CN110638954A - Whitening and freckle removing composition and preparation method thereof - Google Patents

Whitening and freckle removing composition and preparation method thereof Download PDF

Info

Publication number
CN110638954A
CN110638954A CN201910996456.0A CN201910996456A CN110638954A CN 110638954 A CN110638954 A CN 110638954A CN 201910996456 A CN201910996456 A CN 201910996456A CN 110638954 A CN110638954 A CN 110638954A
Authority
CN
China
Prior art keywords
parts
composition
whitening
freckle
removing composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910996456.0A
Other languages
Chinese (zh)
Inventor
杨正书
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yunnan Yunnan Medicine Health Industry Co Ltd
Original Assignee
Yunnan Yunnan Medicine Health Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yunnan Yunnan Medicine Health Industry Co Ltd filed Critical Yunnan Yunnan Medicine Health Industry Co Ltd
Priority to CN201910996456.0A priority Critical patent/CN110638954A/en
Publication of CN110638954A publication Critical patent/CN110638954A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/342—Adenophora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/424—Gynostemma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a whitening and freckle-removing composition and a preparation method thereof, wherein the whitening and freckle-removing composition comprises the following raw materials in parts by weight: 2-8 parts of ginseng, 3-10 parts of astragalus membranaceus, 2-6 parts of angelica sinensis, 0.5-3 parts of safflower, 5-10 parts of coix seeds, 5-10 parts of polygonatum odoratum, 5-10 parts of radix ophiopogonis, 2-10 parts of bletilla striata, 5-10 parts of pearls, 2-6 parts of rhizoma cyperi, 2-6 parts of fingered citron, 2-6 parts of purple perilla, 3-10 parts of Chinese herbaceous peony, 2-8 parts of philippine violet herb, 2-8 parts of fructus forsythiae, 5-10 parts of cortex dictamni, 5-10 parts of fructus kochiae and 2-8 parts of liquorice. The invention firstly adopts three steps of heating reflux extraction of volatile oil, then low-temperature grinding extraction of water extract and finally heating reflux extraction of medicine dregs by ethanol, thereby ensuring complete extraction of effective components of the traditional Chinese medicine, good biological activity and high utilization rate.

