CN110839803A - 一种肿瘤食欲减退的全营养代餐品组合物 - Google Patents
一种肿瘤食欲减退的全营养代餐品组合物 Download PDFInfo
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Abstract
一种用于肿瘤尤消化道肿瘤食欲减退甚厌食症的全营养支持、补充代餐品，属于特殊医学用途食品领域。是现代化精制提取工艺制成的的外用固体饮料，30g/袋，冲服。
Description
技术领域
国外流行病学调查研究发现，在所有癌症病人当中，30％-45％的人是由饮食的构成、饮食的不卫生习惯和不科学的烹调加工所引起的。1991年4月召开的第一届国际营养与肿瘤学术会上，著名的英国肿瘤流行病学家R.D指出：合理膳食可以减少90％的胃瘤和直肠癌、 20％的子宫内膜癌、胆囊癌、胰腺癌、子宫颈癌、口腔癌、咽癌、食管癌，并可降低癌症的再死亡率。营养不良是肿瘤诱发因素之一。肿瘤患者一系列代谢紊乱，需要系统的营养支持作保证，以提高机体的抗氧化能力和免疫功能。适宜的营养治疗至少有3个层面的重要意义：一是可适用于术后、放化疗后中营养辅助，增加耐受，促进伤口愈合，减少并发症，改善临床预后；一是用于改善现有体质、抗氧化、抑制肿瘤细胞增生，刺激人体产生干扰素避免向恶性肿瘤发展；二是可适用于术后、放化疗后中营养辅助，增加耐受，促进伤口愈合，减少并发症，改善临床预后；三是恶液质早期发现和干预在治疗食欲减退、厌食症和代谢紊乱后，提高患者生存质量。本发明提出一种针对食欲减退的全营养固体饮料(开水冲服，非粉剂)的组合物，由搭配合理的营养素与食药同源食材组合而成，饮用方便，适口感好，易于接受，市场前景广泛。
背景技术
2009年ASPEN发布了临床肿瘤病人营养支持治疗新指南，2019年02月国家药监局公布了《特殊医学用途配方食品》通则，《中国肿瘤营养治疗指南2019》CSPEN2019年08月 25日刚刚发布，迫切需要研发出一种简便易行的饮食方法，在适口膳食及中医药理论指导下的食药同源食品中，能有效控制手术、放化疗副作用(如减少铂类化疗后肠道菌群失调) 进行营养支持，补充医疗手段之不足，调节机体代谢，调节免疫。事实上多年以来，食品、卫生、药企在这方面都有探索，但往往个体零散，国人谈癌色变仍很普遍，往往应用不到临床应用，或不被专业人士认可，形不成优势。
例如主分类号A23L33/00(2006.1)I分类号A23L33/00(2006.1)I
涉及一种具有抗肿瘤作用的全营养配方食品，主要由以下重量份的原料制备而成：鸡肉粉 10-20份、鸡蛋粉2-10份、全脂奶粉20-40份、大豆蛋白粉10-30份、鱼油粉10-20份、大米粉1-5份、玉米粉1-5份、麦芽糊精1-10份、果蔬粉1-5份、羧甲基茯苓多糖或茯苓多糖1-5份、低聚半乳糖5-20份、抗性糊精2-10份、维生素预混料1-5份、矿物质预混料 1-5份。天然食品作为原料，更符合中国人长期的饮食习惯，对中国人肠道功能的保护具有积极的作用，该配方食品不仅为肿瘤患者提供了全方面的营养需求，还显著提高了肿瘤患者的免疫力，具有显著的抗肿瘤功效。
又如主分类号：A23L1/305(2006.01)、分类号A23L1/305(2006.01)I A23L1/304(2006.01) I涉及一种用于肿瘤患者的营养食品，是由0.15～1重量份海参、0.5～7重量份香菇、1～10重量份枸杞子、0.1～1.5重量份炒鸡内金提取物、1～10重量份低聚肽、1～10重量份乳钙、1～ 10重量份α-乳白蛋白和0.05～0.5重量份番茄红素混合均匀制成。本发明将传统中药与现代营养物质有机组合，可以全面调节机体状态，滋补强壮，抑制肿瘤细胞的生长与转移，减少放射疗法的毒副作用，充分发挥各种物质的保健功效，适合于作为肿痛患者日常辅助治疗用保健食品。
发明内容
产品组成
藜麦膨化麦片(全营养)：10％
阿根廷奶油南瓜：15.8％
西兰花提取物(营养最全的蔬菜，蛋白含量50％，0.1％萝卜硫素，抗癌)：5％
灰树花提取物：5％灰树花提取物：5％
蛋白草粉(蛋白含量60％)：10％
益生菌粉：10％
茯苓粉：4％
枳壳粉：2％
麦冬粉：3％
砂仁粉：2％
丁香：2％
柿蒂：2％
酸枣仁：2％
复合维生素：10％
维生素C 150mg，维生素E75mg(短链30％粉)、硫胺100mg、维生素B6 2mg、叶酸400mcg、维生素B12 15mcg、生物素30mcg、泛酸5.5mg。
低聚果糖：7％
鱼油：5％
姜黄素：0.2％
风味椰浆粉(含有椰子油)：5％
酵母硒、锌(硒100微克/袋，锌50微克/袋)
上述制备成冲剂，30克/袋，每餐1袋。配合饮食。
功效
消化道肿瘤营养支持补充、代餐。
用途
消化道肿瘤术前、术后、放化疗后、恶液质早期等食欲减退甚至厌食症。
剂型
固体饮料可冲服。
原理
