CN110973610A - 用于青少年儿童益智增高的组合物及制备方法 - Google Patents
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Abstract
本发明公开一种用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：大豆肽1～10份、胆碱0.01～0.2份、牛磺酸0.01～0.1份、赖氨酸0.01～0.1份、精氨酸0.01～0.2份、谷氨酰胺0.01～0.2份、锌0.01～0.1份、钙0.01～0.1份、维生素A 0.001～0.1份、维生素D3 0.001～0.1份、磷脂酰丝氨酸0.001～0.1份、酪蛋白磷酸肽0.001～0.1份、维生素K2 0.001～0.1份、益生菌0.01～0.2份、益生元0.5～1份、富含Omega‑3的物质0.01～0.2份；不仅能够有效补充青少年儿童生长发育期所需的各种营养，促进其身体发育，还能够促进脑发育和提高记忆能力。
Description
技术领域
本发明涉及药品、保健品或食品领域，具体涉及一种用于青少年儿童益智增高的组合物及制备方法。
背景技术
5-18岁的青少年儿童正处于一个生长发育和智力发育同步进行的阶段，他们不仅需要补充足够的能量应对每天的消耗，还需要摄入另外的营养物质用于生长发育和大脑发育，单靠从食物中摄取营养元素远不能满足青少年生长发育的要求，特别是对于偏食、挑食的人群而言，营养元素摄入的不平衡，容易导致其出现营养不良、生长发育缓慢、消瘦矮小、智力低下等问题。众所周知，生长发育落后的儿童，身高和体重明显下降，消化吸收功能差，免疫机能低下，容易造成自卑、胆怯、社交能力差等心理问题；而智能发育迟缓的儿童，学业成绩差，注意力不集中，语言、动作、运动、自理能力、社会技能均明显落后，会给家庭和社会带来沉重的精神和经济负担。
因此，研制出一种既能促进青少年儿童生长发育，又能促进其智力发育的配方，对于青少年儿童及其家属来说都具有重要意义。
发明内容
有鉴于此，本发明提供一种效果好、无毒副作用的用于青少年儿童益智增高的组合物，同时提供了该组合物的制备方法与用途。
本发明的用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：大豆肽1～10份、胆碱0.01～0.2份、牛磺酸0.01～0.1份、赖氨酸0.01～0.1份、精氨酸0.01～0.2份、谷氨酰胺0.01～0.2份、锌0.01～0.1份、钙0.01～0.1份、维生素A 0.001～0.1份、维生素D3 0.001～0.1份、磷脂酰丝氨酸0.001～0.1份、酪蛋白磷酸肽0.001～0.1份、维生素K2 0.001～0.1份、益生菌0.01～0.2份、益生元0.5～1份、富含Omega-3的物质0.01～0.2份；
进一步，按重量份计，包括如下原料组分：大豆肽10份、胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌0.02份、钙0.02份、维生素A 0.002份、维生素D30.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、益生菌0.05份、益生元0.5份、富含Omega-3的物质0.1份；
进一步，所述富含Omega-3的物质为磷虾油、奇亚籽提取物、紫苏子、亚麻籽中的一种或多种；
进一步，所述益生菌由嗜酸乳杆菌、保加利亚乳杆菌、青春双歧杆菌组成；
进一步，所述益生元为低聚异麦芽糖、低聚果糖、低聚木糖中的一种或多种。
本发明的用于青少年儿童益智增高的组合物在制备能促进青少年儿童长身高增智力的食品、药品或保健品中的应用。
本发明的用于青少年儿童益智增高的组合物的制备方法，包括以下步骤：将组合物的原料混合均匀；
进一步，将大豆肽和益生元混合均匀后再与混合均匀的剩余原料混合；
进一步，采用多维混料机进行混合，大豆肽和益生元的混料速度为5-10rpm；剩余原料的混料速度为8-12rpm。
本发明的组合物中可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品；所述保健品或药品可制成液体冲剂、粉剂、片剂、胶囊剂或其他常规剂型。
所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
其中：
填充剂包括：淀粉、预胶化淀粉、乳糖、甘露醇、甲壳素、微晶纤维素、蔗糖等；
崩解剂包括：淀粉、预胶化淀粉、微晶纤维素、羧甲基淀粉钠、交联聚乙烯吡咯烷酮、低取代羟丙纤维素、交联羧甲基纤维素纳等；
