CN109925248A - A kind of skin care compositions containing phloretin, the anti-skin photoage effect of arasaponin - Google Patents
A kind of skin care compositions containing phloretin, the anti-skin photoage effect of arasaponin Download PDFInfo
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- CN109925248A CN109925248A CN201910348254.5A CN201910348254A CN109925248A CN 109925248 A CN109925248 A CN 109925248A CN 201910348254 A CN201910348254 A CN 201910348254A CN 109925248 A CN109925248 A CN 109925248A
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- Prior art keywords
- skin
- photoage
- arasaponin
- phloretin
- skin photoage
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- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 title claims abstract description 75
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 title claims abstract description 37
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 230000000694 effects Effects 0.000 title claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 239000000344 soap Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 49
- 239000003814 drug Substances 0.000 description 16
- 230000032683 aging Effects 0.000 description 14
- 229940079593 drug Drugs 0.000 description 10
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 7
- 239000003963 antioxidant agent Substances 0.000 description 7
- 235000006708 antioxidants Nutrition 0.000 description 7
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 7
- 229960002591 hydroxyproline Drugs 0.000 description 7
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
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- 230000003679 aging effect Effects 0.000 description 4
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- 230000002265 prevention Effects 0.000 description 4
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- 230000005855 radiation Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000003143 Panax notoginseng Nutrition 0.000 description 3
- 241000180649 Panax notoginseng Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 235000017709 saponins Nutrition 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 230000036559 skin health Effects 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
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- 239000000126 substance Substances 0.000 description 2
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- NNWKGXBQNBUTTJ-UHFFFAOYSA-N 2-hydroxy-1-phenyl-3-(4,4,6-trihydroxycyclohexa-1,5-dien-1-yl)propan-1-one Chemical compound OC(C(=O)C1=CC=CC=C1)CC1=CCC(C=C1O)(O)O NNWKGXBQNBUTTJ-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 244000141359 Malus pumila Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
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- 238000003915 air pollution Methods 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008344 brain blood flow Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
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- 230000002950 deficient Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 description 1
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
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- 235000013336 milk Nutrition 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 235000011649 selenium Nutrition 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000003911 water pollution Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of skin care compositions acted on containing phloretin, the anti-skin photoage of arasaponin, the composition is prepared by following components counted in mass ratio: the mass ratio of phloretin and arasaponin is (1-3): (1-3).Traditional Chinese medicinal components composition of the invention has the characteristics that anti-skin photoage, natural safety, synergy.
Description
Technical field
The invention belongs to medical cosmetic fields, and in particular to be a kind of to contain phloretin, the anti-skin of arasaponin
The skin care compositions of light aging effect.
Background technique
As modern industrial society develops, environmental pollution has become the major issue for needing to face in for people's lives.In addition to
The problems such as air pollution, water pollution, along with the destruction of atmospheric ozone layer, using ultraviolet radiation increase as the light pollution of representative
One of the health problem faced is needed as people.
For light pollution, skin health is influenced first.Skin is first of protective barrier of body, for resisting the external world
Infringement maintains interior ambient stable to play an important role, meanwhile, skin is also the maximum organ that is affected by the external environment, ultraviolet
The factors such as line, extraneous chemicals, wind have an impact to its health status, and ultraviolet light is to influence maximum factor.In daylight
Ultraviolet light be broadly divided into tri- parts UVA, UVB, UVC, the big portion UVC is radiated by ozone layer and atmosphere and scattering, UVA can be straight
The deeper skin corium that penetrates to the skin is connect, destroys elastomer and collagenous fibres, prolonged accumulation will cause skin damage, special
Be not deepens skin aging relaxation, wrinkle, follow the string, ?pigementation etc., UVB rank can be higher, for a long time or excessive exposure
Skin can be made erythema, inflammation, aging occur, therefore excessive ultraviolet light will cause skin and the problems such as light aging, light injury occurs, if
It prevents and treats not in time, meeting damaging cells DNA activates proto-oncogene, causes skin neoplasin.Therefore, light problem of aging has become threat
One of the greatest problem of skin health and the hot spot of skin health product research.