藜麦膨化麦片藜麦属于全营养谷物，膨化麦片易消化、适口性好；灰树花健脾开胃、提高免疫力、防癌抗癌，西兰花提取物含萝卜硫苷，为国家药监局规定的固定添加量功能性食品；鱼油富含ω-3不饱和脂肪酸，富含DHA和EPA，消炎降脂，预防心脑血管症状，改善视力。另外，对恶液质有积极作用；果胶粉为多糖聚集物，能保护胃肠粘膜，修复损伤；中药茯苓健脾渗湿，茯苓多糖抗氧化、抗肿瘤、安神宁心；麦冬养阴生津、润肺清心，麦冬皂苷抗免疫、抗肿瘤、抗氧化；枳壳理气行痰消积滞；砂仁化湿醒脾、理气调味、提高食欲；丁香、柿蒂温中益气，降逆止呕。对于气滞痰阻呕吐、呃逆疗效显著；低聚糖果糖是一种水溶性膳食纤维素促进肠道运动，改善胃肠道功能，强化体质耐力；维生素C和E、硒和锌等微量营养素促进胃肠道粘膜修复、减少吸收障碍，清除氧自由基，防止电解质缺乏。整体配方符合补充营养不良、逆转恶液质配比，满足患者需求。
用量
每天1-3袋，每次1袋。
注意事项
1.本代餐品不作为干预临床治疗手段用。
2.可做恢复期以长期代餐。
讨论与结论：
食欲是一种支配摄食和选择食物的生理心理因素。疲劳、紧张、过饮、运动量不足、便秘、精神因素、妊娠都可影响食欲，恶性肿瘤引起的食欲减退本身就是手术、放疗、化疗靶向药刺激引起，同时摄入下降消耗增加致糖耐量不足、蛋白质转换率增加、脂肪分解快、维生素等抗氧化下降，血硒、血锌离子含量降低。另外还有机械性损伤。
消化道肿瘤患者营养治疗的制剂与配方总体上与其他肿瘤没有区别，但是，手术创伤较大，导致免疫力下降，即包含精氨酸、谷氨酰胺、ω-3多不饱和脂肪酸、核酸及具有氧化作用的微量元素(维生素E、维生素C、B胡萝卜素、锌和硒)缺乏或明显不足。所以，此特医食品组方营养支持的原则是：
部分饮食+部分肠内营养部分+部分肠外营养+代餐
配方原则是：
高糖高碳水化合物+高蛋白+低脂肪+维生素、微量元素
应遵循五阶梯治疗模式：
第1阶梯，饮食+营养教育；
第2阶梯，饮食+ONS；
第3阶梯，完全肠内营养；
第4阶梯，首选肠内营养，后选肠外营养；
第5阶梯，首选口服，后选管伺。
当下一阶梯不能满足60％目标能量需求3-5天时，应该选择上一阶梯。
典型病例
男，52岁，2018年11月12日就诊。胃腺癌3期切除手术后病人。
营养支持后10天：体重71kg，PLAB24mg/dl，白蛋白39g/l，左手握力30KG，步行速度1M/s。食欲增加营养支持后20天：体重73kg，PLAB26mg/dl，白蛋白39g/l，左手握力35Kg，步行速度1.2M/s。
放化疗结束营养支持后60天：体重72kg，PLAB21mg/dl，白蛋白38g/l，左手握力30KG，步行速度1M/s。
Claims (1)
1.一种功效是恶性肿瘤尤其消化道肿瘤营养支持、补充的代餐品，用于消化道及其他肿瘤术前术后、放化疗后、恶液体质早期等食欲减退症状制作成固体饮料，其特征在于：由以下组分制备而成：
藜麦膨化麦片(全营养)：10％
阿根廷奶油南瓜：15.8％
西兰花提取物(营养最全的蔬菜，蛋白含量50％，0.1％萝卜硫素，抗癌)：5％
灰树花提取物：5％灰树花提取物：5％
蛋白草粉(蛋白含量60％)：10％
益生菌粉：10％
茯苓粉：4％
枳壳粉：2％
麦冬粉：3％
砂仁粉：2％
丁香：2％
柿蒂：2％
酸枣仁：2％
复合维生素：10％
维生素C 150mg，维生素E 75mg(短链30％粉)、硫胺100mg、维生素B6 2mg、叶酸400mcg、维生素B12 15mcg、生物素30mcg、泛酸5.5mg。
低聚果糖：7％
鱼油：5％
姜黄素：0.2％
风味椰浆粉(含有椰子油)：5％
酵母硒、锌(硒100微克/袋，锌50微克/袋)
上述制备成冲剂，30克/袋，每餐1袋，冲服。
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| CN108771219A (zh) * | 2018-05-31 | 2018-11-09 | 杨秀丽 | 食叶草植物蛋白营养含片及其制备方法 |
| CN108991500A (zh) * | 2018-07-02 | 2018-12-14 | 邦世迪(广东)医用食品股份有限公司 | 一种肿瘤病人用全营养配方食品 |
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| CN105641000A (zh) * | 2015-06-01 | 2016-06-08 | 深圳市康道生物有限公司 | 一种含灰树花提取物的抗肿瘤组合物及其制备方法 |
| CN108771219A (zh) * | 2018-05-31 | 2018-11-09 | 杨秀丽 | 食叶草植物蛋白营养含片及其制备方法 |
| CN108991500A (zh) * | 2018-07-02 | 2018-12-14 | 邦世迪(广东)医用食品股份有限公司 | 一种肿瘤病人用全营养配方食品 |
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