CN107184892A - Composition with blood-nourishing black hair effect and preparation method thereof - Google Patents

Composition with blood-nourishing black hair effect and preparation method thereof Download PDF

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Publication number
CN107184892A
CN107184892A CN201710384307.XA CN201710384307A CN107184892A CN 107184892 A CN107184892 A CN 107184892A CN 201710384307 A CN201710384307 A CN 201710384307A CN 107184892 A CN107184892 A CN 107184892A
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CN
China
Prior art keywords
parts
composition
blood
nourishing
black hair
Prior art date
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Pending
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CN201710384307.XA
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Chinese (zh)
Inventor
杨正书
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Yunnan Yunnan Medicine Health Industry Co Ltd
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Yunnan Yunnan Medicine Health Industry Co Ltd
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Priority to CN201710384307.XA priority Critical patent/CN107184892A/en
Publication of CN107184892A publication Critical patent/CN107184892A/en
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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Abstract

The present invention relates to a kind of composition with blood-nourishing black hair effect and preparation method thereof, the raw material components of composition by weight, including：3~5 parts of 1~3 part of ginseng, 0.2~1 part of donkey-hide gelatin, 3~5 parts of sealwort, 3~5 parts of matrimony vine, 1~3 part of Cordyceps militaris, 3~5 parts of jujube, 3~5 parts of Chinese yam, 5~6 parts of mulberry fruit, 1~3 part of rose, 1~3 part of dried orange peel, 0.5~2 part of fructus amomi, 3~5 parts of hawthorn, 3~5 parts of Poria cocos, 1~3 part of mulberry leaf, 5~6 parts of Semen sesami nigrum, 3~5 parts of black rice and black soya bean.The composition that the present invention is provided, it is using traditional Chinese medicine food therapy theory as foundation, it is formulated based on a variety of medicine and food raw materials such as selected ginseng, donkey-hide gelatin, sealwort, matrimony vine, with modern advanced technology, extracts active components of plants and the composition with black hair effect being refining to obtain；Said composition is actually high-end, fashion dietotherapy health-oriented products, and black hair effect is good, and safety has no side effect, and is adapted to long-term consumption.

Description

Composition with blood-nourishing black hair effect and preparation method thereof
Technical field
The present invention relates to hair health care technology field, and in particular to a kind of composition and its system with blood-nourishing black hair effect Preparation Method.
Background technology
Along with the continuous progress of society, the continuous improvement of living standard, people's rhythm of life also becomes increasingly faster, work Make, life stress increases therewith, dietetic life is irregular all the more, easily trigger the exception of hair, such as occur white hair hair too early Disease is sent out, serious influence is brought to work and life.The reason for white hair causes is a lot, mainly includes：Malnutrition, such as lacks Protein, vitamin and some micro- such as copper, can all make hair bleach；Some chronic wasting diseases such as tuberculosis Deng, the nutritional deficiency caused by, hair is also whiter earlier than common people；Some young men in a short time, the big quantitative change of hair In vain, then cause people's with the severe psychiatric wound such as overanxiexty, sadness or the relevant or huge pressure of spiritual fatigue Hair accidentally just bleaches.
With the rapid progress of beauty science, hair can be carried out contaminating black, can quickly cause white hair blackening, but it is right Human body skin has stimulation, while also only serving the effect cured the symptoms, not the disease with toxic side effect.Therefore, people are no longer full Dyeing of the foot by hair dyeing product to hair, and it is desirable to participate in the metabolism of hair by nutriment, pursue science shield Reason；Under the trend of back to nature, people are in the urgent need to the natural dark hair hair blackening product of safety non-toxic.In the market exists a variety of many The product of the medicine for curing poliosis of sample, however, often effect is not notable enough for existing product, or has certain side effect, also The demand of user can not be met.
The content of the invention
For defect of the prior art, present invention aims at provide a kind of composition with blood-nourishing black hair effect and Its preparation method, to improve the black hair effect of composition, shortening has no side effect the time of white hair blackening, and safety, is adapted to length Phase eats.
To achieve the above object, the technical scheme that provides of the present invention is：
In a first aspect, the invention provides a kind of composition with blood-nourishing black hair effect, the raw material components of composition are pressed Parts by weight meter, including：1~3 part of ginseng, 0.2~1 part of donkey-hide gelatin, 3~5 parts of sealwort, 3~5 parts of matrimony vine, 1~3 part of Cordyceps militaris, jujube 3~5 parts, 3~5 parts of Chinese yam, 5~6 parts of mulberry fruit, 1~3 part of rose, 1~3 part of dried orange peel, 0.5~2 part of fructus amomi, 3~5 parts of hawthorn, 3~5 parts of 3~5 parts of Poria cocos, 1~3 part of mulberry leaf, 5~6 parts of Semen sesami nigrum, 3~5 parts of black rice and black soya bean.
In the further embodiment of the present invention, the raw material components of the composition with blood-nourishing black hair effect also include： 3~5 parts of French beans, 3~5 parts of adlay, 3~5 parts of lotus seeds, 1~3 part of rhizoma atractylodis, 1~3 part of Fructus Aurantii, 3~5 parts of the bighead atractylodes rhizome, the banksia rose 0.5~1 1~3 part of part and radix glycyrrhizae.
In the further embodiment of the present invention, the raw material components of the composition with blood-nourishing black hair effect also include： 3~5 parts of 2~3 parts of Polygonum multiflower knotweed, 1~3 part of cortex albiziae, 3~5 parts of rhizoma cyperi and spina date seed.
In the further embodiment of the present invention, the raw material components of the composition with blood-nourishing black hair effect also include： 1~3 part of rhizoma alismatis, 3~5 parts of cultivated land, 3~5 parts of the bark of eucommia, 3~5 parts of Fructus Corni, 1~3 part of moutan bark, 1~3 part of psoralea corylifolia, meat desert 0.5~1 part of 3~5 parts of Rong and Chinese cassia tree.