Currently, the measure that skin photoage prevents and treats mainly has: before generation, skin and ultraviolet light etc. being avoided to endanger as far as possible
Dangerous factor contact；When early period of origination, a variety of antioxidants can be selected and prevented；After generation, corresponding part or complete may be selected
Body drug is treated.Antioxidant mainly includes vitamin C, vitamin E, beta carotene, zinc and selenium etc., and some plants
Antioxidant, as rutin, resveratrol, green-tea extract also have preferable anti-light aging effect.Light aging is treated, office
The non-steroidal drugs such as aspirin can be used in portion, delay or mitigate inflammation caused by erythemal effect and treatment light injury.α-hydroxyl
The organic acids such as base acid, trichloroacetic acid, salicylic acid have reduction cuticula and epidermal thickness, increase skin corium collagen thickness, reduce
Wrinkle and keratinocyte quantity and the effect for improving dermatoglyph, can treat skin photoage and melanin is extremely calm.These
Drug is although play preferable preventive and therapeutic effect to light aging, and there is also more limitations, such as: antioxidant can play suppression
Oxygenerating stress, but the mitigation of inflammatory reaction is acted on unobvious；And then there is peptic ulcer, disappear in non-steroidal drug
Change bad Deng side effects；Organic acid, which then exists, is used for a long time easy skin ambustion, and the problems such as allergic reaction easily occurs in skin.Therefore,
It finds adverse reaction and side effect is less, can be anti-oxidant but also anti-inflammatory, the drug of skin repair is additionally aided, is anti-light aging
The target of drug research, and unification studies drug dispensing object and is then difficult to take into account above-mentioned function, can from traditional Chinese medicine whole prevention with
The angle for the treatment of develops new anti-light aging drug, is the problem of this field researcher explores always in recent years.
Traditional medicine thinks that skin photoage is to be not enough to moisten flesh since internal organs are deficient, insufficiency of vital energy and blood, body fluid lose
Skin and phlegm-turbidity and blood stasis hinder skin, again caused by photosensitive poison.According to the above-mentioned interpretation of the cause, onset and process of an illness, Chinese medicine mostly uses the therapies such as clearing heat and detoxicating, activating microcirculation and removing stasis medicinal
It is treated.The present invention is according to the above-mentioned interpretation of the cause, onset and process of an illness and therapy, and on the basis of previous experiments, phloretin, arasaponin are formed
" tcm components ", prescription compatible use play clearing heat and detoxicating, qi and activate blood circulation, stagnation resolvation effect, play treating both manifestation and root cause of disease to light aging and make
With.
Phloretin (Phloretin) belongs to the plant polyphenol of dihydrochalcone-type, because it focuses mostly in the root skin of apple tree
Partially gain the name, chemistry entitled 2,4,6- trihydroxy -3- (4- hydroxy phenyl) propiophenone, molecular formula C15H14O5, molecular weight
It is 274.27, sterling is light red, is soluble in methanol, ethyl alcohol and acetone, dissolves in aqueous slkali, is practically insoluble in water.Research hair
Existing, phloretin has anti-oxidant, antitumor, anti-inflammatory, immunosupress, a variety of drug actions of prevention and cure of cardiovascular disease, outside skin
With aspect, phloretin have anti-aging, skin whitening, it is anti-inflammatory, dispel acne and other effects.
Arasaponin (total saponins ofPanax notoginseng, PNS) is mainly having for Chinese medicine Radix Notoginseng
Ingredient is imitated, contains a variety of saponin components, wherein with ginsenoside Rb1, ginsenoside Rg1, Panax Notoginseng saponin R1Content highest.It grinds
Study carefully and show that arasaponin has inhibition platelet aggregation, pre- preventing thrombosis, increases heart and brain blood flow, protection cardiac muscle, improves micro- follow
The effect of ring also has the effects that anti-inflammatory, analgesia, anti-oxidant, anti-radiation and anti-aging.Arasaponin external application, have whitening,
The effects of nti-freckle, anti-light aging.
At this stage, has more report for the effect of arasaponin anti-light aging, studies have shown that arasaponin also has
More significant anti-skin photoage effect.Although above-mentioned phloretin, arasaponin have found to skin photoage have it is certain
Preventive and therapeutic action, but be not widely applied yet clinically, this is generally related with its therapeutic effect.Related component can be adopted
Prescription is carried out with traditional medical theory, plays its wholistic therapy, treating both manifestation and root cause of disease, highly-safe advantage, this is to prevent and controlling
It treats in skin photoage, Chinese medicine especially Chinese medicinal formulae can play the role of outstanding.But during this, how prescription,
The effect of single ingredient how is played, how to determine the proportionate relationship between component, this is to need to screen by many experiments
With it is determining.
Summary of the invention
The purpose of the present invention is overcome the deficiencies of the prior art and provide one kind to contain phloretin, the anti-skin of arasaponin
The skin care compositions of light aging effect and application.
