CN112402307B

CN112402307B - Skin-care fruit oil with effects of fading color spots and delaying skin aging and preparation method and application thereof

Info

Publication number: CN112402307B
Application number: CN202011178326.5A
Authority: CN
Inventors: 童丽; 孔悦; 杨芳; 乌仁塔娜
Original assignee: Qinghai University
Current assignee: Qinghai University
Priority date: 2020-10-29
Filing date: 2020-10-29
Publication date: 2022-02-11
Anticipated expiration: 2040-10-29
Also published as: CN112402307A

Abstract

The invention discloses a skin-care fruit oil with the functions of fading color spots and delaying skin aging, a preparation method and application thereof, wherein the skin-care fruit oil comprises the following components in parts by weight: 0.5-5 parts of cornus macrophylla oil, 1-6 parts of raspberry juice, 1-6 parts of rhodiola rosea extract and 1-10 parts of arbutin, can effectively inhibit the generation of color spots, and has remarkable effect, no side effect and high safety when being applied to skin care products.

Description

Skin-care fruit oil with effects of fading color spots and delaying skin aging and preparation method and application thereof

Technical Field

The invention relates to the field of skin care products, in particular to skin care fruit oil with the effects of fading color spots and delaying skin aging, a preparation method and application thereof.

Background

With the coming of the 5G era, the pace of life of people is faster and faster, and overtime becomes a normal state, which causes irregular living habits, inhibits metabolism, causes endocrine dyscrasia, causes premature aging of skin, deposits color spots and causes facial color spots.

Facial stains are common in chloasma and freckles, and the cause of facial stains is complex and often associated with hyperpigmentation of the underlying skin layer caused by prolonged exposure to sun and radiation and poor lifestyle habits. With the increasing living standard, people pursue beauty more and more strongly, more and more people select skin care products to fade color spots, benefit essence, nourish the face and delay skin aging, the age distribution is wider and wider, and the product market is huge.

The traditional Chinese medicine considers that the facial color spots are related to three organs of liver, spleen and kidney, and the main pathogenesis is that qi and blood can not nourish the face. Skin aging refers to the change of the overall appearance conditions such as skin color, shape, texture and the like caused by the skin function aging damage, which inhibits the defense capability and the regulation capability of the skin to the organism, so that the skin can not adapt to the change of the internal and external environments. Skin aging is mainly divided into endogenous aging and exogenous aging; endogenous aging refers to natural aging of the skin along with the increase of the age, and is clinically manifested by whitening of the skin, fine wrinkles, decreased elasticity, relaxation, dry wrinkles and the like; extrinsic aging refers to photoaging caused by long-term exposure to ultraviolet light, and is clinically manifested by skin yellowing, roughness, dryness, laxity, wrinkle deepening, stain formation, etc.

At present, a plurality of skin care products for fading color spots and delaying skin aging exist in the market, but the color spot fading products have the problems of unobvious effect, easy repeated effect once the products are stopped, easy oxidative denaturation due to the nature of the products, quick response, large dose of effective components needed, easy intolerance to the skin due to the large dose, and the like. For these reasons, it has been shown by investigation that pharmaceutical skin care products are more popular and trusted, and that skin care products made from purely natural ingredients are more durable and safer than skin care products made from synthetic chemicals.

Therefore, the skin care product which has high safety and good speckle fading effect and can delay skin aging has great development value and is always a hotspot of research in the field of skin care products.

Disclosure of Invention

The invention mainly solves the technical problem of providing the skin-care fruit oil which has the effects of fading color spots and delaying skin aging, can effectively inhibit the generation of the color spots and can be used for preparing various types of skin-care products.

In order to solve the technical problems, the invention adopts a technical scheme that:

provides spot-lightening skin care oil which comprises the following components in parts by weight: 0.5-5 parts of cornus macrophylla oil, 1-6 parts of raspberry juice, 1-6 parts of rhodiola rosea extract and 1-10 parts of arbutin.

Cornus walteri oil is approved by the country as a new food raw material in 2013, and fructus Rubi Corchorifolii Immaturus is a rosaceous plant with homology of medicine and food, and both can be used for preparing health products; the rhodiola rosea and the arbutin are common components in skin care products, and the safety of the skin care products is guaranteed.

According to the invention, after the cornus macrophylla oil, the rubus davidiana juice, the rhodiola rosea extract and the arbutin are combined, the effects of fading spots and delaying senescence are superior to those of any single component, and the synergistic effect is fully embodied after the four components are combined.

