CN110638686A

CN110638686A - Skin care composition with effects of inhibiting color spots and resisting skin photoaging and application thereof

Info

Publication number: CN110638686A
Application number: CN201911048021.XA
Authority: CN
Inventors: 朱良; 黄玉婷
Original assignee: South China University of Technology SCUT
Current assignee: South China University of Technology SCUT
Priority date: 2019-10-30
Filing date: 2019-10-30
Publication date: 2020-01-03
Anticipated expiration: 2039-10-30
Also published as: CN110638686B

Abstract

The invention discloses a skin care composition with the functions of inhibiting color spots and resisting skin photoaging and application thereof. The component composition is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is (1-4) to (3-10) to (5-30). The skin care composition provided by the invention has the characteristics of color spot inhibition, skin photoaging resistance, natural safety and synergistic effect. The ferulic acid, the resveratrol, the phloretin and the vitamin C are matched for use, and are synergized to obtain the composition with the functions of preventing photoaging, inhibiting color spots, repairing and resisting oxidation; the formula of the invention has definite and stable effect, and can ensure the treatment effect and safety of the product.

Description

Skin care composition with effects of inhibiting color spots and resisting skin photoaging and application thereof

Technical Field

The invention belongs to the technical field of cosmetics, and relates to a skin care composition with functions of inhibiting color spots and resisting skin photoaging and application thereof.

Background

With the increasing living standard of people and the increasing pursuit of beauty, people pay more and more attention to skin care. More fashionable beauty-loved people hope to maintain youthful appearance by carefully caring the skin to delay skin aging. Skin aging refers to the aging damage of skin function, which causes the protection ability and the regulation ability of the skin to the body to be reduced, so that the skin can not adapt to the change of internal and external environments, and the overall appearance conditions of the skin, such as color, luster, shape, texture, and the like, are changed. Skin aging is mainly classified into endogenous natural aging and exogenous photoaging. The main reason for the photoaging of facial skin is the exposure to sunlight, which is clinically manifested as yellow-waxed, rough, dry, loose skin, and the deepening of wrinkles and formation of spots. The types of facial stains are usually sunburn, chloasma, senile plaque, freckle, etc. The causes of these stains are various and complicated, and ultraviolet irradiation, genetic factors, endocrine disorders, bad lifestyle habits, and the like are common. The extrinsic factor of the formation of color spots is the same as photo-aging, all due to ultraviolet irradiation. Ultraviolet rays can stimulate skin to generate a large amount of free radicals, which cause peroxidation of cell membranes, generate a large amount of melanin, and gradually form black spots on the face.

Although there are also many skin care products on the market today that repair sun-exposed skin, the effect of defensive resistant skin care products is clearly better. And skin care products containing compositions of purely natural ingredients are favored and relied upon over skin care products having synthetic chemical compositions. Research shows that ferulic acid is one of effective components of Chinese medicinal materials such as resina Ferulae, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, cimicifugae rhizoma, herba Equiseti hiemalis, etc., and the safety of the components is tested clinically for a long time. Resveratrol, phloretin and vitamin C are also derived from natural plants.

Ferulic acid, chemically known as 4-hydroxy-3-methoxyphenylacrylic acid, is a phenolic acid from a variety of plants. Ferulic acid has strong antioxidant activity, and has strong scavenging effect on hydrogen peroxide, superoxide radical, hydroxyl radical, and nitroso peroxide. Ferulic acid has good ultraviolet absorption near 290-330nm, and can protect skin from UVB when added into skin care products. Ferulic acid has strong antioxidant activity, and can scavenge free radicals such as hydrogen peroxide, superoxide free radical, hydroxyl free radical, etc. which can cause skin aging. And ferulic acid can inhibit tyrosinase. Therefore, the ferulic acid is very suitable to be used as an ingredient with the effects of resisting skin photoaging, inhibiting color spots and whitening skin and applied to skin care products.

Resveratrol, with the chemical name of (E) -3,5, 4-trihydroxy stilbene, is a non-flavonoid polyphenol compound, has obvious effects of resisting oxidation and free radicals, and has good effect on preventing and treating oxidative stress related to skin aging. Resveratrol has effects of inhibiting tyrosinase in B16 cell, inhibiting melanin synthesis, whitening skin, and inhibiting mottle.

Phloretin, the chemical name of which is 2,4, 6-trihydroxy-3- (4-hydroxyphenyl) propiophenone, is a naturally occurring plant polyphenol of the dihydrochalcone class. Phloretin is effective in protecting skin from damage caused by free radicals generated by cellular metabolism or ultraviolet rays, and thus phloretin is widely used in the field of skin care products for eliminating skin fine lines, pigmentation and preventing skin damage caused by ultraviolet rays.

