CN110871038B - 耐盐的多孔介质 - Google Patents
耐盐的多孔介质 Download PDFInfo
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- CN110871038B CN110871038B CN201910814313.3A CN201910814313A CN110871038B CN 110871038 B CN110871038 B CN 110871038B CN 201910814313 A CN201910814313 A CN 201910814313A CN 110871038 B CN110871038 B CN 110871038B
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Classifications
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Abstract
本发明公开了多孔介质,例如珠粒、纤维或膜,其包含多孔载体和交联的聚合物涂层,其中交联的聚合物涂层的聚合物包含至少一种聚合的单体(A)、至少一种聚合的单体(B)、至少一种聚合的单体(C),其中单体(A)‑(C)如本文中所定义。还公开了制备多孔介质和处理含有希望的蛋白质和一种或更多种带负电荷物类的流体或从用于微电子工业中的有机溶剂中去除金属的方法。
Description
技术领域
本发明涉及耐盐的多孔介质。
背景技术
单克隆抗体(mAb)的生产及其纯化由于方法的高成本而持续成为问题。造成高成本的原因在于生物分子在分离过程中需要经历的若干纯化步骤。例如,纯化步骤之一是蛋白A亲和色谱法,其中葡萄球菌(Staphylococcal)蛋白A以高选择性结合亚类1、2和4的IgG分子,并且与作为药物分子的活性区域的Fab区的相互作用最小。随着生物技术市场的快速发展,这些纯化步骤的改进在以及时的空间和降低的成本将生物制剂推向市场方面变得越来越希望并且变得更有价值。
在蛋白质纯化期间,使用离子交换介质的精制步骤要求介质不仅对杂质具有选择性,而且还需要耐受具有高盐电导率(例如高达15mS/cm以上)的原料。
上述内容表明存在对离子交换介质的未满足的需求,所述离子交换介质不仅对杂质具有选择性,而且还耐受具有高盐电导率的原料。
此外,存在对用于微电子工业的离子交换介质的未满足的需求,所述离子交换介质可以有效地从微电子湿法蚀刻化学品中(WEC)和光刻法中去除痕量金属离子。
发明内容
本发明提供了多孔介质,例如珠粒,纤维和膜,其包含具有负电荷的交联聚合物。该介质具有耐盐性质和在10CV/min流速下高达170mg/mL的生物物质、抗体和/或蛋白质(例如IgG)的高的动态结合能力(DBC)。所述多孔介质还具有去除有机溶剂,例如微电子产业中使用的有机溶剂中存在的金属的高容量。
附图说明
图1示意性描绘了根据本发明的一个实施方案的多孔介质(例如膜)的制备。
图2示意性描绘了根据本发明的另一实施方案的多孔介质(例如膜)的制备。
图3描绘了注射聚(丙烯酰氨基-2-甲基丙磺酸酯-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺)样品的三重检测洗脱曲线,其中1表示折射率(RI),3表示粘度,2表示相对角激光散射(RALS)数据,和4表示log MW。
图4描绘了根据本发明的一个实施方案,从注射聚(丙烯酰氨基-2-甲基丙磺酸酯-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺)样品获得的MW分布图的叠加图,其中1表示归一化重量分数(WF/dlog MW),2表示累积重量份额,3表示Mark-Houwink-Sakurada曲线(log([η])与log(M)的关系。
图5描绘了在不同盐浓度下根据实施例8的多孔膜的IgG 10%穿透DBC。
图6描绘了图5中图示的多孔膜(实心黑色条)的IgG 10%穿透DBC与商业上可得的膜(灰色条)Natrix Sb-HD的穿透性能相比的关系。
图7描绘了实施例8的多孔膜的痕量金属去除效率。
具体实施方式
本发明提供了耐盐的多孔介质,其包含多孔载体和交联聚合物涂层,其中交联聚合物涂层包含至少一种聚合的单体(A)、至少一种聚合的单体(B)和至少一种聚合的单体(C),
其中单体(A)具有下式:
CH2=C(R1)–C(=O)–NH–(CH2)n–N’R2R3,其中n为1-6,
单体(B)具有下式:
CH2=C(R4)–C(=O)–NR5R6,和
单体(C)具有下式:
CH2=C(R8)–C(=O)–NH–C(R7)2–(CH2)m-X,
其中m为1-3,和X为SO3H或COOH;
其中
R1、R4和R8独立地为H或C1-C6烷基,和
R2、R3、R5、R6和R7独立地为H、C1-C6烷基、C6-C10芳基、C1-C烷氧基C1-C烷基或三苯基甲基。
在一个实施方案中,R1为C1-C6烷基,和R4为H。在另一实施方案中,R1为C1-C6烷基,R4为H,和R8为H。
本申请通篇的C1-C6烷基可以具有1、2、3、4、5或6个碳原子;烷基可以为直链或支链的。烷基的实例包括甲基、乙基、正丙基、异丙基、正丁基、异丁基、叔丁基、正戊基、2-甲基丁基、正己基、2-甲基戊基和3-甲基戊基。
在本发明的一个实施方案中,R1为甲基。
在任意上述实施方案中,R2和R3为H,以及R5和R6独立地为C1-C6烷基。
在任意上述实施方案中,R2和R3为H,以及R5和R6为甲基。
在任意上述实施方案中,R2、R3、R5和R6独立地为H、甲基、苯基、甲氧基甲基或三苯基甲基。
在某些实施方案中,R2和R3为H,以及R5和R6独立地为甲基、苯基、甲氧基甲基或三苯基甲基。
在任意上述实施方案中,R7为烷基,优选甲基。
在任意上述实施方案中,所述共聚物包含一种聚合的单体(A)、一种聚合的单体(B)和一种聚合的单体(C)。
在任意上述实施方案中,所述共聚物包含一种聚合的单体(A)、一种聚合的单体(B)和两个不同的聚合的单体(C)。
在任意上述实施方案中,聚合的单体(C)之一中的X为SO3H,和另一种聚合的单体(C)中的X为COOH。
在一个实施方案中,所述介质为多孔膜。
在另一实施方案中,所述介质为珠粒或纤维。
用于多孔介质中的离子交换聚合物可以由任意合适的单体组合制备,例如,
-N,N-二甲基丙烯酰胺、N-(3-氨基丙基)甲基丙烯酰胺和2-丙烯酰氨基-2-甲基丙磺酸盐,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N-异丙基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和叔丁基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和乙基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和苯基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和二乙基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N-(异丁氧基甲基)丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N-(三苯基甲基)丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N,N-二甲基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和N-异丙基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和叔丁基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和苯基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和二乙基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和乙基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和N-(异丁氧基甲基)甲基丙烯酰胺,
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和N-(三苯基甲基)丙烯酰胺和
-2-丙烯酰氨基-2-甲基丙磺酸盐、N-(2-氨基乙基)甲基丙烯酰胺和N,N-二甲基丙烯酰胺。
本发明在实施方案中提供如下的一种或更多种:
-包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N-二甲基丙烯酰胺的三聚物,
-包含丙烯酸、N-(3-氨基丙基)甲基丙烯酰胺和N-二甲基丙烯酰胺的三聚物,
-包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N-二甲基丙烯酰胺并且使用三聚物的伯胺结构部分交联在介质上的三聚物,
-包含2-丙烯酰氨基-2-甲基丙磺酸盐、氨基烷基甲基丙烯酰胺和N-二甲基丙烯酰胺并且使用三聚物的伯胺结构部分交联在介质上的三聚物,
-包含丙烯酸、N-(3-氨基丙基)甲基丙烯酰胺和N-二甲基丙烯酰胺并且使用三聚物的伯胺结构部分交联在介质上的三聚物,
-包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺、N-二甲基丙烯酰胺或任意的烷基丙烯酰胺例如N-叔丁基丙烯酰胺、N-苯基丙烯酰胺、N-二乙基丙烯酰胺、N-异丙基丙烯酰胺、N-乙基丙烯酰胺、N-二乙基甲基丙烯酰胺,N-(异丁氧基甲基)甲基丙烯酰胺和N-(三苯基甲基)甲基丙烯酰胺并且使用三聚物的伯胺结构部分交联在介质上的三聚物,
-来源于三聚物的耐盐的离子交换多孔膜,所述三聚物包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺,N,N-二甲基丙烯酰胺或任意的烷基丙烯酰胺例如N-叔丁基丙烯酰胺、N-苯基丙烯酰胺,N,N-二乙基丙烯酰胺、N-异丙基丙烯酰胺、N-乙基丙烯酰胺,N,N-二乙基甲基丙烯酰胺、N-(异丁氧基甲基)甲基丙烯酰胺和N-(三苯基甲基)甲基丙烯酰胺并且使用三聚物的伯胺结构部分交联在介质上,所述三聚物的伯胺结构部分有利地用于例如捕获单克隆抗体、精制单克隆抗体或病毒载体纯化,
-耐盐的离子交换多孔膜,其中涂布在多孔膜上的三聚物的耐盐的性质有利地受到聚合物的烷基丙烯酰胺部分影响,
-三聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺、N-二甲基丙烯酰胺或任意的烷基丙烯酰胺例如N-叔丁基丙烯酰胺、N-苯基丙烯酰胺、N,N-二乙基丙烯酰胺、N-异丙基丙烯酰胺、N-乙基丙烯酰胺、N,N-二乙基甲基丙烯酰胺、N-(异丁氧基甲基)甲基丙烯酰胺和N-(三苯基甲基)甲基丙烯酰胺并且使用伯胺结构部分交联在介质上以形成阳离子交换多孔膜,所述阳离子交换多孔膜可以有利地用于例如捕获Micro E溶剂中的痕量金属污染物,
-三聚物,其包含丙烯酸、N-(3-氨基丙基)甲基丙烯酰胺和N-二甲基丙烯酰胺,
-三聚物,其包含丙烯酸、N-(3-氨基丙基)甲基丙烯酰胺和N,N-二甲基丙烯酰胺并且使用三聚物的伯胺结构部分交联在介质上,
-四聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺、N,N-二甲基丙烯酰胺和N-叔丁基丙烯酰胺,
-四聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺,N,N-二甲基丙烯酰胺和苯乙烯磺酸,
-四聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺、N,N-二甲基丙烯酰胺和N-叔丁基丙烯酰胺并且使用四聚物的伯胺结构部分交联在介质上,
-四聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺、N,N-二甲基丙烯酰胺和苯乙烯磺酸并且使用四聚物的伯胺结构部分交联在介质上,
-四聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺,N,N-二甲基丙烯酰胺和丙烯酸;和
-四聚物,其包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺,N,N-二甲基丙烯酰胺和丙烯酸并且使用四聚物的伯胺结构部分交联在介质上。
共聚物的分子量可以具有任意合适的范围,例如50-4000kD、100-3500kD或200-1500kD、50-3126kD。最优选的分子量范围在207kD-1270kD,和在实施方案中,为50-3126kD,和优选207kD-1270kD,其中分子量如通过三元GPC检测分析测定。
共聚单体可以以任意合适的摩尔比存在于共聚物中,例如在色谱应用中提供耐高盐性的单体组合,特别是包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和二甲基丙烯酰胺的三聚物的范围为1:0.1:1的摩尔比至5:0.5:2的摩尔比。
在实施方案中,在微电子溶剂应用中提供去除金属离子的高离子交换容量的单体组合,特别是对于包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和任意的烷基丙烯酰胺(例如N-叔丁基丙烯酰胺、N-苯基丙烯酰胺、N,N-二乙基丙烯酰胺、N-异丙基丙烯酰胺、N-乙基丙烯酰胺、N,N-二乙基甲基丙烯酰胺、N-(异丁氧基甲基)甲基丙烯酰胺、丙烯酰胺和N-(三苯基甲基)甲基丙烯酰胺)的范围为1:0.1:1的摩尔比至5:0.5:2的摩尔比。
在实施方案中,对于膜应用,在色谱应用中影响耐盐性,同时仍然允许有效回收蛋白质的单体组合的范围为1:0.25:2的摩尔比至2:0.5:1的摩尔比。当包含2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和任意的烷基丙烯酰胺(例如N,N-二甲基丙烯酰胺、N-叔丁基丙烯酰胺、N-苯基丙烯酰胺,N,N-二乙基丙烯酰胺、N-异丙基丙烯酰胺、N-乙基丙烯酰胺、N,N-二乙基甲基丙烯酰胺、N-(异丁氧基甲基)甲基丙烯酰胺、丙烯酰胺和N-(三苯基甲基)甲基丙烯酰胺)的三聚单体用于形成在膜上交联的聚合物时,该范围特别适用。
在实施方案中,如果2-丙烯酰氨基-2-甲基丙磺酸盐、N-(3-氨基丙基)甲基丙烯酰胺和N,N-二甲基丙烯酰胺的三聚单体用于形成在膜上交联的聚合物用于蛋白质纯化时,影响耐高盐性,同时提供高达200mg/ml IgG的高的动态结合能力的聚合物浓度范围为1%-10%重量。
本发明还提供了用于生产多孔介质的方法,其包括:
(i)聚合单体(A)、(B)和(C)的混合物,以获得三聚物,和
(ii)使用原位交联将在(i)中获得的三聚物涂布在多孔载体上,以获得布置在多孔载体上的共聚物涂层。
可以使用合适的引发剂(自由基、阳离子或阴离子引发剂)进行单体的聚合,并且特别是采用自由基引发剂,例如热活化的自由基引发剂,如偶氮化合物、过硫酸盐、过氧化物、过酸、过乙酸酯/盐和有机金属化合物。自由基引发剂的实例包括AIBN、4,4-偶氮双(4-氰基戊酸)、1,1'-偶氮双(环己烷甲腈)、过氧化苯甲酰、2,2-双(叔丁基过氧基)丁烷、1,1-双(叔丁基过氧基)环己烷、过氧化二异丙苯、过氧苯甲酸叔丁酯、过氧苯甲酸叔戊酯和过硫酸钾。
根据所述方法,所述交联剂包含两个或更多个基团,例如,2、3、4或更多个交联官能团,例如选自二环氧化物、二醛、二卤化物和二酯的交联剂。例如,所述交联剂选自乙二醇二缩水甘油醚、丙二醇二缩水甘油醚、甘油基三缩水甘油醚、聚乙二醇二缩水甘油醚、乙二醇二甲磺酸酯和二甲苯磺酸酯及其任意的组合。
本发明还提供了处理包含痕量金属的流体的方法,该方法包括使所述流体接触如上所述的介质或多孔膜,并且回收包含降低浓度的痕量金属的流体。
根据本发明的一个实施方案,多孔膜可以为纳米多孔膜,例如具有1nm-100nm的孔的膜;或微孔膜,例如,具有直径为0.005μm-10μm的孔的膜。
其上提供有涂层的多孔载体可以是任意合适的材料,例如聚合物、金属或陶瓷,并且特别是聚合物,例如聚砜(PSU),聚醚砜(PES),聚苯醚(PPE),聚亚苯基醚砜(PPES),聚苯氧醚(PPO),聚碳酸酯(PC),二氮杂萘酮联苯聚芳醚砜酮(poly(phthalazinone ethersulfone ketone),PPESK),聚醚醚酮(PEEK),聚醚酮酮(PEKK),聚醚酰亚胺(PEI)及其共混物。
在一个实施方案中,所述共聚物涂布并且交联在多孔高密度聚乙烯膜,聚醚砜膜,聚偏氟乙烯膜,聚四氟乙烯膜,聚苯基砜膜,聚苯硫醚膜,聚乙烯和聚丙烯膜,聚酯膜,熔喷(melt blown)聚酯膜,熔喷聚丙烯膜,纤维素膜,尼龙膜和聚氯乙烯/丙烯腈上,以产生多孔介质或膜。
可以将根据本发明实施方案的多孔介质布置在壳体中,所述壳体包括至少一个入口和至少一个出口,并且在入口与出口之间限定至少一个流体流动路径,其中至少一个本发明的膜或包括至少一个本发明的膜的过滤器横跨流体流动路径,以提供过滤器装置或过滤器模块。在一个实施方案中,提供了一种过滤器装置,其包括:壳体,该壳体包括入口和第一出口,并且限定入口与第一出口之间的第一流体流动路径;和至少一个本发明的膜或包括至少一个本发明的膜的过滤器,将本发明的膜或包括至少一个本发明的膜的过滤器布置在壳体中横跨第一流体流动路径。
对于错流应用,在一个实施方案中,将至少一个本发明的多孔膜或包括至少一个本发明的膜的过滤器布置在壳体中,所述壳体包括至少一个入口和至少两个出口,并且至少限定在入口与第一出口之间第一流体流动路径,以及入口与第二出口之间的第二流体流动路径,其中本发明的膜或包括至少一个本发明的膜的过滤器横跨第一流体流动路径,以提供过滤器装置或过滤器模块。在一个示例性实施方案中,过滤器装置包含错流过滤器模块,壳体包括入口、第一出口和第二出口,所述第一出口包括浓缩物出口,所述第二出口包括渗透物出口,并且所述壳体限定入口与第一流体出口之间的第一流体流动路径以及入口与第二出口之间的第二流体流动路径,其中将至少一个本发明的膜或包括至少一个本发明的膜的过滤器横跨第一流体流动路径布置。
过滤器装置或模块可以是无菌的。可以使用任意合适形状并且提供入口和一个或更多个出口的壳体。
壳体可以由任何合适的刚性不渗透性材料制造,包括任意不渗透性热塑性材料,其与被处理的流体相容。例如,壳体可以由金属,如不锈钢或由聚合物,如透明或半透明聚合物,如丙烯酸、聚丙烯、聚苯乙烯或聚碳酸酯树脂制造。
在本发明的一个实施方案中,交联剂包含两个或更多个交联官能团,其选自二环氧化物、二醛、二卤化物、二酯、二磺酰氯和二酰氯。
以下实施例进一步阐释本发明,但当然不应被解释为以任何方式限制其范围。
实施例1
该实施例阐释根据本发明的实施方案的三聚物溶液的制备方法。
制备三聚物聚(丙烯酰氨基-2-甲基丙磺酸盐-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺)的10%溶液:
将2-丙烯酰氨基-2-甲基丙磺酸盐(15.6g,75mM)、N-(3-氨基丙基)甲基丙烯酰胺盐酸盐(4.5g,25mM)和N,N-二甲基丙烯酰胺(10g,100mM)与去离子水(260g)和8M NaOH(17.1g)混合,将该混合物脱气5分钟,添加过硫酸铵(0.690g,3mM),并且混合。将反应混合物在60℃在氮气下搅拌2小时,使其冷却至室温,以获得三聚物溶液。
实施例2
该实施例阐释根据本发明的另一实施方案的三聚物溶液的制备方法。
制备聚(苯乙烯磺酸-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺)的10%溶液:将4-乙烯基苯磺酸钠(15.46g,75mM)、N-(3-氨基丙基)甲基丙烯酰胺盐酸盐(4.5g,25mM)和N,N-二甲基丙烯酰胺(10g,100mM)与去离子水(260g)和8M NaOH(17.1g)混合,将该混合物脱气5分钟,添加过硫酸铵(0.690g,3mM)。将反应混合物在60℃在氮气下搅拌2小时,使其冷却至室温,以获得三聚物溶液。
实施例3
该实施例阐释根据本发明的另一实施方案的四聚物溶液的制备方法。
制备聚(丙烯酰氨基-2-甲基丙磺酸盐-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺-共-叔丁基丙烯酰胺),9.5%溶液:将2-丙烯酰氨基-2-甲基丙磺酸盐(10.45g,50mM)、N-(3-氨基丙基)甲基丙烯酰胺盐酸盐(2.24g,12.5mM)、N,N-二甲基丙烯酰胺(5g,50mM)和叔丁基丙烯酰胺[1.6g,于IPA(9g)中,12.6mM]与去离子水(164.7g)和8MNaOH(10g)混合,将该混合物脱气5分钟,添加过硫酸铵(0.431g,1.9mM)。将反应混合物在60℃在氮气下搅拌2小时,使其冷却至室温,以获得上述四聚物溶液。
实施例4
该实施例阐释根据本发明的另一实施方案的四聚物溶液的制备方法。
聚(丙烯酰氨基-2-甲基丙磺酸盐-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺-共-丙烯酸),10%溶液的制备:将2-丙烯酰氨基-2-甲基丙磺酸盐(7.3g,35.3mM)、N-(3-氨基丙基)甲基丙烯酰胺盐酸盐(2.52g,14.1mM)、N,N-二甲基丙烯酰胺(7g,70.6mM)和丙烯酸[2.54g,35.3mM和IPA(9g)]与去离子水(155g)和8M NaOH(10g)混合,将该混合物脱气5分钟,添加过硫酸铵(0.532g,2.3mM)。将反应混合物在60℃在氮气下搅拌2小时,使其冷却至室温,以获得上述四聚物溶液。
实施例5
该实施例阐释根据本发明的另一实施方案的四聚物溶液的制备方法。
聚(丙烯酰氨基-2-甲基丙磺酸盐-共-(氨基丙基)甲基丙烯酰胺-共-N,N-二甲基丙烯酰胺-共-苯乙烯磺酸),8%溶液的制备:将4-乙烯基苯磺酸钠(4.16g,20mM)、N-(3-氨基丙基)甲基丙烯酰胺盐酸盐(1.8g,10mM)、2-丙烯酰氨基-2-甲基丙磺酸盐(4.18g,20mM)和N,N-二甲基丙烯酰胺(4g,40mM)与去离子水(156.34g)与8M NaOH(17.1g)混合,脱气5分钟,然后添加过硫酸铵(0.690g,3mM)。将反应混合物在60℃在氮气下搅拌2小时,使其冷却至室温,以获得上述聚合物溶液。
实施例6
该实施例阐释根据本发明的一个实施方案的多孔膜的制备方法。
5%磺酸化的聚合物涂层(100g混合物):将来自实施例1的10%磺酸化聚合物(50g)与水(49g)、聚乙二醇二缩水甘油醚(150mg)和Triton X-100(850mg)混合,搅拌至溶解。用NaOH水溶液将该溶液的pH调节至10,以获得涂料溶液。通过浸涂用该涂料溶液涂布3μm孔径的HDPE膜。使涂布的膜夹在两支移液管之间,从上至下刮擦,以获得HDPE膜上的薄涂层。使膜上的涂层在65℃交联1小时,或在室温交联过夜。将得到的膜在冷水中浸沥24小时,使其干燥。
实施例7
该实施例阐释根据本发明的另一实施方案的多孔膜的制备方法。
将2-丙烯酰氨基-2-甲基丙磺酸盐(104.5g,504mmol)与N,N-二甲基丙烯酰胺(50g,504mmol)、N-(3-氨基丙基)甲基丙烯酰胺盐酸盐(22.4g,126mmol)和去离子水(1.524kg)与170g异丙醇混合。用8M NaOH(100g)将该混合物的pH调节至9.6。用氮气将该反应混合物脱气15分钟,添加过硫酸铵(3.88g 1.5mol%)。将混合物在60℃搅拌2小时,使其冷却至室温,以获得10%聚合物溶液。
由上述10%聚合物溶液与0.85%Triton X100表面活性剂和0.45%二环氧化物交联剂聚乙二醇二缩水甘油醚制备4%聚合物涂料溶液。将溶液的pH调节至10,将3μm孔径的HDPE膜在上述溶液中浸涂。将涂布的膜在65℃热交联1小时,在去离子水中浸沥过夜,在65℃干燥过夜。
实施例8
本实施例示例根据一个实施方案的膜去除痕量金属的能力。
基线:用100mL IPA(10mL/min)、200mL DIW、100mL 5%HCl、200mL去离子水和200mL IPA冲洗0.2μm膜样品。收集100mL样品,用ICP-MS进行金属分析。
金属侵袭:用加标的IPA(1ppb金属)以7mL/min的流出速率攻击0.2μm来自实施例7的膜样品。弃去前10mL流出物,将下一个10mL流出物收集到PFA瓶中。用ICP-MS进行金属分析。重复该实验n=2次。
本文引用的所有参考文献,包括出版物、专利申请和专利在此均通过引用并入本文,其程度如同每篇参考文献被单独且具体地指出通过引用并入并且在本文中完整地阐述一样。
在描述本发明的上下文中(特别是在以下权利要求的上下文中)使用术语“一”和“一个”和“该”和“至少一个”以及类似的指示物将被解释为除非本文另有指示或明确与上下文相矛盾,否则涵盖单数和复数。除非本文另有指示或明确与上下文相矛盾,否则使用术语“至少一个/种”跟随一个或更多个项目的列表(例如,“A和B中的至少一个/种”)应被解释为表示从列出的项目中选择的一个项目(A或B)或所列项目(A和B)中的两个或更多个的任意组合。除非另有注明,否则术语“包括”、“具有”、“包含”和“含有”应被解释为开放式术语(即,意味着“包括但不限于”)。除非本文另有指示,否则本文中对数值范围的描述仅旨在用作单独提及落入该范围内的每个单独值的简写方法,并且将每个单独的值并入本说明书中,如同其在本文中单独引用一样。除非本文另有指示或上下文明显矛盾,否则本文所述的所有方法均可以任意合适的顺序进行。除非另外声明,否则本文提供的任何和所有实例或示例性语言(例如,“如”)的应用仅旨在更好地示例本发明,而不是对本发明的范围进行限制。本说明书中的任何语言都不应被解释为表明任何未要求保护的要素对于本发明的实施是必不可少的。