润滑剂包括：硬脂酸镁、十二烷基硫酸钠、滑石粉、二氧化硅等；
助悬剂包括：聚乙烯吡咯烷酮、微晶纤维素、蔗糖、琼脂、羟丙基甲基纤维素等；
粘合剂包括，淀粉浆、聚乙烯吡咯烷酮、羟丙基甲基纤维素等；
甜味剂包括：糖精钠、阿斯帕坦、蔗糖、甜蜜素、甘草次酸等；
矫味剂包括：甜味剂及各种香精；
防腐剂包括：尼泊金类、苯甲酸、苯甲酸钠、山梨酸及其盐类、苯扎溴铵、醋酸氯乙定、桉叶油等。
本发明的有益效果：
本发明的组合物在进行组分的筛选时，充分考虑了功能上的互补，实现了组分间的协同增效，不仅能够有效补充青少年儿童生长发育期所需的各种营养，促进其身体发育，还能够促进脑发育和提高记忆能力。其中，大豆肽容易被人体吸收，对于增强肌肉力量有重要作用，赖氨酸能够提高食物蛋白质的吸收和利用，可以参与体蛋白如骨骼肌、酶和多肽激素的合成，帮助身体组织吸收钙，防止骨质流失，谷氨酰胺可以为机体提供必需的氮源，促使肌细胞内蛋白质合成，通过细胞增容作用，促进肌细胞的生长和分化，刺激生长激素、胰岛素和睾酮的分泌，使机体处于合成状态，增长肌肉，补锌具有促进生长发育的作用，补钙能够促进骨骼的发育，Omega-3是人体最重要的营养素之一，对于儿童的生长发育也极其重要，维生素K2不仅能激活骨钙素蛋白，还能够抑制破骨细胞活性，能激活羧化谷氨酸蛋白，能有效将血液中钙沉淀到骨骼中，保护血管壁弹性；通过它们的相互协同，能够为儿童的生长发育提供必要的营养元素，对于促进儿童的骨骼和肌肉等发育效果显著。同时，胆碱可以促进脑发育和提高记忆能力，牛磺酸能明显促进神经系统的生长发育和细胞增殖、分化，赖氨酸能够提高中枢神经组织功能，谷氨酰胺可以促进大脑发育，增强记忆，因含有高谷酰胺，能够有效调节神经，补锌能够促进智力发育，Omega-3可以促进脑部发育，磷脂酰丝氨酸能够增强传送大脑信号的神经递质的效率，帮助大脑高速运转，激发大脑的活化状态，增进大脑记忆功能，而且由于其具有很强的亲脂性，吸收后能够迅速通过血脑屏障进入大脑，起到舒缓血管平滑肌细胞，增加脑部供血的作用，通过这些组分复配后的协同配合，能够促进大脑发育，激发大脑活化状态，增进大脑的记忆功能。而益生菌和益生元在复配后，能够促进营养物质的吸收，酪蛋白磷酸肽能促进人体对钙、铁锌等二价矿物质的吸收和利用，通过它们的辅助协同，能够促使儿童更好地吸收组合物中的营养成分，有助于充分发挥这些营养成分的协同作用。
本发明的组合物中采用的组分无毒副作用，成本较低且易于获取，在充分考虑了各组分之间的相互协同作用后，提供了合适的配比，将各组分按照其配比复配后，不仅能够很好地被人体所吸收，还能够在被吸收后，充分发挥各组分之间的相互配合和协同增效作用，制备出用于青少年儿童益智增高的组合物。
具体实施方式
实施例一
本实施例提供一种用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：大豆肽10份、胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌0.02份、钙0.02份、维生素A 0.002份、维生素D30.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、益生菌0.05份、益生元0.5份、富含Omega-3的物质(紫苏子)0.1份。
本实施例中：锌可以通过加入葡萄糖酸锌、硫酸锌、柠檬酸锌、甘氨酸锌或乳酸锌来提供；
钙可以通过加入碳酸钙、葡萄糖酸钙、乳酸钙、柠檬酸钙或氨基酸钙来提供；
所述富含Omega-3的物质为磷虾油、奇亚籽提取物、紫苏子、亚麻籽中的一种或多种；
所述益生菌由嗜酸乳杆菌、保加利亚乳杆菌、青春双歧杆菌等组成；
所述益生元为低聚异麦芽糖、低聚果糖、低聚木糖中的一种或多种。
本实施例提供的组合物的制备方法，包括以下步骤：
①、无菌的条件下称取大豆肽10份，益生元0.5份在200L的多维混料机中混合30min，混料速度5rpm；
②、无菌条件下称取胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、葡萄糖酸锌0.2份、葡萄糖酸钙0.2份、维生素A0.002份、维生素D3 0.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、亚麻籽0.1份，在100L的多维混料机种充分混合，时间30min，混料速度8rpm。
③、无菌条件下将上述①和②放置于500L的多维混料机中混合45min，混料速度5rpm；
