CN110584110A - Anti-hair loss nutritional composition and preparation method and application thereof - Google Patents
Anti-hair loss nutritional composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN110584110A CN110584110A CN201910840074.9A CN201910840074A CN110584110A CN 110584110 A CN110584110 A CN 110584110A CN 201910840074 A CN201910840074 A CN 201910840074A CN 110584110 A CN110584110 A CN 110584110A
- Authority
- CN
- China
- Prior art keywords
- nutritional composition
- vitamin
- extract
- parts
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 98
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 75
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 230000003656 anti-hair-loss Effects 0.000 title description 3
- 201000004384 Alopecia Diseases 0.000 claims abstract description 61
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 58
- 231100000360 alopecia Toxicity 0.000 claims abstract description 45
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims abstract description 31
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 31
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 31
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 31
- 239000011710 vitamin D Substances 0.000 claims abstract description 31
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 31
- 229940046008 vitamin d Drugs 0.000 claims abstract description 31
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 29
- 235000019393 L-cystine Nutrition 0.000 claims abstract description 29
- 239000004158 L-cystine Substances 0.000 claims abstract description 29
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 29
- 229960003067 cystine Drugs 0.000 claims abstract description 29
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 29
- 239000011718 vitamin C Substances 0.000 claims abstract description 29
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 10
- 229930195729 fatty acid Natural products 0.000 claims abstract description 10
- 239000000194 fatty acid Substances 0.000 claims abstract description 10
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 10
- 230000003676 hair loss Effects 0.000 claims abstract description 8
- 208000024963 hair loss Diseases 0.000 claims abstract description 8
- 235000018102 proteins Nutrition 0.000 claims abstract description 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 8
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 58
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 28
- 238000005303 weighing Methods 0.000 claims description 26
- 238000010298 pulverizing process Methods 0.000 claims description 22
- 238000007873 sieving Methods 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 17
- 244000116484 Inula helenium Species 0.000 claims description 16
- 235000002598 Inula helenium Nutrition 0.000 claims description 16
- 238000002791 soaking Methods 0.000 claims description 15
- 229960004329 metformin hydrochloride Drugs 0.000 claims description 13
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims description 13
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 235000021323 fish oil Nutrition 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 10
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 6
- 108010073771 Soybean Proteins Proteins 0.000 claims description 6
- 108010046377 Whey Proteins Proteins 0.000 claims description 6
- 102000007544 Whey Proteins Human genes 0.000 claims description 6
- 235000021119 whey protein Nutrition 0.000 claims description 6
- 238000002137 ultrasound extraction Methods 0.000 claims description 4
- 108010076119 Caseins Proteins 0.000 claims description 3
- 239000005018 casein Substances 0.000 claims description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 3
- 235000021240 caseins Nutrition 0.000 claims description 3
- 244000272264 Saussurea lappa Species 0.000 claims description 2
- 235000006784 Saussurea lappa Nutrition 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 229940001941 soy protein Drugs 0.000 claims description 2
- 102000011632 Caseins Human genes 0.000 claims 1
- 235000018343 nutrient deficiency Nutrition 0.000 abstract description 15
- 230000012010 growth Effects 0.000 abstract description 11
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 210000003780 hair follicle Anatomy 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 6
- 235000015097 nutrients Nutrition 0.000 abstract description 5
- 238000011161 development Methods 0.000 abstract description 4
- 230000009982 effect on human Effects 0.000 abstract description 4
- 210000000952 spleen Anatomy 0.000 abstract description 4
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000036528 appetite Effects 0.000 abstract description 2
- 235000019789 appetite Nutrition 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 230000029087 digestion Effects 0.000 abstract description 2
- 235000015816 nutrient absorption Nutrition 0.000 abstract description 2
- 230000033116 oxidation-reduction process Effects 0.000 abstract description 2
- 230000011712 cell development Effects 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 210000004209 hair Anatomy 0.000 description 45
- 238000012360 testing method Methods 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 11
- 102000004506 Blood Proteins Human genes 0.000 description 10
- 108010017384 Blood Proteins Proteins 0.000 description 10
- 208000002720 Malnutrition Diseases 0.000 description 10
- 102000001554 Hemoglobins Human genes 0.000 description 9
