CN110934295A - 具有强身养肾功效的组合物及制备方法 - Google Patents
具有强身养肾功效的组合物及制备方法 Download PDFInfo
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- CN110934295A CN110934295A CN201911332437.4A CN201911332437A CN110934295A CN 110934295 A CN110934295 A CN 110934295A CN 201911332437 A CN201911332437 A CN 201911332437A CN 110934295 A CN110934295 A CN 110934295A
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Abstract
本发明提供的具有强身养肾功效的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽1～10份、枸杞提取物0.01～1份、覆盆子提取物0.01～1份、牡蛎肽0.01～0.5份、玛卡提取物0.01～0.5份、西洋参提取物0.01～0.2份、刺蒺藜提取物0.01～0.2份、水飞蓟籽提取物0.01～0.2份、左旋肉碱0.01～0.2份、HMB 0.01～0.2份、桑葚提取物0.01～0.2份、绿咖啡豆提取物0.01～0.2份、黑果腺肋花揪果粉0.01～0.2份、肌酸0.01～0.2份、瓜拉纳提取物0.01～0.2份；长期食用，能够起到强身健体、固本培元、减缓衰老、养肾固精的作用。
Description
技术领域
本发明涉及药品、保健品或食品领域，具体涉及一种具有强身养肾功效的组合物及制备方法。
背景技术
随着生活节奏的加快，越来越多的男性朋友感觉自己的身体在加速衰老，做事有心无力，心烦意乱，有时还伴有肾虚肾亏，精气不足等亚健康状态。严重的还伴有性功能低下性功能障碍，阳痿早泄等，影响心情也影响家庭关系，使得本来就浮躁的生活变的更加烦躁不安，降低了生活质量。
因此，为了帮助男性朋友缓解压力，强身健体，固本培元，减缓衰老，养肾固精，需要研制出一种男士用具有强身养肾功效的组合物。
发明内容
有鉴于此，本发明提供一种效果好、低毒副作用的具有强身养肾功效的组合物，同时提供了该组合物的制备方法与用途。
本发明公开一种具有强身养肾功效的组合物，按重量份计，包括如下原料组分：大豆肽1～10份、枸杞提取物0.01～1份、覆盆子提取物0.01～1份、牡蛎肽0.01～0.5份、玛卡提取物0.01～0.5份、西洋参提取物0.01～0.2份、刺蒺藜提取物0.01～0.2份、水飞蓟籽提取物0.01～0.2份、左旋肉碱0.01～0.2份、HMB(β-羟基-β-甲基丁酸盐)0.01～0.2份、桑葚提取物0.01～0.2份、绿咖啡豆提取物0.01～0.2份、黑果腺肋花揪果粉0.01～0.2份、肌酸0.01～0.2份、瓜拉纳提取物0.01～0.2份；
进一步，按重量份计，包括如下原料组分：肽10份、枸杞提取物0.1份、覆盆子提取物0.1份、牡蛎肽0.2份、玛卡提取物0.2份、西洋参提取物0.2份、刺蒺藜提取物0.2份、水飞蓟籽提取物0.1份、左旋肉碱0.1份、HMB 0.1份、桑葚提取物0.1份、绿咖啡豆提取物0.1份、黑果腺肋花揪果0.1份、肌酸0.1份、瓜拉纳提取物0.1份；
进一步，该组合物可加入一种或多种用于改善或治疗兼证的中药。
本发明的组合物在制备具有强身养肾功效的食品、药品或保健品中的应用。
本发明的能促进青少年儿童长身高增智力的组合物的制备方法，其特征在于：包括以下步骤：将组合物的原料混合均匀；
进一步，先将大豆肽和牡蛎肽混合均匀后再与剩余原料混合均匀。
本发明的具有强身养肾功效的组合物中可加入一种或多种用于改善或治疗兼证的中药，例如牛髓、人参、杜仲、续断、地黄、枸杞、灵芝等，滋补肝肾，补中益气，固本培元，强壮筋骨。
本发明的组合物中可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品；所述保健品或药品可制成液体冲剂、粉剂、片剂、胶囊剂或其他常规剂型。
所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
其中：
填充剂包括：淀粉、预胶化淀粉、乳糖、甘露醇、甲壳素、微晶纤维素、蔗糖等；