In the further embodiment of the present invention, the raw material components of the composition with blood-nourishing black hair effect also include： 5~6 parts of the fleece-flower root, 5~6 parts of eclipta, 2~3 parts of the fruit of glossy privet, 5~6 parts of cultivated land, 0.5~1 part of honeysuckle, Semen Cuscutae 3~5 Part, 3~5 parts of the bark of eucommia, 1~3 part of the Fen, Common St.Paulswort Herbs of the fruit of Cherokee rose 1~3,1~3 part of cacumen biotae, 3~5 parts of radix achyranthis bidentatae, 1~3 part of peach kernel With 0.3~1 part of safflower.
The composition that the present invention is provided, has effects that benefiting qi and nourishing blood, enriching yin and nourishing kidney and hair-blackening tonic, available for treatment because The symptom such as soreness and weakness of waist and knees, dizzy tinnitus, poliosis and alopecia caused by insufficiency of vital energy and blood, the deficiency of liver-yin and kidney-yin.Tonifying Qi first in side Medicine ginseng reinforces vital energy, replenished qi to invigorate the spleen, and is equipped with the first medicine donkey-hide gelatin of enriching blood, qi-blood tonifying, is altogether monarch drug in a prescription；Jujube invigorating spleen and reinforcing stomach, benefit Gas blood-nourishing, Chinese yam replenishes qi to invigorate the spleen, and kidney-nourishing supports lung, Poria cocos invigorating spleen to remove dampness, antitoxic heart-soothing and sedative, three's conjunction can help the beneficial spleen of ginseng qi-tonifying it Work(, mulberry fruit yin and blood nourishing, sealwort yin-nourishing tonifying Qi, matrimony vine enriching yin and nourishing kidney, Cordyceps militaris kidney tonifying benefit lung, four things combination can gather donkey-hide gelatin taste The effect that the moon is enriched blood, and energy kidney tonifying, essence replenishing, micro- kidney-replenishing, mean negative and positive with benefit, it is intended to nourish hair, and the collocation of seven things can strengthen people Ginseng, benefiting qi and nourishing blood effect of donkey-hide gelatin, are altogether ministerial drug；Adjuvant hawthorn is promoting blood circulation and removing blood stasis to help blood, digesting and appetizing, dried orange peel promoting the circulation of qi dry Wet, fructus amomi is removed dampness by means of aromatics, and can solve the greasy property of the taste of yin tonics, and mulberry leaf coordinate the numb soup of Semen sesami nigrum composition mulberry, are conducive to strengthening nourishing The work(of liver kidney, while clearing heat and cooling blood, rose soothing liver-qi stagnation is can solve the property of temperate-dryness, and black soya bean, Semen sesami nigrum, black rice priming return kidney, Support black with black, all medicines of monarch are shared, grow and oiliness, mend without dry, negative and positive of qi and blood must be mended, and liver kidney essense marrow must fill, skin, Mao get To support it, this is the wonderful of hair-blackening tonic.
Second aspect, the invention provides the preparation method of the composition with blood-nourishing black hair effect, comprises the following steps： S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder；S2：Hawthorn and sealwort is water-soluble with ethanol Liquid is extracted, after extraction is finished, and the first filtrate and the first filter residue are collected in filtering respectively；S3：By the first filter residue and other residues Raw material components are well mixed, and are then added to the water, regulation pH value to 3.0~3.4, soak preset time；Then regulation pH value is 7.5~8.0, then extracted；After extraction is finished, filtering；The liquid of collection is stood, supernatant is taken；S4：By the first filtrate and Supernatant merges, and then heating concentration, obtains liquid extract；S5：Dried after mixed-powder and liquid extract are well mixed, then powder Broken, sieving, collects fine powder, obtains composition.
In the further embodiment of the present invention, in S2, in ethanol water, the volume fraction of ethanol for 65%~ 70%；Refluxing extraction is extracted as, the number of times of refluxing extraction is 2~3 times, and the time extracted every time is 1.0~1.2h；Extract every time When, the addition quality of ethanol water is 5~10 times of the gross mass of hawthorn and sealwort；In S3, the quality of water is the first filter residue With 8~10 times of the gross mass of other surplus stock components；The temperature of immersion is 35~45 DEG C, and the time of immersion is 2~2.5h； It is extracted as decocting and extracts, it is 2.0~2.5h to decoct the time extracted；The time of standing is 24~28h.
In the further embodiment of the present invention, in S3, after filtration step, before standing step, in addition to step Suddenly：The second filter residue being filtrated to get is added to the water, regulation pH value to 3.0~3.4 soaks preset time；Then pH value is adjusted For 7.5~8.0, then extracted；After extraction is finished, filter again；The filtrate filtered twice in S3 is merged, collected Liquid；Wherein, the quality of water is 8~10 times of the quality of the second filter residue；The temperature of immersion is 35~45 DEG C, and the time of immersion is 2~2.5h；It is extracted as decocting and extracts, it is 2.0~2.5h to decoct the time extracted.
In the further embodiment of the present invention, in S4, the temperature of heating is 60~70 DEG C, and liquid extract is in 25 DEG C of measure Relative density be 1.15~1.2；In S5, dry temperature is 50~60 DEG C, and the particle diameter of fine powder is not higher than 0.150mm.
The third aspect, the present invention also application of the protection above-mentioned composition in blood-nourishing hair blackening product is prepared.
It should be noted that the eating method for the composition with blood-nourishing black hair effect that the present invention is prepared is preferred For：Edible 10~30g (can be directly oral, can also use mixing in water for oral taking), edible 1 time daily every time；Edible time can basis The state of an illness is adjusted.
Composition prepared by the above method can be further prepared into pharmaceutically acceptable formulation as needed.In addition, with Above-mentioned composition is that the medicine that active component is made falls within protection scope of the present invention.By by aforementioned pharmaceutical compositions, directly Connect preparation or add after pharmaceutically acceptable auxiliary material and prepare, can be made into any pharmaceutically acceptable formulation.With external application system Include exemplified by agent：Solution, patch, vina, tincture, gel, liniment, aerosol, spray, ointment and plastics.On Stating the medicine of various formulations can prepare according to the conventional method of pharmaceutical field.