- 108010054147 Hemoglobins Proteins 0.000 description 9
- 239000000706 filtrate Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 206010067482 No adverse event Diseases 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 239000002932 luster Substances 0.000 description 6
- 102000004407 Lactalbumin Human genes 0.000 description 5
- 108090000942 Lactalbumin Proteins 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 230000003779 hair growth Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 235000019710 soybean protein Nutrition 0.000 description 4
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 229960004039 finasteride Drugs 0.000 description 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010024419 Libido decreased Diseases 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 201000002996 androgenic alopecia Diseases 0.000 description 1
- 230000004900 autophagic degradation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000004190 glucose uptake Effects 0.000 description 1
- -1 heat Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000006286 nutrient intake Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a nutritional composition for preventing alopecia, a preparation method and an application thereof, wherein the nutritional composition comprises the following components in parts by weight: radix aucklandiae extract, protein, fatty acid, L-cystine, vitamin C, and vitamin D; wherein vitamin D prevents hair loss due to reduced cell differentiation and reduced follicle growth; fatty acids can increase nutrient absorption by hair follicles; l-cystine can promote the oxidation-reduction capability of organism cells, promote cell growth and development and prevent the development of pathogenic bacteria; the abundant substances such as the taxus chinensis, the cholamine, the costustoot and the like in the costustoot extract can strengthen spleen and promote digestion, activate spleen and stimulate appetite, and promote the absorption of various nutrient substances, so the nutrient composition provided by the invention can effectively solve the alopecia caused by nutrient deficiency by optimizing and limiting various components, and has no toxic or side effect on human bodies.
Description
Technical Field
The invention relates to the technical field of foods, and particularly relates to a nutritional composition for preventing alopecia, and a preparation method and application thereof.
Background
With the continuous acceleration of the pace of life and work of people and unhealthy life style, the phenomenon of alopecia is more and more common. Studies have shown that factors causing alopecia mainly include: genetic, mental stress, overwork, chronic insomnia, nutritional deficiencies, etc., and hair loss caused by frequent hair dyeing, chronic exposure to chemical drugs, physical radiation, etc. The hair loss has more and more influence on the life of people, and the hair loss patient bears the pressure on life and psychology at the same time, thereby influencing the quality of life to a great extent.
The alopecia is generally divided into seborrheic alopecia and alopecia caused by nutritional deficiency, wherein the seborrheic alopecia, also called androgenetic alopecia, is more common for male patients, and researches show that the alopecia is related to the level of male hormones in vivo, mainly because testosterone secreted by testis reaches hair bulb cells in hair follicles along with blood circulation and enters cytoplasm through cell membranes, while 5 alpha-reductase in cytoplasm reacts with testosterone to generate DHT, and the DHT enters into cell nucleus and acts on the metabolic system of cells, so that the growth period of the hair is shortened, and the hair enters into the resting period in advance, and further the alopecia is caused; alopecia caused by nutritional deficiency is mainly caused by insufficient nutrient intake due to irregular diet or long-term bad working and resting habits, for example, the deficiency of nutrient substances such as protein, heat, vitamins and trace elements can affect the biochemistry, energy metabolism, immunity and repair of hair follicles, and further cause alopecia.
At present, many research reports on products for treating alopecia are reported, but most of the products aim at seborrheic alopecia, for example, the most commonly used medicines for treating seborrheic alopecia at present comprise minoxidil and finasteride, through long-term clinical application, although the medicines have good effects, the side effects are many, the applicable population is few, and the medicines can be used in large quantities for a long time, women use finasteride to cause high risk of embryonic congenital malformation, and men use the medicines to cause side effects such as hyposexuality, impotence and the like; chinese patent document CN102000153B discloses a hair growth promoting solution, which has a certain effect on alopecia caused by seborrheic alopecia, but cannot solve alopecia caused by nutritional deficiency.
Disclosure of Invention
Therefore, the invention aims to overcome the defects that the product for treating alopecia in the prior art has toxic and side effects and cannot effectively treat alopecia caused by nutrient deficiency, and provides the alopecia-preventing nutritional composition, the preparation method and the application thereof, which can effectively solve alopecia caused by nutrient deficiency and have no toxic and side effects on human bodies.
