CN110742969A - 一种改善肾阴虚导致的睡眠障碍的组合物制备方法 - Google Patents
一种改善肾阴虚导致的睡眠障碍的组合物制备方法 Download PDFInfo
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Abstract
本发明公开一种改善肾阴虚导致的睡眠障碍的组合物制备方法，以具有滋阴养润功效的铁皮石斛花1‑2份和温润补肾作用的九制黄精2‑3份组合配比，经过提取干燥得到提取物，在提取物中加入具有镇静安神功效的茶氨酸制备得到具有改善睡眠障碍的组合物；该组合物按照中西医结合原理配伍，通过黄精和石斛花配伍滋阴补肾，以茶氨酸镇静安神促进睡眠，标本兼治，改善肾阴虚导致的睡眠障碍，该组合物在保健食品或功能产品中具有重要的应用，实验表明，服用该组合物能够改善睡眠障碍，并且无依赖性，可长期服用。
Description
技术领域
本发明涉及食品和保健食品领域，尤其是一种改善肾阴虚导致的睡眠障碍的组合物制备方法。
背景技术
铁皮石斛花含有多糖、黄酮类、氨基酸、有机酸类和萜类等活性成分，具有抗氧化、抗衰老、抗炎镇痛、调节免疫、滋阴养颜等功效，可应用于化妆品领域。2018年，国家卫健委终止铁皮石斛花新食品原料审查，按照食品管理，因此铁皮石斛花的也可以应用于食品加工。
按照药典规定黄精指黄精（Polygonatum sibiricum）、滇黄精（P． kingianum）和多花黄精（P． cyrtonema） 3种植物的干燥根，是我国传统的药食同源中药材。研究发现黄精含有甾体皂苷类、多糖类、黄酮类、生物碱类、醌类、植物甾醇、挥发油、氨基酸、微量元素等化学成分，具有抗衰老、抗肿瘤、免疫调节、抗菌抗病毒、降血糖血脂、抗骨质疏松等作用与功效。黄精经过传统九蒸九制后，即为九制黄精为临床常用补益药，其性味甘平，有补气养阴、健脾、润肺、益肾等功效，主治脾胃气虚、体倦乏力、胃阴不足、口干食少、肺虚燥咳、劳嗽咳血、精血不足、腰膝酸软、须发早白、内热消渴等症。
茶氨酸是茶叶中特有的游离氨基酸，研究发现茶氨酸具有抗肿瘤、保护神经、增强记忆、抗糖尿病、降血压、抗疲劳、缓解抑郁症、保护心脑血管、减轻酒精对肝脏的伤害、增强对流行性感冒病毒疫苗的免疫响应等生理功能，其镇静安神的功效尤其值得关注。并且茶氨酸已经成为新食品原料，在功能食品中具有重要的应用前景。
随着社会发展、生活节奏的加快以及竞争压力的增加，睡眠障碍的人越来越多，据统计《2018中国睡眠指数》报告显示：中国成人失眠发生率高达38.2％，超过了3亿中国人出现睡眠障碍。持续的睡眠障碍可导致躯体和精神损害、社会经济损失等不良后果，包括心血管疾病、精神疾病的发生，免疫力低下，甚至死亡率的增加等问题，已成为严重公共卫生问题。现代人熬夜增多，饮食辛辣，常导致阴虚，而肾阴虚是导致睡眠障碍的重要原因。
发明内容
针对上述现有技术中的缺陷，发明人基于中西医结合的原则，经过反复试验，发现铁皮石斛花配伍九制黄精能够显著治疗肾阴虚，而茶氨酸具有镇静安神、促睡眠的功效，因此本发明提供一种改善肾阴虚导致的睡眠障碍的组合物的制备方法，该组合物以铁皮石斛花、九制黄精和茶氨酸为原料制成，可以缓解肾阴虚导致的睡眠障碍。该组合物具有配伍简单，其中铁皮石斛花、九制黄精和茶氨酸分别为食品、药食同源中药材和新食品原料，因此原料都是食品级别的，无依赖性和副作用，可长期服用，在食品保健品领域具有巨大的潜力。另外，本发明所用的铁皮石斛花与九制黄精经过闪式提取、浓缩、干燥，尤其闪式提取经过高速旋转剪切，有效物质放含量更高，活性物质收率也更高，提取物功效更显著。
