CN110721131A - 神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方及制备方法 - Google Patents
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Abstract
本发明公开了神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方及制备方法,其中各组份的重量百分比为:水48‑55%,丁二醇2‑8%,聚甲基硅倍半氧烷0.5‑3%,聚二甲基硅氧烷0.5‑3%,异十六烷1‑3%,鲸蜡硬脂基聚甲基硅氧烷0.5‑3%,硬脂醇聚醚‑2为0.2‑0.8%,硬脂醇聚醚‑210.2‑0.8%,红花籽油1‑5%,神经酰胺1为0.5‑1.5%,氢化卵磷脂1‑3%,甲基葡糖醇聚醚‑20为0.1‑0.5%,甘油聚醚‑26为0.1‑0.3%,辛酰羟肟酸0.5‑2.3%,1,2‑己二醇1‑3%,海藻糖1‑3%,赤藓醇为1‑3%,聚二甲基硅氧烷交联聚合物1‑3%,霍霍巴蜡PEG‑120酯类1‑3%,甘油聚醚‑26为0.1‑0.5%,甜菜碱0.5‑2.5%,甘油1‑5%,辛酸/癸酸甘油三酯1‑5%等。本发明通过卵磷脂的乳化能力,提高了神经酰胺在配方中的含量,起到修复皮肤屏障,抗皮肤敏感的作用。
Description
技术领域
本发明涉及化妆品技术领域,尤其涉及神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方及制备方法。
背景技术
神经酰胺被证明,是对细胞有效的皮肤脂质层屏障修复剂,是一种在水中和油性成分中溶解度极低的原料,神经酰胺分子量较大,难于渗透进皮肤发挥原本的修复皮肤屏障的作用,添加进护肤品配方难度较高,目前护肤品配方设计中,涉及到神经酰胺这种原料,采取的办法是降低神经酰胺在配方中的含量,或者利用化学方法改变神经酰胺的化学结构,使其变成易溶于水的水溶性衍生物,但改变化学结构后的衍生物极大的降低了神经酰胺对皮肤脂质层的修复作用,所以现提出了神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方及制备方法。
发明内容
基于背景技术存在的技术问题,本发明提出了神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方及制备方法。
本发明提出的神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方,其中各组份的重量百分比为:水为48-55%,丁二醇为2-8%,聚甲基硅倍半氧烷为0.5-3%,聚二甲基硅氧烷为0.5-3%,异十六烷为1-3%,鲸蜡硬脂基聚甲基硅氧烷为0.5-3%,硬脂醇聚醚-2为0.2-0.8%,硬脂醇聚醚-21为0.2-0.8%,红花籽油为1-5%,神经酰胺1为0.5-1.5%,氢化卵磷脂为1-3%,甲基葡糖醇聚醚-20为0.1-0.5%,甘油聚醚-26为0.1-0.3%,辛酰羟肟酸为0.5-2.3%,1,2-己二醇为1-3%,海藻糖为1-3%,赤藓醇为1-3%,聚二甲基硅氧烷交联聚合物为1-3%,霍霍巴蜡PEG-120酯类为1-3%,甘油聚醚-26为0.1-0.5%,甜菜碱为0.5-2.5%,甘油为1-5%,辛酸/癸酸甘油三酯为1-5%,丙烯酰二甲基牛磺酸铵/VP共聚物为0.1-0.3%,黄原胶为0.2-0.8%,问荆提取物为1-5%,款冬叶提取物为1-5%,EDTA二钠为0.2-0.8%,PEG-40氢化蓖麻油为1-3%。
优选地,其中各组份的重量百分比为:水为52.5%,丁二醇为5%,聚甲基硅倍半氧烷为1.5%,聚二甲基硅氧烷为1.5%,异十六烷为2%,鲸蜡硬脂基聚甲基硅氧烷为1.5%,硬脂醇聚醚-2为0.5%,硬脂醇聚醚-21为0.5%,红花籽油为3%,神经酰胺1为1%,氢化卵磷脂为2%,甲基葡糖醇聚醚-20为0.3%,甘油聚醚-26为0.2%,辛酰羟肟酸为1.5%,1,2-己二醇为2%,海藻糖为2%,赤藓醇为2%,聚二甲基硅氧烷交联聚合物为2%,霍霍巴蜡PEG-120酯类为2%,甘油聚醚-26为0.3%,甜菜碱为1.5%,甘油为3%,辛酸/癸酸甘油三酯为3%,丙烯酰二甲基牛磺酸铵/VP共聚物为0.2%,黄原胶为0.5%,问荆提取物为3%,款冬叶提取物为3%,EDTA二钠为0.5%,PEG-40氢化蓖麻油为2%。
本发明提出的神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方的制备方法,包括如下步骤:
将神经酰胺与氢化卵磷脂按固定比例分散,再投入高压乳化机中加工成粒径为50-150nm的脂质体,其中氢化卵磷脂在外层,神经酰胺在脂质体中心,再与其他组分混合。
本发明中的有益效果为:
1.通过脂质体外层的卵磷脂的乳化能力,使得被包裹的神经酰胺均匀的分散在精华液中,极大的提高了神经酰胺在配方中的含量。
2.神经酰胺与氢化卵磷脂两种成分复配,按照固定的比例,加工成脂质体,添加到精华液的配方中,可以起到修复皮肤屏障,抗皮肤敏感的作用。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。
实施例1,神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方,其中各组份的重量百分比为:水为48-55%,丁二醇为2-8%,聚甲基硅倍半氧烷为0.5-3%,聚二甲基硅氧烷为0.5-3%,异十六烷为1-3%,鲸蜡硬脂基聚甲基硅氧烷为0.5-3%,硬脂醇聚醚-2为0.2-0.8%,硬脂醇聚醚-21为0.2-0.8%,红花籽油为1-5%,神经酰胺1为0.5-1.5%,氢化卵磷脂为1-3%,甲基葡糖醇聚醚-20为0.1-0.5%,甘油聚醚-26为0.1-0.3%,辛酰羟肟酸为0.5-2.3%,1,2-己二醇为1-3%,海藻糖为1-3%,赤藓醇为1-3%,聚二甲基硅氧烷交联聚合物为1-3%,霍霍巴蜡PEG-120酯类为1-3%,甘油聚醚-26为0.1-0.5%,甜菜碱为0.5-2.5%,甘油为1-5%,辛酸/癸酸甘油三酯为1-5%,丙烯酰二甲基牛磺酸铵/VP共聚物为0.1-0.3%,黄原胶为0.2-0.8%,问荆提取物为1-5%,款冬叶提取物为1-5%,EDTA二钠为0.2-0.8%,PEG-40氢化蓖麻油为1-3%。
神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方的制备方法,包括如下步骤:
将神经酰胺与氢化卵磷脂按固定比例分散,再投入高压乳化机中加工成粒径为50-150nm的脂质体,其中氢化卵磷脂在外层,神经酰胺在脂质体中心,再与其他组分混合。
实施例2,与实施1之间的区别在于,其中各组份的重量百分比为:水为52.5%,丁二醇为5%,聚甲基硅倍半氧烷为1.5%,聚二甲基硅氧烷为1.5%,异十六烷为2%,鲸蜡硬脂基聚甲基硅氧烷为1.5%,硬脂醇聚醚-2为0.5%,硬脂醇聚醚-21为0.5%,红花籽油为3%,神经酰胺1为1%,氢化卵磷脂为2%,甲基葡糖醇聚醚-20为0.3%,甘油聚醚-26为0.2%,辛酰羟肟酸为1.5%,1,2-己二醇为2%,海藻糖为2%,赤藓醇为2%,聚二甲基硅氧烷交联聚合物为2%,霍霍巴蜡PEG-120酯类为2%,甘油聚醚-26为0.3%,甜菜碱为1.5%,甘油为3%,辛酸/癸酸甘油三酯为3%,丙烯酰二甲基牛磺酸铵/VP共聚物为0.2%,黄原胶为0.5%,问荆提取物为3%,款冬叶提取物为3%,EDTA二钠为0.5%,PEG-40氢化蓖麻油为2%。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (3)