Therefore, the invention provides the following technical scheme:
the alopecia-preventing nutritional composition comprises the following components in parts by weight: 1-3 parts of costustoot extract, 10-20 parts of protein, 10-20 parts of fatty acid, 3-5 parts of L-cystine, 0.1-0.2 part of vitamin C and 0.001-0.05 part of vitamin D.
Preferably, the nutritional composition further comprises 2-6 parts of metformin hydrochloride.
Preferably, the nutritional composition comprises the following components in parts by weight: 2-6 parts of metformin hydrochloride, 1-2 parts of costustoot extract, 16-20 parts of protein, 10-15 parts of fatty acid, 3-4 parts of L-cystine, 0.1-0.2 part of vitamin C and 0.02-0.05 part of vitamin D.
Wherein the protein is at least one of whey protein, casein and soybean protein.
The fatty acid is fish oil and/or rapeseed oil.
The invention also provides a preparation method of the alopecia preventing nutritional composition, which comprises the following steps:
preparation of an elecampane extract: pulverizing radix aucklandiae, soaking, extracting, filtering, concentrating, and drying to obtain radix aucklandiae extract;
crushing and sieving: pulverizing radix aucklandiae extract, and sieving with 10-50 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing costustoot extract powder and other components according to selected parts for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine to obtain a mixture;
total mixing: mixing the above mixture with the rest components to obtain the nutritional composition;
wherein, the soaking in the preparation step of the costustoot extract refers to adding isopropanol and ethanol with volume fraction of 70-90% into the ground costustoot powder and soaking for 12-24 h; wherein the mass volume ratio of the costustoot powder to the added ethanol and isopropanol is 1-2 g: 5-10 ml: 2-5 ml.
The preparation step of the costus root extract adopts ultrasonic extraction; the mixing humidity in the premixing step and the total mixing step is 45-65%.
The power of ultrasonic extraction is 250-300W, the frequency is 40000-50000Hz, and the time is 10-25 min.
The mixing time in the premixing step and the total mixing step is 20-35min, and the mixing frequency is 12-30 rpm.
The invention also provides application of the anti-alopecia nutritional composition or the nutritional composition prepared by the preparation method of the anti-alopecia nutritional composition in preventing and treating nutritional alopecia.
The technical scheme of the invention has the following advantages:
1. the vitamin D in the anti-alopecia nutritional composition provided by the invention can effectively prevent alopecia caused by differentiation of keratinocytes and slow growth of hair follicles; the fatty acid is helpful for increasing nutrient absorption of hair follicle and promoting hair growth; l-cystine can promote the oxidation reduction capability of organism cells, promote the growth and development of the cells, and prevent the development of pathogenic bacteria; the abundant substances such as the taxus chinensis, the cholamine, the costustoot and the like in the costustoot extract can strengthen spleen and promote digestion, activate spleen and stimulate appetite, and promote the absorption of various nutrient substances, so the nutrient composition provided by the invention can effectively solve the alopecia caused by nutrient deficiency and has no toxic or side effect on human bodies by adding the costustoot extract and optimizing and limiting various components.
2. The metformin hydrochloride added into the anti-hair loss nutritional composition provided by the invention can activate protein kinase AMPK, so that the activity of AMPK substrate acetyl coenzyme A carboxylase is reduced, the oxidation of fatty acid is increased, the synthesis of fat is inhibited, the glucose uptake of skeletal muscle is promoted, the autophagy effect is enhanced, and then hair follicles in a dormant period are activated to promote the growth of hair; the metformin hydrochloride combined composition can effectively solve the problem of alopecia caused by nutrient deficiency and has no toxic or side effect on human bodies.
3. According to the preparation method of the alopecia preventing nutritional composition, provided by the invention, the costustoot is extracted in the mixed solvent of ethanol and isopropanol, so that more effective components are extracted, alopecia caused by lack of nutrition can be effectively solved, and no toxic or side effect is caused to a body.
