CN1107504C - 左布比卡因在儿科手术中的用途 - Google Patents

左布比卡因在儿科手术中的用途 Download PDF

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Publication number
CN1107504C
CN1107504C CN98802993A CN98802993A CN1107504C CN 1107504 C CN1107504 C CN 1107504C CN 98802993 A CN98802993 A CN 98802993A CN 98802993 A CN98802993 A CN 98802993A CN 1107504 C CN1107504 C CN 1107504C
Authority
CN
China
Prior art keywords
chirocaine
bupivacaine
levobupivacaine
dosage
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN98802993A
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English (en)
Chinese (zh)
Other versions
CN1249683A (zh
Inventor
B·A·金纳利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of CN1249683A publication Critical patent/CN1249683A/zh
Application granted granted Critical
Publication of CN1107504C publication Critical patent/CN1107504C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN98802993A 1997-03-03 1998-03-03 左布比卡因在儿科手术中的用途 Expired - Lifetime CN1107504C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9704351.7A GB9704351D0 (en) 1997-03-03 1997-03-03 Levobupivacaine and its use
GB9704351.7 1997-03-03

Publications (2)

Publication Number Publication Date
CN1249683A CN1249683A (zh) 2000-04-05
CN1107504C true CN1107504C (zh) 2003-05-07

Family

ID=10808602

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98802993A Expired - Lifetime CN1107504C (zh) 1997-03-03 1998-03-03 左布比卡因在儿科手术中的用途

Country Status (20)

Country Link
US (1) US5910502A (https=)
EP (1) EP0981348B1 (https=)
JP (1) JP2001513814A (https=)
KR (1) KR100535554B1 (https=)
CN (1) CN1107504C (https=)
AT (1) ATE240731T1 (https=)
AU (1) AU719483B2 (https=)
BR (1) BR9808302A (https=)
CA (1) CA2279498C (https=)
DE (1) DE69814852T2 (https=)
DK (1) DK0981348T3 (https=)
ES (1) ES2199424T3 (https=)
GB (1) GB9704351D0 (https=)
HU (1) HU224227B1 (https=)
IL (1) IL131086A0 (https=)
NO (1) NO324215B1 (https=)
PL (1) PL190896B1 (https=)
PT (1) PT981348E (https=)
WO (1) WO1998038999A1 (https=)
ZA (1) ZA981780B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
IL140899A0 (en) 1998-07-17 2002-02-10 Skyepharma Inc Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
EP1446101B1 (en) * 2001-11-14 2011-03-23 Durect Corporation Catheter injectable depot compositions and uses thereof
DE60239952D1 (de) * 2001-11-14 2011-06-16 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CN1684663A (zh) * 2002-07-31 2005-10-19 阿尔萨公司 可注射的多模式聚合物储库组合物以及其用途
AU2002359397B2 (en) * 2002-07-31 2009-01-29 Durect Corporation Injectable depot compositions and uses thereof
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
EP4415713A4 (en) 2021-10-14 2025-08-06 Pacira Pharmaceuticals Inc MULTIVESICULAR LIPOSOME FORMULATIONS OF BUPIVACAINE AND THEIR USES
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010277A1 (en) * 1993-10-13 1995-04-20 Chiroscience Limited Analgesic agent and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3379266D1 (en) * 1983-08-01 1989-04-06 Astra Laekemedel Ab L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
AU704806B2 (en) * 1995-04-13 1999-05-06 Darwin Discovery Limited Levobupivacaine and its use as an anaesthetic in pregnant women

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010277A1 (en) * 1993-10-13 1995-04-20 Chiroscience Limited Analgesic agent and its use
EP0727210A2 (en) * 1993-10-13 1996-08-21 Chiroscience Limited Analgesic agent and its use

Also Published As

Publication number Publication date
HUP0000963A2 (hu) 2000-09-28
ES2199424T3 (es) 2004-02-16
HU224227B1 (hu) 2005-06-28
BR9808302A (pt) 2000-05-16
PT981348E (pt) 2003-09-30
AU719483B2 (en) 2000-05-11
HK1022649A1 (en) 2000-08-18
KR100535554B1 (ko) 2005-12-08
CA2279498A1 (en) 1998-09-11
WO1998038999A1 (en) 1998-09-11
NO994259L (no) 1999-11-02
JP2001513814A (ja) 2001-09-04
PL190896B1 (pl) 2006-02-28
ATE240731T1 (de) 2003-06-15
AU6631098A (en) 1998-09-22
ZA981780B (en) 1999-03-03
US5910502A (en) 1999-06-08
HUP0000963A3 (en) 2000-10-30
EP0981348A1 (en) 2000-03-01
PL335563A1 (en) 2000-05-08
NO994259D0 (no) 1999-09-02
KR20000075894A (ko) 2000-12-26
DE69814852T2 (de) 2004-01-22
EP0981348B1 (en) 2003-05-21
DK0981348T3 (da) 2003-09-15
GB9704351D0 (en) 1997-04-23
IL131086A0 (en) 2001-01-28
DE69814852D1 (de) 2003-06-26
CN1249683A (zh) 2000-04-05
NO324215B1 (no) 2007-09-10
CA2279498C (en) 2009-05-26

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Granted publication date: 20030507

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