CN110981941A - 生物模拟肽和生物可降解的递送平台 - Google Patents

生物模拟肽和生物可降解的递送平台 Download PDF

Info

Publication number
CN110981941A
CN110981941A CN201911163740.6A CN201911163740A CN110981941A CN 110981941 A CN110981941 A CN 110981941A CN 201911163740 A CN201911163740 A CN 201911163740A CN 110981941 A CN110981941 A CN 110981941A
Authority
CN
China
Prior art keywords
peptide
seq
microparticle
nanoparticle
plga
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911163740.6A
Other languages
English (en)
Chinese (zh)
Inventor
亚历山大·S·波佩尔
尼兰贾·B·潘迪
艾萨克·李
乔丹·J·格林
朗·B·史牟莉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CN110981941A publication Critical patent/CN110981941A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
CN201911163740.6A 2013-06-07 2014-06-09 生物模拟肽和生物可降解的递送平台 Pending CN110981941A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361832290P 2013-06-07 2013-06-07
US61/832,290 2013-06-07
CN201480043222.XA CN105431162B (zh) 2013-06-07 2014-06-09 用于治疗血管生成依赖性和淋巴管生成依赖性疾病的生物模拟肽和生物可降解的递送平台

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480043222.XA Division CN105431162B (zh) 2013-06-07 2014-06-09 用于治疗血管生成依赖性和淋巴管生成依赖性疾病的生物模拟肽和生物可降解的递送平台

Publications (1)

Publication Number Publication Date
CN110981941A true CN110981941A (zh) 2020-04-10

Family

ID=52008639

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480043222.XA Active CN105431162B (zh) 2013-06-07 2014-06-09 用于治疗血管生成依赖性和淋巴管生成依赖性疾病的生物模拟肽和生物可降解的递送平台
CN201911163740.6A Pending CN110981941A (zh) 2013-06-07 2014-06-09 生物模拟肽和生物可降解的递送平台

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201480043222.XA Active CN105431162B (zh) 2013-06-07 2014-06-09 用于治疗血管生成依赖性和淋巴管生成依赖性疾病的生物模拟肽和生物可降解的递送平台

Country Status (11)

Country Link
US (4) US9802984B2 (enExample)
EP (2) EP3643318A1 (enExample)
JP (2) JP6470740B2 (enExample)
CN (2) CN105431162B (enExample)
AU (1) AU2014274703B2 (enExample)
CA (1) CA2914764C (enExample)
DK (1) DK3003343T3 (enExample)
ES (1) ES2774217T3 (enExample)
HU (1) HUE047735T2 (enExample)
IL (1) IL242760B (enExample)
WO (1) WO2014197892A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3003343T3 (da) * 2013-06-07 2020-02-03 Univ Johns Hopkins Biomimetisk peptid og bionedbrydelig leveringsplatform til behandling af angiogenese- og lymfangiogeneseafhængige sygdomme
US20170216363A1 (en) 2014-08-07 2017-08-03 The Johns Hopkins University Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases
KR101748120B1 (ko) * 2015-07-13 2017-06-16 서울대학교산학협력단 나노입자-유리체 기반 단백질 복합체를 유효성분으로 포함하는 혈관신생억제용 조성물 및 이의 용도
KR20180081608A (ko) * 2015-11-19 2018-07-16 아스클리픽스 테라퓨틱스, 엘엘씨. 항-혈관형성, 항-림프관신생, 및 항-부종성 특성을 가진 펩티드 및 나노입자 제제
KR20190066040A (ko) * 2016-10-04 2019-06-12 아스클리픽스 테라퓨틱스, 인크. Tie2 신호전달을 활성화시키기 위한 화합물 및 방법
AU2018266690A1 (en) * 2017-05-08 2019-12-12 Asclepix Therapeutics, Inc. Biodegradable microparticles for sustained delivery of anti-angiogenic peptide
WO2019028427A1 (en) * 2017-08-03 2019-02-07 Asclepix Therapeutics, Llc. METHODS OF IDENTIFYING AND PREPARING PHARMACEUTICAL AGENTS TO ACTIVATE TIE2 RECEPTOR
WO2019075056A1 (en) 2017-10-10 2019-04-18 The Johns Hopkins University BIODEGRADABLE BIOMIMETIC PARTICLES
US11697804B2 (en) 2018-10-01 2023-07-11 The Johns Hopkins University Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy
EP3920894A4 (en) * 2019-02-06 2022-11-09 The University of North Carolina at Chapel Hill COMPOSITIONS AND METHODS TO INHIBIT POSTOPERATIVE ADHESIONS
JP7650074B2 (ja) * 2019-03-26 2025-03-24 アスクレピクス セラピューティクス インコーポレイテッド 眼疾患を治療するための組成物及び方法
CN113144213B (zh) * 2021-03-23 2023-04-07 西安交通大学医学院第一附属医院 一种多级pH响应基因-药物共递送的纳米药物、制备方法及其应用
WO2024044745A2 (en) * 2022-08-26 2024-02-29 Asclepix Therapeutics, Inc. Formulations for intraocular delivery of peptides derived from type iv collagen

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110206760A1 (en) * 2008-07-21 2011-08-25 Compugen Ltd. Angiopoietin derived peptides
US20120114759A1 (en) * 2009-05-15 2012-05-10 The Johns Hopkins University Peptide/particle delivery systems
US20120232012A1 (en) * 2005-09-12 2012-09-13 The Johns Hopkins University Compositions having antiangiogenic activity and uses thereof
US20120270770A1 (en) * 2010-08-03 2012-10-25 Jesse Michael Jaynes Anti-angiogenic peptides and their uses

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009522372A (ja) * 2006-01-09 2009-06-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ワクチンおよび腫瘍免疫療法のためのtnfrsf、tlr、nlr、rhr、プリン受容体、およびサイトカイン受容体アゴニストの組み合わせ免疫刺激剤
ITMI20060625A1 (it) 2006-03-31 2007-10-01 Istituto Naz Per La Ricerca Peptide antiangiogenico e suoi impieghi terapeutici
CA2666709A1 (en) * 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
WO2008085828A2 (en) 2007-01-03 2008-07-17 The Johns Hopkins University Peptide modulators of angiogenesis and use thereof
AU2009245785A1 (en) * 2008-05-06 2009-11-12 Glaxo Group Limited Encapsulation of biologically active agents
WO2011084620A2 (en) 2009-12-16 2011-07-14 Brigham And Women's Hospital, Inc. Particles for multiple agent delivery
US20120192339A1 (en) 2010-07-28 2012-08-02 Honeywell International Inc. Flexible Body Armor Vest with Breast Plate
WO2012079088A2 (en) * 2010-12-10 2012-06-14 The Johns Hopkins University Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases
US8877827B2 (en) 2011-02-24 2014-11-04 Konica Minolta, Inc. Active ray-curable inkjet ink, and image formation method
US12371522B2 (en) 2011-10-12 2025-07-29 The Johns Hopkins University Bioreducible poly (beta-amino ester)s for siRNA delivery
WO2014066898A1 (en) 2012-10-26 2014-05-01 The Johns Hopkins University A layer-by-layer approach to co-deliver dna and sirna via aunps: a potential platform for modifying release kinetics
DK3003343T3 (da) * 2013-06-07 2020-02-03 Univ Johns Hopkins Biomimetisk peptid og bionedbrydelig leveringsplatform til behandling af angiogenese- og lymfangiogeneseafhængige sygdomme

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120232012A1 (en) * 2005-09-12 2012-09-13 The Johns Hopkins University Compositions having antiangiogenic activity and uses thereof
US20110206760A1 (en) * 2008-07-21 2011-08-25 Compugen Ltd. Angiopoietin derived peptides
US20120114759A1 (en) * 2009-05-15 2012-05-10 The Johns Hopkins University Peptide/particle delivery systems
US20120270770A1 (en) * 2010-08-03 2012-10-25 Jesse Michael Jaynes Anti-angiogenic peptides and their uses

Also Published As

Publication number Publication date
US20200361993A1 (en) 2020-11-19
JP6931011B2 (ja) 2021-09-01
EP3643318A1 (en) 2020-04-29
DK3003343T3 (da) 2020-02-03
IL242760B (en) 2021-03-25
US9802984B2 (en) 2017-10-31
EP3003343B1 (en) 2019-10-23
US20160122390A1 (en) 2016-05-05
US11981754B2 (en) 2024-05-14
ES2774217T3 (es) 2020-07-17
HK1222542A1 (zh) 2017-07-07
US20240391957A1 (en) 2024-11-28
AU2014274703A1 (en) 2015-12-10
US20180134753A1 (en) 2018-05-17
AU2014274703B2 (en) 2019-07-04
US10774112B2 (en) 2020-09-15
JP2016521712A (ja) 2016-07-25
JP2019089790A (ja) 2019-06-13
WO2014197892A1 (en) 2014-12-11
CA2914764A1 (en) 2014-12-11
JP6470740B2 (ja) 2019-02-13
CN105431162A (zh) 2016-03-23
CA2914764C (en) 2021-10-26
HUE047735T2 (hu) 2020-05-28
EP3003343A1 (en) 2016-04-13
EP3003343A4 (en) 2016-11-30
CN105431162B (zh) 2019-12-10

Similar Documents

Publication Publication Date Title
US20240391957A1 (en) Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases
US11155603B2 (en) Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases
JP7530394B2 (ja) 血液脳関門を通過して輸送するための組成物及び方法
KR20190066040A (ko) Tie2 신호전달을 활성화시키기 위한 화합물 및 방법
KR20140142733A (ko) Egfl7 표적화 및/또는 결합 폴리펩타이드, 그리고 신생혈관생성을 저해하는 방법
HK40022338A (en) A biomimetic peptide and biodegradable delivery platform
HK1222542B (zh) 用於治疗血管生成依赖性和淋巴管生成依赖性疾病的生物模拟肽和生物可降解的递送平台

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40022338

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200410