CN1108651A - 对神经降压素活性的取代1-萘基-3-吡啶甲酰胺，其制备及含有它们的药物组合物 - Google Patents

对神经降压素活性的取代1-萘基-3-吡啶甲酰胺，其制备及含有它们的药物组合物 Download PDF

Info

Publication number
CN1108651A
CN1108651A CN94117090A CN94117090A CN1108651A CN 1108651 A CN1108651 A CN 1108651A CN 94117090 A CN94117090 A CN 94117090A CN 94117090 A CN94117090 A CN 94117090A CN 1108651 A CN1108651 A CN 1108651A
Authority
CN
China
Prior art keywords
compound
mixture
acid
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94117090A
Other languages
English (en)
Chinese (zh)
Inventor
B·拉贝瓦
D·古利
F·珍珍
J-C·莫利默德
R·布格根纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of CN1108651A publication Critical patent/CN1108651A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN94117090A 1993-10-12 1994-10-12 对神经降压素活性的取代1-萘基-3-吡啶甲酰胺，其制备及含有它们的药物组合物 Pending CN1108651A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9312136 1993-10-12
FR9312136A FR2711140B1 (fr) 1993-10-12 1993-10-12 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
CN1108651A true CN1108651A (zh) 1995-09-20

Family

ID=9451754

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94117090A Pending CN1108651A (zh) 1993-10-12 1994-10-12 对神经降压素活性的取代1-萘基-3-吡啶甲酰胺，其制备及含有它们的药物组合物

Country Status (18)

Country Link
US (3) US5502059A (enExample)
EP (1) EP0647629B1 (enExample)
JP (1) JPH07278114A (enExample)
KR (1) KR950011413A (enExample)
CN (1) CN1108651A (enExample)
AT (1) ATE181911T1 (enExample)
AU (1) AU685154B2 (enExample)
CA (1) CA2117821A1 (enExample)
DE (1) DE69419377D1 (enExample)
FI (1) FI944770L (enExample)
FR (1) FR2711140B1 (enExample)
HU (1) HUT70048A (enExample)
IL (1) IL111239A0 (enExample)
NO (1) NO304595B1 (enExample)
NZ (1) NZ264661A (enExample)
RU (1) RU2140912C1 (enExample)
TW (1) TW300890B (enExample)
ZA (1) ZA947957B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100509788C (zh) * 2002-03-18 2009-07-08 索尔瓦药物有限公司 神经降压素活性的2,3-二芳基-吡唑烷衍生物
CN109320502A (zh) * 2012-12-07 2019-02-12 3B制药有限公司 神经降压肽受体配体

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716991B1 (en) 1993-11-30 2004-04-06 G. D. Searle & Co. Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US6492411B1 (en) 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
FR2732967B1 (fr) * 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
FR2741621B1 (fr) * 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2742148B1 (fr) * 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
US6521561B1 (en) 1998-05-01 2003-02-18 President And Fellows Of Harvard College Main-group metal based asymmetric catalysts and applications thereof
IL142707A0 (en) 2000-04-27 2002-03-10 Pfizer Prod Inc Methods of treating obesity using a neurotensin receptor ligand
KR100425881B1 (ko) * 2001-03-14 2004-04-03 고광호 신규한 몰피난 유도체
WO2002092695A1 (en) * 2001-05-11 2002-11-21 Mitsui Chemicals, Inc. Dopant agent and electroconductive polymer material comprising the same
ATE286023T1 (de) * 2001-07-11 2005-01-15 Boehringer Ingelheim Pharma Neue synthese für heteroarylamin-verbindungen
US6603000B2 (en) 2001-07-11 2003-08-05 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis for heteroarylamine compounds
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
GB0323585D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
CA2594488C (en) * 2005-01-10 2015-04-28 University Of Connecticut Novel heteropyrrole analogs acting on cannabinoid receptors
US7714014B2 (en) * 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules
CA2641441A1 (en) 2006-02-09 2007-08-23 Athersys, Inc. Pyrazoles for the treatment of obesity and other cns disorders
WO2015188073A1 (en) 2014-06-06 2015-12-10 Research Triangle Institute Apelin receptor (apj) agonists and uses thereof
BR112018011784A2 (pt) 2015-12-09 2018-12-04 Res Triangle Inst agonistas aprimorados do receptor de apelina (apj) e usos dos mesmos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5288877A (en) * 1991-07-03 1994-02-22 Ppg Industries, Inc. Continuous process for preparing indolenine compounds
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100509788C (zh) * 2002-03-18 2009-07-08 索尔瓦药物有限公司 神经降压素活性的2,3-二芳基-吡唑烷衍生物
CN109320502A (zh) * 2012-12-07 2019-02-12 3B制药有限公司 神经降压肽受体配体
CN109320502B (zh) * 2012-12-07 2022-06-07 3B制药有限公司 神经降压肽受体配体

