CN110621303A - 抗TNFα抗体的液体制剂 - Google Patents
抗TNFα抗体的液体制剂 Download PDFInfo
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- CN110621303A CN110621303A CN201880031705.6A CN201880031705A CN110621303A CN 110621303 A CN110621303 A CN 110621303A CN 201880031705 A CN201880031705 A CN 201880031705A CN 110621303 A CN110621303 A CN 110621303A
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- formulation
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- adalimumab
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- arginine
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Classifications
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
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Applications Claiming Priority (3)
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| KR20170033188 | 2017-03-16 | ||
| KR10-2017-0033188 | 2017-03-16 | ||
| PCT/KR2018/003097 WO2018169348A1 (ko) | 2017-03-16 | 2018-03-16 | 항-tnf 알파 항체의 액상 제제 |
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| CN110621303A true CN110621303A (zh) | 2019-12-27 |
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| JP (2) | JP7109849B2 (uk) |
| KR (2) | KR20180106974A (uk) |
| CN (1) | CN110621303A (uk) |
| AU (1) | AU2018236651B2 (uk) |
| BR (1) | BR112019019162A2 (uk) |
| CO (1) | CO2019010860A2 (uk) |
| MA (1) | MA46988A1 (uk) |
| MX (1) | MX2019010895A (uk) |
| MY (1) | MY197202A (uk) |
| NZ (1) | NZ757965A (uk) |
| PH (1) | PH12019502075A1 (uk) |
| RU (1) | RU2756619C2 (uk) |
| UA (1) | UA123847C2 (uk) |
| WO (1) | WO2018169348A1 (uk) |
| ZA (1) | ZA201906696B (uk) |
Cited By (1)
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| WO2021164717A1 (zh) * | 2020-02-20 | 2021-08-26 | 百奥泰生物制药股份有限公司 | 抗TNF-α的抗体制剂及其制备方法和用途 |
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| BR112021015034A2 (pt) * | 2019-02-18 | 2021-10-05 | Eli Lilly And Company | Formulação de anticorpo terapêutico |
| TW202102260A (zh) * | 2019-03-21 | 2021-01-16 | 美商再生元醫藥公司 | 含有抗ｉｌ－３３抗體之穩定調配物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104159614A (zh) * | 2012-03-07 | 2014-11-19 | 卡迪拉保健有限公司 | TNF-α抗体的药物制剂 |
| CN104623656A (zh) * | 2011-06-03 | 2015-05-20 | 株式会社Lg生命科学 | 依那西普的稳定液体制剂 |
| WO2015151115A1 (en) * | 2014-04-02 | 2015-10-08 | Intas Pharmaceuticals Limited | Liquid pharmaceutical composition of adalimumab |
| CN105051064A (zh) * | 2013-01-24 | 2015-11-11 | 葛兰素史克知识产权开发有限公司 | 抗TNF-α抗原结合蛋白 |
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| CA2815689C (en) * | 2010-11-11 | 2016-11-22 | Abbvie Biotechnology Ltd. | Improved high concentration anti-tnf.alpha. antibody liquid formulations |
| BR112015004984A2 (pt) | 2012-09-07 | 2017-07-04 | Coherus Biosciences Inc | formulações aquosas estáveis de adalimumab |
| CN105025925A (zh) | 2013-03-15 | 2015-11-04 | 拜尔健康护理有限责任公司 | 抗-催乳素受体抗体制剂 |
| WO2015134406A1 (en) | 2014-03-03 | 2015-09-11 | La Jolla Biologics, Inc. | Stable aqueous recombinant protein formulations |
| LT2946765T (lt) * | 2014-05-23 | 2016-11-25 | Ares Trading S.A. | Skysta farmacinė kompozicija |
| US9821059B2 (en) | 2014-10-17 | 2017-11-21 | Alteogen Inc. | Composition for stabilizing protein and pharmaceutical formulation comprising the same |
| HUP1400510A1 (hu) * | 2014-10-28 | 2016-05-30 | Richter Gedeon Nyrt | Gyógyászati TNFalfa ellenes antitest készítmény |
| WO2016120413A1 (en) * | 2015-01-28 | 2016-08-04 | Mabxience S.A. | Pharmaceutical formulations for anti-tnf-alpha antibodies |
| WO2016162819A1 (en) * | 2015-04-07 | 2016-10-13 | Lupin Limited | Stable aqueous pharmaceutical composition of anti-tnf alpha antibody |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623656A (zh) * | 2011-06-03 | 2015-05-20 | 株式会社Lg生命科学 | 依那西普的稳定液体制剂 |
| CN104159614A (zh) * | 2012-03-07 | 2014-11-19 | 卡迪拉保健有限公司 | TNF-α抗体的药物制剂 |
| CN105051064A (zh) * | 2013-01-24 | 2015-11-11 | 葛兰素史克知识产权开发有限公司 | 抗TNF-α抗原结合蛋白 |
| WO2015151115A1 (en) * | 2014-04-02 | 2015-10-08 | Intas Pharmaceuticals Limited | Liquid pharmaceutical composition of adalimumab |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021164717A1 (zh) * | 2020-02-20 | 2021-08-26 | 百奥泰生物制药股份有限公司 | 抗TNF-α的抗体制剂及其制备方法和用途 |
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| AU2018236651A1 (en) | 2019-10-31 |
| MY197202A (en) | 2023-05-31 |
| AU2018236651B2 (en) | 2020-12-10 |
| ZA201906696B (en) | 2020-08-26 |
| BR112019019162A2 (pt) | 2020-04-14 |
| KR20180106974A (ko) | 2018-10-01 |
| MA46988A1 (fr) | 2020-06-30 |
| RU2019130728A3 (uk) | 2021-04-16 |
| JP2022097600A (ja) | 2022-06-30 |
| MX2019010895A (es) | 2019-11-05 |
| CO2019010860A2 (es) | 2020-01-17 |
| KR20200096472A (ko) | 2020-08-12 |
| UA123847C2 (uk) | 2021-06-09 |
| RU2756619C2 (ru) | 2021-10-04 |
| WO2018169348A1 (ko) | 2018-09-20 |
| PH12019502075A1 (en) | 2020-09-14 |
| NZ757965A (en) | 2022-07-01 |
| KR102342292B1 (ko) | 2021-12-24 |
| JP7109849B2 (ja) | 2022-08-01 |
| JP2020510079A (ja) | 2020-04-02 |
| RU2019130728A (ru) | 2021-04-16 |
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