CN1109885A - 嗜酸性细胞趋化性抑制剂 - Google Patents

嗜酸性细胞趋化性抑制剂 Download PDF

Info

Publication number
CN1109885A
CN1109885A CN94115326A CN94115326A CN1109885A CN 1109885 A CN1109885 A CN 1109885A CN 94115326 A CN94115326 A CN 94115326A CN 94115326 A CN94115326 A CN 94115326A CN 1109885 A CN1109885 A CN 1109885A
Authority
CN
China
Prior art keywords
group
alkyl
represent
hydrogen atom
replaces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94115326A
Other languages
English (en)
Chinese (zh)
Inventor
三宅昭夫
芦田康子
松本辰美
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1109885A publication Critical patent/CN1109885A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN94115326A 1993-09-21 1994-09-20 嗜酸性细胞趋化性抑制剂 Pending CN1109885A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23476493 1993-09-21
JP234764/93 1993-09-21

Publications (1)

Publication Number Publication Date
CN1109885A true CN1109885A (zh) 1995-10-11

Family

ID=16975996

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94115326A Pending CN1109885A (zh) 1993-09-21 1994-09-20 嗜酸性细胞趋化性抑制剂

Country Status (10)

Country Link
US (2) US5922712A (enExample)
EP (2) EP0648491A3 (enExample)
KR (1) KR100280240B1 (enExample)
CN (1) CN1109885A (enExample)
AU (1) AU686210B2 (enExample)
CA (1) CA2132489A1 (enExample)
FI (1) FI944354A0 (enExample)
NO (1) NO307547B1 (enExample)
NZ (1) NZ264479A (enExample)
TW (1) TW304878B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008496A1 (en) * 1994-09-16 1996-03-21 Takeda Chemical Industries, Ltd. Triazolopyridazines process and intermediates for their preparation and their use as medicaments
US6248740B1 (en) 1997-04-25 2001-06-19 Takeda Chemical Industries, Ltd. Condensed pyridazine derivatives, their production and use
CA2319426A1 (en) * 1998-03-04 1999-09-10 Kenichirou Kiyoshima Triazolo-pyridazine derivatives for the treatment of chronic obstructive pulmonary diseases
AU6003099A (en) 1998-10-06 2000-04-26 Takeda Chemical Industries Ltd. Fused pyridazine compounds, process for the preparation of the same and uses thereof
EP1123936B1 (en) * 1998-10-21 2003-12-10 Takeda Chemical Industries, Ltd. Fused pyridazine derivatives, process for the preparation of the same and uses thereof
AU7315900A (en) * 1999-09-20 2001-04-24 Takeda Chemical Industries Ltd. Chemokine/cytokine expression inhibitors
KR20020050275A (ko) * 1999-11-11 2002-06-26 다케다 야쿠힌 고교 가부시키가이샤 융합 피리다진 유도체를 함유하는 점비제
ME02736B (me) 2005-12-21 2017-10-20 Janssen Pharmaceutica Nv Triazolopiridazini kao modulatori tirozin kinaze

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446812A1 (de) * 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (en) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazine compounds, their production and use
US5011835A (en) * 1990-02-07 1991-04-30 Merrell Dow Pharmaceuticals Inc. Substituted triazolopyridazines, pharmaceutical compositions and use
ATE117690T1 (de) * 1990-03-01 1995-02-15 Takeda Chemical Industries Ltd Imidazopyridazine, ihre herstellung und verwendung.
DE4007373A1 (de) * 1990-03-08 1991-09-12 Precitronic Pyrotechnische vorrichtung
EP0561973A1 (en) * 1990-12-14 1993-09-29 Merrell Dow Pharmaceuticals Inc. Antiallergic compounds
TW211013B (enExample) * 1991-12-27 1993-08-11 Takeda Pharm Industry Co Ltd
DE69322673T2 (de) * 1992-03-18 1999-05-06 Takeda Chemical Industries, Ltd., Osaka Imidazopyridazine als Antiasthmatika
LT3200B (en) * 1992-03-18 1995-03-27 Takeda Chemical Industries Ltd Triazolopyridazine methodfor production thereof and use

Also Published As

Publication number Publication date
CA2132489A1 (en) 1995-03-22
FI944354A0 (fi) 1994-09-20
NO307547B1 (no) 2000-04-25
US5945419A (en) 1999-08-31
NO943494D0 (no) 1994-09-20
AU686210B2 (en) 1998-02-05
EP0865790A3 (en) 1999-03-10
EP0648491A3 (en) 1995-07-19
KR100280240B1 (ko) 2001-02-01
KR950007851A (ko) 1995-04-15
NO943494L (no) 1995-03-22
EP0865790A2 (en) 1998-09-23
EP0648491A2 (en) 1995-04-19
TW304878B (enExample) 1997-05-11
AU7292694A (en) 1995-04-06
NZ264479A (en) 1999-05-28
US5922712A (en) 1999-07-13

Similar Documents

Publication Publication Date Title
CN1037439C (zh) 制备具有神经保护作用的吲哚酮及有关衍生物的方法
CN1028758C (zh) 吡唑并嘧啶酮类抗心绞痛剂的制备方法
CN1195755C (zh) 吡咯并[2,3-d]嘧啶化合物
CN1033701C (zh) 9-(2-羟基乙氧基甲基)鸟嘌呤衍生物的制备方法
CN1259951A (zh) 新化合物
CN1084747C (zh) 作为神经活性剂的吡咯并苯并氮杂䓬衍生物
CN1028992C (zh) 1,4,-苯并硫杂吖庚因衍生物的制备方法
CN1172672C (zh) α-酮酰胺多元催化蛋白酶抑制剂
CN1053230A (zh) 新的聚4-氨基-2-羟基-1-甲基化合物脲基衍生物的制备方法
CN1013198B (zh) 抗肿瘤的磺酰脲衍生物的制备方法
CN1219131A (zh) 作为tnf抑制剂和pdc-iv抑制剂的喹啉甲酰胺类化合物
CN1326743A (zh) 1,3-氧硫环戊烷核苷类似物药物组合物的制备方法
CN1717236A (zh) 治疗移植排斥的方法
CN1137275A (zh) 具有免疫抑制活性的o-芳基、o-烷基、o-烯基和o-炔基大环内酯物
CN1049503A (zh) 大环化合物的制备方法
CN1026984C (zh) 偏端霉素衍生物的制备方法
CN1169994A (zh) 具有终端胺化炔醇侧链的黄嘌呤化合物
CN1062729A (zh) 可用作血管紧张肽转化酶抑制剂的含氨基和硝基的三环新化合物
CN1344264A (zh) 四氢吡喃衍生物及其作为治疗药的用途
CN1668592A (zh) 哌啶衍生物和它们用作MIP-1α与受体CCR1结合的选择性抑制剂的应用
CN1047866A (zh) N-杂芳基-嘌呤-6-胺的制备方法及其药用
CN1109885A (zh) 嗜酸性细胞趋化性抑制剂
CN1163494C (zh) 碳青霉烯衍生物、其用途及其中间体化合物
CN1065863A (zh) 增强抗肿瘤药物活性的嘧啶类衍生物
CN1030605C (zh) 4-取代吡唑并[3,4-d]嘧啶衍生物的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned