CN1086299C

CN1086299C - Chinese-medicinal oral nerve growth liquid

Info

Publication number: CN1086299C
Application number: CN99120671A
Authority: CN
Inventors: 顾晓松; 孟凡迅; 张沛云
Original assignee: NANTONG MEDICAL COLLEGE
Current assignee: NANTONG MEDICAL COLLEGE
Priority date: 1999-12-29
Filing date: 1999-12-29
Publication date: 2002-06-19
Anticipated expiration: 2019-12-29
Also published as: CN1263768A

Abstract

The present invention relates to nerve growth-promoting medium oral liquid which is a traditional Chinese medicine mixture, which comprises the ingredients accounting for the gross weight: 20 to 30% of membranous milkvetch root, 20 to 25% of codonopsis pilosula, 15 to 20% of raw largehead atractylodesrhizome, 9 to 12% of tuber fleeceflower root, 15 to 20% of sweet wolfberry fruit and 11 to 15% of angelica. The process comprises the following steps: respectively finishing the ingredients, removing impurities of the ingredients, drying the ingredients, pulverizing the ingredients by a pulverizer, and sieving the ingredients; mixing the membranous milkvetch root, the codonopsis pilosula, the tuber fleeceflower root and the sweet wolfberry fruit, soaking the membranous milkvetch root, the codonopsis pilosula, the tuber fleeceflower root and the sweet wolfberry fruit with water, and steaming, boiling and filtering the membranous milkvetch root, the codonopsis pilosula, the tuber fleeceflower root and the sweet wolfberry fruit for slag removal and concentration; extracting the largehead atractylodesrhizome and the angelica with ethanol, mixing and concentrating the largehead atractylodesrhizome and the angelica, and packing the mixture. The nerve growth-promoting medium oral liquid is suitable for diseases, such as periphery nerve damage, neuron degeneration, etc. The present invention has the advantages of low toxicity of the pure traditional Chinese medicine preparation, exact effective ingredients, definite curative effect, standard clinical quantification, and large-scale development and popularization.

Description

Chinese-medicinal oral nerve growth liquid

A kind of Chinese medicine oral liquid for the treatment of nerve injury, neuron degeneration illness and preparation method thereof

What the present invention relates to is a kind of herb mixture nerve growth decoction oral liquid for the treatment of illness such as nerve injury, neuron degeneration and preparation method thereof.

Adopt illness such as Chinese herbal treatment nerve injury, though long history is arranged, but because of prescription composition complexity, kind come out one after another, efficacy determination differs, be difficult to scale development and apply, there is a kind of medicine for the treatment of illness such as nerve injury to claim nerve growth factor abroad, belongs to Western medicine, cost an arm and a leg, use inconvenience, curative effect is also unsatisfactory.

The objective of the invention is to the defective at above-mentioned existence, propose a kind of herb mixture-nerve growth decoction, it can effectively treat illness such as nerve injury, neuron degeneration.

Technical solution of the present invention: its proportioning components: the Radix Astragali accounts for the 20-30% of gross weight, 20-25%, the 15-20% that Rhizoma Atractylodis Macrocephalae accounts for gross weight, 9-12%, the 15-20% that Fructus Lycii accounts for gross weight, the 11-15% that Radix Angelicae Sinensis accounts for gross weight that Radix Polygoni Multiflori accounts for gross weight that Radix Codonopsis accounts for gross weight.

Its composition also can increase Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, and they respectively account for the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, 8-12%, the 5-10% of Radix Angelicae Sinensis gross weight, 5-10%.Increase Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati are to adapt to better people's taste.

The production craft step branch (1) of herb mixture nerve growth decoction oral liquid is if need promptly get above-mentioned each composition Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati with Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, put, reject impurity respectively in order, and dried, make its water content reach 5-6%; (2) each composition is weighed to scale; (3) pulverize with pulverizer, 60 orders sieve; (4) if need be with Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, the 3-5 water logging doubly that adds its gross weight after also only the Radix Astragali, Radix Codonopsis, Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi being mixed was steeped 24 hours, carry out under the normal temperature condition, after steaming and decocting makes its boiling then, constant temperature 60 minutes, carry out the screen plate filter and remove residue again, concentrate, every milliliter reaches 0.6 gram left and right sides crude drug; (5) with the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Polygonati alcohol extraction; (6) (4) are mixed the back reconcentration with (5), every milliliter reaches 1 gram left and right sides crude drug; (7) packing.

Advantage of the present invention:

This mixture belongs to pure Chinese medicinal preparation, it be in tradition on the basis of proved recipe, utilization modern biology technology is carried out the effect experiment of cellular level to its component, filter out and be rich in the active ingredient that promotes nerve growth, be combined into a kind of novel oral mixture according to Chinese medical theory, take and the result of preliminary clinic trial shows through the SD of sciatic nerve injury rat, this mixture has tangible promotion injured nerve repairing growth, promote the effect of functional rehabilitation, measure through toxicity test, this mixture toxicity is humble, any side effect do not occur, the clinical scope of application: refreshing on every side damage, illness such as neuron degeneration.Its active ingredient is definite, curative effect is clear and definite, clinical quantitative criteria, can scale development and apply.

