CN110585088B - Skin brightening composition and preparation method and application thereof - Google Patents

Skin brightening composition and preparation method and application thereof Download PDF

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Publication number
CN110585088B
CN110585088B CN201910979734.1A CN201910979734A CN110585088B CN 110585088 B CN110585088 B CN 110585088B CN 201910979734 A CN201910979734 A CN 201910979734A CN 110585088 B CN110585088 B CN 110585088B
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skin
composition
anthocyanin
cosmetic
nicotinamide
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CN110585088A (en
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许锐林
陈庆生
孟潇
龚盛昭
吴知情
胡兴国
胡根华
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Guangzhou Huanya Cosmetic Science and Technology Co Ltd
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Guangzhou Huanya Cosmetic Science and Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention provides a skin brightening composition and a preparation method and application thereof. The skin brightening composition disclosed by the invention fully exerts the effects of the components through the scientific proportioning of the components of the hop extract, the nicotinamide, the anthocyanin and the rose water, synergizes, and plays a role in improving the healthy circulation of the skin, eliminating free radicals in the body, improving pigmentation and moisturizing and moistening the skin, so that the skin brightening effect is achieved more durably and effectively.

Description

Skin brightening composition and preparation method and application thereof
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a skin brightening composition as well as a preparation method and application thereof.
Background
With the aging and the influence of environmental pollution, work and life pressure, the skin is burdened, and the skin color is dark. A2017 published 'skin problem research report of Chinese women's 2017 shows that adult women aged 26-35 mainly face skin problems such as dark complexion. Dull complexion is mainly manifested by skin dullness, dryness, yellowing and pigmentation. In response to this phenomenon, people generally deal with the use of whitening products. The whitening cosmetic mainly aims at inhibiting the formation and transfer of melanin, thereby reducing the production of melanin and achieving the whitening effect. This improves skin pigmentation to some extent, but does not contribute substantially to problems such as skin dullness and dryness and lack of water. Therefore, the problem of skin darkness can be fundamentally improved only by starting from the reason of skin darkness. The reasons for skin darkness are: excessive skin pigmentation, oxidation of cuticle, accumulation of waste cuticle, insufficient water locking capacity and the like.
CN105902423A provides a whitening mask composition for enabling skin color to be uniform and brightening skin color, which comprises main materials and auxiliary materials, wherein the main materials comprise the following components in percentage by mass in the whitening mask composition: 0.5 to 1 percent of nicotinamide, 1 to 3 percent of hop extract, 1 to 10 percent of papain aqueous solution, 0.5 to 5 percent of glabridin alcohol solution and 0.1 to 1 percent of chlorphenamine maleate. The composition provided by the invention can lighten the skin color to a certain extent, but has weak strengthening effect on the barrier function of the skin, is difficult to improve the health cycle of the skin, can lighten the skin color only in a short time and gradually weakens the effect in long-time use.
CN109806198A discloses an anhydrous staying-up skin-activating cream and a preparation method thereof, which consists of active substances such as rose water, glycerol, butanediol, carbomer, xanthan gum, ethylene diamine tetraacetic acid disodium, allantoin, p-hydroxyacetophenone, cetearyl alcohol, cetearyl glucoside, nicotinamide and the like.
Therefore, the development of a formula which can simultaneously improve the healthy circulation of the skin, remove free radicals in the body, improve pigmentation and moisturize and moisten the skin has important significance in the field of cosmetics.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a skin brightening composition and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a skin lightening composition comprising hops extract, niacinamide, anthocyanins, and rose water.
The effective components of the hop extract provided by the invention are alpha-acid, extract (alpha-acid and beta-acid) and polyphenol substances. Can inhibit the action of lipoxygenase, and protect oxidation sensitive substances, such as lipid, from being rapidly oxidized by enzyme. Meanwhile, the metal ion chelating agent can be used as a chelating agent to isolate the transfer reaction of heavy metal ions (such as copper and iron metal ions), which is equal to the elimination of the catalytic action of metal and the prevention of the generation of a large amount of oxygen radicals.
The nicotinamide of the invention, also known as vitamin B3, is an important member of vitamin families. Nicotinamide acts on the produced melanin, and can effectively inhibit the transfer of melanin of which the amount is limited to 35-40% from melanocytes to keratinocytes and reduce excessive pigmentation, thereby achieving the effects of improving pigmentation and brightening skin color.
The rose water disclosed by the invention is prepared by a natural distillation mode, contains active ingredients, namely rose essential oil, and a plurality of water-soluble effective ingredients, such as protein, tannin, cyclic peptide and the like in roses, is pleasant in fragrance, and has good moisturizing and antioxidant effects.
The anthocyanin disclosed by the invention is a natural antioxidant which is widely existed in plants in the nature, belongs to a bioflavonoid substance, and has outstanding antioxidant capacity. Anthocyanins can maintain collagen synthesis, inhibit elastase, help the body protect collagen and improve skin elasticity, and improve skin health.
The skin brightening composition disclosed by the invention has the advantages that through scientific proportioning of the components of the hop extract, the nicotinamide, the anthocyanin and the rose water, the effects of the components can be fully exerted, the components are matched with each other to play a role in synergy, and the effects of improving the healthy circulation of the skin, eliminating free radicals in the body, improving pigmentation and moisturizing and moistening the skin are exerted, so that the skin brightening effect is more durably and effectively achieved.
Preferably, the composition comprises the following components in percentage by weight: 1-20% of hop extract, 40-60% of nicotinamide, 1-20% of anthocyanin and the balance of rose water.
In the present invention, the content of the hop extract is 1 to 20%, and may be, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%.
In the present invention, the content of nicotinamide is 40 to 60%, and for example, it may be 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%.
In the present invention, the anthocyanin content is 1 to 20%, and may be, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%.
Preferably, the composition comprises the following components in percentage by weight: 1-10% of hop extract, 50-60% of nicotinamide, 10-20% of anthocyanin and the balance of rose water.
Preferably, the composition comprises the following components in percentage by weight: 5-10% of hop extract, 50-55% of nicotinamide, 10-15% of anthocyanin and the balance of rose water.
Preferably, the anthocyanin is selected from any one or combination of at least two of blackberry anthocyanin, blueberry anthocyanin, cherry anthocyanin, acerose anthocyanin or grape anthocyanin, and is preferably grape anthocyanin.
Preferably, the concentration of the rose essential oil in the rose water is 0.01-0.1% by mass, for example, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, preferably 0.02-0.03%.
In a second aspect, the present invention provides a method for preparing a skin lightening composition according to the first aspect, the method comprising: adding flos Lupuli extract, anthocyanin and nicotinamide into flos Rosae Rugosae water, and mixing well to obtain the skin brightening composition.
Preferably, the mixing time is 10-30min, such as 10min, 12min, 14min, 16min, 18min, 20min, 22min, 24min, 26min, 28min, 30min.
Preferably, the mixing temperature is 20-40 ℃, for example can be 20 ℃, 22 ℃, 24 ℃,26 ℃, 28 ℃, 30 ℃, 32 ℃, 34 ℃, 36 ℃, 38 ℃, 40 ℃.
In a third aspect, the present invention provides a use of a skin lightening composition according to the first aspect in the preparation of a cosmetic.
In a fourth aspect, the present invention provides a cosmetic comprising the skin lightening composition according to the first aspect.
Preferably, the skin lightening composition is added in an amount of 0.1 to 10% by weight of the total mass of the cosmetic, for example, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, preferably 1 to 5%;
preferably, the cosmetic comprises a lotion, essence, skin lotion, skin cream, skin gel, mask or foundation.
Compared with the prior art, the invention has the following beneficial effects:
(1) The skin brightening composition plays a role in improving the health circulation of the skin, eliminating free radicals in the body, improving pigmentation and moisturizing the skin through the synergistic interaction of all functional components, so that the skin brightening effect is achieved more durably and effectively.