崩解剂包括：淀粉、预胶化淀粉、微晶纤维素、羧甲基淀粉钠、交联聚乙烯吡咯烷酮、低取代羟丙纤维素、交联羧甲基纤维素纳等；
润滑剂包括：硬脂酸镁、十二烷基硫酸钠、滑石粉、二氧化硅等；
助悬剂包括：聚乙烯吡咯烷酮、微晶纤维素、蔗糖、琼脂、羟丙基甲基纤维素等；
粘合剂包括，淀粉浆、聚乙烯吡咯烷酮、羟丙基甲基纤维素等；
甜味剂包括：糖精钠、阿斯帕坦、蔗糖、甜蜜素、甘草次酸等；
矫味剂包括：甜味剂及各种香精；
防腐剂包括：尼泊金类、苯甲酸、苯甲酸钠、山梨酸及其盐类、苯扎溴铵、醋酸氯乙定、桉叶油等。
本发明的有益效果：
本发明的组合物在进行组分的筛选时，充分考虑了功能上的互补，实现了组分间的协同增效，长期食用，能够起到强身健体、固本培元、减缓衰老、养肾固精的作用。其中，枸杞提取物富含胡萝卜素、多种维生素和多种矿物质等营养成分，能够增加白细胞活性，促进肝细胞新生，还能够明显的增强骨髓造血功能和各项细胞免疫指标，对于补肝肾、益精血、抗衰老效果显著；覆盆子提取物富含水杨酸、多种维生素和矿物质等营养成分，不仅能够保护心脏，预防心脑血管疾病，还能够补肾壮阳；牡蛎肽富含核酸，容易被肌体吸收，而且能够有效提高男性血清睾酮水平；玛卡提取物能够对平衡人体荷尔蒙分泌，对人体有滋补强身的功用；西洋参提取物能够调节内分泌，增强人体免疫力，发挥补气养血、滋阴补肾、强脾养胃、延缓衰老及养颜等作用；刺蒺藜提取物可以平肝潜阳、祛风止痒、散结祛瘀；水飞蓟籽提取物对肝脏有解毒作用，能够调节肝脏机能，使人体正常排毒，确保人体健康；左旋肉碱能够促使脂肪转化为能量，避免因过多脂肪的积累而影响人体健康；β-羟基-β-甲基丁酸盐(HMB)能够促进蛋白质合成，抑制蛋白质降解，具有调节肌肉消耗和生长的作用，能够预防肌肉减少，增加肌肉量；桑葚提取物能够清除机体过高的自由基，发挥补血滋阴、生津润燥、抗衰老的作用；绿咖啡提取物富含绿原酸，能够促进肾脏机能，清除自由基，增强机体免疫力，还能够燃烧脂肪，提高人体代谢率；黑果腺肋花揪果富含多酚，具有抗氧化、保肝等作用，还可以预防高脂食物对人体产生的不利影响；肌酸可以有效提高肌力、速度和耐力；瓜拉纳提取物可以增强体能水平，滋阴壮阳。通过这些组分的复配协同，不仅能够对体内心脏、肝脏、肾脏等重要器官进行调节，维持其平衡，确保其正常运行，还能够清除机体内多余的自由基和多余的脂肪，增加肌肉量，增强机体体能和免疫力，起到强身健体、固本培元、减缓衰老、养肾固精的作用。
本发明的组合物中采用的组分低毒副作用，成本较低且易于获取，在充分考虑了各组分之间的相互协同作用后，提供了合适的配比，将各组分按照其配比复配后，不仅能够很好地被人体所吸收，还能够在被吸收后，充分发挥各组分之间的相互配合和协同增效作用，制备出具有强身养肾功效的组合物。
具体实施方式
实施例一
本实施例提供一种具有强身养肾功效的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽10份、枸杞提取物0.02份、覆盆子提取物0.02份、牡蛎肽0.1份、玛卡提取物0.1份、西洋参提取物0.1份、刺蒺藜提取物0.1份、水飞蓟籽提取物0.05份、左旋肉碱0.1份、HMB 0.1份、桑葚提取物0.05份、绿咖啡豆提取物0.05份、黑果腺肋花揪果粉0.05份、肌酸0.02份、瓜拉纳提取物0.02份。
本实施例提供的组合物的制备方法，包括以下步骤：
①无菌的条件下称取大豆肽10份，牡蛎肽0.1份在200L的多维混料机中混合30min，混料速度5rpm；
②、无菌条件下称取枸杞提取物0.02份、覆盆子提取物0.02份、玛卡提取物0.1份、西洋参提取物0.1份、刺蒺藜提取物0.1份、水飞蓟籽提取物0.05份、左旋肉碱0.1份、HMB0.1份、桑葚提取物0.05份、绿咖啡豆提取物0.05份、黑果腺肋花揪果粉0.05份、肌酸0.02份、瓜拉纳提取物0.02份，在100L的多维混料机种充分混合，时间60min，混料速度12rpm。
③、无菌条件下将上述①和②放置于500L的多维混料机中混合60min，混料速度10rpm；
④、将上述③中的物料在无菌条件下进行分装。
本实施例提供的组合物中也可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品，所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
本实施例中采用的原料均可通过购买获得。
实施例二