Description

Whitening and freckle removing composition and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, in particular to a whitening and freckle-removing composition and a preparation method thereof.
Background
The stain is a representative of melanin pigmentation which is easily seen on the face, and includes freckle, senile plaque, pigmentation after inflammation, and the like. The melanin is not always black, and the color may be yellow, red, brown, black, etc. according to the degree of melanism. Human skin and hair color is not dependent on the number of melanocytes, but rather on the number, size, distribution, and degree of melanosome. The number of the melanin cells in the human skin of different ethnic groups is basically the same, but the melanosome in the melanosome keratin cell has the advantages of large quantity, large shape, deep melanin formation degree, slow dispersion and degradation, while the melanosome in the leucosome keratin cell has the advantages of small quantity, small shape, light melanin formation degree, poly-aggregate distribution in the phagolyase small body and easy degradation.
Chloasma is a skin disease affecting beauty treatment, which is characterized in that yellow brown or light black speckles appear on the face, are flatly spread on the skin and are not harmful to hands. The formation of chloasma is closely related to the physiological and pathological changes of human bodies, especially women, and the chloasma on the face is mainly formed by pigment deposition caused by the dysfunction of human immunity, endocrine disturbance and incapability of timely discharging metabolites. How to improve skin pigmentation is a difficult problem in the beauty and skin science
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing composition capable of promoting skin metabolism, fading freckles and making skin tender and white, and a preparation method of the composition.
In view of the above problems, the technical solution proposed by the present invention is:
the whitening and freckle-removing composition comprises a composition A, wherein the composition A is prepared from the following raw materials in parts by weight: 2-8 parts of ginseng, 3-10 parts of astragalus membranaceus, 2-6 parts of angelica sinensis, 0.5-3 parts of safflower, 5-10 parts of coix seeds, 5-10 parts of polygonatum odoratum, 5-10 parts of radix ophiopogonis, 2-10 parts of bletilla striata, 5-10 parts of pearls, 2-6 parts of rhizoma cyperi, 2-6 parts of fingered citron, 2-6 parts of purple perilla, 3-10 parts of Chinese herbaceous peony, 2-8 parts of philippine violet herb, 2-8 parts of fructus forsythiae, 5-10 parts of cortex dictamni, 5-10 parts of fructus kochiae and 2-8 parts of liquorice.
Further, the composition B comprises the following raw materials in parts by weight: 2-10 parts of bighead atractylodes rhizome, 2-6 parts of rheum officinale, 5-10 parts of eucommia ulmoides, 2-10 parts of gynostemma pentaphylla, 2-6 parts of mulberry leaf, 2-6 parts of scutellaria baicalensis, 5-10 parts of trichosanthes kirilowii maxim, 2-10 parts of pseudo-ginseng, 2-10 parts of salvia miltiorrhiza, 2-6 parts of ligusticum wallichii, 2-6 parts of radix angelicae and 2-6 parts of rose.
Further, the composition B can also consist of the following raw materials in parts by weight: 2-8 parts of American ginseng, 2-10 parts of codonopsis pilosula, 3-8 parts of lucid ganoderma, 3-8 parts of aloe, 2-10 parts of kudzu root, 2-10 parts of poria cocos, 2-8 parts of ampelopsis japonica, 2-10 parts of rhizoma polygonati, 3-10 parts of cactus, 2-10 parts of radix asparagi and 2-10 parts of lily.
Further, the composition B can also consist of the following raw materials in parts by weight: 2-10 parts of adenophora stricta, 2-6 parts of selfheal, 2-6 parts of houttuynia cordata, 2-6 parts of sophora flavescens, 2-6 parts of lithospermum, 2-6 parts of bamboo leaves, 3-8 parts of divaricate saposhnikovia root, 3-10 parts of polygonum aviculare, 2-10 parts of rhizoma atractylodis, 2-10 parts of poria cocos and 2-6 parts of oldenlandia diffusa.
The invention also provides a preparation method of the whitening and freckle-removing composition, which comprises the following steps:
step one, crushing the Chinese angelica, the fingered citron, the purple perilla and the rhizoma cyperi in the composition A into coarse powder, adding 10 times of water, soaking for 60 minutes, heating and boiling for 60 minutes, collecting volatile oil, and mixing the decoction dregs and the liquid medicine with other medicinal materials.
Step two, grinding the medicine residues and the liquid medicine left in the step one and the cleaned ginseng, the astragalus, the peony, the polygonatum, the dwarf lilyturf tuber, the bletilla striata, the safflower, the cortex dictamni, the belvedere fruit, the coix seed, the pearl, the Chinese violet, the weeping forsythia, the liquorice and the composition B into serous fluid; adding 3 times of purified water into the obtained slurry to prepare a suspension, and feeding the suspension into a colloid mill for milling to obtain an ultrafine grinding mixed solution; centrifuging the mixed solution with a centrifuge to obtain clarified liquid and medicinal residues; concentrating the clear liquid under reduced pressure to obtain extract with specific gravity of 1.25, and drying at low temperature below 60 deg.C to obtain water extract;
and step three, adding 8 times of ethanol with the concentration of 85% into the dregs obtained by the separation in the step two centrifuge, heating and refluxing for 3 hours, centrifugally separating by using the centrifuge to obtain an ethanol extract and dregs, recovering the ethanol from the ethanol extract, concentrating to obtain an extract with the specific gravity of 1.25, and drying at a low temperature of below 60 ℃ to obtain the ethanol extract.
And step four, grinding the water extract and the alcohol extract prepared in the step two and the step three into fine powder of 200 meshes, adding the volatile oil obtained in the step one, and uniformly mixing to prepare the whitening and freckle-removing composition.
The prepared whitening and freckle-removing composition can be prepared into skin care products by adding conventional auxiliary materials according to a conventional process. Wherein the skin care product is a cream, a lotion, a facial cleanser, an essence, a toner or a mask.
The prepared whitening and freckle removing composition can also be added with various conventional auxiliary materials required by preparing different dosage forms, such as a disintegrating agent, a lubricant, an adhesive and the like, and prepared into any one of common oral dosage forms, such as pills, powder, tablets, granules, capsules, oral liquid and the like, by a conventional Chinese medicinal preparation method.