(2) The skin brightening composition has an obvious hydroxyl radical removal rate which can reach over 96.24 percent, and the skin brightening cream prepared by the composition has an obvious pigment fading effect, and the melanin reduction rate can reach 17.84 percent.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Example 1
The present embodiment provides a skin lightening composition, which includes, by weight: 8% of hop extract, 52% of nicotinamide, 12% of grape anthocyanin and 28% of rose water, wherein the content of rose essential oil in the rose water is 0.02wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, grape anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing and stirring at 20 deg.C for 20min to obtain the skin brightening composition.
Example 2
The present embodiment provides a skin lightening composition, which includes, by weight: the hop extract is 7%, the niacinamide is 55%, the grape anthocyanin is 10% and the rose water is 28%, wherein the rose essential oil content in the rose water is 0.03wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, grape anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing and stirring at 40 deg.C for 30min to obtain the skin brightening composition.
Example 3
The present embodiment provides a skin lightening composition, which includes, by weight: 10% of hop extract, 52% of nicotinamide, 10% of grape anthocyanin and 28% of rose water, wherein the content of rose essential oil in the rose water is 0.02wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, grape anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing and stirring at 30 deg.C for 10min to obtain the skin brightening composition.
Example 4
The present embodiment provides a skin lightening composition, which includes, by weight: the hop extract is 5%, the nicotinamide is 55%, the grape anthocyanin is 15% and the rose water is 25%, wherein the rose essential oil content in the rose water is 0.02wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, grape anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing and stirring at 20 deg.C for 20min to obtain the skin brightening composition.
Example 5
The present embodiment provides a skin lightening composition, which includes, by weight: 10% of hop extract, 50% of nicotinamide, 12% of grape anthocyanin and 28% of rose water, wherein the content of rose essential oil in the rose water is 0.02wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, grape anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing and stirring at 20 deg.C for 20min to obtain the skin brightening composition.
Example 6
The present embodiment provides a skin lightening composition, which includes, by weight: the hop extract is 15%, the nicotinamide is 56%, the grape anthocyanin is 4% and the rose water is 25%, wherein the rose essential oil content in the rose water is 0.02wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, anthocyanins from grape flower and nicotinamide to flos Rosae Rugosae water, and mixing and stirring at 20 deg.C for 20min to obtain the skin brightening composition.
Example 7
The present embodiment provides a skin lightening composition, which includes, by weight: 8% of hop extract, 52% of nicotinamide, 12% of bilberry anthocyanin and 28% of rose water, wherein the content of rose essential oil in the rose water is 0.05wt%.
The preparation method of the embodiment comprises the following steps: adding flos Lupuli extract, cowberry flower pigment glycoside and nicotinamide into flos Rosae Rugosae water, mixing and stirring at 20 deg.C for 20min to obtain the skin brightening composition.
Comparative example 1
The difference from example 1 is that the composition contains only a single component of rose water.
Comparative example 2
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 72% of hop extract and 28% of deionized water.
Comparative example 3
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 72% of nicotinamide and 28% of deionized water.
Comparative example 4
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 72% of grape anthocyanin and 28% of deionized water.
Comparative example 5
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 8% of hop extract, 52% of nicotinamide, 12% of grape anthocyanin and 28% of deionized water.
Comparative example 6
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 55% of nicotinamide, 15% of grape anthocyanin and 30% of rose water.
Comparative example 7
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 25% of hop extract, 30% of grape anthocyanin and 45% of rose water.
Comparative example 8
The difference from the example 1 is that the composition comprises the following components in percentage by weight: 12% of hop extract, 56% of nicotinamide and 32% of rose water.
Test example 1
Haemolysis test of erythrocytes
The erythrocyte hemolysis test is one of the alternatives of the rabbit eye irritation test (Draize test), and the basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the dissolution amount and denaturation degree of hemoglobin. The RBC test is used internationally for evaluating eye irritation studies on chemicals such as cosmetics and raw materials.