本实施例提供一种具有强身养肾功效的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽8份、枸杞提取物0.05份、覆盆子提取物0.5份、牡蛎肽0.05份、玛卡提取物0.05份、西洋参提取物0.05份、刺蒺藜提取物0.05份、水飞蓟籽提取物0.02份、左旋肉碱0.03份、HMB 0.03份、桑葚提取物0.03份、绿咖啡豆提取物0.03份、黑果腺肋花揪果粉0.05份、肌酸0.05份、瓜拉纳提取物0.05份。
本实施例提供的组合物的制备方法，包括以下步骤：
①无菌的条件下称取大豆肽8份，牡蛎肽0.05份在200L的多维混料机中混合30min，混料速度5rpm；
②无菌条件下称取枸杞提取物0.05份、覆盆子提取物0.5份、玛卡提取物0.05份、西洋参提取物0.05份、刺蒺藜提取物0.05份、水飞蓟籽提取物0.02份、左旋肉碱0.03份、HMB0.03份、桑葚提取物0.03份、绿咖啡豆提取物0.03份、黑果腺肋花揪果粉0.05份、肌酸0.05份、瓜拉纳提取物0.05份，在100L的多维混料机种充分混合，时间30min，混料速度8rpm。
③、无菌条件下将上述①和②放置于500L的多维混料机中混合45min，混料速度5rpm；
④、将上述③中的物料在无菌条件下进行分装。
本实施例提供的组合物中也可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品，所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
本实施例中采用的原料均可通过购买获得。
实施例三
本实施例提供一种具有强身养肾功效的组合物，其特征在于：按重量份计，包括如下原料组分：肽9份、枸杞提取物0.8份、覆盆子提取物0.5份、牡蛎肽0.5份、玛卡提取物0.08份、西洋参提取物0.05份、刺蒺藜提取物0.05份、水飞蓟籽提取物0.05份、左旋肉碱0.052份、HMB 0.05份、桑葚提取物0.05份、绿咖啡豆提取物0.05份、黑果腺肋花揪果粉0.05份、肌酸0.05份、瓜拉纳提取物0.05份。
本实施例提供的组合物的制备方法，包括以下步骤：
①无菌的条件下称取大豆肽9份，牡蛎肽0.5份在200L的多维混料机中混合30min，混料速度10rpm；
②枸杞提取物0.8份、覆盆子提取物0.5份、玛卡提取物0.08份、西洋参提取物0.05份、刺蒺藜提取物0.05份、水飞蓟籽提取物0.05份、左旋肉碱0.052份、HMB 0.05份、桑葚提取物0.05份、绿咖啡豆提取物0.05份、黑果腺肋花揪果粉0.05份、肌酸0.05份、瓜拉纳提取物0.05份，在100L的多维混料机种充分混合，时间30min，混料速度12rpm。
③无菌条件下将上述①和②放置于500L的多维混料机中混合45min，混料速度10rpm；
④将上述③中的物料在无菌条件下进行分装。
本实施例提供的组合物中也可加入常规辅料，按照常规工艺，制成医学或食品学或保健品学上能够接受的食品、药品或保健品，所述常规辅料包括：填充剂、崩解剂、润滑剂、助悬剂、粘合剂、甜味剂、矫味剂、防腐剂等。
本实施例中采用的原料均可通过购买获得。
上述实施例中，HMB为β-羟基-β-甲基丁酸盐。
实施例四
本实施例的具有强身养肾功效的组合物，按重量份计，包括如下原料组分：大豆肽1份、枸杞提取物0.01份、覆盆子提取物0.01份、牡蛎肽0.01份、玛卡提取物0.01份、西洋参提取物0.01份、刺蒺藜提取物0.01份、水飞蓟籽提取物0.01份、左旋肉碱0.01份、HMB 0.01份、桑葚提取物0.01份、绿咖啡豆提取物0.01份、黑果腺肋花揪果粉0.01份、肌酸0.01份、瓜拉纳提取物0.01份；制备方法同实施例1
实施例五
具有强身养肾功效的组合物，按重量份计，包括如下原料组分：大豆肽10份、枸杞提取物1份、覆盆子提取物1份、牡蛎肽0.5份、玛卡提取物0.5份、西洋参提取物0.2份、刺蒺藜提取物0.2份、水飞蓟籽提取物0.2份、左旋肉碱0.2份、HMB 0.2份、桑葚提取物0.2份、绿咖啡豆提取物0.2份、黑果腺肋花揪果粉0.2份、肌酸0.2份、瓜拉纳提取物0.2份；制备方法同实施例1
实施例六
按重量份计，包括如下原料组分：肽10份、枸杞提取物0.1份、覆盆子提取物0.1份、牡蛎肽0.2份、玛卡提取物0.2份、西洋参提取物0.2份、刺蒺藜提取物0.2份、水飞蓟籽提取物0.1份、左旋肉碱0.1份、HMB 0.1份、桑葚提取物0.1份、绿咖啡豆提取物0.1份、黑果腺肋花揪果0.1份、肌酸0.1份、瓜拉纳提取物0.1份；制备方法同实施例1。
