CN110819658B - 用于RNA向导的基因调节和编辑的正交Cas9蛋白 - Google Patents
用于RNA向导的基因调节和编辑的正交Cas9蛋白 Download PDFInfo
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- CN110819658B CN110819658B CN201910999512.6A CN201910999512A CN110819658B CN 110819658 B CN110819658 B CN 110819658B CN 201910999512 A CN201910999512 A CN 201910999512A CN 110819658 B CN110819658 B CN 110819658B
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910999512.6A CN110819658B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361844844P | 2013-07-10 | 2013-07-10 | |
| US61/844,844 | 2013-07-10 | ||
| PCT/US2014/045700 WO2015006294A2 (en) | 2013-07-10 | 2014-07-08 | Orthogonal cas9 proteins for rna-guided gene regulation and editing |
| CN201910999512.6A CN110819658B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
| CN201480048712.9A CN105517579B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480048712.9A Division CN105517579B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110819658A CN110819658A (zh) | 2020-02-21 |
| CN110819658B true CN110819658B (zh) | 2024-03-22 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910999512.6A Active CN110819658B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
| CN201480048712.9A Active CN105517579B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480048712.9A Active CN105517579B (zh) | 2013-07-10 | 2014-07-08 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10329587B2 (https=) |
| EP (2) | EP3019204B1 (https=) |
| JP (3) | JP6718813B2 (https=) |
| KR (2) | KR102481330B1 (https=) |
| CN (2) | CN110819658B (https=) |
| AU (4) | AU2014287397B2 (https=) |
| BR (1) | BR112016000571B1 (https=) |
| CA (2) | CA3218040A1 (https=) |
| IL (3) | IL282489B (https=) |
| RU (3) | RU2748433C2 (https=) |
| SG (3) | SG10201913015XA (https=) |
| WO (1) | WO2015006294A2 (https=) |
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| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| EP3363902B1 (en) | 2012-12-06 | 2019-11-27 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| CA2895155C (en) * | 2012-12-17 | 2021-07-06 | President And Fellows Of Harvard College | Rna-guided human genome engineering |
| SI2986729T1 (sl) | 2013-04-16 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Ciljana sprememba genoma podgane |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| CA3109801C (en) | 2013-08-22 | 2024-01-09 | Andrew Cigan | Plant genome modification using guide rna/cas endonuclease systems and methods of use |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| EP3418379B1 (en) | 2013-09-18 | 2020-12-09 | Kymab Limited | Methods, cells & organisms |
| US11326209B2 (en) * | 2013-11-07 | 2022-05-10 | Massachusetts Institute Of Technology | Cell-based genomic recorded accumulative memory |
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| US9546384B2 (en) | 2013-12-11 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse genome |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2015134812A1 (en) | 2014-03-05 | 2015-09-11 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa |
| WO2015138510A1 (en) | 2014-03-10 | 2015-09-17 | Editas Medicine., Inc. | Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10) |
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| US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
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| US12460231B2 (en) | 2014-04-02 | 2025-11-04 | Editas Medicine, Inc. | Crispr/CAS-related methods and compositions for treating primary open angle glaucoma |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN108064129A (zh) | 2014-09-12 | 2018-05-22 | 纳幕尔杜邦公司 | 玉米和大豆中复合性状基因座的位点特异性整合位点的产生和使用方法 |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| GB201418965D0 (https=) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
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| AU2015360502A1 (en) | 2014-12-10 | 2017-06-29 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| BR112017017260A2 (pt) | 2015-03-27 | 2018-04-17 | Du Pont | construções de dna, vetor, célula, plantas, semente, método de expressão de rna e método de modificação de local alvo |
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