CN106924517A - A kind of Chinese medicine preparation for treating closo acne and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for treating closo acne and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to technical field of traditional Chinese medicines, specifically disclose a kind of Chinese medicine preparation for treating closo acne, including following weight portion raw material components：8 12 parts of the Radix Astragali, 8 12 parts of spina gleditsiae, 8 12 parts of Radix Angelicae Sinensis, 36 parts of safflower, 6 12 parts of the capsule of weeping forsythia, 26 parts of fritillaria thunbergii, 6 12 parts of Radix Codonopsis, 6 12 parts of radix rehmanniae recen.The formula of the Chinese medicine preparation has functions that clearing heat and detoxicating, promoting blood circulation and removing blood stasis, mass dissipating and swelling eliminating, regulation endocrine, enhance immunity, enhancing skin metabolism are repaired；It is easy to absorb after taking, it is rapid-action；Without skin damaged after healing, without scar.In addition, the present invention saves Chinese medicine, low cost is evident in efficacy, has no toxic side effect, with wide market prospects.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine preparation for treating closo acne and its preparation side
Method.
Background technology
Acne is a kind of chronic inflammatory skin of pilosebaceous unit, mainly with sebum produce increase, hair follicle
Mouthful epithelium angling is hyperfunction and hair follicle in propionic acid Propiobacterium propagation it is relevant, mostly occur in the greasiness such as face and thoracic dorsal area, clinical table
Now based on closed comedones, running sore, tubercle, papule etc., juvenile and youth is mainly apt to occur in, to the psychological and social shadow of patient
Ring very big, the state of an illness is complicated, the course of disease is long.
At present, more than western medical treatment acne using antibiotic, tretinoin, female hormone, corticosteroid hormone, vitamin,
The medicines such as male sex hormone antagonist are for oral administration or external application is treated, and these therapy curative effects not yet can be satisfactory, and the course for the treatment of is all needed
More long, drug resistance and side effect are obvious.
Chinese medicine acne is controlled and takes two classes orally outside being divided into：It is outer control class including face mask of traditional Chinese medicine, tincture, liniment, lotion,
Fumigant, skin scraping therapy with water, liquor or vegetable oil, auricular therapy, autohemotherapy, acupuncture and moxibustion treatment, catgut embedding therapy etc., these external treatment with Chinese medicine therapies are removed tincture, are put on the skin
Outside agent, weak point is that, using inconvenience, some curative effects are not also obvious, and some valuable products, patient is also difficult to receive, and
It is difficult to effect a radical cure easily recurrence；There is a substantial amounts of report the current country of prescription for oral administration of class for oral administration, but its common feature be the course for the treatment of it is long,
The slow, needs that take effect are decocted medicinal herbs and taken, it has not been convenient to, meanwhile, do not treated especially particular for different clinical manifestations.It is open
Number for CN104645146A patent application disclosed in a kind of Chinese medicine composition for treating acne, its raw material for pressing following weight portion
Medicine is made：Herba Andrographitis 17-23 parts, Sculellaria barbata 17-23 parts, rough gentian 17-23 parts, dandelion 17-23 parts, coix seed 13-17 parts, it is grey
Art 13-17 parts, fruit of summer cypress 13-17 parts, folium isatidis 13-17 parts, honeysuckle 13-17 parts, purslane 6-8 parts, root of Dahurain angelica 6-8 parts, it is floating
Duckweed 6-8 parts, rhizoma alismatis 6-8 parts, capsule of weeping forsythia 6-8 parts, Ligusticum wallichii 6-8 parts, radix paeoniae rubrathe 6-8 parts, Chinese violet 6-8 parts, red sage root 6-8 parts, arbor-vitae
Leaf 6-8 parts, cape jasmine 6-8 parts, 6-8 parts of radix rehmanniae recen Huang, root of kudzu vine 6-8 parts, gingko 2-4 parts, henbane seed 2-4 parts, asarum 2-4 parts, when
Return 2-4 parts, safflower 2-4 parts, Radix Glycyrrhizae 2-4 parts.Although said composition can treat acne, flavour of a drug up to 28 tastes, as oral
Drug industries difficulty is very big, and quality is difficult to control to, and with bitter and cold medicines such as Herba Andrographitis, rough gentian as main ingredient, oral bad adaptability.