Also Published As

Publication number Publication date
FI944770A7 (fi) 1995-04-13
FI944770L (fi) 1995-04-13
AU7575394A (en) 1995-05-04
ATE181911T1 (de) 1999-07-15
HUT70048A (en) 1995-09-28
US5502059A (en) 1996-03-26
EP0647629B1 (fr) 1999-07-07
JPH07278114A (ja) 1995-10-24
NO943837L (no) 1995-04-18
RU94036749A (ru) 1996-10-10
US5585497A (en) 1996-12-17
RU2140912C1 (ru) 1999-11-10
HU9402933D0 (en) 1995-01-30
FI944770A0 (fi) 1994-10-11
NZ264661A (en) 1996-08-27
CA2117821A1 (en) 1995-04-13
NO304595B1 (no) 1999-01-18
FR2711140A1 (fr) 1995-04-21
US5523455A (en) 1996-06-04
TW300890B (enExample) 1997-03-21
DE69419377D1 (de) 1999-08-12
FR2711140B1 (fr) 1996-01-05
AU685154B2 (en) 1998-01-15
ZA947957B (en) 1995-05-22
IL111239A0 (en) 1994-12-29
EP0647629A1 (fr) 1995-04-12
KR950011413A (ko) 1995-05-15
NO943837D0 (no) 1994-10-11

Similar Documents

Publication Publication Date Title
CN1072210C (zh) 对神经紧张素受体有活性的1－苯基－3－吡唑甲酰胺类化合物
CN1108651A (zh) 对神经降压素活性的取代1-萘基-3-吡啶甲酰胺，其制备及含有它们的药物组合物
CN1314683C (zh) 用于调节IkB激酶的吲哚或苯并咪唑衍生物
CN1281604C (zh) 取代吡唑化合物
CN1296346C (zh) 酰化的6,7,8,9－四氢－5h－苯并环庚烯基胺和它们作为药物的用途
CN1117077C (zh) 用作nos抑制剂的6－苯基吡啶基－2－胺衍生物
CN1192773C (zh) 环胺ccr3拮抗剂
CN1273128C (zh) 取代的n－[(氨基亚氨基甲基或氨基甲基)苯基]丙基酰胺
CN1976904A (zh) 哒嗪－3(2h)－酮衍生物及其作为pde4抑止剂的应用
CN1016778B (zh) 螺-取代的戊二酸单酰胺
CN1753670A (zh) 新苯并咪唑和咪唑并吡啶衍生物及其作为药物的用途
CN1331688A (zh) 氨基吡啶衍生物
CN1209125A (zh) 作为速激肽拮抗剂的哌嗪类衍生物
CN1086818A (zh) 不对称取代的黄嘌呤
CN1238761A (zh) 苯甲酰胺醛及其作为半胱氨酸蛋白酶抑制剂的用途
CN1852905A (zh) 具有n－取代的苯并咪唑基的c－kit抑制剂
CN1432015A (zh) 可用作细胞增殖抑制剂的被1,1－二氧代异噻唑烷取代的吲唑
CN1067886A (zh) 新的脲衍生物，它们的制备方法及其药物组合物
CN1890218A (zh) 微管蛋白抑制剂
CN1934091A (zh) 治疗神经变性障碍的咪唑化合物
CN1317968A (zh) 用作orl1－受体激动剂2－取代的－1－哌啶基苯并咪唑化合物
CN1050382A (zh) 吡唑衍生物及其制备方法和药用组合物
CN1376156A (zh) 苯并二氮杂䓬衍生物、其制备和用途
CN1128260A (zh) 新的哌啶化合物、其制备方法和含有它们的药用组合物
HK1041486A1 (zh) 作為前列腺素e2激動劑或拮抗劑的噁唑化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned