CN110950780A - 一种类甲硫酸新斯的明化合物、制备方法及用途 - Google Patents
一种类甲硫酸新斯的明化合物、制备方法及用途 Download PDFInfo
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- CN110950780A CN110950780A CN201911285027.9A CN201911285027A CN110950780A CN 110950780 A CN110950780 A CN 110950780A CN 201911285027 A CN201911285027 A CN 201911285027A CN 110950780 A CN110950780 A CN 110950780A
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- Prior art keywords
- compound
- neostigmine
- methylamino
- phenol
- acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1836—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from derivatives of carbamic acid
- C07C273/1845—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from derivatives of carbamic acid comprising the -N-C(O)-Hal moiety
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Priority Applications (1)
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CN201911285027.9A CN110950780A (zh) | 2019-12-13 | 2019-12-13 | 一种类甲硫酸新斯的明化合物、制备方法及用途 |
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CN201911285027.9A CN110950780A (zh) | 2019-12-13 | 2019-12-13 | 一种类甲硫酸新斯的明化合物、制备方法及用途 |
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CN201911285027.9A Pending CN110950780A (zh) | 2019-12-13 | 2019-12-13 | 一种类甲硫酸新斯的明化合物、制备方法及用途 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113277961A (zh) * | 2021-04-09 | 2021-08-20 | 深圳市新浩瑞医药科技有限公司 | 一种溴新斯的明的合成方法 |
CN113651722A (zh) * | 2021-08-13 | 2021-11-16 | 浙江海昇药业股份有限公司 | 一种1-(3-羟基苯基)-1,3,3-三甲基脲的合成方法、中间体及其用途 |
CN113651723A (zh) * | 2021-08-13 | 2021-11-16 | 浙江海昇药业股份有限公司 | 一种3-(3-羟基苯基)-1,1-二甲基脲的合成方法、中间体及用途 |
CN115353466A (zh) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | 一种甲硫酸新斯的明的制备和纯化方法 |
CN115353465A (zh) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | 一种甲硫酸新斯的明的合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5712418A (en) * | 1989-10-23 | 1998-01-27 | Research Corporation Technologies, Inc. | Synthesis and use of amino acid fluorides as peptide coupling reagents |
CN1886362A (zh) * | 2003-07-24 | 2006-12-27 | 皇后医学中心 | 烷基化剂的制备和用途 |
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2019
- 2019-12-13 CN CN201911285027.9A patent/CN110950780A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5712418A (en) * | 1989-10-23 | 1998-01-27 | Research Corporation Technologies, Inc. | Synthesis and use of amino acid fluorides as peptide coupling reagents |
CN1886362A (zh) * | 2003-07-24 | 2006-12-27 | 皇后医学中心 | 烷基化剂的制备和用途 |
Non-Patent Citations (2)
Title |
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PORST HELLA ET AL: "Kinetics of the degradation of neostigmine bromide in aqueous solution", 《PHARMAZIE》 * |
PORST HELLA ET AL: "Structure of degradation products of neostigmine bromide", 《PHARMAZIE》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113277961A (zh) * | 2021-04-09 | 2021-08-20 | 深圳市新浩瑞医药科技有限公司 | 一种溴新斯的明的合成方法 |
CN113651722A (zh) * | 2021-08-13 | 2021-11-16 | 浙江海昇药业股份有限公司 | 一种1-(3-羟基苯基)-1,3,3-三甲基脲的合成方法、中间体及其用途 |
CN113651723A (zh) * | 2021-08-13 | 2021-11-16 | 浙江海昇药业股份有限公司 | 一种3-(3-羟基苯基)-1,1-二甲基脲的合成方法、中间体及用途 |
CN115353466A (zh) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | 一种甲硫酸新斯的明的制备和纯化方法 |
CN115353465A (zh) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | 一种甲硫酸新斯的明的合成方法 |
CN115353466B (zh) * | 2022-10-24 | 2023-08-01 | 云南先施药业有限公司 | 一种甲硫酸新斯的明的制备和纯化方法 |
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Inventor after: Pu Pingli Inventor after: Ma Liyan Inventor after: Wang Xiaoxue Inventor after: Shi Yongzhi Inventor after: Cui Hailong Inventor before: Ma Liyan Inventor before: Wang Xiaoxue Inventor before: Pu Pingli Inventor before: Cui Hailong Inventor before: Shi Yongzhi Inventor before: An Xiaomin |
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Application publication date: 20200403 |