CN110869029A - 组合癌症治疗 - Google Patents

组合癌症治疗 Download PDF

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Publication number
CN110869029A
CN110869029A CN201880046014.3A CN201880046014A CN110869029A CN 110869029 A CN110869029 A CN 110869029A CN 201880046014 A CN201880046014 A CN 201880046014A CN 110869029 A CN110869029 A CN 110869029A
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pharmaceutical composition
acid
inhibitor
use according
subject
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CN201880046014.3A
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Chinese (zh)
Inventor
鲁思·本亚喀尔
斯泰拉·甘格里诺维奇
所司·特斯勒
利亚特·弗莱肖恩
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Biosight Ltd
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Biosight Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201880046014.3A 2017-07-09 2018-07-09 组合癌症治疗 Pending CN110869029A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762530213P 2017-07-09 2017-07-09
US62/530,213 2017-07-09
PCT/IB2018/000852 WO2019012328A1 (en) 2017-07-09 2018-07-09 ANTICANCER POLY THERAPY

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CN110869029A true CN110869029A (zh) 2020-03-06

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US (1) US20200147117A1 (https=)
EP (1) EP3651772A4 (https=)
JP (2) JP7305613B2 (https=)
KR (1) KR20200027548A (https=)
CN (1) CN110869029A (https=)
BR (1) BR112020000492A2 (https=)
CA (1) CA3069558A1 (https=)
IL (1) IL271946B (https=)
WO (1) WO2019012328A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113018430A (zh) * 2021-03-10 2021-06-25 华东理工大学 癌症治疗靶点及其用途
CN114026121A (zh) * 2019-01-28 2022-02-08 赛诺菲 治疗多发性骨髓瘤的方法
CN115461058A (zh) * 2020-04-23 2022-12-09 拜欧赛特有限公司 用于治疗血液癌的方法和方案
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