Vitamin C, chemical name 2,3,5, 6-tetrahydroxy-2-hexenoic acid-4-lactone, is a hexose acid and is widely present in plant tissues. Vitamin C can promote the generation of skin collagen, neutralize free radicals and reduce the damage of the free radicals to skin, and is widely applied to photoaging treatment at present.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention aims to provide a skin care composition with the effects of inhibiting color spots and resisting skin photoaging and application thereof.

The purpose of the invention is realized by at least one of the following technical solutions.

The invention provides a skin care composition with the effects of inhibiting color spots and resisting skin photoaging, which comprises the following components in parts by weight:

preferably, the skin care composition with the effects of inhibiting color spots and resisting skin photoaging comprises the following components in parts by weight:

further preferably, the skin care composition with the effects of inhibiting color spots and resisting skin photoaging comprises the following components in parts by weight:

the skin care composition with the effects of inhibiting color spots and resisting skin photoaging can be applied to preparing skin care products for inhibiting color spots and resisting skin photoaging.

Furthermore, in the skin care product for inhibiting color spots and resisting skin photoaging, which is prepared from the skin care composition for inhibiting color spots and resisting skin photoaging, the skin care composition for inhibiting color spots and resisting skin photoaging is 0.1-10% by mass.

Preferably, in the skin care product for inhibiting color spots and resisting skin photoaging, which is prepared from the skin care composition for inhibiting color spots and resisting skin photoaging, the skin care composition for inhibiting color spots and resisting skin photoaging is 1-8% by mass.

Preferably, in the skin care product for inhibiting color spots and resisting skin photoaging, which is prepared from the skin care composition for inhibiting color spots and resisting skin photoaging, the skin care composition for inhibiting color spots and resisting skin photoaging is 3-5% by mass.

The skin care product for inhibiting color spots and resisting skin photoaging, which is prepared from the skin care composition with the functions of inhibiting color spots and resisting skin photoaging, is an emulsion cosmetic.

The method for preparing the skin care composition with the effects of inhibiting color spots and resisting skin photoaging, provided by the invention, comprises the following steps: and (3) uniformly mixing the components to obtain the composition.

The skin care composition provided by the invention is applied to emulsion cosmetics with the effects of inhibiting color spots and resisting skin photoaging. The skin care composition with the effects of inhibiting color spots and resisting skin photoaging has the mass percentage of 0.1-10%, preferably 1-8%, most preferably 3-5% in emulsion cosmetics with the effects of inhibiting color spots and resisting skin photoaging, and the balance of common matrix of external cosmetic preparations and deionized water or purified water or distilled water.

According to the invention, through researching the optimal effect ratio of ferulic acid, resveratrol, phloretin and vitamin C, the four components are natural, safe and synergistic, and the skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared. The skin care composition with the functions of inhibiting color spots and resisting skin photoaging, which is researched and developed by the invention, has important significance for delaying skin aging.

Compared with the prior art, the invention has the following advantages and beneficial effects:

the skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared by determining the optimal proportion range of the four raw materials through a large number of experimental screens, and can play a role in treating both symptoms and root causes for the prevention and treatment of skin photoaging by using the natural traditional Chinese medicine components in a compatible manner on the basis of the traditional Chinese medicine theory and clinical practice; the ferulic acid, the resveratrol, the phloretin and the vitamin C are matched for use, and are synergized to obtain the composition with the functions of preventing photoaging, inhibiting color spots, repairing and resisting oxidation; the invention has definite and stable formula effect and can ensure the treatment effect and the safety of the product.

Detailed Description

The following examples are presented to further illustrate the practice of the invention, but the practice and protection of the invention is not limited thereto. It is noted that the processes described below, if not specifically described in detail, are all realizable or understandable by those skilled in the art with reference to the prior art. The reagents or apparatus used are not indicated to the manufacturer, and are considered to be conventional products available by commercial purchase.

Example 1

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 1:2:3: 5. Mixing the above materials, and making into tablet.

Example 2

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 2:1:3: 5. Mixing the above materials, and making into tablet.

Example 3

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 3:2:10: 30. Mixing the above materials, and making into tablet.

Example 4

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 2:3:10: 30. Mixing the above materials, and making into tablet.

Example 5

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 1:4:10: 20. Mixing the above materials, and making into tablet.

Example 6

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 4:1:8: 30. Mixing the above materials, and making into tablet.

Example 7

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 3:2:6: 15. Mixing the above materials, and making into tablet.

Example 8

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 2:3:7: 15. Mixing the above materials, and making into tablet.

Example 9

A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is prepared from the following components in percentage by mass: the mass ratio of the ferulic acid to the resveratrol to the phloretin to the vitamin C is 2.5:2.5:6.5: 15. Mixing the above materials, and making into tablet.

Example 10

The influence of the product (skin care composition with the effects of inhibiting stains and resisting skin photoaging) prepared by the embodiment of the invention on a rat skin photoaging model is researched.

1 materials of the experiment

The skin care composition with the effects of inhibiting color spots and resisting skin photoaging, ferulic acid, resveratrol, phloretin and vitamin C provided by embodiments 1-9 of the invention are prepared into a solution with a mass percentage concentration of 1%, and the solvent is a propylene glycol solution (in the propylene glycol solution, the mass percentage concentration of propylene glycol is 80 wt%); SOD detection kit (Nanjing institute of bioengineering), MDA detection kit (Nanjing institute of bioengineering), GSH-Px detection kit (Nanjing institute of bioengineering), and hydroxyproline detection kit (Nanjing institute of bioengineering).

2 method of experiment

(1) Taking 126 rats, wherein the weight of each rat is 180-220 g; the rats were divided into 21 groups of 6 rats (hermaphrodite halves) each. These 21 groups were designated as blank group, model group, example 1 group, example 2 group, example 3 group, example 4 group, example 5 group, example 6 group, example 7 group, example 8 group, example 9 group, ferulic acid group, resveratrol group, phloretin group, vitamin C group, ferulic acid + resveratrol group, ferulic acid + phloretin group, ferulic acid + vitamin C group, resveratrol + phloretin group, resveratrol + vitamin C group and phloretin + vitamin C group, respectively.

(2) The rat was shaved on the back to form about 2.5X 2.5cm²Size of the bare area. Smearing corresponding medicine on the bare skin of back at a dose of 120 μ l/2 h before ultraviolet irradiation, 1 time per day for 10 weeks; wherein equal amounts of propylene glycol solution are applied to the blank group and the model group, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging provided by the example 1 is applied to the group in the example 1, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging provided by the example 2 is applied to the group in the example 2, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging provided by the example 3 is applied to the group in the example 3, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging provided by the example 4 is applied to the group in the example 4, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging provided by the example 5 is applied to the group in the example 5, and the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging provided by the example 6 is applied to the group in the example 6, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging, provided by the example 7, is applied to the group 7, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging, provided by the example 8, is applied to the group 8, the skin care composition solution with the effects of inhibiting color spots and resisting skin photoaging, provided by the example 9, is applied to the group 9, the ferulic acid group is applied to the ferulic acid group, the resveratrol group is applied to the resveratrol group, the phloretin group is applied to the phloretin solution, the vitamin C group is applied to the vitamin C group, and the ferulic acid and resveratrol group is applied to the ferulic acid groupThe composition is a mixed solution of ferulic acid and resveratrol (the mass fractions of the ferulic acid and the resveratrol are both 1 wt%), a mixed solution of the ferulic acid and phloretin is applied to the ferulic acid + phloretin group (the mass fractions of the ferulic acid and the phloretin are both 1 wt%), a mixed solution of the ferulic acid and the vitamin C is applied to the ferulic acid + vitamin C group (the mass fractions of the ferulic acid and the vitamin C are both 1 wt%), a mixed solution of the resveratrol and the phloretin is applied to the resveratrol + phloretin group (the mass fractions of the resveratrol and the phloretin are both 1 wt%), a mixed solution of the resveratrol and the vitamin C is applied to the resveratrol + vitamin C group (the mass fractions of the resveratrol and the vitamin C are both 1 wt%), and a mixed solution of the phloretin and the vitamin C is applied to the phloretin and the vitamin C group (the mass fractions of the phloretin and the vitamin C are both 1 wt%).

(3) After the medicine is coated, a lamp tube of a light irradiation box is preheated for 15min, the rat is placed on a horizontal plane at the position 20cm away from a light source on the back of the rat after the intensity is stable, the irradiation is carried out for 30s in the first week, 40s in the second week, 50s in the third week and 60s in the fourth week, the irradiation is maintained for 60s from the fifth week to the tenth week, and the irradiation is carried out for 4 times per week. After 2h of final irradiation, the cervical vertebrae were removed and the rats were sacrificed by taking the skin size of the removed area to be 2cm²Planning to detect the content of hydroxyproline; taking the rest depilated back skin about 0.5g, homogenizing, and detecting indexes of SOD, MDA, GSH-Px and hydroxyproline.