Compared with the prior art, the invention has the beneficial effects that:
1. the whitening and freckle-removing composition comprises a plurality of traditional Chinese medicine components, wherein the ginseng, the astragalus, the angelica and the safflower are compatible, so that the whitening and freckle-removing composition has good effects of tonifying qi, nourishing blood, promoting blood circulation and removing blood stasis, and the components for promoting blood circulation and removing blood stasis can directly reach focuses and remove ecchymoses no matter the composition is taken orally or externally; the polygonatum, the radix ophiopogonis, the bletilla striata, the semen coicis and the pearl are matched to nourish yin and clear heat, nourish yin and moisten dryness, whiten skin, effectively repair skin damaged by ecchymosis, fade ecchymosis, reduce the generation of facial ecchymosis, and simultaneously can also harmonize qi, nourish blood, activate blood and remove stasis; the nutgrass galingale rhizome and the fingered citron have the effects of soothing the liver, resolving depression, storing liver blood, nourishing skin, relieving muscles and skin, relieving exterior syndrome of purple common perilla, removing blood stasis and removing freckles, the Chinese herbaceous peony has the effects of nourishing blood and softening liver, the Chinese violet and the weeping forsythia have the effects of clearing heat and cooling blood, detoxifying and eliminating carbuncle, the cortex dictamni and the fructus kochiae have the effects of clearing heat and promoting diuresis, dispelling wind and relieving itching, preventing allergy, and.
2. In order to adapt to different people, the people with facial speckle and red blood streak are added with rhubarb and baikal skullcap root which can clear away heat and toxic material, pseudo-ginseng, salvia miltiorrhiza which can promote blood circulation and remove blood stasis, etc.; for people with facial speckle complicated with xerosis cutis, radix Panacis Quinquefolii, rhizoma Polygonati, radix Ampelopsis, Aloe, etc. with effects of invigorating qi and nourishing yin are added; radix Sophorae Flavescentis, radix Arnebiae, radix Saposhnikoviae with effects of eliminating dampness and relieving itching, and herba Hedyotidis Diffusae can be added for treating facial speckle with eczema and pox.
3. The preparation method of the whitening and freckle-removing composition comprises the steps of extracting volatile oil of angelica sinensis, fingered citron, perilla and rhizoma cyperi by a heating extraction method, mixing herb residues and liquid medicine with other medicinal materials, and carrying out water extraction and alcohol extraction, so that the complete extraction of the effective components of the four Chinese medicines containing the volatile oil is fully ensured; compared with the traditional heating and boiling extraction method, the low-temperature extraction and low-temperature drying method combining colloid mill milling and centrifuge separation has the advantages that the polysaccharide effective components in the traditional Chinese medicines such as astragalus, polygonatum, radix ophiopogonis, bletilla striata and the like cannot be damaged by heating, the biological activity is good, and the utilization degree is high.
The foregoing description is only an overview of the technical solutions of the present invention, and the embodiments of the present invention are described below in order to make the technical means of the present invention more clearly understood and to make the above and other objects, features, and advantages of the present invention more clearly understandable.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
The first embodiment is as follows:
the whitening and freckle-removing composition consists of a composition A and a composition B, wherein the composition A consists of the following raw materials in parts by weight: 2 parts of ginseng, 3 parts of astragalus, 2 parts of angelica, 0.5 part of safflower, 5 parts of coix seed, 5 parts of polygonatum, 5 parts of dwarf lilyturf tuber, 2 parts of bletilla striata, 5 parts of pearl, 2 parts of rhizoma cyperi, 2 parts of fingered citron, 2 parts of purple perilla, 3 parts of peony, 2 parts of Chinese violet, 2 parts of forsythia, 5 parts of cortex dictamni, 5 parts of belvedere fruit and 2 parts of liquorice; the composition B comprises the following raw materials in parts by weight: 2 parts of bighead atractylodes rhizome, 2 parts of rheum officinale, 5 parts of eucommia ulmoides, 2 parts of gynostemma pentaphylla, 2 parts of mulberry leaf, 2 parts of scutellaria baicalensis, 5 parts of trichosanthes kirilowii maxim, 2 parts of pseudo-ginseng, 2 parts of salvia miltiorrhiza, 2 parts of ligusticum wallichii, 2 parts of angelica dahurica and 2 parts of rose.
The preparation method of the whitening and freckle-removing composition comprises the following steps:
step one, crushing the Chinese angelica, the fingered citron, the purple perilla and the rhizoma cyperi in the composition A into coarse powder, adding 10 times of water, soaking for 60 minutes, heating and boiling for 60 minutes, collecting volatile oil, and mixing the decoction dregs and the liquid medicine with other medicinal materials.
Step two, grinding the medicine residues and the liquid medicine left in the step one and the cleaned ginseng, the astragalus, the peony, the polygonatum, the dwarf lilyturf tuber, the bletilla striata, the safflower, the cortex dictamni, the belvedere fruit, the coix seed, the pearl, the Chinese violet, the weeping forsythia, the liquorice and the composition B into serous fluid; adding 3 times of purified water into the obtained slurry to prepare a suspension, and feeding the suspension into a colloid mill for milling to obtain an ultrafine grinding mixed solution; centrifuging the mixed solution with a centrifuge to obtain clarified liquid and medicinal residues; concentrating the clear liquid under reduced pressure to obtain extract with specific gravity of 1.25, and drying at low temperature below 60 deg.C to obtain water extract;
and step three, adding 8 times of ethanol with the concentration of 85% into the dregs obtained by the separation in the step two centrifuge, heating and refluxing for 3 hours, centrifugally separating by using the centrifuge to obtain an ethanol extract and dregs, recovering the ethanol from the ethanol extract, concentrating to obtain an extract with the specific gravity of 1.25, and drying at a low temperature of below 60 ℃ to obtain the ethanol extract.
