CA3055883A1 - Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof - Google Patents
Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof Download PDFInfo
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- CA3055883A1 CA3055883A1 CA3055883A CA3055883A CA3055883A1 CA 3055883 A1 CA3055883 A1 CA 3055883A1 CA 3055883 A CA3055883 A CA 3055883A CA 3055883 A CA3055883 A CA 3055883A CA 3055883 A1 CA3055883 A1 CA 3055883A1
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- 238000000034 method Methods 0.000 claims description 175
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 84
- 150000003839 salts Chemical class 0.000 claims description 73
- 229940126575 aminoglycoside Drugs 0.000 claims description 57
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- 125000003118 aryl group Chemical group 0.000 claims description 46
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 45
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201721008996 | 2017-03-15 | ||
| IN201721008996 | 2017-03-15 | ||
| PCT/IL2018/050306 WO2018167794A1 (en) | 2017-03-15 | 2018-03-15 | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3055883A1 true CA3055883A1 (en) | 2018-09-20 |
Family
ID=63521924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3055883A Pending CA3055883A1 (en) | 2017-03-15 | 2018-03-15 | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11136345B2 (enExample) |
| EP (1) | EP3609902A4 (enExample) |
| JP (1) | JP7187471B2 (enExample) |
| CN (2) | CN117466958A (enExample) |
| AU (2) | AU2018235441C1 (enExample) |
| BR (1) | BR112019018834A2 (enExample) |
| CA (1) | CA3055883A1 (enExample) |
| IL (1) | IL269364B (enExample) |
| WO (1) | WO2018167794A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021061873A1 (en) * | 2019-09-23 | 2021-04-01 | Eloxx Pharmaceuticals, Inc. | Methods, compositions, and kits for treating polycystic kidney disease |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897412A (en) | 1972-05-04 | 1975-07-29 | Bristol Myers Co | Paromomycin antibiotic derivatives |
| FR2232326B1 (enExample) | 1973-06-05 | 1977-11-10 | Pfizer | |
| US4029882A (en) | 1974-03-19 | 1977-06-14 | Schering Corporation | Selective acylation of the C-1 amino group of aminoglycoside antibiotics |
| US3996205A (en) | 1975-09-08 | 1976-12-07 | The Upjohn Company | Aminoglycoside antibiotics and intermediates |
| JPS543043A (en) | 1977-06-10 | 1979-01-11 | Meiji Seika Kaisha Ltd | Amino-glycoside antibiotics; 1-n-(omega-aminoalkanesulfonyl)derivatives and their preparation |
| FR2427341A1 (fr) | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| JPH0446189A (ja) | 1990-06-08 | 1992-02-17 | Meiji Seika Kaisha Ltd | 新規なリボスタマイシン誘導体 |
| SI2390255T1 (sl) | 2006-04-03 | 2016-12-30 | Technion Research & Development Foundation Ltd. | Novi aminoglikozidi in njihove uporabe pri zdravljenju genetskih motenj |
| WO2011044538A1 (en) * | 2009-10-09 | 2011-04-14 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| SMT201800019T1 (it) * | 2010-11-18 | 2018-03-08 | Technion Res & Dev Foundation | Amminoglicosidi e relativi usi nel trattamento di malattie genetiche |
| JP2017516835A (ja) * | 2014-06-05 | 2017-06-22 | エロックス ファーマシューティカルズ リミテッド | レット症候群治療におけるアミノグリコシド類縁体の使用 |
| EP3344641A4 (en) | 2015-09-02 | 2019-09-18 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| US11306115B2 (en) * | 2015-09-02 | 2022-04-19 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US10786520B2 (en) * | 2015-09-02 | 2020-09-29 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
-
2018
- 2018-03-15 CA CA3055883A patent/CA3055883A1/en active Pending
- 2018-03-15 US US16/493,732 patent/US11136345B2/en active Active
- 2018-03-15 CN CN202311295323.3A patent/CN117466958A/zh active Pending
- 2018-03-15 EP EP18767330.6A patent/EP3609902A4/en not_active Withdrawn
- 2018-03-15 CN CN201880032661.9A patent/CN110637024B/zh not_active Expired - Fee Related
- 2018-03-15 WO PCT/IL2018/050306 patent/WO2018167794A1/en not_active Ceased
- 2018-03-15 AU AU2018235441A patent/AU2018235441C1/en active Active
- 2018-03-15 JP JP2019551278A patent/JP7187471B2/ja active Active
- 2018-03-15 BR BR112019018834A patent/BR112019018834A2/pt not_active Application Discontinuation
-
2019
- 2019-09-15 IL IL269364A patent/IL269364B/en unknown
-
2021
- 2021-10-04 US US17/493,672 patent/US20220033428A1/en not_active Abandoned
-
2022
- 2022-10-18 AU AU2022256098A patent/AU2022256098C1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110637024B (zh) | 2023-10-24 |
| CN110637024A (zh) | 2019-12-31 |
| US20200079809A1 (en) | 2020-03-12 |
| CN117466958A (zh) | 2024-01-30 |
| AU2018235441B2 (en) | 2022-07-21 |
| JP2020514373A (ja) | 2020-05-21 |
| JP7187471B2 (ja) | 2022-12-12 |
| US20220033428A1 (en) | 2022-02-03 |
| AU2018235441A2 (en) | 2019-11-07 |
| AU2018235441A1 (en) | 2019-09-26 |
| AU2022256098A1 (en) | 2022-11-17 |
| IL269364B (en) | 2022-04-01 |
| AU2022256098B2 (en) | 2024-07-11 |
| AU2018235441C1 (en) | 2024-10-24 |
| EP3609902A1 (en) | 2020-02-19 |
| AU2022256098C1 (en) | 2024-10-31 |
| BR112019018834A2 (pt) | 2020-04-14 |
| IL269364A (en) | 2019-11-28 |
| EP3609902A4 (en) | 2021-01-06 |
| US11136345B2 (en) | 2021-10-05 |
| WO2018167794A1 (en) | 2018-09-20 |
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