The content of the invention
For problems of the prior art, it is an object of the invention to provide a kind of Chinese medicine for treating closo acne
Preparation and preparation method thereof, has significant therapeutic effect for the treatment of closo acne.
In order to achieve the above object, the present invention is achieved using following technical scheme.
A kind of Chinese medicine preparation for treating closo acne, it is characterised in that the raw material components including following weight portion：The Radix Astragali
It is 8-12 parts, spina gleditsiae 8-12 parts, Radix Angelicae Sinensis 8-12 parts, safflower 3-6 parts, capsule of weeping forsythia 6-12 parts, fritillaria thunbergii 2-6 parts, Radix Codonopsis 6-12 parts, raw
Glutinous rehmannia 6-12 parts.
Preferably, the Chinese medicine preparation of the treatment closo acne includes the raw material components of following weight portion：The Radix Astragali
It is 8-10 parts, spina gleditsiae 8-10 parts, Radix Angelicae Sinensis 8-10 parts, safflower 3-5 parts, capsule of weeping forsythia 8-10 parts, fritillaria thunbergii 2-4 parts, Radix Codonopsis 8-10 parts, raw
Glutinous rehmannia 8-10 parts.
It is further preferred that the Chinese medicine preparation of the treatment closo acne includes the raw material components of following weight portion：
8 parts of the Radix Astragali, 8 parts of spina gleditsiae, 8 parts of Radix Angelicae Sinensis, 5 parts of safflower, 8 parts of the capsule of weeping forsythia, 3 parts of fritillaria thunbergii, 9 parts of Radix Codonopsis, 9 parts of radix rehmanniae recen.
It is further preferred that the Chinese medicine preparation of the treatment closo acne includes the raw material components of following weight portion：
9 parts of the Radix Astragali, 9 parts of spina gleditsiae, 9 parts of Radix Angelicae Sinensis, 3 parts of safflower, 10 parts of the capsule of weeping forsythia, 5 parts of fritillaria thunbergii, 8 parts of Radix Codonopsis, 8 parts of radix rehmanniae recen.
It is further preferred that the Chinese medicine preparation of the treatment closo acne includes the raw material components of following weight portion：
10 parts of the Radix Astragali, 10 parts of spina gleditsiae, 10 parts of Radix Angelicae Sinensis, 3 parts of safflower, 10 parts of the capsule of weeping forsythia, 3 parts of fritillaria thunbergii, 10 parts of Radix Codonopsis, 10 parts of radix rehmanniae recen.
The Chinese medicine preparation for the treatment of closo acne of the present invention is granule, hard capsule, tablet or pill.
The preparation method of the Chinese medicine preparation for the treatment of closo acne of the invention, comprises the following steps：By the Radix Astragali, gleditsia sinensis
Thorn, Radix Angelicae Sinensis, safflower, the capsule of weeping forsythia, fritillaria thunbergii, Radix Codonopsis, radix rehmanniae recen, medicinal material merges, and medicinal material weight ratio is added for the first time for 9-11 times is measured
Water, decoct 1-3h, second adds medicinal material weight than be the 8-10 times of water measured, and decocts 1-2h, filtration, merging filtrate twice,
Filtrate decompression is condensed into the clear cream that relative density is 1.05-1.15, plus ethanol makes determining alcohol up to 50-70%, and refrigeration stands 6-
18h, filtration, filtrate obtains final product active ingredient of Chinese herbs, adds auxiliary material through drying under reduced pressure into dried cream powder, sieving, is made of the invention controlling
Treat the Chinese medicine preparation of closo acne.
Preferably, the preparation method of the Chinese medicine preparation for the treatment of closo acne of the invention, comprises the following steps：By Huang
Stilbene, spina gleditsiae, Radix Angelicae Sinensis, safflower, the capsule of weeping forsythia, fritillaria thunbergii, Radix Codonopsis, radix rehmanniae recen, medicinal material merges, and it is 10 that medicinal material weight ratio is added for the first time
The water of amount, decocts 2h again, and second addition medicinal material weight decocts 1.5h than being 9 times of water measured, and filtration merges filtrate twice, filters
Liquid is concentrated under reduced pressure into the clear cream that relative density is 1.1, plus ethanol makes determining alcohol up to 60%, and refrigeration stands 12h, filtration, filtrate warp
Drying under reduced pressure obtains final product active ingredient of Chinese herbs, adds auxiliary material into dried cream powder, sieving, is made treatment closo acne of the invention
Chinese medicine preparation.