The technical scheme that the present invention is provided, with following beneficial effect：(1) present invention using traditional Chinese medicine food therapy theory as according to According to, it is formulated based on a variety of medicine and food raw materials such as selected ginseng, donkey-hide gelatin, sealwort, matrimony vine, with modern advanced technology, Extract active components of plants and be refining to obtain the composition with blood-nourishing black hair effect, actually high-end, fashion dietotherapy health-oriented products； (2) present invention adds French beans, adlay, lotus seeds, rhizoma atractylodis, Fructus Aurantii, the bighead atractylodes rhizome, the banksia rose and radix glycyrrhizae on the basis of basic components, can be with Increase effect of invigorating spleen to remove dampness, it is adaptable to alleviate spleen and stomach function it is weak caused by the symptom such as white hair is more；(3) present invention matches somebody with somebody on basis On the basis of side, Polygonum multiflower knotweed, cortex albiziae, rhizoma cyperi and spina date seed are added, dispersing stagnated hepatoqi, mental-tranquilization effect can be increased, be applicable In white hair symptom caused by alleviation liver-qi depression etc.；(4) present invention adds rhizoma alismatis, cultivated land, Du on the basis of basic components Secondary, Fructus Corni, moutan bark, psoralea corylifolia, saline cistanche and Chinese cassia tree, can increase nourishing liver and kidney effect, it is adaptable to alleviate kidney deficiency and draw The symptom such as the white hair that rises is more；(5) present invention adds the fleece-flower root, eclipta, the fruit of glossy privet, cultivated land, gold on the basis of basic components Honeysuckle flower, Semen Cuscutae, the bark of eucommia, fruit of Cherokee rose, Common St.Paulswort Herbs, cacumen biotae, radix achyranthis bidentatae, peach kernel and safflower, can increase nourishing liver and kidney, promoting blood circulation Stagnation resolvation, effect of black hair strengthen the hair, it is adaptable to the symptom such as intractable alopecia, white hair；(6) composition that the present invention is provided has tonifying Qi Effect of blood-nourishing, enriching yin and nourishing kidney and hair-blackening tonic, effect is notable, available for treatment because of caused by insufficiency of vital energy and blood, the deficiency of liver-yin and kidney-yin The symptom such as soreness and weakness of waist and knees, dizzy tinnitus, poliosis and alopecia；And have no side effect, it is adapted to long-term consumption.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below Example is only used for clearly illustrating technical scheme, therefore is intended only as example, and can not limit this hair with this Bright protection domain.
Experimental method in following embodiments, is conventional method unless otherwise specified.Examination used in following embodiments Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following examples, is respectively provided with three Secondary to repeat to test, data are the average value or mean+SD of three repetition experiments.
Ginseng used, donkey-hide gelatin, sealwort, matrimony vine, jujube, Chinese yam, mulberry fruit, rose, dried orange peel, sand in following embodiments Benevolence, hawthorn, Poria cocos, mulberry leaf, adlay, lotus seeds, rhizoma atractylodis, Fructus Aurantii, the bighead atractylodes rhizome, the banksia rose, radix glycyrrhizae, Polygonum multiflower knotweed, cortex albiziae, rhizoma cyperi, wild jujube Benevolence, rhizoma alismatis, cultivated land, the bark of eucommia, Fructus Corni, moutan bark, psoralea corylifolia, saline cistanche, Chinese cassia tree, the fleece-flower root, eclipta, the fruit of glossy privet, cultivated land, Honeysuckle, Semen Cuscutae, the bark of eucommia, the fruit of Cherokee rose, cacumen biotae, radix achyranthis bidentatae, peach kernel and safflower meet Chinese Pharmacopoeia (version in 2015) one Pertinent regulations under each medicinal material of portion's text.Before feeding intake, by identification, ingredients material object is consistent with title, and quality meets mark It is accurate.
The present invention provides a kind of composition with blood-nourishing black hair effect, and the raw material components of composition by weight, are wrapped Include：1~3 part of ginseng, 0.2~1 part of donkey-hide gelatin, 3~5 parts of sealwort, 3~5 parts of matrimony vine, 1~3 part of Cordyceps militaris, 3~5 parts of jujube, Chinese yam 3~5 parts, 5~6 parts of mulberry fruit, 1~3 part of rose, 1~3 part of dried orange peel, 0.5~2 part of fructus amomi, 3~5 parts of hawthorn, 3~5 parts of Poria cocos, 3~5 parts of 1~3 part of mulberry leaf, 5~6 parts of Semen sesami nigrum, 3~5 parts of black rice and black soya bean.
Preferably, the raw material components of the composition with blood-nourishing black hair effect also include：3~5 parts of French beans, adlay 3~5 1~3 part of part, 3~5 parts of lotus seeds, 1~3 part of rhizoma atractylodis, 1~3 part of Fructus Aurantii, 3~5 parts of the bighead atractylodes rhizome, 0.5~1 part of the banksia rose and radix glycyrrhizae.
Preferably, the raw material components of the composition with blood-nourishing black hair effect also include：2~3 parts of Polygonum multiflower knotweed, cortex albiziae 1 3~5 parts of~3 parts, 3~5 parts of rhizoma cyperi and spina date seed.
Preferably, the raw material components of the composition with blood-nourishing black hair effect also include：1~3 part of rhizoma alismatis, cultivated land 3~5 Part, 3~5 parts of the bark of eucommia, 3~5 parts of Fructus Corni, 1~3 part of moutan bark, 1~3 part of psoralea corylifolia, 3~5 parts of saline cistanche and Chinese cassia tree 0.5~1 Part.
Preferably, the raw material components of the composition with blood-nourishing black hair effect also include：5~6 parts of the fleece-flower root, eclipta 5 ~6 parts, 2~3 parts of the fruit of glossy privet, 5~6 parts of cultivated land, 0.5~1 part of honeysuckle, 3~5 parts of Semen Cuscutae, 3~5 parts of the bark of eucommia, the fruit of Cherokee rose 1 0.3~1 part of~3 1~3 part of Fen, Common St.Paulswort Herbs, 1~3 part of cacumen biotae, 3~5 parts of radix achyranthis bidentatae, 1~3 part of peach kernel and safflower.
