CN110538267A - Traditional Chinese medicine composition with remarkable alopecia prevention effect and preparation method thereof - Google Patents

Traditional Chinese medicine composition with remarkable alopecia prevention effect and preparation method thereof Download PDF

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Publication number
CN110538267A
CN110538267A CN201810555250.XA CN201810555250A CN110538267A CN 110538267 A CN110538267 A CN 110538267A CN 201810555250 A CN201810555250 A CN 201810555250A CN 110538267 A CN110538267 A CN 110538267A
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parts
traditional chinese
medicine composition
alopecia
remarkable
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CN201810555250.XA
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张萌
何永玲
肖竹平
朱海亮
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Nanjing Green Silk Yongsheng Biological Technology Co Ltd
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Nanjing Green Silk Yongsheng Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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Abstract

The invention discloses a traditional Chinese medicine composition with a remarkable alopecia prevention effect and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 2-5 parts of lucid ganoderma, 10-20 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-20 parts of donkey-hide gelatin, 10-20 parts of medlar, 5-15 parts of peach kernel, 15-20 parts of tuckahoe, 5-10 parts of American ginseng, 20-25 parts of dwarf lilyturf tuber, 10-15 parts of Chinese date and 10-20 parts of astragalus root. The traditional Chinese medicine composition has obvious effect on alopecia caused by various reasons, particularly seborrheic alopecia; the preparation method adopts organic solvent and ultrasonic wave for auxiliary extraction, and has high extraction efficiency.

Description

traditional Chinese medicine composition with remarkable alopecia prevention effect and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with remarkable effects of preventing alopecia and leukotrichia and a preparation method thereof.
background
The modern people lead to the rapid increase of the number of the alopecia and the white hair and the trend towards the youth due to a plurality of factors such as the accelerated pace of life, the increased working pressure, the overdraft of energy, the environmental pollution and the like, thereby not only bringing adverse effects to the working life of patients, but also causing heavy psychological pressure to the patients. Generally speaking, alopecia is more prevalent in men than in women. The male pattern alopecia includes hereditary alopecia, androgenetic alopecia, seborrheic alopecia, etc.
According to the latest investigation of relevant authorities, about 2 hundred million patients with alopecia and poliosis in China, about 4000 million RMB in market capacity, and the investigation of 15 large-scale cities such as Beijing, Shanghai, Guangzhou, Chengdu and the like shows that the population with alopecia accounts for about 12 percent of the total population, but the data are continuously increased, and the alopecia population tends to be younger.
Because western medicines have strong side effects, are painful to operate and treat and are expensive, how to treat alopecia becomes a mysterious study, and because no real reliable product is available for solving the pain point of the problem, the market for preventing alopecia becomes a huge market with 2 hundred million people demands and 4000 hundred million business opportunities. The traditional Chinese medicine treatment has the advantages of mild property of medicinal components, small side effect, convenient taking, low price and the like, and is more advantageous in the treatment of preventing alopecia.
Disclosure of Invention
The invention aims to overcome the defects of the existing anti-hair loss treatment technology, provides a traditional Chinese medicine composition with good anti-hair loss and white hair effects and a preparation method thereof, and aims to provide a reliable and efficient medical technical means for anti-hair loss treatment and serve the society.
The technology comprises the following main contents:
a traditional Chinese medicine composition with a remarkable alopecia prevention effect is composed of the following raw materials in parts by weight: 2-5 parts of lucid ganoderma, 10-20 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-20 parts of donkey-hide gelatin, 10-20 parts of medlar, 5-15 parts of peach kernel, 15-20 parts of tuckahoe, 5-10 parts of American ginseng, 20-25 parts of dwarf lilyturf tuber, 10-15 parts of Chinese date and 10-20 parts of astragalus root.
The preferable formula of the raw materials is as follows: 3 parts of lucid ganoderma, 18 parts of prepared rehmannia root, 7 parts of Chinese yam, 13 parts of donkey-hide gelatin, 10 parts of medlar, 13 parts of peach kernel, 18 parts of tuckahoe, 5 parts of American ginseng, 15 parts of dwarf lilyturf tuber, 15 parts of Chinese date and 13 parts of astragalus root.
The preparation method of the medicinal components of the traditional Chinese medicine composition with the obvious alopecia prevention effect comprises the following steps:
Step 1, weighing raw materials according to the mixture ratio of the traditional Chinese medicinal materials, crushing the raw material mixture by using a high-speed crusher, soaking the raw material mixture in 70% ethanol water for 2-3 hours, then performing ultrasonic extraction for 3 times, wherein the material-liquid ratio is 1: 20, extracting for 30min each time, filtering to remove filter residues, and combining the filtrates;
And 2, concentrating the filtrate by using a rotary evaporator, freeze-drying to remove water, purifying the crude extract to improve the effective medicinal components to 80-90%, adding an additive, and fusing with the health tea.
The additives used include: perfumes, ph regulators, humectants, surfactants, preservatives, antimicrobials, stabilizers, excipients, and mixtures thereof.
Detailed Description
The invention is further illustrated by the following examples.
Examples 1
Weighing 3 parts of lucid ganoderma, 18 parts of prepared rehmannia root, 7 parts of Chinese yam, 13 parts of donkey-hide gelatin, 10 parts of medlar, 13 parts of peach kernel, 18 parts of tuckahoe, 5 parts of American ginseng, 15 parts of dwarf lilyturf tuber, 15 parts of Chinese date and 13 parts of astragalus.
The preparation method of the medicinal components of the traditional Chinese medicine composition with the obvious alopecia prevention effect comprises the following steps:
step 1, weighing raw materials according to the mixture ratio of the traditional Chinese medicinal materials, crushing the raw material mixture by using a high-speed crusher, soaking the raw material mixture in 70% ethanol water for 2-3 hours, then performing ultrasonic extraction for 3 times, wherein the material-liquid ratio is 1: 20, extracting for 30min each time, filtering to remove filter residues, and combining the filtrates;
And 2, concentrating the filtrate by using a rotary evaporator, freeze-drying to remove water, purifying the crude extract to improve the effective medicinal components to 80-90%, adding an additive, and fusing with the health tea.
The additives used include: perfumes, ph regulators, humectants, surfactants, preservatives, antimicrobials, stabilizers, excipients, and mixtures thereof.
the present invention is further explained with reference to the specific examples, but the present invention is not limited to the specific examples. Unless otherwise indicated, the reagents and methods referred to in the examples are those commonly used in the art.