The skin lightening compositions prepared in examples 1 to 7 and the compositions prepared in comparative examples 1 to 8 were subjected to a red blood cell hemolysis test according to the RBC test method and grading standards of the European Alternatives validation center (ECVAM). ECVAM. ECVAM DB-ALM INVITOX Protoco, red blood cells test system INVITOX No.37 Ispra. Italy ECVAM,1994 ], ECVAM cosmetic products RBC experimental irritation grading criteria are shown in Table 1:
TABLE 1
Figure BDA0002234785960000081
Figure BDA0002234785960000091
The results of the hemolysis test of the skin lightening compositions prepared in examples 1 to 7 and the compositions prepared in comparative examples 1 to 8 are shown in Table 2, wherein L/D is HD 50 The HD50 is the concentration of the sample at which 50% of the erythrocytes are hemolyzed, compared to the DI, which is the index of protein denaturation.
TABLE 2
Figure BDA0002234785960000092
Figure BDA0002234785960000101
As can be seen from the results of the erythrocyte hemolysis experiment in table 2, the irritation of the skin-lightening control compositions prepared in examples 1 to 7 of the present invention is classified as non-irritating, which indicates that the oil-controlling astringent compositions of the present invention are mild and non-irritating, and that the four active ingredients of the present invention cooperate with each other to significantly reduce the toxic and side effects and irritation of the compositions after synergistic interaction, so as to achieve the purpose of reducing the degree of hemolysis of the cells and the denaturation of the proteins.
Test example 2
Measurement of hydroxyl radical scavenging ability
Sequentially adding 2mmol/L FeSO into a 25mL colorimetric tube 4 3mL，1mmol/L H 2 O 2 3mL, shaking up, then adding 3mL of salicylic acid with the concentration of 6mmol/L, shaking up, heating in a water bath at 37 ℃ for 15min, taking out, and measuring the absorbance; respectively add one toShaking the solution to be tested with a certain concentration, heating in water bath for 15min, and taking out to test its absorbance. The test fluid samples were the skin lightening compositions prepared in examples 1-7 and the compositions prepared in comparative examples 1-8, the blank was replaced with 1mL of solvent, and the results of the radical scavenging test are shown in table 3.
Wherein OH clearance (%) = (A3-A2)/A1X 100%
In the formula, A1 is the absorbance value of a reaction system before adding a medicament; a2 is the absorbance value of the system after OH is removed from the sample; a3 is the absorbance value of the system after the blank control is cleared of OH.
TABLE 3
Figure BDA0002234785960000102
Figure BDA0002234785960000111
As can be seen from table 3, compared with the comparative example, the composition of the example has a higher hydroxyl radical scavenging rate, which indicates that the efficacy of the composition is significantly better than that of a single component, the composition of the present invention has a hydroxyl radical scavenging rate of over 79%, wherein the composition prepared in example 1 has the highest scavenging rate of 96.24%, which proves that the ratio of each functional component of the skin brightening composition of the present invention is more scientific and reasonable, has a synergistic effect, and can play a role in improving skin health cycle and scavenging free radicals in vivo, thereby achieving a skin brightening effect more durably and effectively.
Test example 3
In vitro weighing method moisturizing performance test research
The principle of the in vitro weighing method for testing the moisture retention performance is as follows: according to the difference of moisture absorption and retention performances of different components, the acting force of different humectant molecules on water molecules is different, and the capacities of absorbing and retaining water are different. The adhesive tape is used for simulating biological materials such as cuticle and the like, the adhesive tape is coated with the humectant and placed for a period of time under the conditions of constant temperature and constant humidity, the mass of the sample placed for different periods of time is weighed, and the moisture retention rate of the sample can be calculated, so that the moisture retention performance of the sample can be evaluated.
The skin lightening compositions prepared according to examples 1-7 above and the compositions prepared according to comparative examples 1-8 were tested using a cosmetic conventional high performance humectant glycerin as a control sample. The test was as follows:
1. experimental procedure
Glycerin, the skin lightening compositions prepared in examples 1 to 7 and 0.2000g of the compositions prepared in comparative examples 1 to 8 were weighed, respectively, and uniformly coated on a 5cm by 5cm glass plate to which a microporous vent tape was attached, respectively, and the glass plate was placed in a constant temperature and humidity dryer, and the mass of the glass plate after being left for 4 hours and 8 hours was measured, respectively, and the moisture retention rate was calculated.