Further, the composition comprises the following components in parts by weight: 1-2 parts of cornus macrophylla oil, 2-3 parts of raspberry juice, 2-3 parts of rhodiola rosea extract and 2-5 parts of arbutin.

Further, the composition comprises the following components in parts by weight: 2 parts of cornus macrophylla oil, 3 parts of raspberry juice, 2-3 parts of rhodiola rosea extract and 2-3 parts of arbutin.

Further, the composition comprises the following components in parts by weight: 2 parts of cornus macrophylla oil, 3 parts of raspberry juice, 3 parts of rhodiola rosea extract and 2 parts of arbutin.

The invention also provides a preparation method of the spot-fading skin care oil, which comprises the following steps: all the raw materials are mixed according to the weight portion.

The invention also provides application of the spot-fading skin care oil in preparing skin external products.

The invention also provides a skin care product which comprises the speckle-lightening skin care oil.

Furthermore, the mass concentration of the spot-lightening skin care oil in the skin care product is more than or equal to 1 percent.

In the specific embodiment of the invention, the mass concentration of the spot-fading skin care oil in the skin care product is 1%, and the skin care product has a remarkable treatment effect on facial skin spot fading and aging prevention, so that a person skilled in the art can judge that the spot can be effectively faded when the mass concentration of the spot-fading skin care oil in the skin care product is more than or equal to 1%. The specific concentration in the practical application can be adjusted according to the needs, and the skin care product can be prepared by adding the common matrix of the external preparation of the cosmetics and deionized water.

Under the general condition, the effective components of essence in the skin care product are 1-10%, and if the concentration is increased continuously, the effect is not obviously improved, so that waste is caused.

Furthermore, the mass concentration of the spot-fading skin care oil in the skin care product is 3-8%, and preferably 4-6%.

Further, the skin care product is selected from the group consisting of a toner, an emulsion, an essence, a cream, and a mask essence.

The invention has the beneficial effects that:

(1) the skin care fruit oil with the effects of fading color spots and delaying skin aging can effectively inhibit the generation of color spots by combining the cornus macrophylla oil, the raspberry juice, the rhodiola rosea extract and the arbutin, tests prove that the combination of the components has obvious synergistic effect, the inhibition effect after combination is superior to that of the inhibition effect of the independent action of the components, and meanwhile, the safety factor is very high, and the four natural components are safe to use, efficient and durable and have high efficiency.

(2) The skin-care fruit oil with the effects of fading color spots and delaying skin aging is prepared by finally determining the optimal proportion range of the four raw materials through a large number of experimental screens, and is prepared by using the traditional Chinese medicine extracting agent and natural plant components in a compatible manner based on the theory of traditional Chinese medicine and clinical practice, so that the effects of fading color spots and delaying skin aging are achieved, the effects of internal and external regulation and treating both symptoms and root causes are achieved, no toxic or side effect is caused, and the curative effect is relatively stable.

(3) The skin-care fruit oil with the effects of fading color spots and delaying skin aging can be applied to preparing skin-care products in various formulations, has obvious and lasting effect, can ensure the effectiveness and safety of the products, has important significance for the development of products for fading color spots and delaying skin aging, and has wide market prospect.

Detailed Description

The technical solutions of the present invention are described clearly and completely below, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. It is noted that the processes described below, if not specifically described in detail, are all realizable or understandable by those skilled in the art with reference to the prior art. The reagents or apparatus used are not indicated to the manufacturer, and are considered to be conventional products available by commercial purchase.

In the specific embodiment of the invention, the rhodiola rosea extract (the product specification: 1 Kg/bag, wherein salidroside is 1% -98%) and the rubus davidianus juice (the rubus davidianus fruit is cleaned, crushed and pulped, and the pomace is removed by filtering, thus obtaining the rubus davidianus juice).

Example 1

A skin care fruit oil with effects of fading color spots and delaying skin photoaging is prepared from the following components in parts by mass, namely cornus macrophylla oil, rubus davidiana juice, rhodiola rosea extract and arbutin in a mass ratio of 1:2:3: 4. Mixing the above materials, and making into tablet.

Example 2

A skin care fruit oil with effects of fading color spots and delaying skin photoaging is prepared from the following components in parts by mass, namely cornus macrophylla oil, rubus davidiana juice, rhodiola rosea extract and arbutin in a mass ratio of 1:2:2: 5. Mixing the above materials, and making into tablet.