Preferably, auxiliary material is honey, and the Chinese medicine preparation for being made treatment closo acne of the invention is honeyed bolus.
Preferably, the quality of the honey is 1-2 times of the quality of the active ingredient of Chinese herbs.
When the Chinese medicine preparation is granule, auxiliary material is dextrin or sucrose, by gained active ingredient of Chinese herbs and appropriate paste
Essence, sucrose are mixed, granulation, are dried, and are made granule.
When the Chinese medicine preparation is hard capsule, auxiliary material is starch or carboxymethylcellulose calcium, by gained active ingredient of Chinese herbs
Mixed with appropriate starch, carboxymethylcellulose calcium, granulation is encapsulated, is made hard capsule.
When the Chinese medicine preparation is tablet, auxiliary material is starch or dextrin, by gained active ingredient of Chinese herbs and appropriate starch
Or dextrin is mixed, granulation is tabletted.
The Chinese medicine preparation be dispersant when, auxiliary material be microcrystalline cellulose or lactose, by gained active ingredient of Chinese herbs with it is micro-
Crystalline cellulose or lactose are made dispersant.
Fang Zhong each side medicine source and efficacy effect are as follows：
The Radix Astragali, is legume astragalus mongolicus Astragalus membranaceus (Fisch.)
Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge.'s
Dry root.Spring and autumn is excavated, and removes fibrous root and root head, is dried, and is cut into slices, and raw use or honey process use.Sweet, the tepor of property.Return lung, spleen
Through.Effect, tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, the stagnant logical numbness of row, pus draining and toxin expelling, expelling pus and promoting granulation.
Spina gleditsiae, is that legume Chinese honey locust dries quil.Whole year can harvest, and dry, or take advantage of fresh slices, dry.Property
It is pungent, temperature.Return liver, stomach.Wind, desinsection are searched in effect, eliminating toxic of subsiding a swelling, apocenosis.
Radix Angelicae Sinensis, is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Autumn Mo excavates,
Fibrous root and silt are removed, after moisture slightly evaporates, wisp is bundled into, upper canopy, with pyrotechnics slowly smoke-dried beancurd.It is warm in nature, taste is pungent.Return liver, the heart,
The spleen channel.Effect, replenishing and activating blood relaxes bowel.
Safflower, is that drying for feverfew safflower Carthamus tinctorius L. is spent.Plucked when summer spends orange red,
Dry in the shade, dry or dry.Property it is sweet, temperature.The thoughts of returning home, Liver Channel.Effect, invigorate blood circulation, scattered silt analgesic.
The capsule of weeping forsythia, is Oleaceae forsythia.Property it is bitter, be slightly cold.Return lung, the heart, small intestinl channel.Effect, clearing heat and detoxicating, Sweeling-eliminating medicine powder
Knot, dispelling wind and heat from the body.
Fritillaria thunbergii, is this fritillaria Fritillatia thunbergii Miq. of Liliaceae Fritillaria Linn
The bulb of [F.verticillata Willd.var.thunbergii (Miq) Bad.].The 5-6 months excavate, and clean soil, size
Separate, big person plucks heart bud, is allocated as 2, in ingot shape, claim BULBUS FRITILLARIAE THUNBERGII, small person claims pearl shellfish.Put respectively in wiping cage, wipe crust,
Plus lime is mixed thoroughly, by a night, lime is penetrated into, dry or dry.Property it is bitter, tremble with fear.Return lung, the heart channel of Hang-Shaoyin.Effect, detoxicating and resolving a mass disappears
Carbuncle.
Radix Codonopsis, is the dry root of samphire Radix changii Changium smyrnioides Wolff.4~May excavates,
Fibrous root is removed, is cleaned, put and boil in boiling water to without the white heart, taken out, scrape off crust, rinsed, dried.It is mild-natured, sweet, micro- acid.Returns spleen,
Lung channel.Effect, nourishes blood and promotes the production of body fluid, strengthening the spleen and tonifying the lung.
Radix rehmanniae recen, is the root tuber of scrophulariaceae rehmannia glutinosa plant.Autumn excavates, except removing LU, fibrous root and silt, by glutinous rehmannia slowly
Bakee to about eighty per cant and do.Property it is sweet, tremble with fear.The thoughts of returning home, liver and kidney channel.Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.
Closo acne is blocked mainly due to pilosebaceous orifices by horn cell, angling thing and sebum fill wherein,
It is not communicated with, so as to what is formed, being mainly in face with the external world, is tiny subcutaneous fat bolt, shows as the hemispherical white of grain of rice size
Parcel, matter is hard, no conscious sympton.The present invention is guidance with the compatibility theory of traditional Chinese medicine monarch, and natural Chinese medicinal herb is processed
Into the Chinese patent drug for the treatment of closo acne, according to each stage parting symptomatic treatment of development acne, the effect of Synergistic is played, made
Obtaining side entirely has clearing heat and detoxicating, promoting blood circulation and removing blood stasis, mass dissipating and swelling eliminating, adjusts endocrine, enhance immunity, strengthens skin metabolism reparation
Effect；It is easy to absorb after taking, it is rapid-action；Without skin damaged after healing, without scar.In addition, present invention saving Chinese medicine, low cost,
It is evident in efficacy, have no toxic side effect, with wide market prospects.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
It will be appreciated that the following example is merely to illustrate the present invention, and it is not construed as limiting the scope of the present invention.
(1) present invention offer is a kind of treats Chinese medicine preparation of closo acne and preparation method thereof, now by detail below
Embodiment is described in detail to the solution of the present invention.
Embodiment 1
Take Radix Astragali 8g, spina gleditsiae 8g, Radix Angelicae Sinensis 8g, safflower 5g, capsule of weeping forsythia 8g, fritillaria thunbergii 3g, Radix Codonopsis 9g, radix rehmanniae recen 9g；First
Secondary addition boils 2h with medicinal material weight than the decocting for 10 times of amounts, and second addition is boiled with medicinal material weight than the decocting for 9 times of amounts
1.5h, filtration merges filtrate twice, and filtrate decompression is condensed into the clear cream that relative density is 1.1, plus ethanol reaches determining alcohol
60%, refrigeration stands 12h, and filtration, filtrate adds suitable starch, carboxymethyl cellulose through drying under reduced pressure into dried cream powder, sieving
Element, mixing, granulation, filling is made hard capsule.
Embodiment 2
Take Radix Astragali 9g, spina gleditsiae 9g, Radix Angelicae Sinensis 9g, safflower 3g, capsule of weeping forsythia 10g, fritillaria thunbergii 5g, Radix Codonopsis 8g, radix rehmanniae recen 8g；First
Secondary addition boils 2h with medicinal material weight than the decocting for 10 times of amounts, and second addition is boiled with medicinal material weight than the decocting for 9 times of amounts
1.5h, filtration merges filtrate twice, and filtrate decompression is condensed into the clear cream that relative density is 1.1, plus ethanol reaches determining alcohol
60%, refrigeration stands 12h, and filtration, filtrate adds suitable magnesium stearate through drying under reduced pressure into dried cream powder, sieving, and lactose is auxiliary
Material, mixing, granulation is made granule.
Embodiment 3
Take Radix Astragali 10g, spina gleditsiae 10g, Radix Angelicae Sinensis 10g, safflower 3g, capsule of weeping forsythia 10g, fritillaria thunbergii 3g, Radix Codonopsis 10g, radix rehmanniae recen
10g；Add for the first time and boils 2h than the decoctings for 10 times of amounts with medicinal material weight, second adds with medicinal material weight than for 9 times are measured
1.5h is boiled in decocting, filtration, merges filtrate twice, and filtrate decompression is condensed into the clear cream that relative density is 1.1, plus ethanol makes determining alcohol
Up to 60%, refrigeration stands 12h, and filtration, filtrate adds suitable proper honey and be made through drying under reduced pressure into dried cream powder, sieving
Honeyed bolus.
Embodiment 4
Take Radix Astragali 10g, spina gleditsiae 10g, Radix Angelicae Sinensis 10g, safflower 3g, capsule of weeping forsythia 10g, fritillaria thunbergii 3g, Radix Codonopsis 10g, radix rehmanniae recen
10g；Add for the first time and boils 2h than the decoctings for 10 times of amounts with medicinal material weight, second adds with medicinal material weight than for 10 times are measured
2h is boiled in decocting, filtration, merges filtrate twice, and filtrate decompression is condensed into the clear cream that relative density is 1.1, plus ethanol reaches determining alcohol
60%, refrigeration stands 12h, and filtration, filtrate adds suitable microcrystalline cellulose, form sediment through drying under reduced pressure into dried cream powder, sieving
Powder, mixing, granulation is tabletted.
Embodiment 5
Take Radix Astragali 10g, spina gleditsiae 10g, Radix Angelicae Sinensis 10g, safflower 3g, capsule of weeping forsythia 8g, fritillaria thunbergii 3g, Radix Codonopsis 10g, radix rehmanniae recen 9g；
Add for the first time and boil 2h than the decocting for 10 times of amounts with medicinal material weight, add for the second time with medicinal material weight than being 10 times of decoctings of amount
2h is boiled, is filtered, merge filtrate twice, filtrate decompression is condensed into the clear cream that relative density is 1.1, plus ethanol reaches determining alcohol
60%, refrigeration stands 12h, and filtration, filtrate adds suitable proper honey and be made honey through drying under reduced pressure into dried cream powder, sieving
Ball.
(2) in order to further verify the curative effect of finished product preparation of the present invention, we will prepare in above-mentioned specific embodiment 3
Pill, has carried out corresponding clinical test, is now reported as follows result.
(2.1) physical data
Selection outpatient service is diagnosed as 152 patients with closo acne and is studied, symptom, the state of an illness according to patient,
It is randomly divided into two groups, respectively control group and treatment group；Wherein, treatment group 81, age 17-35 Sui, average age
(25.59 ± 4.24) year, average course of disease (1.56 ± 0.23) year；Control group 71, age 17-40 Sui, average age (26.78
The aspects such as ± 3.43) year, average course of disease (1.77 ± 0.62) year, two groups of patients, age, the course of disease and coincident with severity degree of condition compare,
No significant difference (P ＞ 0.05), with comparativity.
(2.2) test method
The oral minocycline of control group, uses to specifications.The course for the treatment of 3 months.
The Chinese medicine preparation for the treatment of closo acne prepared by the oral embodiments of the invention 3 for the treatment of group, twice daily, 15 days
1 course for the treatment of.The course for the treatment of 3 months.
(2.3) criterion of therapeutical effect
Recovery from illness：Closo acne symptom all disappears, and skin is without scar and skin damaged, and the colour of skin is normal.
Effectively：Closo acne symptom substantially mitigates, and close to criterion of cure, pockmark is thin out, and the colour of skin is basic in treatment face 70%
Normally, without skin damaged.
It is invalid：Closo symptom is without being clearly better or aggravate.
(2.4) statistical analysis
Statistical analysis is carried out to the data obtained using the softwares of SPSS 13.0, measurement data is represented with (x ± s), compares use
T is checked, and enumeration data uses χ2Inspection, is that difference is statistically significant with P ＜ 0.05.
1 two groups of Clinical efficacy comparisons of table
Note：Compare with after control group treatment, * P ＜ 0.05.
Knowable to the clinical test results of table 1, the cure rate for the treatment of group is 96.3%, and effective percentage is 100%, and control group
Cure rate be 26.8%, effective percentage be 32.3%, treatment group is significantly better than control group, and comparing difference has statistical significance (P
＜ 0.05).
(3) it is random below to take passages medical case notes in the past in order to confirm significant curative effect of the invention：
Case 1
Lee's ××, female, 24 years old, Weinan people from Tongguan County, the first visit of March 4 in 2014, closo acne 10 years, yellow complexion was dark,
Tired, in terror, night dream, alopecia, blood pressure is normal, and winter four limbs are ice-cold；Take the Chinese medicine preparation treatment 1 of the embodiment of the present invention 3
After the course for the treatment of, small pus point is continuously discharged, it is basic to recover after 2 courses for the treatment of, after 3 courses for the treatment of, recovery from illness, skin was without scar and skin damaged, 1 year
Follow-up is without recurrence afterwards.