The moisture retention rate calculation formula is as follows:
moisture retention rate inhibition rate/% = (M) 2 -M 0 )/(M 1 -M 0 )×100％
Wherein M is 0 Is the mass/g, M, of the glass sheet 1 For the mass/g, M of the glass plate after sample application 2 The glass sheet mass/g after standing in the desiccator for several hours.
2. Results of the experiment
The results of the in vitro weighing method for determining the moisturizing rates of the skin lightening compositions prepared in examples 1 to 7 of the present invention, the compositions prepared in comparative examples 1 to 8, and the glycerin as a control sample are shown in the following table 4:
TABLE 3
Figure BDA0002234785960000121
Figure BDA0002234785960000131
As can be seen from table 3, the skin lightening compositions prepared in examples 1 to 7 all have higher moisturizing rates at 4h and 8h, and are all above 19%, and the moisturizing effect is stable; the moisturizing rates of the skin brightening compositions prepared in examples 1 to 7 at 4h and 8h are higher than those of glycerin, which shows that the moisturizing performance of the skin brightening composition is superior to that of the traditional high-efficiency moisturizing agent glycerin, and the skin brightening composition has an excellent moisturizing effect. Meanwhile, the experimental results show that the extracts prepared in comparative examples 1 to 8 have a moisturizing rate of 4h,8h lower than that of the skin brightening composition described in the present application, and a moisturizing effect less stable than that of the skin brightening composition described in the present application, which indicates that the components of the traditional Chinese medicine composition of the present invention cooperate with each other to exert a synergistic effect so as to exert effects on moisturizing and nourishing skin, thereby achieving the effect of skin brightening more durably and effectively.
Application example 1
Skin lightening creams prepared using the skin lightening composition prepared in example 1 of the present invention were prepared from the components in the mass percentages indicated in table 4 (i.e. the numbers in the table represent the weight percentage, for example 1 for 1%).
TABLE 4
Figure BDA0002234785960000141
The preparation method comprises the following steps:
(1) Adding the component A into an emulsifying pot, and stirring and dissolving the component A uniformly at 80 ℃;
(2) Adding the component B into an oil phase pot, and stirring and dissolving the component B uniformly at 80 ℃;
(3) Adding the component B into an emulsifying pot at 80 ℃, homogenizing and emulsifying at 9000rpm for 3 minutes, and keeping the temperature for 10 minutes;
(4) Cooling to 50 ℃, adding the component C into an emulsifying pot, and stirring and dissolving uniformly;
(5) Cooling to room temperature, and defoaming in vacuum to obtain the skin-brightening cream.
Application example 2
The same as application example 1, except that the skin glow composition prepared in example 1 in the C component was replaced with the skin glow composition prepared in example 2, and the contents of other components and the preparation method were not changed.
Application example 3
The same as in application example 1, except that the skin glow composition prepared in example 1 in the C component was replaced with the skin glow composition prepared in example 3, and the contents of other components and the preparation method were not changed.
Application example 4
The same as in application example 1, except that the skin glow composition prepared in example 1 in the C component was replaced with the skin glow composition prepared in example 4, and the contents of other components and the preparation method were not changed.
Application example 5
The same as in application example 1, except that the skin glow composition prepared in example 1 in the C component was replaced with the skin glow composition prepared in example 5, and the contents of other components and the preparation method were not changed.
Application example 6
The same as in application example 1, except that the skin glow composition prepared in example 1 in the C component was replaced with the skin glow composition prepared in example 6, and the contents of other components and the preparation method were not changed.
Application example 7
The same as in application example 1, except that the skin glow composition prepared in example 1 was replaced with the skin glow composition prepared in example 7 in the C component, and the contents of other components and the preparation method were not changed.