1.一种神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方,其中各组份的重量百分比为:水为48-55%,丁二醇为2-8%,聚甲基硅倍半氧烷为0.5-3%,聚二甲基硅氧烷为0.5-3%,异十六烷为1-3%,鲸蜡硬脂基聚甲基硅氧烷为0.5-3%,硬脂醇聚醚-2为0.2-0.8%,硬脂醇聚醚-21为0.2-0.8%,红花籽油为1-5%,神经酰胺1为0.5-1.5%,氢化卵磷脂为1-3%,甲基葡糖醇聚醚-20为0.1-0.5%,甘油聚醚-26为0.1-0.3%,辛酰羟肟酸为0.5-2.3%,1,2-己二醇为1-3%,海藻糖为1-3%,赤藓醇为1-3%,聚二甲基硅氧烷交联聚合物为1-3%,霍霍巴蜡PEG-120酯类为1-3%,甘油聚醚-26为0.1-0.5%,甜菜碱为0.5-2.5%,甘油为1-5%,辛酸/癸酸甘油三酯为1-5%,丙烯酰二甲基牛磺酸铵/VP共聚物为0.1-0.3%,黄原胶为0.2-0.8%,问荆提取物为1-5%,款冬叶提取物为1-5%,EDTA二钠为0.2-0.8%,PEG-40氢化蓖麻油为1-3%。
2.根据权利要求1所述的神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方,其中各组份的重量百分比为:水为52.5%,丁二醇为5%,聚甲基硅倍半氧烷为1.5%,聚二甲基硅氧烷为1.5%,异十六烷为2%,鲸蜡硬脂基聚甲基硅氧烷为1.5%,硬脂醇聚醚-2为0.5%,硬脂醇聚醚-21为0.5%,红花籽油为3%,神经酰胺1为1%,氢化卵磷脂为2%,甲基葡糖醇聚醚-20为0.3%,甘油聚醚-26为0.2%,辛酰羟肟酸为1.5%,1,2-己二醇为2%,海藻糖为2%,赤藓醇为2%,聚二甲基硅氧烷交联聚合物为2%,霍霍巴蜡PEG-120酯类为2%,甘油聚醚-26为0.3%,甜菜碱为1.5%,甘油为3%,辛酸/癸酸甘油三酯为3%,丙烯酰二甲基牛磺酸铵/VP共聚物为0.2%,黄原胶为0.5%,问荆提取物为3%,款冬叶提取物为3%,EDTA二钠为0.5%,PEG-40氢化蓖麻油为2%。
3.根据权利要求1所述的神经酰胺与卵磷脂搭配的皮肤抗敏感精华配方的制备方法,其特征在于,包括如下步骤:
将神经酰胺与氢化卵磷脂按固定比例分散,再投入高压乳化机中加工成粒径为50-150nm的脂质体,其中氢化卵磷脂在外层,神经酰胺在脂质体中心,再与其他组分混合。
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CN114028260A (zh) * | 2021-11-09 | 2022-02-11 | 上海药坦药物研究开发有限公司 | 一种神经酰胺e乳化剂及其制备方法与在化妆品中的应用 |
CN114028260B (zh) * | 2021-11-09 | 2023-12-08 | 上海药坦药物研究开发有限公司 | 一种神经酰胺e乳化剂及其制备方法与在化妆品中的应用 |
CN115364005A (zh) * | 2021-12-23 | 2022-11-22 | 广州雅纯化妆品制造有限公司 | 一种含有神经酰胺脂质体的凝露及其制备方法 |
CN115364005B (zh) * | 2021-12-23 | 2023-10-20 | 广州雅纯化妆品制造有限公司 | 一种含有神经酰胺脂质体的凝露及其制备方法 |
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