④、将上述③中的物料在无菌条件下进行分装。
本实施例提供的组合物中也可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品，所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
实施例二
本实施例提供一种用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：大豆肽8份、胆碱0.02份、牛磺酸0.02份、赖氨酸盐0.02份、精氨酸0.02份、谷氨酰胺0.01份、锌(葡萄糖酸锌)0.05份、钙(葡萄糖酸钙)0.05份、维生素A 0.002份、维生素D30.002份、磷脂酰丝氨酸0.003份、酪蛋白磷酸肽0.005份、维生素K2 0.002份、益生菌0.05份、益生元0.8份、富含Omega-3的物质(亚麻籽)0.02份。
所述富含Omega-3的物质为磷虾油、奇亚籽提取物、紫苏子、亚麻籽中的一种或多种；
所述益生菌由嗜酸乳杆菌、保加利亚乳杆菌、青春双歧杆菌等组成；
所述益生元为低聚异麦芽糖、低聚果糖、低聚木糖中的一种或多种。
本实施例提供的组合物的制备方法，包括以下步骤：
①无菌的条件下称取大豆肽8份，益生元0.8份在200L的多维混料机中混合60min，混料速度10rpm；
②胆碱0.02份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.01份、锌(葡萄糖酸锌)0.05份、钙(葡萄糖酸钙)0.05份、维生素A 0.002份、维生素D3 0.002份、磷脂酰丝氨酸0.003份、酪蛋白磷酸肽0.005份、维生素K2 0.002份、益生菌0.05份、益生元0.8份、紫苏子油0.02份。，在100L的多维混料机种充分混合，时间60min，混料速度12rpm。
③、无菌条件下将上述①和②放置于500L的多维混料机中混合60min，
混料速度10rpm；
④、将上述③中的物料在无菌条件下进行分装。
本实施例提供的组合物中也可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品，所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
实施例三
本实施例提供一种用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：肽8份、胆碱0.05份、牛磺酸0.06份、赖氨酸盐(L-赖氨酸盐酸盐？)0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌(葡萄糖酸锌)0.05份、钙(葡萄糖酸钙)0.05份、维生素A 0.004份、维生素D3 0.004份、磷脂酰丝氨酸0.004份、酪蛋白磷酸肽0.004份、维生素K2 0.004份、益生菌0.09份、益生元0.7份、富含Omega-3的物质0.2份。
本实施例中：锌可以通过加入葡萄糖酸锌、硫酸锌、柠檬酸锌、甘氨酸锌或乳酸锌来提供
钙可以通过加入碳酸钙、葡萄糖酸钙、乳酸钙、柠檬酸钙或氨基酸钙来提供
所述富含Omega-3的物质为磷虾油、奇亚籽提取物、紫苏子、亚麻籽中的一种或多种；
所述益生菌由嗜酸乳杆菌、保加利亚乳杆菌、青春双歧杆菌等组成；
所述益生元为低聚异麦芽糖、低聚果糖、低聚木糖中的一种或多种。
本实施例提供的组合物的制备方法，包括以下步骤：
①无菌的条件下称取大豆肽8份，益生元0.8份在200L的多维混料机中混合30min，混料速度10rpm；
②胆碱0.05份、牛磺酸0.06份、赖氨酸盐0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌(葡萄糖酸锌)0.05份、(葡萄糖酸钙)0.05份、维生素A 0.004份、维生素D3 0.004份、磷脂酰丝氨酸0.004份、酪蛋白磷酸肽0.004份、维生素K2 0.004份、益生菌0.09份、富含Omega-3的物质0.2份，在100L的多维混料机种充分混合，时间30min，混料速度12rpm。
③无菌条件下将上述①和②放置于500L的多维混料机中混合45min，混料速度10rpm；
④将上述③中的物料在无菌条件下进行分装。
本实施例提供的组合物中也可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品，所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等.