Example 3

A skin care fruit oil with the effects of fading color spots and delaying skin photoaging is prepared from the following components in parts by mass: the mass ratio of the cornus macrophylla oil to the raspberry juice to the rhodiola rosea extract to the arbutin is 2:2:2: 2. Mixing the above materials, and making into tablet.

Example 4

A skin care fruit oil with the effects of fading color spots and delaying skin photoaging is prepared from the following components in parts by mass: the mass ratio of the cornus macrophylla oil to the raspberry juice to the rhodiola rosea extract to the arbutin is 2:3:2: 2. Mixing the above materials, and making into tablet.

Example 5

A skin care fruit oil with the effects of fading color spots and delaying skin photoaging is prepared from the following components in parts by mass: the mass ratio of the cornus macrophylla oil to the raspberry juice to the rhodiola rosea extract to the arbutin is 2:3:2: 3. Mixing the above materials, and making into tablet.

Example 6

A skin care fruit oil with the effects of fading color spots and delaying skin photoaging is prepared from the following components in parts by mass: the mass ratio of the cornus macrophylla oil to the raspberry juice to the rhodiola rosea extract to the arbutin is 2:3:3: 2. Mixing the above materials, and making into tablet.

The influence of the skin-care fruit oil on a rat skin photoaging model is researched through test examples, and the spot-fading effect and the synergistic interaction of the components of the skin-care fruit oil are verified:

test example 1

1. Experimental Material

The skin care fruit oil, the cornus macrophylla oil, the raspberry juice, the rhodiola rosea extract and the arbutin prepared in the embodiments 1-6 are respectively prepared into solutions with the mass percentage concentration of 1% for later use, and the solvent is a propylene glycol aqueous solution (in the propylene glycol solution, the mass percentage concentration of the propylene glycol is 80 wt%);

MDA detection kit, SOD detection kit (Nanjing institute of bioengineering), T-AOC detection kit, and hydroxyproline detection kit.

2. Experimental methods

(1) Taking 120 rats, wherein the weight of each rat is 160-200 g; the rats were divided into 12 groups of 10 rats each (hermaphrodite half). These 12 groups were designated as blank group, model group, example 1 group, example 2 group, example 3 group, example 4 group, example 5 group, example 6 group, cornus oil group, raspberry juice group, rhodiola rosea extract group, arbutin group, respectively.

(2) The backs of the rats were shaved to form an exposed area of about 2.0cm x 2.0 cm. 2h before ultraviolet irradiation, smearing corresponding medicine on the bare skin of the back according to 2 mL/time, 1 time per day, for 10 weeks in total; the blank group and the model group are coated with equal amount of propylene glycol solution, the group of example 1 is coated with the solution of the skin care fruit oil prepared in example 1, the group of example 2 is coated with the solution of the skin care fruit oil prepared in example 2, the group of example 3 is coated with the solution of the skin care fruit oil prepared in example 3, the group of example 4 is coated with the solution of the skin care fruit oil prepared in example 4, the group of example 5 is coated with the solution of the skin care fruit oil prepared in example 5, the group of example 6 is coated with the solution of the skin care fruit oil prepared in example 6, the group of cornus macrophylla is coated with the solution of cornus macrophylla oil, the group of raspberry juice is coated with the solution of raspberry juice, the group of rhodiola rosea extract is coated with the solution of rhodiola rosea, and the group of arbutin is coated with the solution of arbutin.

(3) After the medicine is coated, a lamp tube of a light irradiation box is preheated for 30min, the rat is placed on a horizontal plane at a position 30cm away from a light source at the exposed position of the back of the rat after the intensity is stable, the irradiation is carried out for 20s in the first week, 30s in the second week, 40s in the third week, 50s in the fourth week, 60s in the fifth week, 60s in the sixth week to the tenth week, and 4 times per week. After 2h of final irradiation, the rat is killed by removing the cervical vertebra, the skin size of the unhairing part is 2.0cm x 2.0cm, and the detection of hydroxyproline content is planned; taking about 1g of depilated back skin, homogenizing, and detecting the contents of MDA, SOD, T-AOC and hydroxyproline.

3 statistical method

The test data is statistically analyzed by SPSS21.0 statistical software

Shown, comparisons between groups were analyzed by one-way anova.

4 results

The following table 1 is a data table for detecting the contents of MDA, SOD, T-AOC and Hyp in the skin of a rat with a photoaging model of fruit oil.

