-80:200 and 500, wherein 0.05g-0.2g of borneol is added into each 100ml of mint essential oil.
Further limiting, the volume ratio of the mint essential oil, the angelica essential oil and the essential oil auxiliary material is 100:50:400, and 0.05g of borneol is added into each 100ml of mint essential oil.
Further limited, the essential oil auxiliary materials comprise cedar essential oil, gardenia essential oil and bergamot essential oil.
Further limiting, the volume ratio of cedar essential oil, gardenia essential oil and bergamot essential oil contained in the essential oil auxiliary material is 2:1: 1.
Further limited, the essential oil auxiliary materials also comprise rose essential oil, jasmine essential oil, citronella essential oil and calendula essential oil.
Further limiting, the volume ratio of cedar essential oil, gardenia essential oil, bergamot essential oil, rose essential oil, jasmine essential oil, citronella essential oil and calendula essential oil contained in the essential oil auxiliary materials is 2:1:1:1:1: 1.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving Borneolum Syntheticum with oleum Menthae Dementholatum, adding oleum Menthae Dementholatum for several times, stirring, adding radix Angelicae Dahuricae essential oil, stirring, and making into base solution;
2) adding essential oil adjuvants into the basic solution, stirring, and mixing to obtain the Chinese medicinal refreshing compound essential oil.
Further limited, the preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) adding 0.05g-0.2g of borneol into 5-20ml of mint essential oil, then adding the mint essential oil for multiple times, adding the mint essential oil for each time, stirring until the total adding volume of the mint essential oil is 100ml, adding 30ml-80ml of angelica essential oil, stirring until the mixture is uniformly mixed, and preparing a basic solution;
2) adding 200 plus 500ml of essential oil auxiliary materials into the basic solution, and stirring and uniformly mixing to form the traditional Chinese medicine refreshing compound essential oil.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine refreshing compound essential oil comprises peppermint essential oil, angelica essential oil, borneol and essential oil auxiliary materials, wherein the volume ratio of the peppermint essential oil to the angelica essential oil to the essential oil auxiliary materials is 100: 30-80:200 and 500, wherein 0.05g-0.2g of borneol is added into each 100ml of mint essential oil. When a person is in a state of drowsiness, fatigue and weakness, the mint essential oil, the angelica essential oil and the borneol in the medicine emit the medicine properties to stimulate nerve centers through olfaction, thereby achieving the effects of improving and regulating body functions, relieving depression, removing fatigue and refreshing; is very suitable for the crowds who are easy to have work fatigue, such as office workers, student workers, drivers and the like.
2. The essential oil auxiliary materials comprise cedar essential oil, gardenia essential oil, bergamot essential oil, rose essential oil, jasmine essential oil, citronella essential oil and calendula essential oil, and the odor, aroma and strength of the basic solution are blended through the essential oil auxiliary materials, so that the product has better odor and high durability.
3. The traditional Chinese medicine refreshing compound essential oil is prepared by mutual compatibility of the medicinal properties of the mint essential oil, the angelica essential oil and the borneol, can be selectively used by time, place and people, can refresh the brain, relieve fatigue and improve mood while playing the effect of the essential oil, has good effects of relieving depression, removing fatigue and refreshing the brain, and is suitable for use after being developed for each time; meanwhile, the population in the sub-health state can be integrally regulated and controlled, and is not limited to improving local symptoms; the health-care principle of preventing diseases before and after diseases and preventing changes is followed to achieve the aims of strengthening the body resistance, preserving essence and nourishing spirit and both shape and spirit.
4. The traditional Chinese medicine refreshing compound essential oil can be filled in small bottles, is packaged by using novel liquid small ball type, bead coating type, traditional spraying type and other modes, and is convenient to carry and use.
Detailed Description
The technical aspects of the present invention will be further explained below with reference to specific embodiments, but the present invention is not limited to the embodiments explained below.