Case 2
Old ××, female, 30 years old, people from Fuping County, the first visit of April 19 in 2013 was diagnosed as face, lower jaw, rear neck closure
Type acne；After taking 2 courses for the treatment of of Chinese medicine preparation treatment of the embodiment of the present invention 3, recovery from illness, skin without scar and skin damaged, after 1 year
Follow-up is without recurrence.
Case 3
Wu's ××, female, 17 years old, people from Sanyuan County, the first visit on the 9th of August in 2014 was diagnosed as closo acne, takes the present invention
After 1 course for the treatment of of Chinese medicine preparation treatment of embodiment 3, recovery from illness, without scar and skin damaged, follow-up is without recurrence after 1 year for skin.
Case 4
Korea Spro's ××, female, 42 years old, people from Jingyang County, the first visit of October 8 in 2014 was diagnosed as lower jaw part closo acne 3 years,
After taking 2 courses for the treatment of of Chinese medicine preparation treatment of the embodiment of the present invention 3, recovery from illness, without scar and skin damaged, follow-up is without recurrence for skin.
Case 5
King's ××, female, 28 years old, Xi'an people from Baqiao District, the first visit of December 19 in 2013, facial closo acne, color spot, tongue
The lower stasis of blood is stagnant, and yellow complexion is dark, cold limbs, after taking 2 courses for the treatment of of Chinese medicine preparation treatment of the embodiment of the present invention 3, recovery from illness, skin without
Scar and skin damaged, follow-up is without recurrence.
Case 6
Poplar ××, female, 28 years old, Weinan City people, the first visit of July 7 in 2010 was diagnosed as the tiny closo Cuo of shirtfront back
Sore, body is thin, and the colour of skin is dark, after taking 2 courses for the treatment of of Chinese medicine preparation treatment of the embodiment of the present invention 3, hence it is evident that take a turn for the better, and the colour of skin improves, nothing
Skin damaged, follow-up is without recurrence.
By clinical practice and observation, prescription of the present invention is rigorous, and convenient material drawing, cure rate is high, evident in efficacy safe and reliable,
Easily received by many patients.
Although the present invention is described in detail with a general description of the specific embodiments in this specification,
But on the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.
Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed model
Enclose.
Claims (10)
1. a kind of Chinese medicine preparation for treating closo acne, it is characterised in that the raw material components including following weight portion：Radix Astragali 8-
12 parts, spina gleditsiae 8-12 parts, Radix Angelicae Sinensis 8-12 parts, safflower 3-6 parts, capsule of weeping forsythia 6-12 parts, fritillaria thunbergii 2-6 parts, Radix Codonopsis 6-12 parts, the dried rhizome of rehmannia
It is yellow 6-12 parts.
2. it is according to claim 1 treatment closo acne Chinese medicine preparation, it is characterised in that the treatment closo Cuo
The Chinese medicine preparation of sore includes the raw material components of following weight portion：Radix Astragali 8-10 parts, spina gleditsiae 8-10 parts, Radix Angelicae Sinensis 8-10 parts, safflower
3-5 parts, capsule of weeping forsythia 8-10 parts, fritillaria thunbergii 2-4 parts, Radix Codonopsis 8-10 parts, radix rehmanniae recen 8-10 parts.
3. it is according to claim 2 treatment closo acne Chinese medicine preparation, it is characterised in that the treatment closo Cuo
The Chinese medicine preparation of sore includes the raw material components of following weight portion：8 parts of the Radix Astragali, 8 parts of spina gleditsiae, 8 parts of Radix Angelicae Sinensis, 5 parts of safflower, the capsule of weeping forsythia 8
Part, 3 parts of fritillaria thunbergii, 9 parts of Radix Codonopsis, 9 parts of radix rehmanniae recen.
4. it is according to claim 2 treatment closo acne Chinese medicine preparation, it is characterised in that the treatment closo Cuo
The Chinese medicine preparation of sore includes the raw material components of following weight portion：9 parts of the Radix Astragali, 9 parts of spina gleditsiae, 9 parts of Radix Angelicae Sinensis, 3 parts of safflower, the capsule of weeping forsythia 10
Part, 5 parts of fritillaria thunbergii, 8 parts of Radix Codonopsis, 8 parts of radix rehmanniae recen.