4. According to the preparation method of the alopecia-preventing nutritional composition, provided by the invention, the elecampane is extracted in an ultrasonic manner, so that the operation is simple, the extraction time is short, and heating is not required; moreover, the effective components of the traditional Chinese medicine are extracted more fully, the alopecia caused by lack of nutrition can be effectively solved, and the traditional Chinese medicine has no toxic or side effect on human bodies.
Detailed Description
The following examples are provided to further understand the present invention, not to limit the scope of the present invention, but to provide the best mode, not to limit the content and the protection scope of the present invention, and any product similar or similar to the present invention, which is obtained by combining the present invention with other prior art features, falls within the protection scope of the present invention.
The examples do not show the specific experimental steps or conditions, and can be performed according to the conventional experimental steps described in the literature in the field. The reagents or instruments used are not indicated by manufacturers, and are all conventional reagent products which can be obtained commercially.
Metformin hydrochloride in this example was purchased from Shanghai Ji to Biochemical technology, Inc.
Example 1
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 500ml and isopropanol 200ml, soaking for 12 hr, extracting with ultrasonic wave of 250W and 50000Hz for 20min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 10 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 4g of metformin hydrochloride, 3g of costustoot extract, 10g of lactalbumin, 20g of fish oil, 3g of L-cystine, 0.1g of vitamin C and 0.05g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at the frequency of 12rpm for 20min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at humidity of 50% and frequency of 12rpm for 20min to obtain the nutritional composition.
Example 2
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 1000ml and isopropanol 500ml, soaking for 24 hr, extracting with ultrasonic wave of 300W and 40000Hz for 10min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 50 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 6g of metformin hydrochloride, 2g of elecampane extract, 16g of casein, 15g of rapeseed oil, 4g of L-cystine, 0.2g of vitamin C and 0.02g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at 30rpm for 35min under the condition that the humidity is 45% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at 30rpm under humidity of 45% for 35min to obtain the nutritional composition.
Example 3
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 70% ethanol 250ml and isopropanol 300ml, soaking for 24 hr, extracting with 300W, 50000Hz ultrasonic wave for 25min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 30 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 2g of metformin hydrochloride, 1g of costustoot extract, 20g of soybean protein, 10g of fish oil, 5g of L-cystine, 0.2g of vitamin C and 0.001g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at a frequency of 20rpm for 25min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at 20rpm under humidity of 50% for 25min to obtain the nutritional composition.
Example 4
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 500ml and isopropanol 400ml, soaking for 24 hr, extracting with ultrasonic wave of 250W and 50000Hz for 25min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 40 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 5g of metformin hydrochloride, 2g of elecampane extract, 10g of whey protein, 5g of soybean protein, 6g of fish oil, 6g of rapeseed oil, 3g of L-cystine, 0.1g of vitamin C and 0.006g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at a frequency of 20rpm for 25min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at 20rpm under humidity of 50% for 25min to obtain the nutritional composition.
Example 5
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 500ml and isopropanol 350ml, soaking for 24 hr, extracting with ultrasonic wave of 250W and 50000Hz for 12min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 40 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 3g of metformin hydrochloride, 1g of elecampane extract, 10g of whey protein, 5g of soybean protein, 6g of fish oil, 6g of rapeseed oil, 3g of L-cystine, 0.1g of vitamin C and 0.006g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at a frequency of 20rpm for 25min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at 20rpm under humidity of 50% for 25min to obtain the nutritional composition.
Example 6
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 500ml and isopropanol 200ml, soaking for 12 hr, extracting with ultrasonic wave of 250W and 50000Hz for 20min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 10 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 3g of costustoot extract, 10g of lactalbumin, 20g of fish oil, 3g of L-cystine, 0.1g of vitamin C and 0.05g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at the frequency of 12rpm for 20min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at humidity of 50% and frequency of 12rpm for 20min to obtain the nutritional composition.
Example 7
The present example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 500ml and isopropanol 350ml, soaking for 24 hr, extracting with ultrasonic wave of 250W and 50000Hz for 12min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 40 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 1g of elecampane extract, 10g of lactalbumin, 5g of soy protein, 6g of fish oil, 6g of rapeseed oil, 3g of L-cystine, 0.1g of vitamin C and 0.006g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at a frequency of 20rpm for 25min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at 20rpm under humidity of 50% for 25min to obtain the nutritional composition.
Comparative example 1
The present comparative example provides a nutritional composition and a method of making the same.
Weighing: weighing 10g of whey protein, 20g of fish oil, 3g of L-cystine, 0.1g of vitamin C and 0.05g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at the frequency of 12rpm for 20min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at humidity of 50% and frequency of 12rpm for 20min to obtain the nutritional composition.
Comparative example 2
The present comparative example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g of radix aucklandiae, adding 90% ethanol 500ml and isopropanol 200ml, soaking for 12 hr, extracting under shaking twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 10 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 3g of costustoot extract, 10g of lactalbumin, 20g of fish oil, 3g of L-cystine, 0.1g of vitamin C and 0.05g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at the frequency of 12rpm for 20min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at humidity of 50% and frequency of 12rpm for 20min to obtain the nutritional composition.
Comparative example 3
The present comparative example provides a nutritional composition and a method of making the same.
Weighing: weighing 4g of metformin hydrochloride, 10g of whey protein, 20g of fish oil, 3g of L-cystine, 0.1g of vitamin C and 0.05g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at the frequency of 12rpm for 20min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at humidity of 50% and frequency of 12rpm for 20min to obtain the nutritional composition.
Comparative example 4
The present comparative example provides a nutritional composition and a method of making the same.
Preparation of an elecampane extract: pulverizing 100g radix aucklandiae, adding 90% ethanol 500ml and isopropanol 200ml, soaking for 12 hr, extracting with ultrasonic wave of 250W and 50000Hz for 20min, filtering, extracting twice, mixing filtrates, concentrating, and drying at room temperature to obtain radix aucklandiae extract;
crushing and sieving: pulverizing the radix aucklandiae extract, and sieving with 10 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing 3g of costustoot extract, 10g of lactalbumin, 20g of fish oil, 3g of L-cystine, 0.1g of vitamin C and 0.05g of vitamin D for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine at the frequency of 12rpm for 20min under the condition that the humidity is 50% to obtain a mixture;
total mixing: mixing the above mixture and the rest components at humidity of 50% and frequency of 12rpm for 20min to obtain the nutritional composition.
Experimental examples this experimental example demonstrates the beneficial effects of the present invention in combination with clinical experimental data:
770 nutritional alopecia patients are selected from alopecia patients in the doctor of Beijing Hongqi traditional Chinese medicine hospital, and the selection criteria are as follows: after the total serum protein and hemoglobin contents in the blood examination are lower than the normal value range, 770 patients are randomly divided into seven treatment groups and four control groups, wherein each group comprises 70 patients, wherein 260 men and 230 women in the treatment groups are treated; the average age is 20-65 years old, the average age is 35 years old, and the area of alopecia is 3.1-8.5cm2(ii) a Male in control group155, women 125; age 22-63 years, mean 32 years; the area of the alopecia is 1.8-7.9cm2。
Grouping: treatment group 1 was treated with the nutritional composition prepared in example 1, treatment group 2 was treated with the nutritional composition prepared in example 2, treatment group 3 was treated with the nutritional composition prepared in example 3, treatment group 4 was treated with the nutritional composition prepared in example 4, treatment group 5 was treated with the nutritional composition prepared in example 5, treatment group 6 was treated with the nutritional composition prepared in example 6, treatment group 7 was treated with the nutritional composition prepared in example 7, control group 1 was treated with the nutritional composition prepared in comparative example 1, control group 2 was treated with the nutritional composition prepared in comparative example 2, control group 3 was treated with the nutritional composition prepared in comparative example 3, and control group 4 was treated with the nutritional composition prepared in comparative example 4.
The treatment method comprises the following steps: 5g each time, and is taken once a day, morning and evening, and 1.5 months is a treatment course.
The observation method comprises the following steps: after 3 months, the area change of the alopecia area and the hair growth condition of the patient are observed and recorded in detail by a specialist, and the adverse reaction condition of the patient is recorded.