Example 1
The traditional Chinese medicine refreshing compound essential oil comprises 0.05g of borneol, 100ml of mint essential oil, 50ml of angelica essential oil and 200ml of essential oil auxiliary materials, wherein the essential oil auxiliary materials comprise 100ml of cedar essential oil, 50ml of gardenia essential oil and 50ml of bergamot essential oil.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving 0.05g of borneol in 5ml of mint essential oil, stirring to mix uniformly, adding 20ml of mint essential oil, stirring to mix uniformly, then adding the remaining 75ml of mint essential oil, stirring to mix uniformly, adding 50ml of angelica essential oil, and preparing a basic solution;
2) and adding 100ml of cedar essential oil, 50ml of gardenia essential oil and 50ml of bergamot essential oil into the basic solution in sequence, and fully stirring and uniformly mixing to form the traditional Chinese medicine refreshing compound essential oil.
Example 2
The traditional Chinese medicine refreshing compound essential oil comprises 0.05g of borneol, 100ml of mint essential oil, 40ml of angelica essential oil and 300ml of essential oil auxiliary materials, wherein the essential oil auxiliary materials comprise 150ml of cedar essential oil, 75ml of gardenia essential oil and 75ml of bergamot essential oil.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving 0.05g of borneol in 10ml of mint essential oil, stirring to mix uniformly, adding 30ml of mint essential oil, stirring to mix uniformly, then adding the rest 60ml of mint essential oil, stirring to mix uniformly, adding 50ml of angelica essential oil, and preparing a basic solution;
2) and sequentially adding 150ml of cedar essential oil, 75ml of gardenia essential oil and 75ml of bergamot essential oil into the basic solution, and fully stirring and uniformly mixing to form the traditional Chinese medicine refreshing compound essential oil.
Example 3
The traditional Chinese medicine refreshing compound essential oil comprises 0.08g of borneol, 100ml of mint essential oil, 60ml of angelica essential oil and 400ml of essential oil auxiliary materials, wherein the essential oil auxiliary materials comprise 200ml of cedar essential oil, 100ml of gardenia essential oil and 100ml of bergamot essential oil.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving 0.08g of borneol in 12ml of mint essential oil, stirring to mix uniformly, adding 28ml of mint essential oil, stirring to mix uniformly, then adding the rest 70ml of mint essential oil, stirring to mix uniformly, adding 60ml of angelica essential oil, and preparing a basic solution;
2) and sequentially adding 200ml of cedar essential oil, 100ml of gardenia essential oil and 100ml of bergamot essential oil into the basic solution, and fully stirring and uniformly mixing to form the traditional Chinese medicine refreshing compound essential oil.
Example 4
The traditional Chinese medicine refreshing compound essential oil comprises 0.1g of borneol, 100ml of mint essential oil, 70ml of angelica essential oil and 400ml of essential oil auxiliary materials, wherein the essential oil auxiliary materials comprise 50ml of cedar essential oil, 25ml of gardenia essential oil, 25ml of bergamot essential oil, 25ml of rose essential oil, 25ml of jasmine essential oil, 25ml of citronella essential oil and 25ml of calendula essential oil.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving 0.1g of borneol in 15ml of mint essential oil, stirring to mix uniformly, adding 25ml of mint essential oil, stirring to mix uniformly, then adding the rest 60ml of mint essential oil, stirring to mix uniformly, adding 70ml of angelica essential oil, and preparing a basic solution;
2) adding 50ml of cedar essential oil, 25ml of gardenia essential oil, 25ml of bergamot essential oil, 25ml of rose essential oil, 25ml of jasmine essential oil, 25ml of citronella essential oil and 25ml of calendula essential oil into the basic solution in sequence, and fully stirring until the mixture is completely mixed to form the traditional Chinese medicine refreshing compound essential oil.
