CN110637036A - 具有针对可溶性蛋白质的亲和性物质、切割性部分及反应性基团的化合物或其盐 - Google Patents

具有针对可溶性蛋白质的亲和性物质、切割性部分及反应性基团的化合物或其盐 Download PDF

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Publication number
CN110637036A
CN110637036A CN201880027775.4A CN201880027775A CN110637036A CN 110637036 A CN110637036 A CN 110637036A CN 201880027775 A CN201880027775 A CN 201880027775A CN 110637036 A CN110637036 A CN 110637036A
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China
Prior art keywords
soluble protein
residue
group
formula
residues
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Pending
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CN201880027775.4A
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English (en)
Chinese (zh)
Inventor
山田慧
松田丰
藤井友博
敷田奈都纪
汤地玲子
新保和高
伊东祐二
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of CN110637036A publication Critical patent/CN110637036A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880027775.4A 2017-04-28 2018-04-27 具有针对可溶性蛋白质的亲和性物质、切割性部分及反应性基团的化合物或其盐 Pending CN110637036A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017090679 2017-04-28
JP2017-090679 2017-04-28
PCT/JP2018/017345 WO2018199337A1 (ja) 2017-04-28 2018-04-27 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩

Publications (1)

Publication Number Publication Date
CN110637036A true CN110637036A (zh) 2019-12-31

Family

ID=63918939

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CN201880027775.4A Pending CN110637036A (zh) 2017-04-28 2018-04-27 具有针对可溶性蛋白质的亲和性物质、切割性部分及反应性基团的化合物或其盐

Country Status (8)

Country Link
US (2) US12024549B2 (enExample)
EP (2) EP4603507A3 (enExample)
JP (4) JP7222347B2 (enExample)
KR (3) KR20240046307A (enExample)
CN (1) CN110637036A (enExample)
AU (2) AU2018259856B2 (enExample)
CA (1) CA3061467A1 (enExample)
WO (1) WO2018199337A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112262152A (zh) * 2018-06-14 2021-01-22 味之素株式会社 具有针对抗体的亲和性物质、切割性部分及反应性基团的化合物或其盐
CN112261954A (zh) * 2018-06-14 2021-01-22 味之素株式会社 具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐
WO2023179723A1 (zh) * 2022-03-25 2023-09-28 中国科学院上海药物研究所 亲和片段导向的可裂解片段，其设计、合成及在制备定点药物偶联物中的应用