实施例四
本实施例的用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：大豆肽1份、胆碱0.01份、牛磺酸0.01份、赖氨酸0.01份、精氨酸0.01份、谷氨酰胺0.01份、锌0.01份、钙0.01份、维生素A 0.001份、维生素D3 0.001份、磷脂酰丝氨酸0.001份、酪蛋白磷酸肽0.001份、维生素K2 0.001份、益生菌0.01份、益生元0.5份、富含Omega-3的物质(磷虾油)0.01份。制备方法同实施例1。
实施例五
本实施例的用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：大豆肽10份、胆碱0.2份、牛磺酸0.1份、赖氨酸0.1份、精氨酸0.2份、谷氨酰胺0.2份、锌0.1份、钙0.1份、维生素A0.1份、维生素D3 0.1份、磷脂酰丝氨酸～0.1份、酪蛋白磷酸肽～0.1份、维生素K20.1份、益生菌0.2份、益生元1份、富含Omega-3的物质(紫苏子、亚麻籽)0.2份。制备方法同实施例2。
实施例六
大豆肽10份、胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌0.02份、钙0.02份、维生素A 0.002份、维生素D3 0.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、益生菌0.05份、益生元0.5份、富含Omega-3的物质(奇亚籽提取物)0.1份。制备方法同实施例3。
上实施实施例2-6均优于实施例1。
对比例1
本对比例提供的组合物与实施例一不同的是，在实施例一提供的组合物中去掉益生菌、益生元和酪蛋白磷酸肽，其它同实施例一。
对比例2
本对比例提供的组合物与实施例一不同的是，在实施例一提供的组合物中去掉肽、谷氨酰胺和维生素K2，其它同实施例一。
对比例3
本实施例提供一种用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：远志10份、胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌0.02份、钙0.02份、维生素A 0.002份、维生素D3 0.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、益生菌0.05份、益生元0.5份、富含Omega-3的物质(紫苏子)0.1份。其余与实施例1同。本实施例中，将大豆肽替换为远志，其效果明显低于实施例一。
对比例4
本实施例提供一种用于青少年儿童益智增高的组合物，按重量份计，包括如下原料组分：远志10份、胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌0.02份、钙0.02份、维生素A 0.002份、维生素D3 0.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、益生菌0.05份、益生元0.5份、富含Omega-3的物质(紫苏子)0.1份。本实施例中，将本实施例中，将大豆肽替换为石斛，其效果明显低于实施例一。
取上述实施例一制得的组合物作为供试品，测试它们的效果：
在全市随机选取5-18岁青少年儿童200名，随机分成四组——实验组和3个对照组。四组一般资料比较差异无统计学意义(P>0.05)，具有可比性。
实验组除正常饮食外，服用实施例一制得的组合物，10g/次，每日3次，连续六个月；
对照组1和对照组2除正常饮食外，分别服用对比例1和对比例3制得的组合物，10g/次，每日3次，连续六个月；对照组三正常饮食，连续六个月；观察四组青少年儿童的一般情况、身高和体重变化情况。
一般情况：实验组的青少年儿童服用实施例一制得的组合物后，未见任何不良反应，食欲增加，精神活泼，面色红润，睡眠安稳，记忆力增强。
身高：
