CN110621675B - 用于治疗增殖性疾病的三环化合物 - Google Patents

用于治疗增殖性疾病的三环化合物 Download PDF

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Publication number
CN110621675B
CN110621675B CN201880031972.3A CN201880031972A CN110621675B CN 110621675 B CN110621675 B CN 110621675B CN 201880031972 A CN201880031972 A CN 201880031972A CN 110621675 B CN110621675 B CN 110621675B
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hydroxy
alkyl
indol
propyl
pyridin
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CN110621675A (zh
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安德鲁·莫利
丽贝卡·米勒
尼古拉斯·拉·唐格
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Aguno Treatment Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880031972.3A 2017-03-17 2018-03-16 用于治疗增殖性疾病的三环化合物 Active CN110621675B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1704325.8A GB201704325D0 (en) 2017-03-17 2017-03-17 Compounds
GB1704325.8 2017-03-17
PCT/EP2018/056675 WO2018167276A1 (en) 2017-03-17 2018-03-16 Tricyclic compounds for use in treatment of proliferative disorders

Publications (2)

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CN110621675A CN110621675A (zh) 2019-12-27
CN110621675B true CN110621675B (zh) 2023-09-19

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US (1) US11274098B2 (cg-RX-API-DMAC10.html)
EP (1) EP3596073B1 (cg-RX-API-DMAC10.html)
JP (1) JP7308765B2 (cg-RX-API-DMAC10.html)
KR (1) KR102604942B1 (cg-RX-API-DMAC10.html)
CN (1) CN110621675B (cg-RX-API-DMAC10.html)
CA (1) CA3056726A1 (cg-RX-API-DMAC10.html)
ES (1) ES2925115T3 (cg-RX-API-DMAC10.html)
GB (1) GB201704325D0 (cg-RX-API-DMAC10.html)
WO (1) WO2018167276A1 (cg-RX-API-DMAC10.html)

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GB201905780D0 (en) 2019-04-25 2019-06-05 La Thangue Nicholas Cancer therapy
KR102282712B1 (ko) * 2019-08-09 2021-07-27 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물
WO2021029450A1 (ko) * 2019-08-09 2021-02-18 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물
KR102278691B1 (ko) * 2019-08-09 2021-07-16 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체
WO2021066578A1 (ko) 2019-10-02 2021-04-08 에스케이바이오팜 주식회사 바이사이클릭 화합물 및 이의 용도
CN111454260B (zh) * 2020-05-25 2023-02-28 贵州大学 一类含异丙醇胺亚结构的1，2，3，4-四氢-β-咔啉类化合物及其制备方法和应用
CN111892593B (zh) * 2020-08-19 2021-11-16 南通大学 一种8-甲氧基-5H-吡啶并[4,3-b]吲哚及其合成方法
CN117062816A (zh) * 2021-02-04 2023-11-14 美国安进公司 三环-酰胺-双环prmt5抑制剂
CN113105517B (zh) * 2021-04-10 2022-03-01 台州仙琚药业有限公司 雄甾-1,4,9-三烯-3,17-二酮的合成方法
GB202108383D0 (en) * 2021-06-11 2021-07-28 Argonaut Therapeutics Ltd Compounds useful in the treatment or prevention of a prmt5-mediated disorder
GB202117230D0 (en) 2021-11-29 2022-01-12 Argonaut Therapeutics Ltd Peptide vaccine
GB202203588D0 (en) 2022-03-15 2022-04-27 Argonaut Therapeutics Ltd Cancer diagnostic
CN115521306B (zh) * 2022-09-26 2024-03-26 贵州大学 一种1,2,3,4-四氢-β-咔啉衍生物及其制备方法和应用
CN117088891B (zh) * 2023-07-13 2026-06-16 浙江大学 含四氢苯并[4,5]呋喃[2,3-c]吡啶类羟肟酸化合物及其制备方法和应用
CN121226371B (zh) * 2025-10-28 2026-07-14 百色学院 四氢吡嗪[1,2-a]吲哚类组蛋白去乙酰化酶抑制剂及其制备方法与应用

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JP7308765B2 (ja) 2023-07-14
US11274098B2 (en) 2022-03-15
GB201704325D0 (en) 2017-05-03
CN110621675A (zh) 2019-12-27
US20200325132A1 (en) 2020-10-15
ES2925115T3 (es) 2022-10-13
CA3056726A1 (en) 2018-09-20
EP3596073A1 (en) 2020-01-22
EP3596073B1 (en) 2022-05-11
KR102604942B1 (ko) 2023-11-21
WO2018167276A1 (en) 2018-09-20
KR20190129071A (ko) 2019-11-19
JP2020510092A (ja) 2020-04-02

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