本发明通过如下技术方案实现：一种改善肾阴虚导致的睡眠障碍的铁皮石斛花、九制黄精和茶氨酸的组合物制备方法，步骤如下：
（1）按照中西结合的原理，以滋阴养润功能的铁皮石斛花1-2份和温润补肾的九制黄精2-3份组合配比；
（2）按照质量体积比1：10，加入配好的组合物质量的10倍体积的30-80%的食用乙醇浸泡5-10d，每天用闪式提取器5次，过滤，滤液40℃减压浓缩至1/10体积，-60℃冷冻或50℃、0.07-0.08MPa减压真空干燥，得到淡黄色粉末；
（3）按照淡黄色粉末质量，加入3-5%的具有镇静安神功效的茶氨酸，即得到组合物。
优选的，浸泡期间每天采用闪式提取，5000转/分钟，每次3分钟，间歇提取5次，浸提效率更高。
本发明的改善肾阴虚导致的睡眠障碍的组合物可应用在日化、食品、保健食品和医药产品作为原料。
本发明组合物按照中西医结合原理配伍，通过黄精和石斛花配伍滋阴补肾，以茶氨酸镇静安神促进睡眠，标本兼治，改善肾阴虚导致的睡眠障碍，该组合物在保健食品或功能产品中具有重要的应用。实验表明，服用该组合物能够改善睡眠障碍，并且无依赖性，可长期服用。
具体实施方式
下面将结合本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有付出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
称取铁皮石斛花200g，九制黄精400g，加入6升浓度50%的食用乙醇浸泡提取10天，每天应用闪式提取，5000转/分钟，每次3分钟，提取5次，过滤，滤液减压浓缩至600毫升。冷冻干燥得到120克黄色粉末，粉末中加入6克茶氨酸，混匀得到组合物。
实施例2
称取铁皮石斛花2kg，九制黄精3kg，加入50升浓度60%的食用乙醇浸泡提取8天，每天应用闪式提取，5000转/分钟，每次3分钟，提取5次，过滤，滤液减压浓缩至5升。50℃真空减压干燥得到2kg黑黄色粉末，粉末中加入100克茶氨酸，混匀得到组合物。
实施例3
实施例1或2所得组合物2kg，按照1g/袋包装成2000袋，制备为固体饮料。
实施例4
160位具有阴虚导致的睡眠障碍志愿者，每天服用睡前1h服用实施例3所得的产品1袋，服用5d后，据回访，志愿者的睡眠障碍均得到改善，并且耳鸣、面色赤红的阴虚症状也得到改善。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (4)
1.一种改善肾阴虚导致的睡眠障碍的组合物制备方法，其特征在于，制备步骤如下：
（1）按照质量比例，以滋阴养润功能的铁皮石斛花1-2份和温润补肾的九制黄精2-3份配成混合物料；
（2）以混合物料质量10倍体积的浓度30-80%的食用乙醇浸泡5-10d，每天用闪式提取器5次，过滤，滤液在40℃减压浓缩至1/10体积，于-60℃冷冻或50℃、0.07-0.08MPa减压真空干燥，得到淡黄色粉末；
（3）按照淡黄色粉末质量，加入3-5%的具有镇静安神功效的茶氨酸，即得到改善肾阴虚导致的睡眠障碍的组合物。
2.根据权利要求1所述的组合物制备方法，其特征在于，以滋阴养润功能的铁皮石斛花1-2份和温润补肾的九制黄精2-3份配成混合物料，经过提取干燥得到提取物，在提取物中加入具有镇静安神功效的茶氨酸制备得到组合物。
3.根据权利要求1所述的组合物制备方法，其特征在于，步骤（2）的浸泡期间每天采用闪式提取器提取，5000转/分钟，每次3分钟，间歇提取5次，浸提效率更高。
4.根据权利要求1-3任一所述改善肾阴虚导致的睡眠障碍的组合物应用在制备日化、食品、保健食品和医药产品的原料。
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