本文描述了本发明的优选实施方案,包括本发明人已知的实施本发明的最佳方式。在阅读上述描述时,那些优选实施例的变型对于本领域普通技术人员而言可以变得显而易见。如果适合,本发明人预期本领域技术人员可以采用这些变型,并且本发明人预期本发明以不同于本文具体描述的方式实施。因此,本发明包括适用法律所允许的待批权利要求中所述主题的所有变型和等效方案。此外,除非本文另有指示或上下文明显矛盾,否则本发明涵盖上述要素的所有可能变型的任意组合。
Claims (20)
1.多孔介质,其包含多孔载体和交联的聚合物涂层,
其中通过如下方式制备交联的聚合物涂层:聚合包含至少一种单体A、至少一种单体B、和至少一种单体C的单体混合物,并用交联剂交联所得的共聚物,所述交联剂选自丙二醇二缩水甘油醚、甘油基三缩水甘油醚、聚乙二醇二缩水甘油醚、二醛、二卤化物、二酯、二磺酰氯和二酰氯,
其中,
单体A具有下式:
CH2=C(R1)–C(=O)–NH–(CH2)n–N’R2R3,其中n为1-6,
单体B具有下式:
CH2=C(R4)–C(=O)–NR5R6,和
单体C具有下式:
CH2=C(R8)–C(=O)–NH–C(R7)2–(CH2)m-X,
其中m为1-3,和X为SO3H或COOH;
其中
R1、R4和R8独立地为H或C1-C6烷基,和
R2、R3、R5、R6和R7独立地为H、C1-C6烷基、C6-C10芳基、甲氧基甲基或三苯基甲基。
2.根据权利要求1所述的多孔介质,其中R1为C1-C6烷基,和R4为H。
3.根据权利要求1或2所述的多孔介质,其中R1为甲基。
4.根据权利要求1或2所述的多孔介质,其中R2和R3为H,以及R5和R6独立地为C1-C6烷基。
5.根据权利要求4所述的多孔介质,其中R5和R6为甲基。
6.根据权利要求1或2所述的多孔介质,其中R2、R3、R5和R6独立地为H、甲基、苯基、甲氧基甲基或三苯基甲基。
7.根据权利要求1或2所述的多孔介质,其中R2和R3为H,以及R5和R6独立地为甲基、苯基、甲氧基甲基或三苯基甲基。
8.根据权利要求1或2所述的多孔介质,其中R7为烷基。
9.根据权利要求8所述的多孔介质,其中R7为甲基。
10.根据权利要求1或2所述的多孔介质,其中所述单体混合物包含一种单体A、一种单体B和一种单体C。
11.根据权利要求1或2所述的多孔介质,其中所述单体混合物包含一种单体A、一种单体B和两种不同的单体C。
12.根据权利要求11所述的多孔介质,其中单体C之一中的X为SO3H,和另一种单体C中的X为COOH。
13.根据权利要求1或2所述的多孔介质,其为多孔膜。
14.根据权利要求1或2所述的多孔介质,其为珠粒或纤维。
15.用于生产根据权利要求1-14任一项所述的多孔介质的方法,其包括:
(i)聚合包含至少一种单体A、至少一种单体B和至少一种单体C的混合物,以获得共聚物,和
(ii)用交联剂和原位交联将在(i)中获得的共聚物涂布在多孔载体上,以获得布置在多孔载体上的交联的涂层。
16.根据权利要求15所述的方法,其中所述二酯和/或二磺酰氯交联剂选自二醇二甲磺酸酯、二甲苯磺酸酯和二醇二甲磺酰氯(glycol dimesoyl chloride)及其任意的组合。
17.处理包含希望的蛋白质和一种或更多种杂质的流体的方法,所述方法包括使所述流体与根据权利要求1-14任一项所述的多孔介质接触,并且回收具有降低浓度的杂质的希望的蛋白质。
18.根据权利要求17所述的方法,其中所述希望的蛋白质为抗体。
19.根据权利要求17所述的方法,其中所述希望的蛋白质为生物物质。
20.处理包含痕量金属的流体的方法,所述方法包括使所述流体与根据权利要求1-14任一项所述的多孔介质接触,并且回收包含降低浓度的痕量金属的流体。
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