Application comparative example 1
The same as in application example 1, except that the skin lightening composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 1, and the contents of other components and the preparation method were not changed.
Comparative application example 2
The same as in application example 1, except that the skin lightening composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 2, and the contents of other components and the preparation method were not changed.
Comparative application example 3
The same as in application example 1, except that the skin lightening composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 3, and the contents of other components and the preparation method were not changed.
Application comparative example 4
The same as application example 1 except that the skin glow composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 4, and the contents of other components and the preparation method were not changed.
Comparative application example 5
The same as in application example 1, except that the skin lightening composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 5, and the contents of other components and the preparation method were not changed.
Comparative application example 6
The same as in application example 1, except that the skin lightening composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 7, and the contents of other components and the preparation method were not changed.
Application comparative example 7
The same as application example 1 except that the skin glow composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 7, and the contents of other components and the preparation method were not changed.
Comparative application example 8
The same as in application example 1, except that the skin lightening composition prepared in example 1 in the C component was replaced with the composition prepared in comparative example 8, and the contents of other components and the preparation method were not changed.
Test example 4
Measurement of depigmenting ability
150 volunteers with healthy skin and no allergy history of skin care products are selected and divided into 15 groups, 10 persons in each group are respectively coated with the skin brightening cream prepared in application examples 1-7 and the cream prepared in application comparative examples 1-8. It is applied in the morning and evening for 2 months, and can be prevented from being washed off by water after application. The melanin content in the skin was examined with MX18 skin melanin tester before use and after every 1 week, respectively.
The rate of change of skin melanin was calculated as follows: melanin reduction rate = (1-skin melanin content measured after sample application/skin melanin content measured before sample application) × 100%, and the melanin reduction rate test results of the skin-lightening cream prepared in application examples 1 to 7 applied and the cream prepared in application comparative examples 1 to 8 are shown in table 5.
TABLE 5
Figure BDA0002234785960000171
Figure BDA0002234785960000181
As can be seen from the test data in table 5, each application example and each application comparative example have an average melanin reduction effect, and the melanin reduction rate of the application examples is higher, and after 8 weeks of use, the melanin reduction rate is over 13.42%, so that the melanin reduction effect of the skin lightening composition added into cosmetics is better than that of a composition with a single component or without any active component on the whole, which indicates that the four active components of the skin lightening composition cooperate with each other, and after synergistic interaction, the skin lightening composition can play a role in improving pigmentation, so that the skin lightening effect is more durably and effectively achieved.
Test example 5
Consumer sensory evaluation test
In order to evaluate the actual using effect of the skin brightening composition, the skin brightening cream prepared in application examples 1-7, the cream prepared in application comparative examples 1-8 and the commercially available skin care cream with the effects of resisting oxidation and brightening skin color are taken as test samples, 320 volunteers are selected for sensory evaluation test and divided into 16 groups, 20 people in each group are respectively tested, the test items are the brightening skin color, the lightening pigment, the mildness and the overall effect evaluation of the product, the test items are respectively used for 1 time in the morning and at night every day, the test period is 2 months, and the test values indicate the number of volunteer subjects which can recognize the corresponding product. The test results are shown in table 6:
TABLE 6
Sample (I) Brightening skin color Pigment desalination Mildness property General evaluation
Application example 1 17 14 16 18
Application example 2 16 15 15 16
Application example 3 10 11 15 14
Application example 4 13 12 14 15
Application example 5 15 10 16 16
Application example 6 12 14 11 14
Application example 7 15 10 13 15
Application comparative example 1 5 3 2 5
Comparative application example 2 1 2 2 2
Comparative application example 3 5 4 6 5
Application comparative example 4 2 4 4 3
Comparative application example 5 5 3 4 5
Comparative application example 6 8 4 5 6
Comparative application example 7 6 4 6 5
Comparative application example 8 8 4 6 7
Commercially available product 9 11 8 10
As can be seen from the test results in table 4, the results of sensory evaluation of the skin-lightening cream prepared in application examples 1 to 7, the cream prepared in application comparative examples 1 to 8, and the commercially available skin-care cream with antioxidant and skin color-lightening effects show that the cream added with the skin-lightening composition of the present invention has higher evaluation, and simultaneously, the cream has higher mildness in addition to the skin-lightening effect, and does not cause adverse effects on the skin. In summary, the use effect of the cream added with the skin brightening composition is better, and the use angle of consumers further verifies that the skin brightening composition plays a role in four aspects of improving the healthy circulation of skin, clearing free radicals in vivo, improving pigmentation and moisturizing skin through the synergistic interaction of all functional components, so that the skin brightening effect is achieved more durably and effectively.