The curative effect standard is as follows: after the hair is healed, new hairs grow out completely, the distribution density, the hair thickness and the color are the same as those of normal hair, and the light-drawing test is negative; the effect is shown, new hairs grow by more than 50 percent, more vellus hairs become terminal hairs, and the light-drawing test is negative; effective, new hairs grow more than 10% (including vellus hairs), but grow slowly, and are negative or positive in the light pull test; no new growth, no new growth or less than 10% new growth or shedding while growing. The light-pulling test is to grasp some hairs in the alopecia area or the alopecia marginal area and observe the hair loss amount by lightly pulling the hairs with fingers. Usually 1-2 hairs are fallen out once, if 3-10 hairs are fallen out once, the hairs are positive; the light pull test was performed on day 3 after shampooing.
TABLE 1 treatment groups and control group data
Adverse reactions: no adverse reaction is seen in patients in the seven treatment groups during the treatment process, and no abnormality is found in blood routine, urine routine, liver and kidney functions before and at the end of the treatment.
As can be seen from the data in table 1 above, the nutritional composition of the present invention has a significant effect on nutritional deficiency alopecia and is non-toxic to human body.
Typical cases are:
a certain Liu, male, 49 years old, is treated in 11 months in 2017, the total serum protein content in blood examined by a patient after the treatment is 50g/L, the hemoglobin content is 90g/L, and the total serum protein content and the hemoglobin content are all lower than the normal value range, the doctor judges that the nutritional deficiency alopecia is caused, and after 1 month of continuous treatment, the patient newly grows more than 59 percent (including vellus hairs) by using the nutritional composition described in example 1 every morning and evening and 5g every day, and the patient is observed by a specialist, but the slight-pulling test is negative; after the patient insists on the treatment for 2 courses of treatment, new hairs of the patient all grow out, the distribution density, the hair thickness and the color and luster are the same as those of normal hairs, and the light-pulling test is negative; and the whole treatment process has no adverse reaction.
After a certain Wang, a woman in 36 years old is treated in 2017 for 6 months, the total serum protein content in blood examined by a patient after the treatment is 51g/L, the hemoglobin content is 86g/L, and the ranges are all lower than normal values, and the doctor judges that nutritional deficiency alopecia is caused, and uses the nutritional composition described in example 3, the hair grows for more than 56% newly in the morning and evening every day and 5g every time after continuous treatment for 2 months, and the hair becomes terminal hair after observation of a specialist, and the mild-drawing test is negative; after the patient insists on the treatment for 2 courses of treatment, new hairs of the patient all grow out, the distribution density, the hair thickness and the color and luster are the same as those of normal hairs, and the light-pulling test is negative; and the whole treatment process has no adverse reaction.
In Song Dynasty, male, age 32, the patient was treated in 2016 at 9 months, the total serum protein content in the blood was 46g/L and the hemoglobin content was 100g/L, both of which were lower than the normal range, and the patient was judged by the doctor to be nutritional deficiency alopecia, and after 1 month of continuous treatment, the patient had new growth of 41% (including vellus hair) and had slow growth, and a gentle-drawing test was negative, with the nutritional composition described in example 3, once every morning and evening and 5g each time; after the patient insists on the treatment for 3 courses of treatment, new hairs of the patient all grow out, the distribution density, the hair thickness and the color and luster are the same as those of normal hairs, and the light-pulling test is negative; and the whole treatment process has no adverse reaction.
Zhengqi a male, 25 years old, and the patient is diagnosed 6 months in 2018, the total serum protein content in blood examined after the patient is diagnosed is 49g/L, the hemoglobin content is 101g/L, which are all lower than the normal value range, the doctor judges that the nutrition-deficient alopecia is caused, the nutrition composition described in example 2 is used, 5g is performed each time in the morning and evening every day, after 2 months of continuous treatment, the observation of a specialist shows that the new hair grows by more than 58%, and the mild-pulling test is negative; after the patient insists on the treatment for 3 courses of treatment, new hairs of the patient all grow out, the distribution density, the hair thickness and the color and luster are the same as those of normal hairs, and the light-pulling test is negative; and the whole treatment process has no adverse reaction.