And step four, grinding the water extract and the alcohol extract prepared in the step two and the step three into fine powder of 200 meshes, adding the volatile oil obtained in the step one, and uniformly mixing to prepare the whitening and freckle-removing composition.
Example two:
the whitening and freckle-removing composition consists of a composition A and a composition B, wherein the composition A consists of the following raw materials in parts by weight: 8 parts of ginseng, 10 parts of astragalus membranaceus, 6 parts of angelica sinensis, 3 parts of safflower, 10 parts of semen coicis, 10 parts of polygonatum odoratum, 10 parts of radix ophiopogonis, 10 parts of bletilla striata, 10 parts of pearl, 6 parts of rhizoma cyperi, 6 parts of fingered citron, 6 parts of purple perilla, 10 parts of peony, 8 parts of Chinese violet, 8 parts of fructus forsythiae, 10 parts of cortex dictamni, 10 parts of fructus kochiae and 8 parts of liquorice, wherein the composition B is prepared from the following raw materials in parts by weight: 10 parts of bighead atractylodes rhizome, 6 parts of rheum officinale, 10 parts of eucommia ulmoides, 10 parts of gynostemma pentaphylla, 6 parts of mulberry leaf, 6 parts of scutellaria baicalensis, 10 parts of snakegourd fruit, 10 parts of pseudo-ginseng, 10 parts of salvia miltiorrhiza, 6 parts of ligusticum wallichii, 6 parts of angelica dahurica and 6 parts of rose.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as that of the embodiment I.
Example three:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 5 parts of ginseng, 6 parts of astragalus membranaceus, 4 parts of angelica sinensis, 1.7 parts of safflower, 7 parts of semen coicis, 7 parts of polygonatum odoratum, 7 parts of radix ophiopogonis, 6 parts of bletilla striata, 7 parts of pearl, 4 parts of rhizoma cyperi, 4 parts of fingered citron, 4 parts of purple perilla, 6 parts of peony, 5 parts of Chinese violet, 5 parts of fructus forsythiae, 7 parts of cortex dictamni, 7 parts of fructus kochiae and 5 parts of liquorice, wherein the composition B is prepared from the following raw materials in parts by weight: 6 parts of bighead atractylodes rhizome, 4 parts of rheum officinale, 7 parts of eucommia ulmoides, 6 parts of gynostemma pentaphylla, 4 parts of mulberry leaf, 4 parts of scutellaria baicalensis, 7 parts of snakegourd fruit, 6 parts of pseudo-ginseng, 6 parts of salvia miltiorrhiza, 4 parts of ligusticum wallichii, 4 parts of radix angelicae and 4 parts of rose.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
Example four:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 2 parts of ginseng, 3 parts of astragalus, 2 parts of angelica, 0.5 part of safflower, 5 parts of coix seed, 5 parts of polygonatum, 5 parts of dwarf lilyturf tuber, 2 parts of bletilla striata, 5 parts of pearl, 2 parts of rhizoma cyperi, 2 parts of fingered citron, 2 parts of purple perilla, 3 parts of peony, 2 parts of Chinese violet, 2 parts of forsythia, 5 parts of cortex dictamni, 5 parts of belvedere fruit and 2 parts of liquorice; the composition B can also consist of the following raw materials in parts by weight: 2 parts of American ginseng, 2 parts of codonopsis pilosula, 3 parts of lucid ganoderma, 3 parts of aloe, 2 parts of kudzu root, 2 parts of poria cocos, 2 parts of ampelopsis japonica, 2 parts of rhizoma polygonati, 3 parts of cactus, 2 parts of asparagus and 2 parts of lily.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
Example five:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 8 parts of ginseng, 10 parts of astragalus, 6 parts of angelica, 3 parts of safflower, 10 parts of coix seed, 10 parts of polygonatum, 10 parts of dwarf lilyturf tuber, 10 parts of bletilla striata, 10 parts of pearl, 6 parts of nutgrass galingale rhizome, 6 parts of finger citron, 6 parts of purple perilla, 10 parts of peony, 8 parts of Chinese violet, 8 parts of weeping forsythia, 10 parts of cortex dictamni, 10 parts of belvedere fruit and 8 parts of liquorice; the composition B can also consist of the following raw materials in parts by weight: 8 parts of American ginseng, 10 parts of codonopsis pilosula, 8 parts of lucid ganoderma, 8 parts of aloe, 10 parts of kudzu root, 10 parts of poria cocos, 8 parts of Japanese ampelopsis root, 10 parts of rhizoma polygonati, 10 parts of cactus, 10 parts of radix asparagi and 10 parts of lily.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
Example six:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 5 parts of ginseng, 6 parts of astragalus, 4 parts of angelica, 1.7 parts of safflower, 7 parts of coix seed, 7 parts of polygonatum, 7 parts of dwarf lilyturf tuber, 6 parts of bletilla striata, 7 parts of pearl, 4 parts of rhizoma cyperi, 4 parts of fingered citron, 4 parts of purple perilla, 6 parts of peony, 5 parts of Chinese violet, 5 parts of forsythia, 7 parts of cortex dictamni, 7 parts of belvedere fruit and 5 parts of liquorice; the composition B can also consist of the following raw materials in parts by weight: 5 parts of American ginseng, 6 parts of codonopsis pilosula, 5 parts of lucid ganoderma, 5 parts of aloe, 5 parts of kudzu root, 5 parts of poria cocos, 5 parts of Japanese ampelopsis root, 6 parts of rhizoma polygonati, 6 parts of cactus, 6 parts of radix asparagi and 6 parts of lily.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
Example seven:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 2 parts of ginseng, 3 parts of astragalus, 2 parts of angelica, 0.5 part of safflower, 5 parts of coix seed, 5 parts of polygonatum, 5 parts of dwarf lilyturf tuber, 2 parts of bletilla striata, 5 parts of pearl, 2 parts of rhizoma cyperi, 2 parts of fingered citron, 2 parts of purple perilla, 3 parts of peony, 2 parts of Chinese violet, 2 parts of forsythia, 5 parts of cortex dictamni, 5 parts of belvedere fruit and 2 parts of liquorice; the composition B can also consist of the following raw materials in parts by weight: 2 parts of adenophora stricta, 2 parts of prunella vulgaris, 2 parts of houttuynia cordata, 2 parts of sophora flavescens, 2 parts of lithospermum, 2 parts of bamboo leaves, 3 parts of divaricate saposhnikovia roots, 3 parts of polygonum aviculare, 2 parts of rhizoma atractylodis, 2 parts of poria cocos and 2 parts of oldenlandia diffusa.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
Example eight:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 8 parts of ginseng, 10 parts of astragalus, 6 parts of angelica, 3 parts of safflower, 10 parts of coix seed, 10 parts of polygonatum, 10 parts of dwarf lilyturf tuber, 10 parts of bletilla striata, 10 parts of pearl, 6 parts of nutgrass galingale rhizome, 6 parts of finger citron, 6 parts of purple perilla, 10 parts of peony, 8 parts of Chinese violet, 8 parts of weeping forsythia, 10 parts of cortex dictamni, 10 parts of belvedere fruit and 8 parts of liquorice; the composition B can also consist of the following raw materials in parts by weight: 10 parts of adenophora stricta, 6 parts of prunella vulgaris, 6 parts of houttuynia cordata, 6 parts of sophora flavescens, 6 parts of lithospermum, 6 parts of bamboo leaves, 8 parts of divaricate saposhnikovia roots, 10 parts of polygonum aviculare, 10 parts of rhizoma atractylodis, 10 parts of poria cocos and 6 parts of oldenlandia diffusa.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
Example nine:
the whitening and freckle-removing composition comprises a composition A and a composition B, wherein the composition A comprises the following raw materials in parts by weight: 5 parts of ginseng, 6 parts of astragalus, 4 parts of angelica, 1.7 parts of safflower, 7 parts of coix seed, 7 parts of polygonatum, 7 parts of dwarf lilyturf tuber, 6 parts of bletilla striata, 7 parts of pearl, 4 parts of rhizoma cyperi, 4 parts of fingered citron, 4 parts of purple perilla, 6 parts of peony, 5 parts of Chinese violet, 5 parts of forsythia, 7 parts of cortex dictamni, 7 parts of belvedere fruit and 5 parts of liquorice; the composition B can also consist of the following raw materials in parts by weight: 6 parts of adenophora stricta, 4 parts of prunella vulgaris, 4 parts of houttuynia cordata, 4 parts of sophora flavescens, 4 parts of lithospermum, 4 parts of bamboo leaves, 5 parts of divaricate saposhnikovia roots, 6 parts of polygonum aviculare, 6 parts of rhizoma atractylodis, 6 parts of poria cocos and 4 parts of oldenlandia diffusa.
The preparation method of the whitening and freckle-removing composition described in the embodiment is the same as the implementation method.
The whitening and freckle-removing composition prepared in the first to third embodiments is mainly used for people who have speckles on the face and red blood streaks, and the ginseng, the astragalus, the angelica and the safflower in the composition A are compatible in the first to third embodiments, so that the composition has good effects of tonifying qi, nourishing blood, promoting blood circulation and removing blood stasis, and the components for promoting blood circulation and removing blood stasis can directly reach the focus and remove ecchymosis no matter the composition is orally taken or externally used; the polygonatum, the radix ophiopogonis, the bletilla striata, the semen coicis and the pearl are matched to nourish yin and clear heat, nourish yin and moisten dryness, whiten skin, effectively repair skin damaged by ecchymosis, fade ecchymosis, reduce the generation of facial ecchymosis, and simultaneously can also harmonize qi, nourish blood, activate blood and remove stasis; the rhizoma cyperi and the fingered citron have the effects of soothing the liver, resolving depression, storing liver blood, nourishing skin, relieving muscles and skin, relieving exterior syndrome of muscles, removing blood stasis and removing freckles, the Chinese herbaceous peony has the effects of nourishing blood and softening the liver, the Chinese violet and the weeping forsythia have the effects of clearing heat and cooling blood, detoxifying and eliminating carbuncles, the cortex dictamni and the fructus kochiae have the effects of clearing heat and promoting diuresis, dispelling wind and relieving itching and preventing allergy, and the liquorice has the effects of clearing heat and detoxifying, the rhubarb and the scutellaria baicalensis in the composition B have the effects of clearing heat.
And (3) clinical trials:
the whitening and freckle-removing composition prepared in the first embodiment of the invention is prepared into oral liquid 01 by a conventional traditional Chinese medicine preparation method, and patients with chloasma and red blood streak on the face are clinically treated, 400 patients are treated, 200 patients take traditional freckle-removing oral medicines on the market, 200 patients take 137 men and 263 women in 01,400 patients who are finally prepared from the first embodiment of the invention, the youngest people are 17 years old, 16 people under 25 years old (including 25 years old), 159 people under 25-35 years old (including 35 years old), 178 people under 35-45 years old (including 45 years old), 47 people under 45-55 years old have chloasma for the longest 27 years, the youngest people are 1 year old, and the taking period is 3 months.
And (4) testing standard: and (3) healing: the yellow and brown spots on the lesion part disappear, the blood streak on the face disappears, and the normal skin color is recovered and is brighter than the original skin color; the effect is remarkable: chloasma becomes shallow, facial blood streak is reduced, the color of the skin is close to that of the skin, and the skin becomes white at the colorless spot; improvement: the chloasma becomes lighter. Note that: during the treatment period, vegetables and fruits are eaten more, and the sleep is ensured to be more than 8 hours every day.
The results of using the traditional spot-removing oral medicine on the market are as follows:
Figure BDA0002239854610000101
the final results of oral liquid 01 prepared using the first example of the present invention are as follows:
Figure BDA0002239854610000102
the experimental examples show that the whitening and freckle-removing composition prepared by the first embodiment of the invention is finally prepared into oral liquid 01, and the effect of the oral liquid for patients with chloasma and blood streak on the face is superior to that of the traditional freckle-removing oral medicine in the market.
The whitening and freckle-removing composition prepared in the fourth to sixth embodiments is mainly used for people who have speckled faces and dry and lusterless skins, and the composition A in the composition has good effects of tonifying qi and nourishing blood, and promoting blood circulation to remove blood stasis due to compatibility of ginseng, astragalus mongholicus, angelica sinensis and safflower carthamus in the four to six related embodiments, so that the components for promoting blood circulation to remove blood stasis can directly reach focuses and remove ecchymoses no matter the composition is taken orally or externally; the polygonatum, the radix ophiopogonis, the bletilla striata, the semen coicis and the pearl are matched to nourish yin and clear heat, nourish yin and moisten dryness, whiten skin, effectively repair skin damaged by ecchymosis, fade ecchymosis, reduce the generation of facial ecchymosis, and simultaneously can also harmonize qi, nourish blood, activate blood and remove stasis; the nutgrass galingale rhizome and the fingered citron have the effects of soothing the liver, resolving depression, storing liver blood, nourishing skin, relieving muscles and skin surface, removing blood stasis and removing freckles, the Chinese herbaceous peony has the effects of nourishing the blood and softening the liver, the Chinese violet and the weeping forsythia have the effects of clearing heat and cooling blood, detoxifying and eliminating carbuncles, the cortex dictamni and the fructus kochiae have the effects of clearing heat and promoting diuresis, dispelling wind and relieving itching, preventing allergy and the liquorice has the effects of clearing heat and detoxifying, and the American ginseng, the rhizoma polygonati, the Japanese ampelopsis root, the aloe and the like in the composition B.
And (3) testing the efficacy:
the whitening and freckle-removing composition prepared in the fourth embodiment of the invention is added with conventional auxiliary materials by a conventional process to prepare a mask 01, and the traditional mask on the market is tested.
The tested population is female, the number is 100, and the age is as follows: the skin is 25-55 years old, and has color spots of different degrees, dry skin, rough skin, large pores and the like;
grouping: the test group used the mask 01 prepared according to the present invention, and the control group used a commercial conventional mask, each group containing 50 persons, each group having an average age of 38 + -2 years. .
The test method comprises the following steps: after the subjects cleaned their face, the membrane cloth was unrolled inwards and gently applied to the face, gently pressed to full fit, applied for 15 minutes, 2 times a week and used in the evening for 4 consecutive weeks.
The test evaluation results are as follows:
test group trial feedback summary table:
Figure BDA0002239854610000121
the comparison group trial feedback summary table:
Figure BDA0002239854610000122
according to the test examples, the whitening and freckle-removing composition prepared in the fourth embodiment of the invention is added with conventional auxiliary materials through a conventional process to prepare the mask with high recognition degree (01), and subjects show that the mask has good moisturizing effect and feel moist after use; after the mask is used for 4 weeks, the situations of dry skin, roughness, large pores and the like are obviously improved, the fine lines on the face are reduced, color spots and the like are obviously faded or faded, and the skin is obviously smooth, moist and elastic. Meanwhile, no people in the questionnaire of the subject have adverse phenomena such as allergy, red and swollen skin and the like.
The whitening and freckle-removing composition prepared in the seventh to ninth embodiments is mainly used for people who have speckles on the face and have eczema, acnes and acnes on the skin, and because the seven to nine related embodiments are adopted, the ginseng, the astragalus, the angelica and the safflower in the composition A are compatible, so that the whitening and freckle-removing composition has good effects of tonifying qi, nourishing blood, promoting blood circulation and removing blood stasis, and the components for promoting blood circulation and removing blood stasis can directly reach focuses and remove ecchymoses no matter the composition is taken orally or externally; the polygonatum, the radix ophiopogonis, the bletilla striata, the semen coicis and the pearl are matched to nourish yin and clear heat, nourish yin and moisten dryness, whiten skin, effectively repair skin damaged by ecchymosis, fade ecchymosis, reduce the generation of facial ecchymosis, and simultaneously can also harmonize qi, nourish blood, activate blood and remove stasis; the rhizoma cyperi and the fingered citron have the effects of soothing the liver, resolving depression, storing liver blood, nourishing skin, relieving muscles and skin, relieving exterior syndrome of muscles, removing blood stasis and removing freckles, the Chinese herbaceous peony has the effects of nourishing blood and softening the liver, the Chinese violet and the weeping forsythia have the effects of clearing heat and cooling blood, detoxifying and eliminating carbuncles, the cortex dictamni and the fructus kochiae have the effects of clearing heat and promoting diuresis, dispelling wind and relieving itching and preventing allergy, the liquorice has the effects of clearing heat and detoxifying, the radix sophorae flavescentis and the lithospermum in the composition B have the effects of cooling blood and reducing swelling, the oldenlandia diffusa has the effects of clearing damp, relieving itching.
And (3) testing the efficacy:
the whitening and freckle-removing composition prepared in the seventh embodiment of the invention is added with conventional auxiliary materials through a conventional process to prepare the essence cream 01, and the conventional essence cream on the market is tested.
The tested population is female, the number is 100, and the age is as follows: 20-40 years old, and has different degrees of mottle, eczema, acne mark, etc.;
grouping: the test group uses the essence cream 01 prepared by the invention, the control group uses the traditional essence cream on the market, 50 people are used in each group, and the average age of each group is 30 +/-2 years old. .
The test method comprises the following steps: after a subject cleans the face, the mung bean essence cream is taken to be in the palm, the two hands are combined to rub and preheat, and after the essence is emulsified, the essence is uniformly smeared on the face from outside to inside along the skin lines and from bottom to top; the medicine is taken in the morning and evening for 8 weeks.
The test evaluation results are as follows:
feedback summary table for trial use of test group
Figure BDA0002239854610000141
Comparison group trial feedback summary table
Figure BDA0002239854610000142
According to the experimental examples, the whitening and freckle-removing composition prepared in the fourth embodiment of the invention is added with the conventional auxiliary materials through the conventional process to prepare the essence cream with high acceptance degree, and all subjects show that the essence cream has obviously reduced or eliminated the color spots and the like after use, and the eczema, the acne and the acne marks are also obviously improved. The skin is obviously smooth, moist and elastic. Meanwhile, no people in the questionnaire of the subject have adverse phenomena such as allergy, red and swollen skin and the like.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims (5)

1. The whitening and freckle-removing composition is characterized by comprising a composition A, wherein the composition A is prepared from the following raw materials in parts by weight: 2-8 parts of ginseng, 3-10 parts of astragalus membranaceus, 2-6 parts of angelica sinensis, 0.5-3 parts of safflower, 5-10 parts of coix seeds, 5-10 parts of polygonatum odoratum, 5-10 parts of radix ophiopogonis, 2-10 parts of bletilla striata, 5-10 parts of pearls, 2-6 parts of rhizoma cyperi, 2-6 parts of fingered citron, 2-6 parts of purple perilla, 3-10 parts of Chinese herbaceous peony, 2-8 parts of philippine violet herb, 2-8 parts of fructus forsythiae, 5-10 parts of cortex dictamni, 5-10 parts of fructus kochiae and 2-8 parts of liquorice.
2. The whitening and freckle-removing composition according to claim 1, further comprising a composition B, wherein the composition B is prepared from the following raw materials in parts by weight: 2-10 parts of bighead atractylodes rhizome, 2-6 parts of rheum officinale, 5-10 parts of eucommia ulmoides, 2-10 parts of gynostemma pentaphylla, 2-6 parts of mulberry leaf, 2-6 parts of scutellaria baicalensis, 5-10 parts of trichosanthes kirilowii maxim, 2-10 parts of pseudo-ginseng, 2-10 parts of salvia miltiorrhiza, 2-6 parts of ligusticum wallichii, 2-6 parts of radix angelicae and 2-6 parts of rose.
3. The whitening and freckle-removing composition according to claim 2, wherein the composition B further comprises the following raw materials in parts by weight: 2-8 parts of American ginseng, 2-10 parts of codonopsis pilosula, 3-8 parts of lucid ganoderma, 3-8 parts of aloe, 2-10 parts of kudzu root, 2-10 parts of poria cocos, 2-8 parts of ampelopsis japonica, 2-10 parts of rhizoma polygonati, 3-10 parts of cactus, 2-10 parts of radix asparagi and 2-10 parts of lily.
4. The whitening and freckle-removing composition according to any one of claims 2 or 3, wherein the composition B further comprises the following raw materials in parts by weight: 2-10 parts of adenophora stricta, 2-6 parts of selfheal, 2-6 parts of houttuynia cordata, 2-6 parts of sophora flavescens, 2-6 parts of lithospermum, 2-6 parts of bamboo leaves, 3-8 parts of divaricate saposhnikovia root, 3-10 parts of polygonum aviculare, 2-10 parts of rhizoma atractylodis, 2-10 parts of poria cocos and 2-6 parts of oldenlandia diffusa.
5. The preparation method of the whitening and freckle-removing composition is characterized by comprising the following steps:
step one, crushing the Chinese angelica, the fingered citron, the purple perilla and the rhizoma cyperi in the composition A into coarse powder, adding 10 times of water, soaking for 60 minutes, heating and boiling for 60 minutes, collecting volatile oil, and mixing the decoction dregs and the liquid medicine with other medicinal materials.
Step two, grinding the medicine residues and the liquid medicine left in the step one and the cleaned ginseng, the astragalus, the peony, the polygonatum, the dwarf lilyturf tuber, the bletilla striata, the safflower, the cortex dictamni, the belvedere fruit, the coix seed, the pearl, the Chinese violet, the weeping forsythia, the liquorice and the composition B into serous fluid; adding 3 times of purified water into the obtained slurry to prepare a suspension, and feeding the suspension into a colloid mill for milling to obtain an ultrafine grinding mixed solution; centrifuging the mixed solution with a centrifuge to obtain clarified liquid and medicinal residues; concentrating the clear liquid under reduced pressure to obtain extract with specific gravity of 1.25, and drying at low temperature below 60 deg.C to obtain water extract;
and step three, adding 8 times of ethanol with the concentration of 85% into the dregs obtained by the separation in the step two centrifuge, heating and refluxing for 3 hours, centrifugally separating by using the centrifuge to obtain an ethanol extract and dregs, recovering the ethanol from the ethanol extract, concentrating to obtain an extract with the specific gravity of 1.25, and drying at a low temperature of below 60 ℃ to obtain the ethanol extract.
And step four, grinding the water extract and the alcohol extract prepared in the step two and the step three into fine powder of 200 meshes, adding the volatile oil obtained in the step one, and uniformly mixing to prepare the whitening and freckle-removing composition.
CN201910996456.0A 2019-10-19 2019-10-19 Whitening and freckle removing composition and preparation method thereof Pending CN110638954A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910996456.0A CN110638954A (en) 2019-10-19 2019-10-19 Whitening and freckle removing composition and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910996456.0A CN110638954A (en) 2019-10-19 2019-10-19 Whitening and freckle removing composition and preparation method thereof