According to the evaluation results, the skin brightening composition disclosed by the invention achieves a more remarkable skin brightening effect than a single component through scientific proportioning of the functional components. The actual use of consumers proves that the composition has the obvious and excellent effects of brightening the skin color and lightening the pigment, and compared with similar products sold in the market, the consumer acceptance degree is higher.
The applicant states that the present invention is illustrated by the above examples to show the skin lightening composition of the present invention, the preparation method and the application thereof, but the present invention is not limited to the above examples, that is, it does not mean that the present invention must be implemented by the above examples. It will be apparent to those skilled in the art that any modification of the present invention, equivalent substitutions of selected materials and additions of auxiliary components, selection of specific modes and the like, which are within the scope and disclosure of the present invention, are contemplated by the present invention.

Claims (8)

1. The skin brightening composition with the hydroxyl radical clearance rate of more than 96.24 percent is characterized by comprising the following components in percentage by weight: 8-10% of hop extract, 52-55% of nicotinamide, 12-15% of anthocyanin and the balance of rose water; the anthocyanin is grape anthocyanin;
the mass percentage concentration of the rose essential oil in the rose water is 0.01-0.1%;
the skin lightening composition is prepared by the following method:
adding flos Lupuli extract, anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing at 20-40 deg.C for 10-30min, and making into the skin brightening composition.
2. The skin rejuvenating composition as defined in claim 1, wherein the rose essential oil is present in the rose water at a concentration of 0.02 to 0.03% by weight.
3. A method of making a skin lightening composition according to any one of claims 1 to 2, wherein the method of making is: adding flos Lupuli extract, anthocyanin and nicotinamide into flos Rosae Rugosae water, mixing at 20-40 deg.C for 10-30min, and making into the skin brightening composition.
4. Use of a skin lightening composition according to any one of claims 1 to 2 in the preparation of a cosmetic product.
5. A cosmetic comprising the skin lightening composition of any one of claims 1 to 2.
6. The cosmetic of claim 5, wherein the skin lightening composition is added in an amount of 0.1 to 10% by weight of the total weight of the cosmetic.
7. The cosmetic of claim 5, wherein the skin lightening composition is added in an amount of 1 to 5% by weight of the total weight of the cosmetic.
8. The cosmetic according to claim 5, wherein the cosmetic comprises a lotion, essence, skin care emulsion, skin cream, skin gel, mask or foundation.
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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN106389194A (en) * 2016-09-05 2017-02-15 上海萧雅生物科技股份有限公司 Double-layer spray essence with efficacies of preserving moisture, brightening skin and weakening wrinkles and preparation method of double-layer spray essence

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EP2853254B1 (en) * 2013-09-26 2017-11-08 Symrise AG A composition for lightening skin and/or hair
CN106691909A (en) * 2015-11-14 2017-05-24 威海高科医疗设备有限公司 Composition formula of rose mask
CN105902423A (en) * 2016-04-15 2016-08-31 欧标（广州）化妆品有限公司 Whitening mask composition for uniformizing skin color and brightening skin

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Publication number Priority date Publication date Assignee Title
CN106389194A (en) * 2016-09-05 2017-02-15 上海萧雅生物科技股份有限公司 Double-layer spray essence with efficacies of preserving moisture, brightening skin and weakening wrinkles and preparation method of double-layer spray essence

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