In order to achieve the above-mentioned object of the invention, technical scheme is as follows:
A kind of skin care compositions containing phloretin, the anti-skin photoage effect of arasaponin, the composition is by following
The component counted in mass ratio is prepared: the mass ratio of phloretin and arasaponin is (1-3): (1-3).
The method provided by the invention for preparing the composition includes the following steps: to mix aforementioned each component, obtains institute
State composition.
The present invention also provides a kind of anti-skin photoage product, effective component is aforementioned combination provided by the invention
Object.
A kind of skin care compositions containing phloretin, the anti-skin photoage effect of arasaponin is old in anti-skin light
Changing the mass percentage in skin care item is 0.1-10%, and preferred mass percentage composition is 1-8%, remaining is cosmetics external preparation
The common matrix and deionized water or purified water or distilled water of type.By common process, it can be made into anti-skin photoage and wash one's face
Milk, anti-skin photoage Cleansing Foam, anti-skin photoage are washed one's face frost, anti-skin photoage cream, anti-skin photoage frost, anti-skin
Light ageing emulsion, anti-skin photoage water, anti-skin photoage facial mask, anti-skin photoage gel or anti-skin photoage soap.
The present invention is on the basis of being recognized based on traditional medicine the skin photoage interpretation of the cause, onset and process of an illness and therapy, in conjunction with modern study skill
Art and means find phloretin, arasaponin composition " tcm components ", can play clear by many experiments preferably with verifying
Thermal detoxification, qi and activate blood circulation, stagnation resolvation effect, play apparent anti-skin photoage skin care effect.Formula preferred for this invention, passes through
Domestic and foreign literature retrieval, does not find related application, is screened in addition by many experiments, and gained formula rate is optimum formula ratio
Example, formula science, and it is highly-safe, it can be used for the prevention and treatment of skin photoage.
The invention has the following advantages that
(1) it screens through a large number of experiments, it is determined that the optimal proportion range of raw material, it is ensured that the effect that product of the present invention uses
Fruit；
(2) in tcm theory and on the basis of clinical practice, by by traditional Chinese medicinal components compatible use, to skin photoage
Prevention and treatment play the role for the treatment of both manifestation and root cause of disease；
(3) inventive formulation definite effect and stabilization, it is ensured that the therapeutic effect and safety of product.
Specific embodiment
Technical solution of the invention is further illustrated combined with specific embodiments below, these embodiments should not be understood as
It is the limitation to technical solution.
Embodiment 1
A kind of skin care compositions containing the anti-skin photoage effect of phloretin, arasaponin, the components composition by
Following components counted in mass ratio are prepared: the mass ratio of phloretin and arasaponin is 1:1.Each component is mixed, i.e.,
?.
Embodiment 2
A kind of skin care compositions containing the anti-skin photoage effect of phloretin, arasaponin, the components composition by
Following components counted in mass ratio are prepared: the mass ratio of phloretin and arasaponin is 2:1.Each component is mixed, i.e.,
?.
Embodiment 3
A kind of skin care compositions containing the anti-skin photoage effect of phloretin, arasaponin, the components composition by
Following components counted in mass ratio are prepared: the mass ratio of phloretin and arasaponin is 3:1.Each component is mixed, i.e.,
?.
Embodiment 4
A kind of skin care compositions containing the anti-skin photoage effect of phloretin, arasaponin, the components composition by
Following components counted in mass ratio are prepared: the mass ratio of phloretin and arasaponin is 1:2.Each component is mixed, i.e.,
?.
Embodiment 5
A kind of skin care compositions containing the anti-skin photoage effect of phloretin, arasaponin, the components composition by
Following components counted in mass ratio are prepared: the mass ratio of phloretin and arasaponin is 1:3.Each component is mixed, i.e.,
?.
Embodiment 6
A kind of skin care compositions containing the anti-skin photoage effect of phloretin, arasaponin, the components composition by
Following components counted in mass ratio are prepared: the mass ratio of phloretin and arasaponin is 3:2.Each component is mixed, i.e.,
?.
Embodiment 7
Influence of the product of the embodiment of the present invention to Mice Photoaging model
1 experimental material
1-6 of embodiment of the present invention composition and phloretin, arasaponin, are configured to the solution of 1% mass concentration；
SOD, MDA, GSH-Px, hydroxyproline kit (Bioengineering Research Institute is built up in Nanjing).