When a certain plum, a female, 50 years old, is treated in 2019 for 1 month, the total serum protein content in blood examined by a patient after the treatment is 47g/L, the hemoglobin content is 89g/L, and the total serum protein content and the hemoglobin content are all lower than the normal value range, and the patient is judged to have nutritional deficiency alopecia by a doctor, the nutritional composition described in example 4 is used, the patient has 49% new hair growth (including vellus hair) after 5g treatment for 1.5 months, and the hair growth is slow and is negative in a light-drawing test; after the patient insists on the treatment for 3 courses of treatment, new hairs of the patient all grow out, the distribution density, the hair thickness and the color and luster are the same as those of normal hairs, and the light-pulling test is negative; and the whole treatment process has no adverse reaction.
After a certain populus, a female, aged 46 years, is treated in 2019 for 2 months, the total serum protein content in blood examined by the patient after the treatment is 43g/L, the hemoglobin content is 90g/L, and the total serum protein content is lower than the normal value range, and the doctor judges that the nutritional deficiency alopecia is caused, the nutritional composition described in example 6 is used for treating the patient for 1.5 months continuously, and the patient newly grows for 41 percent (including vellus hairs) in the morning and at night every day, and the growth is slow and the mild-drawing test is negative; after the patient insists on the treatment for 3 courses of treatment, new hairs of the patient all grow out, the distribution density, the hair thickness and the color and luster are the same as those of normal hairs, and the light-pulling test is negative; and the whole treatment process has no adverse reaction.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the spirit or scope of the invention.
Claims (10)
1. The alopecia-preventing nutritional composition is characterized by comprising the following components in parts by weight: 1-3 parts of costustoot extract, 10-20 parts of protein, 10-20 parts of fatty acid, 3-5 parts of L-cystine, 0.1-0.2 part of vitamin C and 0.001-0.05 part of vitamin D.
2. The nutritional composition according to claim 1, further comprising 2 to 6 parts of metformin hydrochloride.
3. The nutritional composition according to claim 1 or 2, wherein the protein is at least one of whey protein, casein protein, soy protein.
4. The nutritional composition according to claim 3, wherein the fatty acid is fish oil and/or rapeseed oil.
5. The nutritional composition according to claim 2, wherein the nutritional composition comprises the following components in parts by weight: 2-6 parts of metformin hydrochloride, 1-2 parts of costustoot extract, 16-20 parts of protein, 10-15 parts of fatty acid, 3-4 parts of L-cystine, 0.1-0.2 part of vitamin C and 0.02-0.05 part of vitamin D.
6. The method for preparing the alopecia preventing nutritional composition as described in any one of claims 1 to 5, comprising the steps of:
preparation of an elecampane extract: pulverizing radix aucklandiae, soaking, extracting, filtering, concentrating, and drying to obtain radix aucklandiae extract;
crushing and sieving: pulverizing radix aucklandiae extract, and sieving with 10-50 mesh sieve to obtain radix aucklandiae extract powder;
weighing: weighing costustoot extract powder and other components according to selected parts for later use;
premixing: mixing the weighed vitamin C, vitamin D and L-cystine to obtain a mixture;
total mixing: mixing the above mixture with the rest components to obtain the nutritional composition;
wherein, the soaking in the preparation step of the costustoot extract refers to adding isopropanol and ethanol with volume fraction of 70-90% into the ground costustoot powder and soaking for 12-24 h; wherein the mass volume ratio of the costustoot powder to the added ethanol and isopropanol is 1-2 g: 5-10 ml: 2-5 ml.
7. The method according to claim 6, wherein the extraction in the step of preparing the extract of saussurea lappa Clarke is ultrasonic extraction; the mixing humidity in the premixing step and the total mixing step is 45-65%.
8. The method as claimed in claim 6, wherein the power of the ultrasonic extraction is 250-300W, the frequency is 40000-50000Hz, and the time is 10-25 min.
9. The method according to any one of claims 6 to 8, wherein the mixing time in the premixing step and the total mixing step is 20 to 35min, and the mixing frequency is 12 to 30 rpm.