Example 5
The traditional Chinese medicine refreshing compound essential oil comprises 0.15g of borneol, 100ml of mint essential oil, 80ml of angelica essential oil and 400ml of essential oil auxiliary materials, wherein the essential oil auxiliary materials comprise 100ml of cedar essential oil, 50ml of gardenia essential oil, 50ml of bergamot essential oil, 50ml of rose essential oil, 50ml of jasmine essential oil, 50ml of citronella essential oil and 50ml of calendula essential oil.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving 0.15g of borneol in 20ml of mint essential oil, stirring to mix uniformly, adding 80ml of angelica essential oil, and preparing a basic solution;
2) adding 100ml of cedar essential oil, 50ml of gardenia essential oil, 50ml of bergamot essential oil, 50ml of rose essential oil, 50ml of jasmine essential oil, 50ml of citronella essential oil and 50ml of calendula essential oil into the basic solution in sequence, and fully stirring until the mixture is completely mixed to form the traditional Chinese medicine refreshing compound essential oil.
Example 6
The traditional Chinese medicine refreshing compound essential oil comprises 0.2g of borneol, 100ml of mint essential oil, 30ml of angelica essential oil and 500ml of essential oil auxiliary materials, wherein the essential oil auxiliary materials comprise 140ml of cedar essential oil, 60ml of gardenia essential oil, 60ml of bergamot essential oil, 60ml of rose essential oil, 60ml of jasmine essential oil, 60ml of citronella essential oil and 60ml of calendula essential oil.
The preparation method of the traditional Chinese medicine refreshing compound essential oil comprises the following steps:
1) dissolving 0.2g of borneol in 20ml of mint essential oil, stirring to mix uniformly, adding 80ml of mint essential oil, stirring to mix uniformly, adding 30ml of angelica essential oil, and preparing a basic solution;
2) adding 140ml of cedar essential oil, 60ml of gardenia essential oil, 60ml of bergamot essential oil, 60ml of rose essential oil, 60ml of jasmine essential oil, 60ml of citronella essential oil and 60ml of calendula essential oil into the basic solution in sequence, and fully stirring the mixture until the mixture is completely mixed to form the traditional Chinese medicine refreshing compound essential oil.
Experimental group 1: 2ml of the Chinese medicinal refreshing compound essential oil prepared in the example 1 is taken, added with 20ml of distilled water, diluted and mixed evenly.
Experimental group 2: 2ml of essential balm is taken, 20ml of distilled water is added, diluted and mixed evenly.
Blank group: 20ml of distilled water.
12 mice were taken and left in the animal laboratory for 3 days to acclimatize. Dividing into 3 groups after three days, wherein each group comprises 4 mice, respectively placing the three groups into a transparent plastic box filled with diluted Chinese medicinal refreshing compound essential oil of an experimental group 1 for 15 minutes, a transparent plastic box filled with diluted essential balm of an experimental group 2 for 15 minutes and a transparent plastic box filled with blank distilled water for 15 minutes, then taking out the three groups of mice, placing the mice in an air environment for 15 minutes, irradiating pentobarbital sodium solution with the mass ratio of 50mg/kg and the concentration of 5% into abdominal cavities of the three groups of mice, taking the injection time until the mouse turning-over reflex appears as a sleep latency, taking the turning-over reflex disappearance duration time as the sleep time, and recording the injection time, the turning-over reflex time of the mice and the turning-over reflex disappearance time; the above experimental procedure was repeated 3 times every other day.
The specific time of each group of mice is counted by using SPSS statistical software, and the average sleep time and the average water surface latency of each group of mice are calculated, and the result is shown in the following table 1:
table 1: average sleep time and average sleep latency for each group of mice
Figure BDA0003075489370000051
As can be seen from table 1, compared with the essential balm, the traditional Chinese medicine refreshing compound essential oil prepared in example 1 has the advantages that the average sleep time is shortened by about 17 groups, and the sleep time is reduced by nearly 50%; compared with distilled water, the average sleep time is shortened by about 28 percent, and the sleep time is reduced by nearly 60 percent; therefore, the traditional Chinese medicine refreshing compound essential oil prepared in the embodiment 1 can obviously shorten the sleep time and prolong the water surface latency, and has good refreshing and consciousness restoring effects.
