CN1107504C - 左布比卡因在儿科手术中的用途 - Google Patents

左布比卡因在儿科手术中的用途 Download PDF

Info

Publication number
CN1107504C
CN1107504C CN98802993A CN98802993A CN1107504C CN 1107504 C CN1107504 C CN 1107504C CN 98802993 A CN98802993 A CN 98802993A CN 98802993 A CN98802993 A CN 98802993A CN 1107504 C CN1107504 C CN 1107504C
Authority
CN
China
Prior art keywords
chirocaine
bupivacaine
levobupivacaine
dosage
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN98802993A
Other languages
English (en)
Chinese (zh)
Other versions
CN1249683A (zh
Inventor
B·A·金纳利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of CN1249683A publication Critical patent/CN1249683A/zh
Application granted granted Critical
Publication of CN1107504C publication Critical patent/CN1107504C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN98802993A 1997-03-03 1998-03-03 左布比卡因在儿科手术中的用途 Expired - Lifetime CN1107504C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9704351.7A GB9704351D0 (en) 1997-03-03 1997-03-03 Levobupivacaine and its use
GB9704351.7 1997-03-03

Publications (2)

Publication Number Publication Date
CN1249683A CN1249683A (zh) 2000-04-05
CN1107504C true CN1107504C (zh) 2003-05-07

Family

ID=10808602

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98802993A Expired - Lifetime CN1107504C (zh) 1997-03-03 1998-03-03 左布比卡因在儿科手术中的用途

Country Status (20)

Country Link
US (1) US5910502A (https=)
EP (1) EP0981348B1 (https=)
JP (1) JP2001513814A (https=)
KR (1) KR100535554B1 (https=)
CN (1) CN1107504C (https=)
AT (1) ATE240731T1 (https=)
AU (1) AU719483B2 (https=)
BR (1) BR9808302A (https=)
CA (1) CA2279498C (https=)
DE (1) DE69814852T2 (https=)
DK (1) DK0981348T3 (https=)
ES (1) ES2199424T3 (https=)
GB (1) GB9704351D0 (https=)
HU (1) HU224227B1 (https=)
IL (1) IL131086A0 (https=)
NO (1) NO324215B1 (https=)
PL (1) PL190896B1 (https=)
PT (1) PT981348E (https=)
WO (1) WO1998038999A1 (https=)
ZA (1) ZA981780B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1030652B1 (en) 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
AU752225B2 (en) 1998-07-17 2002-09-12 Pacira Pharmaceuticals, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US20030096000A1 (en) * 2001-05-31 2003-05-22 Solis Rosa Maria Encapsulation of nanosuspensions in liposomes and microspheres
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
KR20040058101A (ko) * 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
JP2006503004A (ja) * 2002-07-31 2006-01-26 アルザ・コーポレーション 射出可能なデポ組成物及びその使用
DE60325742D1 (de) * 2002-07-31 2009-02-26 Alza Corp Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
GB2627096A (en) 2021-10-14 2024-08-14 Pacira Pharmaceuticals Inc Bupivacaine multivesicular liposome formulations and uses thereof
US12251468B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12246092B1 (en) 2024-05-20 2025-03-11 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010277A1 (en) * 1993-10-13 1995-04-20 Chiroscience Limited Analgesic agent and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151110B1 (en) * 1983-08-01 1989-03-01 Astra Läkemedel Aktiebolag L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
AU704806B2 (en) * 1995-04-13 1999-05-06 Darwin Discovery Limited Levobupivacaine and its use as an anaesthetic in pregnant women

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010277A1 (en) * 1993-10-13 1995-04-20 Chiroscience Limited Analgesic agent and its use
EP0727210A2 (en) * 1993-10-13 1996-08-21 Chiroscience Limited Analgesic agent and its use

Also Published As

Publication number Publication date
NO324215B1 (no) 2007-09-10
DE69814852D1 (de) 2003-06-26
ATE240731T1 (de) 2003-06-15
KR100535554B1 (ko) 2005-12-08
GB9704351D0 (en) 1997-04-23
WO1998038999A1 (en) 1998-09-11
HUP0000963A3 (en) 2000-10-30
HUP0000963A2 (hu) 2000-09-28
PL335563A1 (en) 2000-05-08
KR20000075894A (ko) 2000-12-26
DE69814852T2 (de) 2004-01-22
CA2279498A1 (en) 1998-09-11
ZA981780B (en) 1999-03-03
BR9808302A (pt) 2000-05-16
PT981348E (pt) 2003-09-30
AU6631098A (en) 1998-09-22
NO994259L (no) 1999-11-02
US5910502A (en) 1999-06-08
HU224227B1 (hu) 2005-06-28
ES2199424T3 (es) 2004-02-16
JP2001513814A (ja) 2001-09-04
PL190896B1 (pl) 2006-02-28
HK1022649A1 (en) 2000-08-18
CN1249683A (zh) 2000-04-05
IL131086A0 (en) 2001-01-28
EP0981348A1 (en) 2000-03-01
NO994259D0 (no) 1999-09-02
CA2279498C (en) 2009-05-26
AU719483B2 (en) 2000-05-11
DK0981348T3 (da) 2003-09-15
EP0981348B1 (en) 2003-05-21

Similar Documents

Publication Publication Date Title
CN1107504C (zh) 左布比卡因在儿科手术中的用途
Karalliedde et al. Acute organophosphorus insecticide poisoning in Sri Lanka
Agarwal et al. Seizures occurring in pediatric patients receiving continuous infusion of bupivacaine
Gautier et al. Intrathecal ropivacaine for ambulatory surgery: a comparison between intrathecal bupivacaine and intrathecal ropivacaine for knee arthroscopy
de Boer et al. Reversal of rocuronium-induced (1.2 mg/kg) profound neuromuscular block by sugammadex: a multicenter, dose-finding and safety study
Smith et al. Efficacy of esmolol versus alfentanil as a supplement to propofol-nitrous oxide anesthesia
Hodgson et al. A comparison of ropivacaine with fentanyl to bupivacaine with fentanyl for postoperative patient-controlled epidural analgesia
Wadon et al. Atracurium infusion in the intensive care unit
Whelan Baclofen in treatment of the'stiff-man'syndrome
Powles et al. Use of vecuronium in the management of tetanus
Wauquier et al. Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia
RU2152215C1 (ru) Применение ропивакаина при изготовлении фармацевтического препарата с анальгезирующим действием с минимальной моторной блокадой
Adu-Gyamfi Epidural morphine plus bupivacaine for relief of postoperative pain following Harrington rod insertion for correction of idiopathic scoliosis
Broadman et al. Caudal blocks
MXPA99008057A (en) The use of levobupivacaine in paediatric surgery
HK1022649B (en) The use of levobupivacaine in paediatric surgery
Leoni et al. Pain control with low-dose alfentanil in children undergoing minor abdominal and genito-urinary surgery
Pandey et al. Comparative Study of 0.5% Bupivacaine, 0.5% Ropivacaine, and 0.75% Ropivacaine With Fentanyl as a Continuous Intraoperative Epidural Infusion on Post-operative Analgesia
BRITTON et al. Hexafluorenium bromide: current status and a review
Kestin Assessing the block for caesarean section: more thoughts
Karraz et al. Ambulatory labor analgesia: clinical experience
Cameron et al. Which beta blocker?
Jackson creased respiratory resistance provoked by ultrasonic aerosols
Evans Chlorhexidine as a cause of anaphylaxis
Berry et al. On Use of Priming With Vecuronium in a Patient With an Open Globe and a Full Stomach

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
PB01 Publication
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20030507

CX01 Expiry of patent term