5. it is according to claim 2 treatment closo acne Chinese medicine preparation, it is characterised in that the treatment closo Cuo
The Chinese medicine preparation of sore includes the raw material components of following weight portion：10 parts of the Radix Astragali, 10 parts of spina gleditsiae, 10 parts of Radix Angelicae Sinensis, 3 parts of safflower, even
Stick up 10 parts, 3 parts of fritillaria thunbergii, 10 parts of Radix Codonopsis, 10 parts of radix rehmanniae recen.
6. claim 1-5 it is any it is described treatment closo acne Chinese medicine preparation, it is characterised in that the treatment closo Cuo
The Chinese medicine preparation of sore is granule, hard capsule, tablet or pill.
7. described in claim 6 treatment closo acne Chinese medicine preparation preparation method, it is characterised in that including following step
Suddenly：The Radix Astragali, spina gleditsiae, Radix Angelicae Sinensis, safflower, the capsule of weeping forsythia, fritillaria thunbergii, Radix Codonopsis, radix rehmanniae recen are added into medicinal material weight ratio for 9-11 for the first time
The water of amount, decocts 1-3h again, and second addition medicinal material weight than being the 8-10 times of water measured, filter twice by decoction 1-2h, filtration, merging
Liquid, filtrate decompression is condensed into the clear cream that relative density is 1.05-1.15, plus ethanol makes determining alcohol up to 50-70%, and refrigeration stands 6-
18h, filtration, filtrate obtains final product the active component of Chinese medicine, adds auxiliary material, be made of the invention through drying under reduced pressure into dried cream powder, sieving
Treat the Chinese medicine preparation of closo acne.
8. it is according to claim 7 treatment closo acne Chinese medicine preparation preparation method, it is characterised in that including with
Lower step：By the Radix Astragali, spina gleditsiae, Radix Angelicae Sinensis, safflower, the capsule of weeping forsythia, fritillaria thunbergii, Radix Codonopsis, radix rehmanniae recen adds the medicinal material weight ratio to be for the first time
10 times of water of amount, decoct 2h, and second addition medicinal material weight decocts 1.5h than being 9 times of water of amount, and filtration merges filtrate twice,
Filtrate decompression is condensed into the clear cream that relative density is 1.1, plus ethanol makes determining alcohol up to 60%, and refrigeration stands 12h, filtration, filtrate
Through drying under reduced pressure into dried cream powder, sieving obtains final product active ingredient of Chinese herbs, adds auxiliary material, is made treatment closo acne of the invention
Chinese medicine preparation.
9. it is according to claim 8 treatment closo acne Chinese medicine preparation preparation method, it is characterised in that it is described auxiliary
Expect to be honey, the Chinese medicine preparation for being made the treatment closo acne is honeyed bolus.
10. it is according to claim 9 treatment closo acne Chinese medicine preparation preparation method, it is characterised in that it is described
The quality of honey is 1-2 times of the quality of the active ingredient of Chinese herbs.
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|---|---|---|---|
| CN201710182412.5A CN106924517A (en) | 2017-03-24 | 2017-03-24 | A kind of Chinese medicine preparation for treating closo acne and preparation method thereof |
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| CN201710182412.5A CN106924517A (en) | 2017-03-24 | 2017-03-24 | A kind of Chinese medicine preparation for treating closo acne and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403918A (en) * | 2018-05-14 | 2018-08-17 | 中国人民解放军广州军区武汉总医院 | A kind of Chinese medicine preparation and application method for treating acne |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272143A (en) * | 2013-04-25 | 2013-09-04 | 孙胜波 | Traditional Chinese medicine composition for treating acne |
| KR20160001478A (en) * | 2014-06-27 | 2016-01-06 | 동신대학교산학협력단 | Composition for Improving Acne |
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2017
- 2017-03-24 CN CN201710182412.5A patent/CN106924517A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272143A (en) * | 2013-04-25 | 2013-09-04 | 孙胜波 | Traditional Chinese medicine composition for treating acne |
| KR20160001478A (en) * | 2014-06-27 | 2016-01-06 | 동신대학교산학협력단 | Composition for Improving Acne |
Non-Patent Citations (1)
| Title |
|---|
| 霍晓玲: "从"郁"辨治痤疮", 《湖南中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403918A (en) * | 2018-05-14 | 2018-08-17 | 中国人民解放军广州军区武汉总医院 | A kind of Chinese medicine preparation and application method for treating acne |
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