In addition, present invention also offers the preparation method of the above-mentioned composition with blood-nourishing black hair effect, including following step Suddenly：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 2~3 times with volume fraction for 65%~70% ethanol water, Extract and filtered after finishing every time, the filtrate being filtrated to get after each extract is merged, the first filtrate is obtained, and collect last The filter residue being filtrated to get after secondary extraction is the first filter residue；Wherein, the time extracted every time is 1.0~1.2h；When extracting every time, second The addition quality of alcohol solution is 5~10 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 8~10 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.0~3.4,35~45 DEG C of 2~2.5h of immersion； Then regulation pH value is 7.5~8.0, then carries out decocting 2.0~2.5h of extraction, after extraction is finished, filtering；By be filtrated to get Two filter residues are added to the water, and the quality of water is 8~10 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH The step of value, decoction are extracted and filtered；The filtrate being filtrated to get twice in S3 is merged, the liquid collected；By collection Liquid stands 24~28h, takes supernatant.
S4：First filtrate and supernatant are merged, then 60~70 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure Spend the liquid extract for 1.15~1.2.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 50~60 DEG C, then crushes, sieve, receive Collection particle diameter is not higher than 0.150mm fine powder, obtains composition.
Composition with blood-nourishing black hair effect provided with reference to specific embodiment the present invention and preparation method thereof It is described further.
Embodiment one
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 1 part, 1 part of donkey-hide gelatin, 3 parts of sealwort, 5 parts of matrimony vine, 1 part of Cordyceps militaris, 5 parts of jujube, 3 parts of Chinese yam, 6 parts of mulberry fruit, 1 part of rose, dried orange peel 3 5 parts of part, 0.5 part of fructus amomi, 5 parts of hawthorn, 3 parts of Poria cocos, 1 part of mulberry leaf, 6 parts of Semen sesami nigrum, 3 parts of black rice and black soya bean.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 2 times for 65% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.0h；When extracting every time, the addition of ethanol water Quality is 5 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 10 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.0,35 DEG C of immersion 2h；Then regulation pH value is 7.5, then carry out decocting extraction 2.0h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 10 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 24h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 60 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.15 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 50 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment two
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 3 parts, it is 0.2 part of donkey-hide gelatin, 5 parts of sealwort, 3 parts of matrimony vine, 3 parts of Cordyceps militaris, 3 parts of jujube, 5 parts of Chinese yam, 5 parts of mulberry fruit, 3 parts of rose, old 3 parts of 1 part of skin, 2 parts of fructus amomi, 3 parts of hawthorn, 5 parts of Poria cocos, 3 parts of mulberry leaf, 5 parts of Semen sesami nigrum, 5 parts of black rice and black soya bean.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 3 times for 70% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.2h；When extracting every time, the addition of ethanol water Quality is 10 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 8 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.4,45 DEG C of immersion 2.5h；Then regulation pH value is 8.0, then carry out decocting extraction 2.5h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 8 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 28h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 70 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.2 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 60 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment three
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 1 part, 1 part of donkey-hide gelatin, 3 parts of sealwort, 5 parts of matrimony vine, 1 part of Cordyceps militaris, 5 parts of jujube, 3 parts of Chinese yam, 6 parts of mulberry fruit, 1 part of rose, dried orange peel 3 Part, 0.5 part of fructus amomi, 5 parts of hawthorn, 3 parts of Poria cocos, 1 part of mulberry leaf, 6 parts of Semen sesami nigrum, 3 parts of black rice, 5 parts of black soya bean, 3 parts of French beans, adlay 5 1 part of part, 3 parts of lotus seeds, 3 parts of rhizoma atractylodis, 1 part of Fructus Aurantii, 3 parts of the bighead atractylodes rhizome, 1 part of the banksia rose and radix glycyrrhizae.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 2 times for 65% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.0h；When extracting every time, the addition of ethanol water Quality is 5 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 10 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.0,35 DEG C of immersion 2h；Then regulation pH value is 7.5, then carry out decocting extraction 2.0h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 10 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 24h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 60 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.15 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 50 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Example IV
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 3 parts, it is 0.2 part of donkey-hide gelatin, 5 parts of sealwort, 3 parts of matrimony vine, 3 parts of Cordyceps militaris, 3 parts of jujube, 5 parts of Chinese yam, 5 parts of mulberry fruit, 3 parts of rose, old 1 part of skin, 2 parts of fructus amomi, 3 parts of hawthorn, 5 parts of Poria cocos, 3 parts of mulberry leaf, 5 parts of Semen sesami nigrum, 5 parts of black rice, 3 parts of black soya bean, 5 parts of French beans, adlay 3 3 parts of part, 5 parts of lotus seeds, 1 part of rhizoma atractylodis, 3 parts of Fructus Aurantii, 5 parts of the bighead atractylodes rhizome, 0.5 part of the banksia rose and radix glycyrrhizae.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 3 times for 70% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.2h；When extracting every time, the addition of ethanol water Quality is 10 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 8 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.4,45 DEG C of immersion 2.5h；Then regulation pH value is 8.0, then carry out decocting extraction 2.5h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 8 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 28h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 70 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.2 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 60 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment five
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 1 part, 1 part of donkey-hide gelatin, 3 parts of sealwort, 5 parts of matrimony vine, 1 part of Cordyceps militaris, 5 parts of jujube, 3 parts of Chinese yam, 6 parts of mulberry fruit, 1 part of rose, dried orange peel 3 Part, 0.5 part of fructus amomi, 5 parts of hawthorn, 3 parts of Poria cocos, 1 part of mulberry leaf, 6 parts of Semen sesami nigrum, 3 parts of black rice, 5 parts of black soya bean, 2 parts of Polygonum multiflower knotweed, silk tree 3 parts of 1 part of skin, 5 parts of rhizoma cyperi and spina date seed.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 2 times for 65% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.0h；When extracting every time, the addition of ethanol water Quality is 5 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 10 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.0,35 DEG C of immersion 2h；Then regulation pH value is 7.5, then carry out decocting extraction 2.0h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 10 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 24h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 60 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.15 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 50 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment six