Publications (1)

Publication Number Publication Date
CN110638954A true CN110638954A (en) 2020-01-03

Family

ID=69013089

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910996456.0A Pending CN110638954A (en) 2019-10-19 2019-10-19 Whitening and freckle removing composition and preparation method thereof

Country Status (1)

Country Link
CN (1) CN110638954A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113116753A (en) * 2021-04-23 2021-07-16 厦门力嘉诚生物科技有限公司 Rose essential oil face cream and preparation method thereof
CN114181325A (en) * 2021-12-20 2022-03-15 淮安唯尔美化妆品有限公司 Melanin synthesis inhibitor and whitening application thereof
CN115177695A (en) * 2022-08-17 2022-10-14 天地慈(东莞)生物科技有限公司 Traditional Chinese medicine composition for whitening skin and removing freckles and application thereof
CN115844784A (en) * 2022-12-22 2023-03-28 广州市科能化妆品科研有限公司 Allergy-relieving and anti-inflammatory composition for dry skin and application and preparation method thereof
CN115844784B (en) * 2022-12-22 2024-06-11 广州市科能化妆品科研有限公司 Composition for relieving inflammation of dry skin and application and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105558537A (en) * 2014-10-16 2016-05-11 理想科技集团有限公司 Skin whitening and freckle removing composition and taking method thereof
CN105640869A (en) * 2016-02-22 2016-06-08 广州科玛生物科技有限公司 Multiple-effect repairing mask liquid and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105558537A (en) * 2014-10-16 2016-05-11 理想科技集团有限公司 Skin whitening and freckle removing composition and taking method thereof
CN105640869A (en) * 2016-02-22 2016-06-08 广州科玛生物科技有限公司 Multiple-effect repairing mask liquid and preparation method thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113116753A (en) * 2021-04-23 2021-07-16 厦门力嘉诚生物科技有限公司 Rose essential oil face cream and preparation method thereof
CN113116753B (en) * 2021-04-23 2022-06-03 厦门力嘉诚生物科技有限公司 Rose essential oil face cream and preparation method thereof
CN114181325A (en) * 2021-12-20 2022-03-15 淮安唯尔美化妆品有限公司 Melanin synthesis inhibitor and whitening application thereof
CN115177695A (en) * 2022-08-17 2022-10-14 天地慈(东莞)生物科技有限公司 Traditional Chinese medicine composition for whitening skin and removing freckles and application thereof
CN115177695B (en) * 2022-08-17 2024-01-02 天地慈(东莞)生物科技有限公司 Traditional Chinese medicine composition for whitening skin and removing freckles and application thereof
CN115844784A (en) * 2022-12-22 2023-03-28 广州市科能化妆品科研有限公司 Allergy-relieving and anti-inflammatory composition for dry skin and application and preparation method thereof
CN115844784B (en) * 2022-12-22 2024-06-11 广州市科能化妆品科研有限公司 Composition for relieving inflammation of dry skin and application and preparation method thereof

Similar Documents

Publication Publication Date Title
CN100339114C (en) Medicinal composition for treating alopecta and its prearation method
CN102451126B (en) Hair-growing cosmetic composition, and preparation method thereof
CN105055289A (en) Multi-effect skin caring and smoothening traditional Chinese medicine lotion and preparation method thereof
CN102266445B (en) Eye protection Chinese medicinal composition with health care and treatment effects
CN110638954A (en) Whitening and freckle removing composition and preparation method thereof
CN104784507A (en) Traditional Chinese medicine composition with multiple cosmetic effects and application
CN104984074A (en) Feature-beautifying skin-care product and production method and application thereof
CN101279012A (en) Chinese medicine tea for weight reduction, toxin elimination and beauty treatment and matching Chinese medicinal composition
KR100585444B1 (en) Cosmetic composition using a herb medicine
CN111214430A (en) Codonopsis pilosula and astragalus membranaceus composite Chinese herbal medicine base whitening anti-inflammatory moisturizing mask and preparation method thereof
CN111840197B (en) A traditional Chinese medicine-based whitening anti-inflammatory moisturizing facial mask containing radix Codonopsis and radix astragali, and its preparation method
CN111658558A (en) Traditional Chinese medicine freckle-removing essence and preparation method thereof
CN112315871A (en) Traditional Chinese medicine shampoo for scalp and hair care and preparation method thereof
CN102743313B (en) Natural medicinal composition for delaying skin aging and application thereof
CN102319337A (en) Beautifying capsules and preparation method thereof
CN111759919A (en) Freckle-removing traditional Chinese medicine composition and preparation method thereof, freckle-removing traditional Chinese medicine face cream and preparation method thereof
CN112999306A (en) Traditional Chinese medicine composition for whitening skin and removing freckles and application thereof
CN1090932C (en) External-use ointment for face and its preparing process
CN106109968A (en) Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition and preparation method thereof
CN101700276B (en) Application of medicinal preparation for preparing medicine used for treating chloasma disease
CN112754972A (en) Traditional Chinese medicine hair-blacking composition and preparation thereof
CN108704040B (en) Traditional Chinese medicine composition and application thereof
CN102988890A (en) Pure Chinese medicine preparation for treating chloasma
CN106924517A (en) A kind of Chinese medicine preparation for treating closo acne and preparation method thereof
CN115844801A (en) Pure natural edible skin care product preparation and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20200103