Claims (10)

1. A traditional Chinese medicine composition with a remarkable alopecia prevention effect is characterized by being prepared from the following medicinal material extracts: ganoderma lucidum, radix rehmanniae Preparata, rhizoma Dioscoreae, colla Corii Asini, fructus Lycii, semen Persicae, Poria, radix Panacis Quinquefolii, radix Ophiopogonis, fructus Jujubae, and radix astragali.
2. The traditional Chinese medicine composition with the significant alopecia preventing effect according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 2-5 parts of lucid ganoderma, 10-20 parts of prepared rehmannia root, 10-15 parts of Chinese yam, 10-20 parts of donkey-hide gelatin, 10-20 parts of medlar, 5-15 parts of peach kernel, 15-20 parts of tuckahoe, 5-10 parts of American ginseng, 20-25 parts of dwarf lilyturf tuber, 10-15 parts of Chinese date and 10-20 parts of astragalus root.
3. The traditional Chinese medicine composition with the significant alopecia preventing effect according to claim 2, characterized in that the composition is composed of the following raw materials in parts by weight: 3 parts of lucid ganoderma, 18 parts of prepared rehmannia root, 7 parts of Chinese yam, 13 parts of donkey-hide gelatin, 10 parts of medlar, 13 parts of peach kernel, 18 parts of tuckahoe, 5 parts of American ginseng, 15 parts of dwarf lilyturf tuber, 15 parts of Chinese date and 13 parts of astragalus root.
4. The traditional Chinese medicine composition with the significant alopecia preventing effect according to claim 1, characterized in that the composition contains additives.
5. The Chinese herbal medicine composition with remarkable alopecia preventing effect according to claim 4, characterized in that the composition contains additives comprising: perfumes, ph regulators, humectants, surfactants, preservatives, antimicrobials, stabilizers, excipients, and mixtures thereof.
6. the preparation method of the traditional Chinese medicine composition with the significant alopecia preventing effect according to claim 1 is characterized by comprising the following steps:
Step 1, weighing raw materials according to the mixture ratio of the traditional Chinese medicinal materials, crushing the raw material mixture by using a high-speed crusher, soaking the raw material mixture in 70% ethanol water for 2-3 hours, then performing ultrasonic extraction for 3 times, wherein the material-liquid ratio is 1: 20, extracting for 30min each time, filtering to remove filter residues, and combining the filtrates;
And 2, concentrating the filtrate by using a rotary evaporator, freeze-drying to remove water, purifying the crude extract to improve the effective medicinal components to 80-90%, adding an additive, and fusing with the health tea.
7. The method for preparing a Chinese medicinal composition with a remarkable alopecia preventing effect according to claim 6, wherein in the step 1, the extract of the raw material powder is an ethanol aqueous solution with a mass concentration of 70%.
8. The method for preparing a Chinese medicinal composition with a remarkable alopecia preventing effect according to claim 6, wherein in the step 1, the mass ratio of the raw materials to the extracting solution is 1: 20.
9. The method for preparing a Chinese medicinal composition with a remarkable alopecia preventing effect according to claim 6, wherein in the step 1, the extraction method of the medicinal components is ultrasonic extraction.
10. The method for preparing a Chinese medicinal composition with a remarkable alopecia preventing effect according to claim 6, wherein in the step 1, the extraction method of the medicinal components comprises soaking in an ethanol aqueous solution for 2-3 hours, and extracting for 3 times with 30min each time.
CN201810555250.XA 2018-05-28 2018-05-28 Traditional Chinese medicine composition with remarkable alopecia prevention effect and preparation method thereof Pending CN110538267A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087267A (en) * 1992-11-23 1994-06-01 梅晓春 A kind of prescription for the treatment of seborrheic alopecia
CN107184892A (en) * 2017-05-26 2017-09-22 云南滇药医药健康产业有限公司 Composition with blood-nourishing black hair effect and preparation method thereof
CN107638509A (en) * 2017-10-11 2018-01-30 广州勇达生物科技有限公司 A kind of Anti-hair loss traditional Chinese medicine composition and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087267A (en) * 1992-11-23 1994-06-01 梅晓春 A kind of prescription for the treatment of seborrheic alopecia
CN107184892A (en) * 2017-05-26 2017-09-22 云南滇药医药健康产业有限公司 Composition with blood-nourishing black hair effect and preparation method thereof
CN107638509A (en) * 2017-10-11 2018-01-30 广州勇达生物科技有限公司 A kind of Anti-hair loss traditional Chinese medicine composition and preparation method thereof

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