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 3 parts, it is 0.2 part of donkey-hide gelatin, 5 parts of sealwort, 3 parts of matrimony vine, 3 parts of Cordyceps militaris, 3 parts of jujube, 5 parts of Chinese yam, 5 parts of mulberry fruit, 3 parts of rose, old 1 part of skin, 2 parts of fructus amomi, 3 parts of hawthorn, 5 parts of Poria cocos, 3 parts of mulberry leaf, 5 parts of Semen sesami nigrum, 5 parts of black rice, 3 parts of black soya bean, 3 parts of Polygonum multiflower knotweed, conjunction Joyous 5 parts of 3 parts of skin, 3 parts of rhizoma cyperi and spina date seed.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 3 times for 70% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.2h；When extracting every time, the addition of ethanol water Quality is 10 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 8 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.4,45 DEG C of immersion 2.5h；Then regulation pH value is 8.0, then carry out decocting extraction 2.5h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 8 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 28h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 70 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.2 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 60 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment seven
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 1 part, 1 part of donkey-hide gelatin, 3 parts of sealwort, 5 parts of matrimony vine, 1 part of Cordyceps militaris, 5 parts of jujube, 3 parts of Chinese yam, 6 parts of mulberry fruit, 1 part of rose, dried orange peel 3 Part, 0.5 part of fructus amomi, 5 parts of hawthorn, 3 parts of Poria cocos, 1 part of mulberry leaf, 6 parts of Semen sesami nigrum, 3 parts of black rice, 5 parts of black soya bean, 1 part of rhizoma alismatis, cultivated land 3 1 part of part, 5 parts of the bark of eucommia, 3 parts of Fructus Corni, 1 part of moutan bark, 3 parts of psoralea corylifolia, 3 parts of saline cistanche and Chinese cassia tree.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 2 times for 65% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.0h；When extracting every time, the addition of ethanol water Quality is 5 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 10 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.0,35 DEG C of immersion 2h；Then regulation pH value is 7.5, then carry out decocting extraction 2.0h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 10 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 24h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 60 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.15 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 50 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment eight
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 3 parts, it is 0.2 part of donkey-hide gelatin, 5 parts of sealwort, 3 parts of matrimony vine, 3 parts of Cordyceps militaris, 3 parts of jujube, 5 parts of Chinese yam, 5 parts of mulberry fruit, 3 parts of rose, old 1 part of skin, 2 parts of fructus amomi, 3 parts of hawthorn, 5 parts of Poria cocos, 3 parts of mulberry leaf, 5 parts of Semen sesami nigrum, 5 parts of black rice, 3 parts of black soya bean, 3 parts of rhizoma alismatis, cultivated land 5 0.5 part of part, 3 parts of the bark of eucommia, 5 parts of Fructus Corni, 3 parts of moutan bark, 1 part of psoralea corylifolia, 5 parts of saline cistanche and Chinese cassia tree.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 3 times for 70% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.2h；When extracting every time, the addition of ethanol water Quality is 10 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 8 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.4,45 DEG C of immersion 2.5h；Then regulation pH value is 8.0, then carry out decocting extraction 2.5h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 8 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 28h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 70 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.2 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 60 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment nine
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 1 part, 1 part of donkey-hide gelatin, 3 parts of sealwort, 5 parts of matrimony vine, 1 part of Cordyceps militaris, 5 parts of jujube, 3 parts of Chinese yam, 6 parts of mulberry fruit, 1 part of rose, dried orange peel 3 Part, 0.5 part of fructus amomi, 5 parts of hawthorn, 3 parts of Poria cocos, 1 part of mulberry leaf, 6 parts of Semen sesami nigrum, 3 parts of black rice, 5 parts of black soya bean, 6 parts of the fleece-flower root, ink drought 5 parts of lotus, 3 parts of the fruit of glossy privet, 5 parts of cultivated land, 1 part of honeysuckle, 3 parts of Semen Cuscutae, 5 parts of the bark of eucommia, 3 parts of the Fen, Common St.Paulswort Herbs of the fruit of Cherokee rose 1, arbor-vitae 1 part of 1 part of leaf, 5 parts of radix achyranthis bidentatae, 1 part of peach kernel and safflower.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 2 times for 65% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.0h；When extracting every time, the addition of ethanol water Quality is 5 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 10 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.0,35 DEG C of immersion 2h；Then regulation pH value is 7.5, then carry out decocting extraction 2.0h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 10 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 24h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 60 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.15 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 50 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
Embodiment ten
The present embodiment provides a kind of composition with blood-nourishing black hair effect, raw material components by weight, including：Ginseng 3 parts, it is 0.2 part of donkey-hide gelatin, 5 parts of sealwort, 3 parts of matrimony vine, 3 parts of Cordyceps militaris, 3 parts of jujube, 5 parts of Chinese yam, 5 parts of mulberry fruit, 3 parts of rose, old 1 part of skin, 2 parts of fructus amomi, 3 parts of hawthorn, 5 parts of Poria cocos, 3 parts of mulberry leaf, 5 parts of Semen sesami nigrum, 5 parts of black rice, 3 parts of black soya bean, 5 parts of the fleece-flower root, ink Non-irrigated 6 parts of lotus, 2 parts of the fruit of glossy privet, 6 parts of cultivated land, 0.5 part of honeysuckle, 5 parts of Semen Cuscutae, 3 parts of the bark of eucommia, 1 part of the Fen, Common St.Paulswort Herbs of the fruit of Cherokee rose 3, 0.3 part of 3 parts of cacumen biotae, 3 parts of radix achyranthis bidentatae, 3 parts of peach kernel and safflower.
By above-mentioned raw material, prepared by the preparation method of the composition with blood-nourishing black hair effect provided using the present invention Composition with blood-nourishing black hair effect：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder.
S2：Hawthorn and sealwort are subjected to refluxing extraction 3 times for 70% ethanol water with volume fraction, extracted every time Filtered after finishing, the filtrate being filtrated to get after each extract is merged, obtain the first filtrate, and collect mistake after last time is extracted It is the first filter residue to filter obtained filter residue；Wherein, the time extracted every time is 1.2h；When extracting every time, the addition of ethanol water Quality is 10 times of the gross mass of hawthorn and sealwort.