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7291395B2 (ja) * 2017-06-16 2023-06-15 国立大学法人 鹿児島大学 ＩｇＧ結合ペプチド、及び該ペプチドによる抗体の特異的修飾
JPWO2020090979A1 (ja) * 2018-10-31 2021-09-24 味の素株式会社 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
CN113631539B (zh) * 2019-01-23 2025-08-15 阿比蒂斯有限公司 用于制备抗体-载荷部分偶联物的化合物及其用途
WO2020184944A1 (ko) * 2019-03-08 2020-09-17 앱티스 주식회사 위치특이적 항체 콘쥬게이션 및 이의 구체예로서의 항체-약물 콘쥬게이트
CA3155284A1 (en) 2019-10-24 2021-04-29 Yuji Ito Method for producing monovalent ccap product
AU2020388383A1 (en) * 2019-11-18 2022-03-31 Kleo Pharmaceuticals, Inc. Directed conjugation technologies
US20230046947A1 (en) * 2019-12-03 2023-02-16 Debiopharm Research & Manufacturing S.A. Reactive conjugates
WO2022078566A1 (en) * 2020-10-12 2022-04-21 Debiopharm Research & Manufacturing S.A. Reactive conjugates
CA3208290A1 (en) 2021-01-18 2022-07-21 Ajinomoto Co., Inc. Compound or salt thereof, and antibody obtained by using the same
CN116829573A (zh) * 2021-01-18 2023-09-29 味之素株式会社 化合物或其盐、及由它们得到的抗体
WO2022191283A1 (ja) 2021-03-11 2022-09-15 味の素株式会社 化合物またはその塩、およびそれらにより得られる抗体
JPWO2022196675A1 (enExample) 2021-03-16 2022-09-22
CN113292633B (zh) * 2021-05-13 2023-08-29 中国科学技术大学 可见光诱导甘氨酸衍生物的肼化修饰方法
KR20240012380A (ko) * 2021-05-17 2024-01-29 바이오하벤 테라퓨틱스 리미티드 지향 접합 기술용 제제 및 접합 생성물
JP2024521092A (ja) * 2021-05-19 2024-05-28 バイオヘイブン・セラピューティクス・リミテッド 細胞傷害性薬剤を送達するためのｍａｔｅｓ技術を使用する抗体薬物コンジュゲート
EP4349373A1 (en) 2021-06-01 2024-04-10 Ajinomoto Co., Inc. Conjugate of antibody and functional substance or salt of said conjugate, and compound for use in production of said conjugate or salt of said compound
CA3224147A1 (en) 2021-07-09 2023-01-12 Vijaya Raghavan PATTABIRAMAN Antibody conjugates and manufacture thereof
WO2023281479A1 (en) 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Checkpoint inhibitors conjugated to il-2, and uses thereof
WO2023281483A1 (en) 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Modified tnf-antibodies and uses thereof
US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
JP2024529297A (ja) 2021-07-09 2024-08-06 ブライト ピーク セラピューティクス エージー Ｉｌ－２を有するチェックポイント阻害剤のコンジュゲート及びその使用
CA3231257A1 (en) 2021-09-08 2023-03-16 Yuji Ito Compound, salt of compound, antibody modification reagent, method for producing modified antibody, and modified antibody
WO2023054714A1 (ja) 2021-09-30 2023-04-06 味の素株式会社 抗体および機能性物質の位置選択的なコンジュゲートまたはその塩、ならびにその製造に用いられる抗体誘導体および化合物またはそれらの塩
KR20240073035A (ko) 2021-09-30 2024-05-24 아지노모토 가부시키가이샤 항체 및 기능성 물질의 컨쥬게이트 또는 그 염, 및 그 제조에 사용되는 항체 유도체 및 화합물 또는 그 염
EP4482531A1 (en) 2022-02-23 2025-01-01 Bright Peak Therapeutics AG Immune antigen specific il-18 immunocytokines and uses thereof
US20250163101A1 (en) 2022-03-04 2025-05-22 AbTis Co., Ltd. Method for increasing production yield of antibody-drug conjugate by using thiol-reactive additive
JPWO2023234416A1 (enExample) * 2022-06-02 2023-12-07
KR20240125071A (ko) 2022-11-01 2024-08-19 앱티스 주식회사 Fc 결합성 유닛을 포함하는 화합물 및 이를 이용하여 제조된 컨쥬게이트
US20240417436A1 (en) 2023-01-11 2024-12-19 Bright Peak Therapeutics Ag Conditionally activated immunocytokines and methods of use
US20240424127A1 (en) 2023-01-11 2024-12-26 Bright Peak Therapeutics Ag Il-7 polypeptides, immunocytokines comprising same, and uses thereof
EP4682173A1 (en) * 2023-03-15 2026-01-21 Kagoshima University Method for producing radiolabeled antibody, radiolabeled antibody, and radioactive medicine
KR20250172615A (ko) 2023-04-04 2025-12-09 아지노모토 가부시키가이샤 항체 및 기능성 물질의 컨쥬게이트, 항체 유도체 및 화합물, 또는 그것들의 염
JPWO2024210178A1 (enExample) 2023-04-05 2024-10-10
US20250188166A1 (en) 2023-08-23 2025-06-12 Bright Peak Therapeutics Ag Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025041102A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Targeted immune activation with il-18 immunocytokines
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250144234A1 (en) 2023-11-02 2025-05-08 Capstan Therapeutics Inc. RNA for In vivo Transfection with Increased Expression
US20250332281A2 (en) 2023-12-15 2025-10-30 Capstan Therapeutics, Inc. Humanized anti-cd8 antibodies and uses thereof
WO2025158412A1 (en) 2024-01-26 2025-07-31 Biohaven Therapeutics Ltd. BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025181697A1 (en) 2024-02-26 2025-09-04 Biohaven Therapeutics Ltd. Bifunctional degraders of anti-pla2r antibody
WO2025210538A1 (en) 2024-04-02 2025-10-09 Biohaven Therapeutics Ltd. Bifunctional degraders
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09327288A (ja) * 1996-06-11 1997-12-22 Nof Corp 修飾蛋白質の製造法及びコンタクトレンズ用汚れ除去剤
EP1056474B1 (en) * 1997-11-07 2002-06-12 ConjuChem, Inc. Affinity markers for human serum albumin
WO2015191883A1 (en) * 2014-06-12 2015-12-17 Dophen Biomedical Homogenous antibody drug conjugates via enzymatic methods
CN105377307A (zh) * 2013-06-24 2016-03-02 韩华石油化学株式会社 具有改进的稳定性的抗体-药物缀合物及其用途
WO2016186206A1 (ja) * 2015-05-20 2016-11-24 国立大学法人鹿児島大学 ＩｇＧ結合ペプチドによる抗体の特異的修飾

