AU2018235441C1 - Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof - Google Patents

Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof Download PDF

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Publication number
AU2018235441C1
AU2018235441C1 AU2018235441A AU2018235441A AU2018235441C1 AU 2018235441 C1 AU2018235441 C1 AU 2018235441C1 AU 2018235441 A AU2018235441 A AU 2018235441A AU 2018235441 A AU2018235441 A AU 2018235441A AU 2018235441 C1 AU2018235441 C1 AU 2018235441C1
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protected
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acceptor
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AU2018235441A
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AU2018235441B2 (en
AU2018235441A2 (en
AU2018235441A1 (en
Inventor
Mani Bushan KOTALA
Michael Mizhiritskii
Ravinder PALADI
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Eloxx Pharmaceuticals Ltd
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Eloxx Pharmaceuticals Ltd
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Publication of AU2018235441A1 publication Critical patent/AU2018235441A1/en
Publication of AU2018235441A2 publication Critical patent/AU2018235441A2/en
Publication of AU2018235441B2 publication Critical patent/AU2018235441B2/en
Priority to AU2022256098A priority Critical patent/AU2022256098C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2018235441A 2017-03-15 2018-03-15 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof Active AU2018235441C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022256098A AU2022256098C1 (en) 2017-03-15 2022-10-18 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201721008996 2017-03-15
IN201721008996 2017-03-15
PCT/IL2018/050306 WO2018167794A1 (en) 2017-03-15 2018-03-15 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022256098A Division AU2022256098C1 (en) 2017-03-15 2022-10-18 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Publications (4)

Publication Number Publication Date
AU2018235441A1 AU2018235441A1 (en) 2019-09-26
AU2018235441A2 AU2018235441A2 (en) 2019-11-07
AU2018235441B2 AU2018235441B2 (en) 2022-07-21
AU2018235441C1 true AU2018235441C1 (en) 2024-10-24

Family

ID=63521924

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018235441A Active AU2018235441C1 (en) 2017-03-15 2018-03-15 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
AU2022256098A Active AU2022256098C1 (en) 2017-03-15 2022-10-18 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022256098A Active AU2022256098C1 (en) 2017-03-15 2022-10-18 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Country Status (9)

Country Link
US (2) US11136345B2 (enExample)
EP (1) EP3609902A4 (enExample)
JP (1) JP7187471B2 (enExample)
CN (2) CN117466958A (enExample)
AU (2) AU2018235441C1 (enExample)
BR (1) BR112019018834A2 (enExample)
CA (1) CA3055883A1 (enExample)
IL (1) IL269364B (enExample)
WO (1) WO2018167794A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021061873A1 (en) * 2019-09-23 2021-04-01 Eloxx Pharmaceuticals, Inc. Methods, compositions, and kits for treating polycystic kidney disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017037717A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897412A (en) 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
FR2232326B1 (enExample) 1973-06-05 1977-11-10 Pfizer
US4029882A (en) 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
US3996205A (en) 1975-09-08 1976-12-07 The Upjohn Company Aminoglycoside antibiotics and intermediates
JPS543043A (en) 1977-06-10 1979-01-11 Meiji Seika Kaisha Ltd Amino-glycoside antibiotics; 1-n-(omega-aminoalkanesulfonyl)derivatives and their preparation
FR2427341A1 (fr) 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
JPH0446189A (ja) 1990-06-08 1992-02-17 Meiji Seika Kaisha Ltd 新規なリボスタマイシン誘導体
SI2390255T1 (sl) 2006-04-03 2016-12-30 Technion Research & Development Foundation Ltd. Novi aminoglikozidi in njihove uporabe pri zdravljenju genetskih motenj
WO2011044538A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
SMT201800019T1 (it) * 2010-11-18 2018-03-08 Technion Res & Dev Foundation Amminoglicosidi e relativi usi nel trattamento di malattie genetiche
JP2017516835A (ja) * 2014-06-05 2017-06-22 エロックス ファーマシューティカルズ リミテッド レット症候群治療におけるアミノグリコシド類縁体の使用
EP3344641A4 (en) 2015-09-02 2019-09-18 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
US10786520B2 (en) * 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017037717A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders

Also Published As

Publication number Publication date
CN110637024B (zh) 2023-10-24
CN110637024A (zh) 2019-12-31
US20200079809A1 (en) 2020-03-12
CN117466958A (zh) 2024-01-30
AU2018235441B2 (en) 2022-07-21
JP2020514373A (ja) 2020-05-21
CA3055883A1 (en) 2018-09-20
JP7187471B2 (ja) 2022-12-12
US20220033428A1 (en) 2022-02-03
AU2018235441A2 (en) 2019-11-07
AU2018235441A1 (en) 2019-09-26
AU2022256098A1 (en) 2022-11-17
IL269364B (en) 2022-04-01
AU2022256098B2 (en) 2024-07-11
EP3609902A1 (en) 2020-02-19
AU2022256098C1 (en) 2024-10-31
BR112019018834A2 (pt) 2020-04-14
IL269364A (en) 2019-11-28
EP3609902A4 (en) 2021-01-06
US11136345B2 (en) 2021-10-05
WO2018167794A1 (en) 2018-09-20

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Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 27 SEP 2019

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ MIZHIRITSKII, MICHAEL; KOTALA, MANI BUSHAN AND PALADI, RAVINDER

FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 26 JUN 2024

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 26 JUN 2024