CN110917182A - 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用 - Google Patents

双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用 Download PDF

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Publication number
CN110917182A
CN110917182A CN201911397959.2A CN201911397959A CN110917182A CN 110917182 A CN110917182 A CN 110917182A CN 201911397959 A CN201911397959 A CN 201911397959A CN 110917182 A CN110917182 A CN 110917182A
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CN
China
Prior art keywords
disease
disulfiram
nlrp3 inflammasome
related diseases
use according
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CN201911397959.2A
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English (en)
Chinese (zh)
Inventor
胡文辉
杨忠金
孙平
邓文敏
熊兮
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Guangzhou Medical University
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Guangzhou Medical University
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Priority to CN201911397959.2A priority Critical patent/CN110917182A/zh
Publication of CN110917182A publication Critical patent/CN110917182A/zh
Priority to PCT/CN2020/127775 priority patent/WO2021135654A1/fr
Priority to CN202011642796.2A priority patent/CN112641768A/zh
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201911397959.2A 2019-12-30 2019-12-30 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用 Withdrawn CN110917182A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201911397959.2A CN110917182A (zh) 2019-12-30 2019-12-30 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用
PCT/CN2020/127775 WO2021135654A1 (fr) 2019-12-30 2020-11-10 Usage du disulfirame dans la préparation d'un médicament pour la prévention et le traitement de maladies associées à l'inflammasome nlrp3
CN202011642796.2A CN112641768A (zh) 2019-12-30 2020-12-30 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911397959.2A CN110917182A (zh) 2019-12-30 2019-12-30 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用

Publications (1)

Publication Number Publication Date
CN110917182A true CN110917182A (zh) 2020-03-27

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CN201911397959.2A Withdrawn CN110917182A (zh) 2019-12-30 2019-12-30 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用
CN202011642796.2A Pending CN112641768A (zh) 2019-12-30 2020-12-30 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用

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CN (2) CN110917182A (fr)
WO (1) WO2021135654A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111494380A (zh) * 2020-06-01 2020-08-07 中国药科大学 Db-1在制备防治nlrp3炎症小体相关疾病的药物中的应用及其药物组合物
CN111658625A (zh) * 2020-07-10 2020-09-15 南方医科大学第三附属医院（广东省骨科研究院） 双硫仑在制备治疗系统性红斑狼疮药物中的应用
CN112641768A (zh) * 2019-12-30 2021-04-13 广州医科大学 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用
CN115245507A (zh) * 2021-04-28 2022-10-28 中南大学湘雅医院 一种药物组合物及其应用、双硫仑和/或双硫仑的盐的应用
CN115844864A (zh) * 2022-12-05 2023-03-28 复旦大学附属中山医院 双硫仑在制备防治主动脉瘤和主动脉夹层药物中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114469995B (zh) * 2021-06-30 2023-05-05 四川大学 一种治疗急性肾损伤的药物组合物及其制备方法和用途
US20230107173A1 (en) * 2021-09-23 2023-04-06 Regeneron Pharmaceuticals, Inc. Methods Of Treating Chronic Kidney Disease (CKD) With Inhibitors Of Protective Loss-Of-Function Genes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548540B2 (en) * 1998-09-08 2003-04-15 Charlotte-Mecklenburg Hospital Authority Method of treating cancer using dithiocarbamate derivatives
CN103301097A (zh) * 2012-03-14 2013-09-18 上海市肿瘤研究所 双硫仑在制备抗肝硬化或抗肝纤维化药物中的应用
CN104825416B (zh) * 2015-05-22 2016-10-26 湖南赛沃药业有限公司 双硫仑植入剂及其制备方法
CN107522641B (zh) * 2016-06-22 2020-05-05 复旦大学 联芳基脲类衍生物或其盐及其制备方法和用途
US11926600B2 (en) * 2017-08-15 2024-03-12 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
CN110585182A (zh) * 2019-07-10 2019-12-20 郴州市第一人民医院 双硫仑在制备治疗和预防高血脂药物或动脉粥样硬化药物中的用途
CN110917182A (zh) * 2019-12-30 2020-03-27 广州医科大学 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112641768A (zh) * 2019-12-30 2021-04-13 广州医科大学 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用
WO2021135654A1 (fr) * 2019-12-30 2021-07-08 广州医科大学 Usage du disulfirame dans la préparation d'un médicament pour la prévention et le traitement de maladies associées à l'inflammasome nlrp3
CN111494380A (zh) * 2020-06-01 2020-08-07 中国药科大学 Db-1在制备防治nlrp3炎症小体相关疾病的药物中的应用及其药物组合物
CN111494380B (zh) * 2020-06-01 2022-06-28 中国药科大学 Db-1在制备防治nlrp3炎症小体相关疾病的药物中的应用及其药物组合物
CN111658625A (zh) * 2020-07-10 2020-09-15 南方医科大学第三附属医院（广东省骨科研究院） 双硫仑在制备治疗系统性红斑狼疮药物中的应用
CN115245507A (zh) * 2021-04-28 2022-10-28 中南大学湘雅医院 一种药物组合物及其应用、双硫仑和/或双硫仑的盐的应用
CN115844864A (zh) * 2022-12-05 2023-03-28 复旦大学附属中山医院 双硫仑在制备防治主动脉瘤和主动脉夹层药物中的应用

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CN112641768A (zh) 2021-04-13
WO2021135654A1 (fr) 2021-07-08

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