10. Use of the nutritional composition for preventing and treating nutritional hair loss, which is prepared by the nutritional composition for preventing and treating hair loss according to any one of claims 1 to 5 or the nutritional composition for preventing and treating hair loss according to any one of claims 6 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910840074.9A CN110584110A (en) | 2019-09-05 | 2019-09-05 | Anti-hair loss nutritional composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910840074.9A CN110584110A (en) | 2019-09-05 | 2019-09-05 | Anti-hair loss nutritional composition and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110584110A true CN110584110A (en) | 2019-12-20 |
Family
ID=68857871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910840074.9A Pending CN110584110A (en) | 2019-09-05 | 2019-09-05 | Anti-hair loss nutritional composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110584110A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207114A1 (en) * | 2004-03-16 | 2007-09-06 | Lg Household & Health Care Ltd. | Hair Growth Agent Composition |
| CN107184892A (en) * | 2017-05-26 | 2017-09-22 | 云南滇药医药健康产业有限公司 | Composition with blood-nourishing black hair effect and preparation method thereof |
-
2019
- 2019-09-05 CN CN201910840074.9A patent/CN110584110A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207114A1 (en) * | 2004-03-16 | 2007-09-06 | Lg Household & Health Care Ltd. | Hair Growth Agent Composition |
| CN107184892A (en) * | 2017-05-26 | 2017-09-22 | 云南滇药医药健康产业有限公司 | Composition with blood-nourishing black hair effect and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 刘矛: "如何防脱发", 《农业知识》 * |
| 卓纳: "维生素D及其受体与毛发的关系", 《中国组织工程研究》 * |
| 柳文敏主编: "《制药工程专业实验》", 31 December 2016 * |
| 赛柏蓝: "《https://www.cn-healthcare.comarticlewm20190630content-1064934.html》", 3 July 2019 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101606706B (en) | Health food prepared from compound bee product raw materials | |
| CN103494199B (en) | Peony seed oil soft capsule with lipid-lowering effect and preparation method thereof | |
| CN102614499B (en) | Yak skin collagen compound traditional Tibetan medicine with anti-fatigue effect and preparation process thereof | |
| CN115678805B (en) | Preparation method and application of tricholoma matsutake yeast fermentation liquor with repairing and anti-aging effects | |
| CN105211651A (en) | Feed feed and the production method thereof of wild boar children pig | |
| KR19990073127A (en) | Process for Producing the Fermented Food using as Health Aid | |
| CN101356975A (en) | Health food capable of increasing human immunity and promoting intelligence and strengthening brain and preparation method thereof | |
| CN110584110A (en) | Anti-hair loss nutritional composition and preparation method and application thereof | |
| CN108125231A (en) | A kind of health food containing ginseng and preparation method thereof | |
| Tussupbekova et al. | The study of hematological parameters of animals in the application of enterosorbent food fiber | |
| CN101637268B (en) | Health-care food having functions of freckle elimination and radiation resistance and preparation method thereof | |
| CN101336705B (en) | Health food and its preparation method | |
| CN106834039A (en) | A kind of preparation method of bletilla striata health liquor | |
| CN110214955B (en) | Composition with function of nourishing ovaries and preparation method thereof | |
| CN110236047A (en) | A kind of ferment drink of slim beauty and preparation method thereof | |
| KR20000036423A (en) | A manufacturing method of mulberry rice | |
| CN106418498A (en) | Method for preparing enzyme by using lemons and galangal as main materials | |
| CN1287837A (en) | Forest forg's sprawn and its application | |
| CN110063504A (en) | A kind of natural dietary fiber replenishers and preparation method thereof with effect for reducing fat | |
| CN110585107A (en) | Wonderful age essence capable of firming skin, moistening skin, beautifying skin and deeply replenishing water and preparation method thereof | |
| CN110250514A (en) | Health food of functions of removing chloasma and preparation method thereof | |
| CN112717074B (en) | Medicated wine for preventing and treating alopecia and preparation method | |
| CN1062174C (en) | Method for preparing animal and plant full natural nutrient solution and its product | |
| CN117427142B (en) | Composition for replenishing blood, replenishing qi, regulating menstruation and maintaining beauty and preparation method thereof | |
| CN112167364B (en) | Nutritional healthy edible oil and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191220 |