CN110637024B - 假三糖氨基糖苷及其中间体的大规模制备 - Google Patents

假三糖氨基糖苷及其中间体的大规模制备 Download PDF

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Publication number
CN110637024B
CN110637024B CN201880032661.9A CN201880032661A CN110637024B CN 110637024 B CN110637024 B CN 110637024B CN 201880032661 A CN201880032661 A CN 201880032661A CN 110637024 B CN110637024 B CN 110637024B
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formula
group
compound represented
protected
compound
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Expired - Fee Related
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CN201880032661.9A
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English (en)
Chinese (zh)
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CN110637024A (zh
Inventor
迈克尔·米吉瑞斯齐
马尼·布珊·科塔拉
拉文德尔·帕拉迪
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Eloxx Pharmaceuticals Ltd
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Eloxx Pharmaceuticals Ltd
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Priority to CN202311295323.3A priority Critical patent/CN117466958A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201880032661.9A 2017-03-15 2018-03-15 假三糖氨基糖苷及其中间体的大规模制备 Expired - Fee Related CN110637024B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311295323.3A CN117466958A (zh) 2017-03-15 2018-03-15 假三糖氨基糖苷及其中间体的大规模制备

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201721008996 2017-03-15
IN201721008996 2017-03-15
PCT/IL2018/050306 WO2018167794A1 (en) 2017-03-15 2018-03-15 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311295323.3A Division CN117466958A (zh) 2017-03-15 2018-03-15 假三糖氨基糖苷及其中间体的大规模制备

Publications (2)

Publication Number Publication Date
CN110637024A CN110637024A (zh) 2019-12-31
CN110637024B true CN110637024B (zh) 2023-10-24

Family

ID=63521924

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202311295323.3A Pending CN117466958A (zh) 2017-03-15 2018-03-15 假三糖氨基糖苷及其中间体的大规模制备
CN201880032661.9A Expired - Fee Related CN110637024B (zh) 2017-03-15 2018-03-15 假三糖氨基糖苷及其中间体的大规模制备

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Application Number Title Priority Date Filing Date
CN202311295323.3A Pending CN117466958A (zh) 2017-03-15 2018-03-15 假三糖氨基糖苷及其中间体的大规模制备

Country Status (9)

Country Link
US (2) US11136345B2 (enExample)
EP (1) EP3609902A4 (enExample)
JP (1) JP7187471B2 (enExample)
CN (2) CN117466958A (enExample)
AU (2) AU2018235441C1 (enExample)
BR (1) BR112019018834A2 (enExample)
CA (1) CA3055883A1 (enExample)
IL (1) IL269364B (enExample)
WO (1) WO2018167794A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021061873A1 (en) * 2019-09-23 2021-04-01 Eloxx Pharmaceuticals, Inc. Methods, compositions, and kits for treating polycystic kidney disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012066546A1 (en) * 2010-11-18 2012-05-24 Technion Research & Development Foundation Ltd. Aminoglycosides and uses thereof in treating genetic disorders
WO2017037718A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897412A (en) 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
FR2232326B1 (enExample) 1973-06-05 1977-11-10 Pfizer
US4029882A (en) 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
US3996205A (en) 1975-09-08 1976-12-07 The Upjohn Company Aminoglycoside antibiotics and intermediates
JPS543043A (en) 1977-06-10 1979-01-11 Meiji Seika Kaisha Ltd Amino-glycoside antibiotics; 1-n-(omega-aminoalkanesulfonyl)derivatives and their preparation
FR2427341A1 (fr) 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
JPH0446189A (ja) 1990-06-08 1992-02-17 Meiji Seika Kaisha Ltd 新規なリボスタマイシン誘導体
SI2390255T1 (sl) 2006-04-03 2016-12-30 Technion Research & Development Foundation Ltd. Novi aminoglikozidi in njihove uporabe pri zdravljenju genetskih motenj
WO2011044538A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
JP2017516835A (ja) * 2014-06-05 2017-06-22 エロックス ファーマシューティカルズ リミテッド レット症候群治療におけるアミノグリコシド類縁体の使用
EP3344641A4 (en) 2015-09-02 2019-09-18 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
US11306115B2 (en) * 2015-09-02 2022-04-19 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012066546A1 (en) * 2010-11-18 2012-05-24 Technion Research & Development Foundation Ltd. Aminoglycosides and uses thereof in treating genetic disorders
WO2017037718A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Alessandro Dondoni，等.Total Synthesis of Thymine Polgoxin C.《Tetrahedron Letters》.1994,第35卷(第50期),第9439-9442页. *
Brimacombe, J. S.，等.The Deamination of methyl 5-amino-5,6-dideoxy-2,3-O-isopropylidene- α-L- talo- and -β-D-allo-furanosides with nitrous acid.《Carbohydrate Research》.1972,第25卷(第1期),第267-269页. *
The Deamination of methyl 5-amino-5,6-dideoxy-2,3-O-isopropylidene- α-L- talo- and -β-D-allo-furanosides with nitrous acid;Brimacombe, J. S.，等;《Carbohydrate Research》;19721231;第25卷(第1期);第267-269页 *
Total Synthesis of Thymine Polgoxin C;Alessandro Dondoni，等;《Tetrahedron Letters》;19941231;第35卷(第50期);第9439-9442页 *

Also Published As

Publication number Publication date
CN110637024A (zh) 2019-12-31
US20200079809A1 (en) 2020-03-12
CN117466958A (zh) 2024-01-30
AU2018235441B2 (en) 2022-07-21
JP2020514373A (ja) 2020-05-21
CA3055883A1 (en) 2018-09-20
JP7187471B2 (ja) 2022-12-12
US20220033428A1 (en) 2022-02-03
AU2018235441A2 (en) 2019-11-07
AU2018235441A1 (en) 2019-09-26
AU2022256098A1 (en) 2022-11-17
IL269364B (en) 2022-04-01
AU2022256098B2 (en) 2024-07-11
AU2018235441C1 (en) 2024-10-24
EP3609902A1 (en) 2020-02-19
AU2022256098C1 (en) 2024-10-31
BR112019018834A2 (pt) 2020-04-14
IL269364A (en) 2019-11-28
EP3609902A4 (en) 2021-01-06
US11136345B2 (en) 2021-10-05
WO2018167794A1 (en) 2018-09-20

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Inventor after: Mani Busan kotala

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