TABLE 1 MDA, SOD, T-AOC and Hyp content in rat skin of each group

The experimental results in table 1 show that compared with the blank group, the rat skin tissue SOD and T-AOC content of the model group is obviously reduced, while the MDA content is obviously increased, which indicates that the skin tissue has stronger oxidative stress reaction and the skin tissue is seriously damaged. The products of the groups 1 to 6, the cornus oil group, the rubus davidianus juice group, the rhodiola rosea extract and the arbutin group have certain in vivo oxidation prevention effect, the test effect of each group is judged by the mean value of the percentage change of the four indexes of each group, and the percentage mean values of the products of the groups 1 to 6 are 31.2%, 36.8%, 36.2%, 42.5%, 52.6% and 57.6%, respectively, so that the products of the groups 4, 5 and 6 have stronger effects and have obvious difference compared with the model group, particularly the product synergistic effect of the products of the groups 5 and 6 is obvious.

Test example 2 clinical test

Clinical observation and study are carried out on the skin-care fruit oil disclosed by the invention, taking the skin-care fruit oil in example 6 as an example, 20 skin problem test volunteers (all informed consent) are included, the age is distributed between 20 and 50 years, 7 male patients and 13 female patients use 4mL of 1% by mass of skin-care fruit oil solution (example 6) (the solvent is the same as the propylene glycol aqueous solution in the test example 1) with the effects of fading stains and delaying skin aging on the face of each person every day, and the total test time is 4 weeks. The results of the analysis according to the skin condition are shown in Table 2. Table 2 is a statistical table of the treatment effect data of the skin care mask with the effects of lightening color spots and delaying skin aging on patients with skin problems, provided in example 6.

TABLE 2

From these results, it can be seen that the skin care mask solution having the effects of lightening color spots and delaying skin photoaging, provided in example 6, has a significant therapeutic effect on lightening color spots and preventing aging of facial skin, and also has the effects of moisturizing and brightening skin.

Clinical tests on skin care mask solutions prepared from the fruit oils of other examples show that the skin care mask solutions all have treatment effects on facial skin stains and skin aging, but the effects are not significant in example 6, and can be seen in table 1.

In conclusion, the skin care fruit oil disclosed by the invention has a synergistic effect after the components are combined, has an obvious freckle removing effect on various freckles and dark skin, has no toxic or side effect and high safety and can obviously improve the skin quality.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The spot-lightening skin care oil is characterized by comprising the following components in parts by weight: 0.5-5 parts of cornus macrophylla oil, 1-6 parts of raspberry juice, 1-6 parts of rhodiola rosea extract and 1-10 parts of arbutin.

2. The spot-lightening skin care oil according to claim 1, which comprises the following components in parts by weight: 1-2 parts of cornus macrophylla oil, 2-3 parts of raspberry juice, 2-3 parts of rhodiola rosea extract and 2-5 parts of arbutin.

3. The spot-lightening skin care oil according to claim 1, which comprises the following components in parts by weight: 2 parts of cornus macrophylla oil, 3 parts of raspberry juice, 2-3 parts of rhodiola rosea extract and 2-3 parts of arbutin.

4. The spot-lightening skin care oil according to claim 1, which comprises the following components in parts by weight: 2 parts of cornus macrophylla oil, 3 parts of raspberry juice, 3 parts of rhodiola rosea extract and 2 parts of arbutin.

5. A method for preparing the spot-lightening skin care oil as claimed in any one of claims 1 to 4, which is characterized by comprising the following steps: all the raw materials are mixed according to the weight portion.

6. Use of the spot-lightening skin care oil according to any one of claims 1 to 4 for the preparation of a skin external product.

7. A skin care product comprising the spot-lightening skin care oil according to any one of claims 1 to 4.

8. The skin care product of claim 7, wherein the mass concentration of the spot-lightening skin care oil in the skin care product is not less than 1%.

9. The skin care product according to claim 8, wherein the mass concentration of the spot-lightening skin care oil in the skin care product is 1-10%.

10. The skin care product according to claim 8, wherein the mass concentration of the spot-lightening skin care oil in the skin care product is 3-8%.

11. The skin care product according to claim 10, wherein the mass concentration of the spot-lightening skin care oil in the skin care product is 4-6%.

12. The skin care product according to any one of claims 7 to 11, wherein the skin care product is selected from the group consisting of a toner, an emulsion, an essence, a cream, and a mask essence.