上述实施例中，其余实施例效果均优于实施例一。
对比例1
本对比例提供的组合物与实施例一不同的是，在实施例一提供的组合物中去掉水飞蓟籽提取物、黑果腺肋花揪果和瓜拉纳提取物，其它同实施例一。
对比例2
本对比例提供的组合物与实施例一不同的是，在实施例一提供的组合物中去掉刺蒺藜提取物、HMB和绿咖啡提取物，其它同实施例一。该对比例2的效果低于对比例1
对比例3
本对比例中，将水飞蓟籽提取物按照同等重量份替换为金锁阳，效果明显低于实施例一。
对比例4
本对比例中，将刺蒺藜提取物按照同等重量份替换为黄芪，效果明显低于实施例一。该例效果低于对比例4
取上述实施例一、对比例一和对比例二制得的组合物作为供试品，分别测试它们的效果：
选取年龄在40～50岁，临床症状为精力不足且不易集中、易疲劳、困倦乏力、反应迟钝、性功能低下(阳痿、早泄等)的男性患者150例，随机分为1个实验组和2个对照组，每组50例。四组一般资料比较差异无统计学意义(P>0.05)，具有可比性。
实验组口服实施例一制备的组合物，5g/次(食用剂量可以修改)，每日3次，与主食同时食用；对照组一和对照组二分别口服对比例1、对比例3制备的组合物，5g/次，每日3次，与主食同时食用。
实验期间，试验对象均正常进食工作，不加餐，不吃夜宵，不服用任何有关的药品及其他保健品。
分别记录各组的患者的恢复情况：
实验组的患者，最快的连续服用实施例一制备的组合物6天后，症状就开始好转，症状减轻，连续服用25天后，临床症状消失，最慢的连续服用实施例一制备的组合物10天后，症状就开始好转，症状减轻，连续服用30天后，临床症状消失，未见副作用；
对照组一的患者，最快的连续服用对比例1制备的组合物12天后，症状就开始好转，症状减轻，连续服用45天后，临床症状消失，最慢的连续服用实施例一制备的组合物20天后，症状就开始好转，症状减轻，连续服用60天后，临床症状消失，未见副作用；
对照组二的患者，最快的连续服用对比例3制备的组合物15天后，症状就开始好转，症状减轻，连续服用55天后，临床症状消失，最慢的连续服用实施例一制备的组合物20天后，症状就开始好转，症状减轻，连续服用65天后，临床症状消失，未见副作用；
对比可见，实施例一制得的组合物见效快，效果显著。
最后说明的是，以上实施例仅用以说明本发明的技术方案而非限制，尽管参照较佳实施例对本发明进行了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的宗旨和范围，其均应涵盖在本发明的权利要求范围当中。
Claims (6)
1.一种具有强身养肾功效的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽1～10份、枸杞提取物0.01～1份、覆盆子提取物0.01～1份、牡蛎肽0.01～0.5份、玛卡提取物0.01～0.5份、西洋参提取物0.01～0.2份、刺蒺藜提取物0.01～0.2份、水飞蓟籽提取物0.01～0.2份、左旋肉碱0.01～0.2份、HMB 0.01～0.2份、桑葚提取物0.01～0.2份、绿咖啡豆提取物0.01～0.2份、黑果腺肋花揪果粉0.01～0.2份、肌酸0.01～0.2份、瓜拉纳提取物0.01～0.2份。
2.根据权利要求1所述的具有强身养肾功效的组合物，其特征在于：按重量份计，包括如下原料组分：大豆肽10份、枸杞提取物0.1份、覆盆子提取物0.1份、牡蛎肽0.2份、玛卡提取物0.2份、西洋参提取物0.2份、刺蒺藜提取物0.2份、水飞蓟籽提取物0.1份、左旋肉碱0.1份、HMB 0.1份、桑葚提取物0.1份、绿咖啡豆提取物0.1份、黑果腺肋花揪果0.1份、肌酸0.1份、瓜拉纳提取物0.1份。
3.根据权利要求1或2所述的具有强身养肾功效的组合物，其特征在于：该组合物可加入一种或多种用于改善或治疗兼证的中药。
4.权利要求1或2中任一权利要求所述的组合物在制备具有强身养肾功效的食品、药品或保健品中的应用。
5.一种权利要求1所述的能促进青少年儿童长身高增智力的组合物的制备方法，其特征在于：包括以下步骤：将组合物的原料混合均匀。
6.根据权利要求5所述的能促进青少年儿童长身高增智力的组合物的制备方法，其特征在于：先将大豆肽和牡蛎肽混合均匀后再与剩余原料混合均匀。
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