The above mouse experiment was repeated using the herbal refreshing compound essential oil prepared in example 2 to example 11, and the experimental results were the same as in example 1. Therefore, the traditional Chinese medicine refreshing compound essential oil can obviously shorten the sleep time and prolong the water surface incubation period, and has good refreshing and consciousness restoring effects.

Claims (8)

1. The traditional Chinese medicine refreshing compound essential oil is characterized by comprising borneol, mint essential oil, angelica essential oil and essential oil auxiliary materials, wherein the volume ratio of the mint essential oil to the angelica essential oil to the essential oil auxiliary materials is 100: 30-80:200 and 500, wherein 0.05g-0.2g of borneol is added into each 100ml of mint essential oil.
2. The traditional Chinese medicine refreshing compound essential oil as claimed in claim 1, wherein the volume ratio of the mint essential oil, the angelica essential oil and the essential oil auxiliary material is 100:50:400, and 0.05g of borneol is added in each 100ml of mint essential oil.
3. The traditional Chinese medicine refreshing compound essential oil according to claim 2, wherein the essential oil auxiliary materials comprise cedar essential oil, gardenia essential oil and bergamot essential oil.
4. The traditional Chinese medicine refreshing compound essential oil as claimed in claim 3, wherein the volume ratio of cedar essential oil, gardenia essential oil and bergamot essential oil contained in the essential oil auxiliary material is 2:1: 1.
5. The traditional Chinese medicine refreshing compound essential oil according to claim 4, wherein the essential oil auxiliary materials further comprise rose essential oil, jasmine essential oil, citronella essential oil and calendula essential oil.
6. The traditional Chinese medicine refreshing compound essential oil as claimed in claim 5, wherein the volume ratio of cedar essential oil, gardenia essential oil, bergamot essential oil, rose essential oil, jasmine essential oil, citronella essential oil and calendula essential oil contained in the essential oil auxiliary materials is 2:1:1:1:1: 1.
7. The preparation method of the traditional Chinese medicine refreshing compound essential oil based on claim 6 is characterized by comprising the following steps:
1) dissolving Borneolum Syntheticum with oleum Menthae Dementholatum, adding oleum Menthae Dementholatum for several times, stirring, adding radix Angelicae Dahuricae essential oil, stirring, and making into base solution;
2) adding essential oil adjuvants into the basic solution, stirring, and mixing to obtain the Chinese medicinal refreshing compound essential oil.
8. The preparation method of the traditional Chinese medicine refreshing compound essential oil as claimed in claim 7, which is characterized by comprising the following steps:
1) adding 0.05g-0.2g of borneol into 5-20ml of mint essential oil, then adding the mint essential oil for multiple times, adding the mint essential oil for each time, stirring until the total adding volume of the mint essential oil is 100ml, adding 30ml-80ml of angelica essential oil, stirring until the mixture is uniformly mixed, and preparing a basic solution;
2) adding 200 plus 500ml of essential oil auxiliary materials into the basic solution, and stirring and uniformly mixing to form the traditional Chinese medicine refreshing compound essential oil.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115737713A (en) * 2022-12-28 2023-03-07 安徽工业大学 Atomized essential oil with refreshing function and preparation method thereof
CN116196352A (en) * 2022-09-07 2023-06-02 威高(北京)医疗科技有限公司 Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116196352A (en) * 2022-09-07 2023-06-02 威高(北京)医疗科技有限公司 Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof
CN116196352B (en) * 2022-09-07 2024-05-17 威高(北京)医疗科技有限公司 Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof
CN115737713A (en) * 2022-12-28 2023-03-07 安徽工业大学 Atomized essential oil with refreshing function and preparation method thereof
CN115737713B (en) * 2022-12-28 2023-11-28 安徽工业大学 Atomized essential oil with refreshing effect and preparation method thereof

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