2 experimental methods
Back of mice shaving forms it into the exposed region of about 2.5 × 2.5cm2 size.It is put into self-control irradiation case (installation
UVA and UVB fluorescent tube, UVA and UVB dose of radiation are than being about 9.3:0.7) in, on the horizontal plane at light source 20cm.Fluorescent tube is pre-
Hot 15min starts to irradiate after intensity stabilization, and the irradiation of mouse same position is irradiated (15s-120s) in short-term, and with ultraviolet
Radiometer records corresponding dose of radiation, observes irradiated site after irradiation for 24 hours, corresponds to agent to generate the irradiation time of light red spot first
Amount is used as MED, and irradiation time can be used as the Con trolling index of exposure dose.After the mouse skin of MED prerun restores 7 days, start
Formal test.It is within exposure intensity first week 1MED, second week, which rises, increases weekly 1MED to 4th week, later ten weeks the 5th Zhou Zhi
Maintain 4MED weekly.It irradiates 4 times weekly, reaches UVA the and UVB total radiation dose of document record.Each group mouse is shone in ultraviolet light
Preceding 2h is penetrated, only corresponding drug or blank propylene glycol solution is smeared on the baring skin of back by 120 μ l/, 1 time a day, amounts to
10 weeks.After last irradiates 2h, cervical dislocation puts to death mouse, takes depilation area skin about 1cm2, the detection of work done in the manner of a certain author hydroxyproline content；It takes
Remaining depilation skin of back 0.1g or so, after homogenate, the indexs such as detection SOD, MDA, GSH-Px.
3 statistical methods
Test data is for statistical analysis using SPSS21.0 statistical software, statistic means standard deviation (x ± s) table
Show, comparison among groups one-way analysis of variance.
4 results
Shadow of 1 present composition of table to SOD, MDA, GSH-Px, hydroxyproline content in light Ageing Model mouse skin
It rings (x ± s, n=10)
Note: compared with model group, P < 0.01 * P < 0.05, * *.
Table 1 the experimental results showed that, compared with normal group, light Ageing Model mice skin tissue SOD, GSH-Px content is obvious
Reduce, and MDA content is then significantly raised, illustrate that stronger response to oxidative stress occurs in skin histology, dermal tissue insult compared with
Seriously.The antioxidation of embodiment 1-6 product and phloretin, arasaponin is obvious, each group mice skin tissue SOD,
GSH-Px content is significantly raised, and MDA content is then substantially reduced, compared with model group, have extremely significant sex differernce (P < 0.05 or
0.01).Hydroxyproline is intradermal rich content and more stable amino acid, its content can directly reflect intradermal
The changes of contents of collagenous fibres, and collagenous fibres (main chemical compositions are collagen) are the important components in dermis of skin,
Their content decline, will lead to cutis laxa and elasticity reduces, and forms wrinkle.Therefore, the variation of hydroxyproline content can be said
The degree of bright skin aging.Table 1 the result shows that, light Ageing Model mice skin tissue hydroxyproline content significantly reduce, explanation
Skin aging degree is higher, and embodiment 1-6 product and phloretin, arasaponin each group mice skin tissue hydroxyproline contain
Although amount is improved in various degree to restore to normal mouse level, compared with model group, there is extremely significant sex differernce
(P<0.01).1 result of table is also shown that 6 product of embodiment (phloretin: arasaponin=3:2) in all embodiment products
Effect it is optimal, anti-light aging effect be better than other embodiments product.
In conclusion phloretin, arasaponin are used cooperatively, anti-skin photoage can be played the role of, wherein You Yishi
It is obvious to apply 6 product synergistic effect of example.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (4)
1. a kind of skin care compositions containing phloretin, the anti-skin photoage effect of arasaponin, the composition are pressed by following
The component of mass ratio meter is prepared: the mass ratio of phloretin and arasaponin is (1-3): (1-3).
2. application according to claim 1, it is characterised in that: described old containing phloretin, the anti-skin light of arasaponin
Mass percentage of the skin care compositions of change effect in anti-skin photoage skin care item is 0.1-10%.
3. application according to claim 2, it is characterised in that: described old containing phloretin, the anti-skin light of arasaponin
Mass percentage of the skin care compositions of change effect in anti-skin photoage skin care item is 1-8%.
4. application according to claim 2, it is characterised in that: the anti-skin photoage skin care item are anti-skin photoage
Facial cleanser, anti-skin photoage Cleansing Foam, anti-skin photoage are washed one's face frost, anti-skin photoage cream, anti-skin photoage frost, anti-
Skin photoage lotion, anti-skin photoage water, anti-skin photoage facial mask, anti-skin photoage gel or anti-skin photoage
Soap.
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| CN110638686A (en) * | 2019-10-30 | 2020-01-03 | 华南理工大学 | Skin care composition with effects of inhibiting color spots and resisting skin photoaging and application thereof |
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