实验组的青少年儿童身高增长平均值为2.2cm，最高增长至为4.1cm，最低增长至为1.9cm；
对照组1的青少年儿童身高增长平均值为1.9cm，最高增长至为3.8cm，最低增长至为1.1cm；
对照组2的青少年儿童身高增长平均值为1.3cm，最高增长至为2.1cm，最低增长至为0.5cm；
对照组3的青少年儿童身高增长平均值为1.7cm，最高增长至为2.9cm，最低增长至为0.3cm。
四组比较具有非常显著的意义(P＜0.01)。
体重：
实验组的青少年儿童体重平均增加2.9kg，最高增加4.1kg，最低增加0.9kg；
对照组1的青少年儿童体重平均增加2.9kg，最高增加3.3kg，最低增加1.0kg；
对照组2的青少年儿童体重平均增加3.1kg，最高增加5.0kg，最低增加2.1kg；
对照组3的青少年儿童体重平均增加4.3kg，最高增加5.6kg，最低增加2.5kg；
四组比较具有非常显著的意义(P＜0.01)。
经过6个月的观察，服用本发明组合物的实验组较对照组身高和体重的增加效果更加显著，且服用本发明组合物后食欲增加，精神活泼，面色红润，睡眠安稳，记忆力增强。
最后说明的是，以上实施例仅用以说明本发明的技术方案而非限制，尽管参照较佳实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的宗旨和范围，其均应涵盖在本发明的权利要求范围当中。
Claims (9)
1.一种用于青少年儿童益智增高的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽1～10份、胆碱0.01～0.2份、牛磺酸0.01～0.1份、赖氨酸0.01～0.1份、精氨酸0.01～0.2份、谷氨酰胺0.01～0.2份、锌0.01～0.1份、钙0.01～0.1份、维生素A 0.001～0.1份、维生素D30.001～0.1份、磷脂酰丝氨酸0.001～0.1份、酪蛋白磷酸肽0.001～0.1份、维生素K2 0.001～0.1份、益生菌0.01～0.2份、益生元0.5～1份、富含Omega-3的物质 0.01～0.2份。
2.根据权利要求1所述的用于青少年儿童益智增高的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽10份、胆碱0.01份、牛磺酸0.02份、赖氨酸0.02份、精氨酸0.02份、谷氨酰胺0.02份、锌0.02份、钙0.02份、维生素A 0.002份、维生素D30.002份、磷脂酰丝氨酸0.002份、酪蛋白磷酸肽0.01份、维生素K2 0.01份、益生菌0.05份、益生元0.5份、富含Omega-3的物质0.1份。
3.根据权利要求1或2所述的用于青少年儿童益智增高的组合物，其特征在于：所述富含Omega-3的物质为磷虾油、奇亚籽提取物、紫苏子、亚麻籽中的一种或多种。
4.根据权利要求1或2所述的用于青少年儿童益智增高的组合物，其特征在于：所述益生菌由嗜酸乳杆菌、保加利亚乳杆菌、青春双歧杆菌组成。
5.根据权利要求1或2所述的用于青少年儿童益智增高的组合物，其特征在于：所述益生元为低聚异麦芽糖、低聚果糖、低聚木糖中的一种或多种。
6.权利要求1或2中任一权利要求所述的组合物在制备能促进青少年儿童长身高增智力的食品、药品或保健品中的应用。
7.一种权利要求1或2中任一权利要求所述的用于青少年儿童益智增高的组合物的制备方法，其特征在于：包括以下步骤：将组合物的原料混合均匀。
8.根据权利要求7所述的具有减肥美容功效的组合物的制备方法，其特征在于：将大豆肽和益生元混合均匀后再与混合均匀的剩余原料混合。
9.根据权利要求8所述的具有减肥美容功效的组合物的制备方法，其特征在于：采用多维混料机进行混合，大豆肽和益生元的混料速度为5-10rpm；剩余原料的混料速度为8-12rpm。
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