CN110804578A - 一种牛血清去除IgG的生产方法 - Google Patents
一种牛血清去除IgG的生产方法 Download PDFInfo
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- CN110804578A CN110804578A CN201911135676.0A CN201911135676A CN110804578A CN 110804578 A CN110804578 A CN 110804578A CN 201911135676 A CN201911135676 A CN 201911135676A CN 110804578 A CN110804578 A CN 110804578A
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- Prior art keywords
- igg
- bovine serum
- filtrate
- filtering
- adsorbent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
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- 150000002632 lipids Chemical class 0.000 description 2
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- 102000004196 processed proteins & peptides Human genes 0.000 description 2
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- 238000000746 purification Methods 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
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- 230000009286 beneficial effect Effects 0.000 description 1
- PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
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- -1 enzymes Chemical class 0.000 description 1
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- 230000008588 hemolysis Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
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- 238000011031 large-scale manufacturing process Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 201000005404 rubella Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 125000001174 sulfone group Chemical group 0.000 description 1
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- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
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CN201911135676.0A CN110804578B (zh) | 2019-11-19 | 2019-11-19 | 一种牛血清去除IgG的生产方法 |
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CN201911135676.0A CN110804578B (zh) | 2019-11-19 | 2019-11-19 | 一种牛血清去除IgG的生产方法 |
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CN110804578A true CN110804578A (zh) | 2020-02-18 |
CN110804578B CN110804578B (zh) | 2023-04-14 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112083158A (zh) * | 2020-08-29 | 2020-12-15 | 赵峻岭 | 一种封闭液用牛血清的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102268401A (zh) * | 2011-06-08 | 2011-12-07 | 庞观龙 | 一种去除免疫球蛋白的新生牛血清生产方法 |
CN102757930A (zh) * | 2011-04-27 | 2012-10-31 | 长春安贝生物科技有限公司 | 超低IgG新生牛血清生产工艺 |
CN110066762A (zh) * | 2018-01-22 | 2019-07-30 | 范清春 | 工业化生产新生牛纯化血清的方法 |
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2019
- 2019-11-19 CN CN201911135676.0A patent/CN110804578B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102757930A (zh) * | 2011-04-27 | 2012-10-31 | 长春安贝生物科技有限公司 | 超低IgG新生牛血清生产工艺 |
CN102268401A (zh) * | 2011-06-08 | 2011-12-07 | 庞观龙 | 一种去除免疫球蛋白的新生牛血清生产方法 |
CN110066762A (zh) * | 2018-01-22 | 2019-07-30 | 范清春 | 工业化生产新生牛纯化血清的方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112083158A (zh) * | 2020-08-29 | 2020-12-15 | 赵峻岭 | 一种封闭液用牛血清的制备方法 |
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CN110804578B (zh) | 2023-04-14 |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A production method for removing IgG from bovine serum Effective date of registration: 20230625 Granted publication date: 20230414 Pledgee: Inner Mongolia Bank Co.,Ltd. Hohhot Ordos East Street Branch Pledgor: Inner Mongol Wei Kesheng Biotechnology Ltd. Registration number: Y2023150000091 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20230414 Pledgee: Inner Mongolia Bank Co.,Ltd. Hohhot Ordos East Street Branch Pledgor: Inner Mongol Wei Kesheng Biotechnology Ltd. Registration number: Y2023150000091 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |