CN111039900B - 1-吗啉-4-(2,4,5-三氟苯基)丁烷-1,3-二酮的制备方法 - Google Patents
1-吗啉-4-(2,4,5-三氟苯基)丁烷-1,3-二酮的制备方法 Download PDFInfo
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- CN111039900B CN111039900B CN201910151454.1A CN201910151454A CN111039900B CN 111039900 B CN111039900 B CN 111039900B CN 201910151454 A CN201910151454 A CN 201910151454A CN 111039900 B CN111039900 B CN 111039900B
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- XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 108010083476 phenylalanyltryptophan Proteins 0.000 description 1
- 108010007513 prolyl-glycyl-prolyl-leucine Proteins 0.000 description 1
- 108010093296 prolyl-prolyl-alanine Proteins 0.000 description 1
- 108010087846 prolyl-prolyl-glycine Proteins 0.000 description 1
- 108010015796 prolylisoleucine Proteins 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 108010048397 seryl-lysyl-leucine Proteins 0.000 description 1
- 229960004034 sitagliptin Drugs 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/54—Preparation of carboxylic acid anhydrides
- C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (5)
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Citations (6)
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CN1387523A (zh) * | 1999-07-22 | 2002-12-25 | 美露香株式会社 | 制备异香豆素及其中间体的方法 |
WO2009091040A1 (ja) * | 2008-01-18 | 2009-07-23 | Takasago International Corporation | (2e,6z,8e)-n-イソブチル-2,6,8-デカトリエナミド(スピラントール)の製造方法、及びそれを含有する飲食品、香粧品、医薬品 |
CN101638391A (zh) * | 2009-08-21 | 2010-02-03 | 山东大学 | 2-[(取代苯氨基)羰基甲硫基]-6-(2,6-二氯苄基)-3h-嘧啶-4-酮类衍生物及其制备方法与应用 |
WO2015145333A1 (en) * | 2014-03-26 | 2015-10-01 | Sun Pharmaceutical Industries Limited | Process for the preparation of sitagliptin and its intermediate |
CN107365809A (zh) * | 2016-05-13 | 2017-11-21 | 上海朴颐化学科技有限公司 | 一种转氨酶法合成(r)-n-boc-3-氨基-4-(2,4,5-三氟苯基)丁酸的方法 |
CN108586346A (zh) * | 2018-05-10 | 2018-09-28 | 中国国际医药卫生有限公司 | 一种生物催化合成西他列汀及其中间体的方法 |
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2019
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CN1387523A (zh) * | 1999-07-22 | 2002-12-25 | 美露香株式会社 | 制备异香豆素及其中间体的方法 |
WO2009091040A1 (ja) * | 2008-01-18 | 2009-07-23 | Takasago International Corporation | (2e,6z,8e)-n-イソブチル-2,6,8-デカトリエナミド(スピラントール)の製造方法、及びそれを含有する飲食品、香粧品、医薬品 |
CN101638391A (zh) * | 2009-08-21 | 2010-02-03 | 山东大学 | 2-[(取代苯氨基)羰基甲硫基]-6-(2,6-二氯苄基)-3h-嘧啶-4-酮类衍生物及其制备方法与应用 |
WO2015145333A1 (en) * | 2014-03-26 | 2015-10-01 | Sun Pharmaceutical Industries Limited | Process for the preparation of sitagliptin and its intermediate |
CN107365809A (zh) * | 2016-05-13 | 2017-11-21 | 上海朴颐化学科技有限公司 | 一种转氨酶法合成(r)-n-boc-3-氨基-4-(2,4,5-三氟苯基)丁酸的方法 |
CN108586346A (zh) * | 2018-05-10 | 2018-09-28 | 中国国际医药卫生有限公司 | 一种生物催化合成西他列汀及其中间体的方法 |
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