3 statistical method

The test data were statistically analyzed using SPSS21.0 statistical software, the statistics are expressed as mean. + -. standard deviation, and the comparisons between groups were analyzed by one-way variance.

4 results

The following table 1 is a data table of the influence of the composition of the invention on the contents of SOD, MDA, GSH-Px and hydroxyproline in rat skin of a photoaging model.

TABLE 1

Note: p <0.05 compared to model group.

The experimental results in table 1 show that compared with the blank group, the rat skin tissue contents of SOD and GSH-Px in the model group are obviously reduced, while the MDA content is obviously increased, which indicates that the skin tissue has stronger oxidative stress reaction and the skin tissue is seriously damaged. The products of examples 1-9 and ferulic acid, resveratrol, phloretin and vitamin C, ferulic acid + resveratrol, ferulic acid + phloretin, ferulic acid + vitamin C, resveratrol + phloretin, resveratrol + vitamin C, phloretin + vitamin C all have certain in vivo antioxidation, wherein examples 1, 2, 7, 8, 9 and the like all have stronger effects and have obvious difference compared with model groups.

In conclusion, the ferulic acid, the resveratrol, the phloretin and the vitamin C are used in a matching way to play a role in resisting skin photoaging, wherein the synergistic effect of the products in the examples 7, 8 and 9 is obvious.

EXAMPLE 11 clinical trial

The clinical observation study of example 9 of the present invention was conducted, and 30 skin problem test volunteers (all 18 informed consent) were included, and the age was ranged from 21 to 49 years, wherein 11 men and 19 women used 5mL of skin care composition solution (example 9) with 3% mass fraction for inhibiting pigmented spots and resisting skin photoaging on the face daily, and the total test time was 30 days. The results of the analysis according to the skin condition are shown in Table 2. Table 2 is a statistical table of the treatment effect of the skin care composition with stain-inhibiting and anti-photoaging effects on skin problems patients provided in example 9.

TABLE 2

From these results, it is understood that the skin care composition solution having the effects of inhibiting color spots and preventing skin photoaging provided in example 9 has an excellent therapeutic effect on color spots on facial skin and skin photoaging. The skin care composition solutions prepared in other examples, which have the effects of inhibiting skin spots and resisting skin photoaging, also have good treatment effects on facial skin spots and skin photoaging, and can be seen in table 2.

The above examples are only preferred embodiments of the present invention, which are intended to be illustrative and not limiting, and those skilled in the art should understand that they can make various changes, substitutions and alterations without departing from the spirit and scope of the invention.

Claims

1. A skin care composition with the effects of inhibiting color spots and resisting skin photoaging is characterized by comprising the following components in parts by weight:

1-4 parts of ferulic acid;

1-4 parts of resveratrol;

3-10 parts of phloretin;

5-30 parts of vitamin C.

2. The skin care composition with the effects of inhibiting stains and resisting skin photoaging as claimed in claim 1, which comprises the following components in parts by weight:

2-3 parts of ferulic acid;

2-3 parts of resveratrol;

5-8 parts of phloretin;

10-20 parts of vitamin C.

3. The skin care composition with the effects of inhibiting stains and resisting skin photoaging as claimed in claim 1, which comprises the following components in parts by weight:

2-3 parts of ferulic acid;

2-3 parts of resveratrol;

6-7 parts of phloretin;

14-16 parts of vitamin C.

4. The use of the skin care composition of claim 1 for inhibiting color spots and resisting skin photoaging in the preparation of a skin care product for inhibiting color spots and resisting skin photoaging.

5. The use of the skin care composition with the effects of inhibiting color spots and resisting skin photoaging in the preparation of skin care products with the effects of inhibiting color spots and resisting skin photoaging as claimed in claim 4, wherein the skin care composition with the effects of inhibiting color spots and resisting skin photoaging is 0.1-10% by mass.

6. The use of the skin care composition with the effects of inhibiting color spots and resisting skin photoaging in the preparation of skin care products with the effects of inhibiting color spots and resisting skin photoaging as claimed in claim 4, wherein the skin care composition with the effects of inhibiting color spots and resisting skin photoaging is 1% -8% by mass.

7. The use of the skin care composition with the effects of inhibiting color spots and resisting skin photoaging in the preparation of skin care products with the effects of inhibiting color spots and resisting skin photoaging as claimed in claim 4, wherein the skin care composition with the effects of inhibiting color spots and resisting skin photoaging is 3% -5% by mass.

8. The use of the skin care composition with the effects of inhibiting color spots and resisting skin photoaging according to claim 4 in the preparation of a skin care product for inhibiting color spots and resisting skin photoaging, wherein the skin care product for inhibiting color spots and resisting skin photoaging is an emulsion type cosmetic.