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89220A (en) 1988-02-11 1994-02-27 Bristol Myers Squibb Co Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
JP2000503639A (ja) 1995-12-22 2000-03-28 ブリストル―マイヤーズ スクイブ カンパニー 分枝ヒドラゾンのリンカー類
EP1757311B1 (en) 1999-12-24 2009-02-11 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
DE60030323T2 (de) 1999-12-24 2007-10-11 Genentech, Inc., South San Francisco Verfahren und verbindungen zur verlängerung der halbwertzeiten bei der ausscheidung von biowirksamen verbindungen
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
DE10162773A1 (de) 2001-12-20 2003-07-10 Knf Flodos Ag Sursee Dosierpumpe
CA2802205C (en) 2002-07-31 2016-01-19 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
EP1560599A1 (en) 2002-11-14 2005-08-10 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
CN103394083B (zh) 2003-11-06 2017-07-18 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
NZ550934A (en) 2004-05-19 2010-05-28 Medarex Inc Chemical linkers and conjugates thereof
JP5167473B2 (ja) 2005-03-03 2013-03-21 コヴェックス・テクノロジーズ・アイルランド・リミテッド 抗血管新生化合物
US8637656B2 (en) 2005-07-05 2014-01-28 Ribomic Inc. Nucleic acid capable of binding to immunoglobulin G and use thereof
EP1989547A1 (en) 2006-02-28 2008-11-12 Medical Research Council Targeted iron oxide nanoparticles
EP2093287A4 (en) 2006-11-02 2010-04-21 Univ Kagoshima PEPTIDE BINDER IGG
WO2008056346A2 (en) 2006-11-10 2008-05-15 Covx Technologies Ireland Limited Anti-angiogenic compounds
WO2011121560A2 (en) * 2010-03-31 2011-10-06 Universite De Geneve Stabilized antibody preparations and uses thereof
CN103890174B (zh) 2011-08-24 2015-12-23 大塚化学株式会社 IgG结合性肽及利用其检测和纯化IgG的方法
DK2863955T3 (en) 2012-06-26 2017-01-23 Sutro Biopharma Inc MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF
US20160000933A1 (en) * 2014-07-01 2016-01-07 Andrei POLUKHTIN Conjugated biological molecules and their preparation
JP5827769B1 (ja) 2015-03-27 2015-12-02 義徳 川窪 掃除装置
TWI703158B (zh) * 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
BR112018012388A2 (pt) 2015-12-18 2018-12-04 Eisai R&D Management Co., Ltd. imunoglobulinas conjugadas de lisina terminal-c
JP7020403B2 (ja) * 2016-05-02 2022-02-16 味の素株式会社 アジド基含有Ｆｃタンパク質
CN109071606A (zh) * 2016-06-13 2018-12-21 国立大学法人鹿儿岛大学 利用IgG结合肽的位点特异性放射性同位素标记抗体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09327288A (ja) * 1996-06-11 1997-12-22 Nof Corp 修飾蛋白質の製造法及びコンタクトレンズ用汚れ除去剤
EP1056474B1 (en) * 1997-11-07 2002-06-12 ConjuChem, Inc. Affinity markers for human serum albumin
CN105377307A (zh) * 2013-06-24 2016-03-02 韩华石油化学株式会社 具有改进的稳定性的抗体-药物缀合物及其用途
WO2015191883A1 (en) * 2014-06-12 2015-12-17 Dophen Biomedical Homogenous antibody drug conjugates via enzymatic methods
WO2016186206A1 (ja) * 2015-05-20 2016-11-24 国立大学法人鹿児島大学 ＩｇＧ結合ペプチドによる抗体の特異的修飾

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ERIK S. ZIMMERMAN等: "Production of Site-Specific Antibody-Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System", 《BIOCONJUGATE CHEMISTRY》 *
ERIK S. ZIMMERMAN等: "Production of Site-Specific Antibody-Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System", 《BIOCONJUGATE CHEMISTRY》, vol. 25, no. 2, 17 January 2014 (2014-01-17), pages 1 - 11, XP055107336, DOI: 10.1021/bc400490z *
HAYASHI, T.等: "Traceless affinity labeling of endogenous proteins for fuctional analysis in living cells", ACCOUNTS OF CHEMICAL RESEARCH, vol. 45, no. 9, 31 December 2012 (2012-12-31), pages 1460 - 1469 *
HOUZONG YAO等: "Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)", 《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》 *
HOUZONG YAO等: "Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)", 《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》, vol. 17, no. 2, 2 February 2016 (2016-02-02), pages 1 - 16, XP055416120, DOI: 10.3390/ijms17020194 *
KYOJI TSUCHIKAMA等: "Antibody-drug conjugates: recent advances in conjugation and linker chemistries", 《PROTEIN & CELL》 *
KYOJI TSUCHIKAMA等: "Antibody-drug conjugates: recent advances in conjugation and linker chemistries", 《PROTEIN & CELL》, vol. 9, no. 1, 14 October 2016 (2016-10-14), pages 1 - 14 *
高冰;欧瑜;: "蛋白质药物的聚乙二醇定点修饰", 药物生物技术, no. 03, pages 61 - 65 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112262152A (zh) * 2018-06-14 2021-01-22 味之素株式会社 具有针对抗体的亲和性物质、切割性部分及反应性基团的化合物或其盐
CN112261954A (zh) * 2018-06-14 2021-01-22 味之素株式会社 具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐
CN112261954B (zh) * 2018-06-14 2025-06-24 味之素株式会社 具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐
WO2023179723A1 (zh) * 2022-03-25 2023-09-28 中国科学院上海药物研究所 亲和片段导向的可裂解片段，其设计、合成及在制备定点药物偶联物中的应用

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