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, the quality of water is the first filter 8 times of the gross mass of slag and other surplus stock components；PH value is adjusted to 3.4,45 DEG C of immersion 2.5h；Then regulation pH value is 8.0, then carry out decocting extraction 2.5h, after extraction is finished, filtering；The second filter residue being filtrated to get is added to the water, the quality of water It is 8 times of the quality of the second filter residue；It is repeated in adjusting pH value, immersion in S3, adjusts pH value, decocts the step of extracting and filter；Will The filtrate being filtrated to get twice in S3 merges, the liquid collected；The liquid of collection is stood into 28h, supernatant is taken.
S4：First filtrate and supernatant are merged, then 70 DEG C of heating concentrations, obtain be in the relative densities of 25 DEG C of measure 1.2 liquid extract.
S5：Mixed-powder and liquid extract are well mixed, dried at a temperature of 60 DEG C, then crushes, sieve, collect grain Footpath is not higher than 0.150mm fine powder, obtains composition.
The eating method for the composition with blood-nourishing black hair effect that the present invention is prepared is preferably：Each edible 10~ 30g (can be directly oral, mixing in water for oral taking can also be used), it is edible 1 time daily；Edible time can be adjusted according to the state of an illness.
The composition with blood-nourishing black hair effect that the embodiment of the present invention one to embodiment ten is prepared, passes through function Learn experiment and carry out system evaluation its effect.
1st, black hair overall efficacy clinical trial
Method of testing：The volunteer's (30~60 years old age) 500 that there are a large amount of white hairs is recruited, 10 groups are randomly divided into, respectively Experimental group is 50 volunteers, and carries out comprehensive mug (the 0th day) to every volunteer.Every group of volunteer is allowed to distinguish The composition with blood-nourishing black hair effect that edible embodiment one to the embodiment ten of correspondence is prepared, eats 15g and (uses water every time Take after mixing it with water), it is edible 1 time daily, it is continuous edible 2 months, volunteer is paid a return visit at 1 month and 2 months, and mug.
Evaluation method：The photo of 1 month and 2 months and the photo of the 0th day are contrasted, wherein white hair substantially tail off, Hair becomes glossy black to be effective；What white hair slightly had reduction is effective；White hair phenomenon do not change to be invalid.
Test result：Volunteer is paid a return visit after on probation 1 month and 2 months, allergic, stomach does not occur not It is suitable to wait adverse reaction, show the composition safety non-toxic that the present invention is provided, shown in the specific following Tables 1 and 2 of test result.
Table 1 tries out 1 month result statistical form
Table 2 tries out 2 months result statistical forms
Group Number (example) Effective (example) Effectively (example) Invalid (example)
Embodiment one 50 38 12 0
Embodiment two 50 35 15 0
Embodiment three 50 47 3 0
Example IV 50 45 5 0
Embodiment five 50 46 4 0
Embodiment six 50 45 5 0
Embodiment seven 50 50 0 0
Embodiment eight 50 48 2 0
Embodiment nine 50 49 1 0
Embodiment ten 50 50 0 0
2nd, the specific eficac Clinical test of black hair
Test method：Subject's selection standard and packet：The people of subject 500 with more white hair is chosen, is classified as 10 groups, every group of 50 people.Before subject's head is divided into, in, left and right, rear five regions, position respectively, respectively choose 1cm2Mark On schedule as measurement position, the average value of white hair radical is taken.
Allow what every group of volunteer corresponded to that edible embodiment one to embodiment ten prepares respectively there is blood-nourishing black hair effect Composition, 15g (using mixing in water for oral taking) is eaten every time, it is edible 1 time daily, continuous edible 2 months.By hoary hair's root of hair in the region Number obtains average value as stated above.
Result of the test：White hair radical before white hair radical average value divided by consumable products after consumable products is averaged Value, calculates white hair blackening ratio, then calculates the white hair blackening ratio average of all subjects of this group and record in following table, specifically such as Shown in table 3.
Each group subject white hair blackening ratio situation after the edible composition of table 3
3rd, toxicity test
(1) test medicine and medication
Blank control：Physiological saline, it is commercially available.
Test specimen：The embodiment of the present invention one, embodiment three, embodiment five, embodiment seven and embodiment nine are prepared The composition with blood-nourishing black hair effect.
Experimental animal：Rabbit, body weight 2kg or so, male and female half and half are purchased from Experimental Animal Center.
Administration time and dosage：Using gavage mode, administration phase is 12 weeks, and convalescence is 1 week, and dosage is 0.5g/ Kg/ times, once a day.
(2) experimental method and observation index
Experimental animal is grouped at random, is divided into one group of embodiment, three groups of embodiment, five groups of embodiment, seven groups of embodiment, implementation Nine groups of example and blank control group, in addition to blank control group gives physiological saline, remaining group drug dose is 0.5g/Kg/ times, often Group animal 10.Successive administration 12 weeks；Control group gavage physiological saline under the same conditions.
Overview：Observe general behavior movable, fecal character, appetite and changes of weight etc., gait, mental act, the heart Nausea and vomiting etc. are secreted and whether there is in rate, pupil size, nose and oral cavity.To 1 week after last dose from being administered first 7 days, daily Observed and recorded 1 time；Wherein heart rate and pupil are measured 1 time for every 2 days, and body weight claims weekly 1 time.
Electrocardiographic examination：Rabbit is derived from right erect position, traces II lead, and administration is traced 2 times, traced within every 3 weeks after administration for first 7 days 1 time.
Blood blood examination is looked into：Extracting vein blood, red, leucocyte and quantitative blood red egg are counted with Couter blood counts (Britain's production) In vain；With general microscopic counting blood platelet and leukocyte differential count.It is administered first 2 weeks, often weekly check 1 time；Every 3 weekly check 1 after administration It is secondary.
Blood biochemistry checking：Venous blood sampling, anticoagulant heparin, separated plasma；Surveyed with automatic biochemical analyzer (Corona, Sweden's production) Determine glutamic-pyruvic transaminase (GPT) and creatinine (CRTN), urea nitrogen (BUN) and sulfobromophthalein sodium (BSP) are determined with laboratory conventional method Retention rate；The same hematological examination of sampling and measuring time.
Uroscopy：The red matter of urine pH, albumen, glucose, ketoboidies, UBG, courage of rabbit is checked with urine test paper and is dived Blood etc., microscopy cast, RBC and WBC etc., time of taking a sample to check same hematological examination.
System postmortem：3 are killed in every group of each work of animal in 24 hours after last dose, 1 week again after other rabbit last doses Row system postmortem is entered in work.
Histological examination：Divide 2 batches, every batch every group each 5 are checked (time homologous ray postmortem).The scope of examination includes Brain, the heart, lung, liver, kidney, adrenal gland, spleen, stomach, jejunum, pancreas and testis (hero).
Convalescence checks：Convalescence, its detection content was identical with administration phase in addition to by reagent is not given.
(3) result of the test
Overview：Each group animal does not occur obvious dry (mycteroxerosis and oral secretion after being administered 2~3 weeks Less), Nausea and vomiting and anorexia (feed is reduced)；Activity and behavior and fecal character are had no significant effect；Body weight：Respectively Body weight is without obvious change before and after group animal drugs；Pupil：Each group animal does not have obvious expansion pupil phenomenon；Heart rate：The each group animal heart Rate changes equal no significant difference；Electrocardiogram：Electrocardiogram after the administration of each group animal, in addition to there is stopping up property increased heart rate early stage, without it He substantially changes；Blood biochemical：GPT, BSP retention rate, blood urea nitrogen (BUN) (BUN) and creatinine after the administration of each group animal is without bright It is aobvious to change, show to have no significant effect hepatic and renal function；Hematology：RBC and WBC sums, Hb, blood platelet after the administration of each group animal Had no significant change with leukocyte differential count；Urine：Urine pH, albumen after the administration of each group animal, glucose, ketoboidies, the red matter of courage With occult blood and microscopy finding, compare, change without obvious with preceding and blank control group is administered；System postmortem：Upon administration 12 weeks and the living blank control group killed and each embodiment group animal after being discontinued 1 week, system postmortem no significant difference, each group also have no Abnormal change；Histological examination：Each group animal administration after 12 weeks and drug withdrawal 1 week after, do not found and medicine in 11 kinds of internal organs such as brain The relevant pathological change of thing toxicity, and blank control group no significant difference.Conclusion：As a result show that all animals are administered 12 weeks and stopped After medicine 1 week, urine, hematology and blood biochemical analysis inspection, system postmortem and histological examination have no significant change.Show this hair The group with blood-nourishing black hair effect that bright embodiment one, embodiment three, embodiment five, embodiment seven and embodiment nine are prepared Compound security is credible.
It should be noted that situation about being enumerated to embodiment ten except above-described embodiment one, is matched somebody with somebody from other raw material components Than and preparation method thereof parameter be also feasible.
The technical scheme that the present invention is provided, with following beneficial effect：(1) present invention using traditional Chinese medicine food therapy theory as according to According to, it is formulated based on a variety of medicine and food raw materials such as selected ginseng, donkey-hide gelatin, sealwort, matrimony vine, with modern advanced technology, Extract active components of plants and be refining to obtain the composition with blood-nourishing black hair effect, actually high-end, fashion dietotherapy health-oriented products； (2) present invention adds French beans, adlay, lotus seeds, rhizoma atractylodis, Fructus Aurantii, the bighead atractylodes rhizome, the banksia rose and radix glycyrrhizae on the basis of basic components, can be with Increase effect of invigorating spleen to remove dampness, it is adaptable to alleviate spleen and stomach function it is weak caused by the symptom such as white hair is more；(3) present invention matches somebody with somebody on basis On the basis of side, Polygonum multiflower knotweed, cortex albiziae, rhizoma cyperi and spina date seed are added, dispersing stagnated hepatoqi, mental-tranquilization effect can be increased, be applicable In white hair symptom caused by alleviation liver-qi depression etc.；(4) present invention adds rhizoma alismatis, cultivated land, Du on the basis of basic components Secondary, Fructus Corni, moutan bark, psoralea corylifolia, saline cistanche and Chinese cassia tree, can increase nourishing liver and kidney effect, it is adaptable to alleviate kidney deficiency and draw The symptom such as the white hair that rises is more；(5) present invention adds the fleece-flower root, eclipta, the fruit of glossy privet, cultivated land, gold on the basis of basic components Honeysuckle flower, Semen Cuscutae, the bark of eucommia, fruit of Cherokee rose, Common St.Paulswort Herbs, cacumen biotae, radix achyranthis bidentatae, peach kernel and safflower, can increase nourishing liver and kidney, promoting blood circulation Stagnation resolvation, effect of black hair strengthen the hair, it is adaptable to the symptom such as intractable alopecia, white hair；(6) composition that the present invention is provided has tonifying Qi Effect of blood-nourishing, enriching yin and nourishing kidney and hair-blackening tonic, effect is notable, available for treatment because of caused by insufficiency of vital energy and blood, the deficiency of liver-yin and kidney-yin The symptom such as soreness and weakness of waist and knees, dizzy tinnitus, poliosis and alopecia；And have no side effect, it is adapted to long-term consumption.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because This, other examples of exemplary embodiment can have different values.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not It is interpreted as indicating or implies relative importance or the implicit quantity for indicating indicated technical characteristic.Thus, define " the One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention, " multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology The scope of scheme, it all should cover among protection scope of the present invention.

Claims (10)

1. a kind of composition with blood-nourishing black hair effect, it is characterised in that the raw material components of the composition by weight, Including：
1~3 part of ginseng, 0.2~1 part of donkey-hide gelatin, 3~5 parts of sealwort, 3~5 parts of matrimony vine, 1~3 part of Cordyceps militaris, 3~5 parts of jujube, mountain 3~5 parts of medicine, 5~6 parts of mulberry fruit, 1~3 part of rose, 1~3 part of dried orange peel, 0.5~2 part of fructus amomi, 3~5 parts of hawthorn, Poria cocos 3~5 3~5 parts of part, 1~3 part of mulberry leaf, 5~6 parts of Semen sesami nigrum, 3~5 parts of black rice and black soya bean.
2. the composition according to claim 1 with blood-nourishing black hair effect, it is characterised in that the raw material of the composition Component also includes：
3~5 parts of French beans, 3~5 parts of adlay, 3~5 parts of lotus seeds, 1~3 part of rhizoma atractylodis, 1~3 part of Fructus Aurantii, 3~5 parts of the bighead atractylodes rhizome, the banksia rose 0.5 ~1 part and 1~3 part of radix glycyrrhizae.
3. the composition according to claim 1 with blood-nourishing black hair effect, it is characterised in that the raw material of the composition Component also includes：
3~5 parts of 2~3 parts of Polygonum multiflower knotweed, 1~3 part of cortex albiziae, 3~5 parts of rhizoma cyperi and spina date seed.
4. the composition according to claim 1 with blood-nourishing black hair effect, it is characterised in that the raw material of the composition Component also includes：
1~3 part of rhizoma alismatis, 3~5 parts of cultivated land, 3~5 parts of the bark of eucommia, 3~5 parts of Fructus Corni, 1~3 part of moutan bark, 1~3 part of psoralea corylifolia, 0.5~1 part of 3~5 parts of saline cistanche and Chinese cassia tree.
5. the composition according to claim 1 with blood-nourishing black hair effect, it is characterised in that the raw material of the composition Component also includes：
5~6 parts of the fleece-flower root, 5~6 parts of eclipta, 2~3 parts of the fruit of glossy privet, 5~6 parts of cultivated land, 0.5~1 part of honeysuckle, Semen Cuscutae 3 ~5 parts, 3~5 parts of the bark of eucommia, 1~3 part of the Fen, Common St.Paulswort Herbs of the fruit of Cherokee rose 1~3,1~3 part of cacumen biotae, 3~5 parts of radix achyranthis bidentatae, peach kernel 1~3 0.3~1 part of part and safflower.
6. the preparation method of the composition with blood-nourishing black hair effect described in claim any one of 1-5, it is characterised in that bag Include following steps：
S1：Crushed after ginseng, donkey-hide gelatin, Cordyceps militaris and fructus amomi are mixed, obtain mixed-powder；
S2：Hawthorn and sealwort are extracted with ethanol water, after extraction is finished, the first filtrate and the are collected in filtering respectively One filter residue；
S3：First filter residue and other surplus stock components are well mixed, are then added to the water, regulation pH value to 3.0~ 3.4, soak preset time；Then regulation pH value is 7.5~8.0, then is extracted；After extraction is finished, filtering；By the liquid of collection Body is stood, and takes supernatant；
S4：First filtrate and the supernatant are merged, then heating concentration, obtains liquid extract；
S5：Dried after the mixed-powder and the liquid extract are well mixed, then crush, sieve, collect fine powder, obtain institute State composition.
7. the preparation method of the composition according to claim 6 with blood-nourishing black hair effect, it is characterised in that：
In the S2, in the ethanol water, the volume fraction of ethanol is 65%~70%；It is described to be extracted as refluxing extraction, The number of times of the refluxing extraction is 2~3 times, and the time extracted every time is 1.0~1.2h；When extracting every time, ethanol water Addition quality is 5~10 times of the gross mass of the hawthorn and sealwort；
In the S3, the quality of the water is 8~10 times of first filter residue and the gross mass of other surplus stock components；Institute The temperature for stating immersion is 35~45 DEG C, and the time of the immersion is 2~2.5h；Described to be extracted as decocting extraction, the decoction is carried The time taken is 2.0~2.5h；The time of the standing is 24~28h.
8. the preparation method of the composition according to claim 6 with blood-nourishing black hair effect, it is characterised in that：
In the S3, after the filtration step, before the standing step, in addition to step：It is filtrated to get described Second filter residue is added to the water, regulation pH value to 3.0~3.4, soaks preset time；Then regulation pH value is 7.5~8.0, then is entered Row is extracted；After extraction is finished, filter again；The filtrate filtered twice in S3 is merged, the liquid collected；Wherein, it is described The quality of water is 8~10 times of the quality of second filter residue；The temperature of the immersion is 35~45 DEG C, the time of the immersion For 2~2.5h；Described to be extracted as decocting extraction, the time for decocting extraction is 2.0~2.5h.
9. the preparation method of the composition according to claim 6 with blood-nourishing black hair effect, it is characterised in that：
In the S4, the temperature of the heating is 60~70 DEG C, the liquid extract 25 DEG C of measure relative densities for 1.15~ 1.2；
In the S5, the temperature of the drying is 50~60 DEG C, and the particle diameter of the fine powder is not higher than 0.150mm.
10. application of the composition in blood-nourishing hair blackening product is prepared described in claim any one of 1-5.
CN201710384307.XA 2017-05-26 2017-05-26 Composition with blood-nourishing black hair effect and preparation method thereof Pending CN107184892A (en)

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CN109966404A (en) * 2019-03-27 2019-07-05 广州今典精方医药科技有限公司 A kind of rhizoma polygonati jujube composition and preparation method thereof
CN110496185A (en) * 2019-09-20 2019-11-26 徐州三源医药科技集团有限公司 A kind of beautifying face and moistering lotion cream and preparation method thereof
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Publication number Priority date Publication date Assignee Title
CN110538267A (en) * 2018-05-28 2019-12-06 南京青丝永盛生物科技有限公司 Traditional Chinese medicine composition with remarkable alopecia prevention effect and preparation method thereof
CN110604784A (en) * 2018-05-28 2019-12-24 南京青丝永盛生物科技有限公司 Traditional Chinese medicine composition with remarkable alopecia prevention effect and application of traditional Chinese medicine composition in hair growth
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CN110584110A (en) * 2019-09-05 2019-12-20 北京康爱营养医学研究院 Anti-hair loss nutritional composition and preparation method and application thereof
CN110496185A (en) * 2019-09-20 2019-11-26 徐州三源医药科技集团有限公司 A kind of beautifying face and moistering lotion cream and preparation method thereof

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Application publication date: 20170922