Embodiment 1

Get 4 kilograms of the Radixs Astragali, 3 kilograms of Radix Codonopsis, 2.5 kilograms of Rhizoma Atractylodis Macrocephalae, 1.9 kilograms of Radix Polygoni Multiflori, 2.5 kilograms of Fructus Lycii, 2.1 kilograms of Radix Angelicae Sinensis

Production craft step branch (1) is got above-mentioned each composition Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, puts, rejects impurity respectively in order, and dried, makes its water content reach 5%; (2) each composition is weighed to scale; Get 3 kilograms of the Radixs Astragali, 2 kilograms of Radix Codonopsis, 1.5 kilograms of Rhizoma Atractylodis Macrocephalae, 0.9 kilogram of Radix Polygoni Multiflori, 1.5 kilograms of Fructus Lycii, 1.1 kilograms of Radix Angelicae Sinensis; (3) pulverize with pulverizer, 60 orders sieve; (4) only soaked 24 hours adding 30 kg of water after the Radix Astragali, Radix Codonopsis, Radix Polygoni Multiflori, the Fructus Lycii mixing, carry out under the normal temperature condition, after steaming and decocting made its boiling then, constant temperature 60 minutes carried out the screen plate filter and remove residue again, concentrated, and every milliliter reaches 0.6 gram crude drug; (5) with Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis alcohol extraction; (6) (4) are mixed the back reconcentration with (5), every milliliter reaches 1 gram crude drug; (7) packing.

Embodiment 2

Get 3 kilograms of the Radixs Astragali, 3.3 kilograms of Radix Codonopsis, 2.7 kilograms of Rhizoma Atractylodis Macrocephalae, 2 kilograms of Radix Polygoni Multiflori, 2.7 kilograms of Fructus Lycii, 2.3 kilograms of Radix Angelicae Sinensis.

Increase by 1.9 kilograms of Fructus Jujubaes, 2.0 kilograms of Radix Et Caulis Acanthopanacis Senticosis, 2.0 kilograms of Rhizoma Polygonatis,

Production craft step branch (1) is got above-mentioned each composition Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, puts, rejects impurity respectively in order, and dried, makes its water content reach 6%; (2) get 2 kilograms of the Radixs Astragali, 2.3 kilograms of Radix Codonopsis, 1.7 kilograms of Rhizoma Atractylodis Macrocephalae, 1 kilogram of Radix Polygoni Multiflori, 1.7 kilograms of Fructus Lycii, 1.3 kilograms of Radix Angelicae Sinensis.Increase by 0.9 kilogram of Fructus Jujubae, 1.0 kilograms of Radix Et Caulis Acanthopanacis Senticosis, 1.0 kilograms of Rhizoma Polygonatis, (3) each composition is pulverized with pulverizer, and 60 orders sieve; (3) water logging that adds 64.5 kilograms after the Radix Astragali, Radix Codonopsis, Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae, the Radix Et Caulis Acanthopanacis Senticosi mixing was steeped 24 hours, carry out under the normal temperature condition, after steaming and decocting makes its boiling then, constant temperature 60 minutes, carry out the screen plate filter and remove residue again, concentrate, every milliliter reaches 0.6 gram left and right sides crude drug; (5) with Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Polygonati alcohol extraction; (6) (4) are mixed the back reconcentration with (5), every milliliter reaches 1 gram left and right sides crude drug; (7) packing

Claims

1, a kind of Chinese medicine oral liquid for the treatment of nerve injury, neuron degeneration illness.It is characterized in that: it is mainly made by following raw materials according: the Radix Astragali accounts for the 20-30% of gross weight, 20-25%, the 15-20% that Rhizoma Atractylodis Macrocephalae accounts for gross weight, 9-12%, the 15-20% that Fructus Lycii accounts for gross weight, the 11-15% that Radix Angelicae Sinensis accounts for gross weight that Radix Polygoni Multiflori accounts for gross weight that Radix Codonopsis accounts for gross weight.

2, Chinese medicine oral liquid according to claim 1 is characterized in that its raw material also has Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, and they respectively account for the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, 8-12%, the 5-10% of Radix Angelicae Sinensis gross weight, 5-10%.

3, the preparation method of Chinese medicine oral liquid according to claim 1, the processing step branch (1) that it is characterized in that it is got above-mentioned each composition Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, put, reject impurity respectively in order, and dried, make its water content reach 5-6%; (2) each composition is weighed to scale; (3) pulverize with pulverizer, 60 orders sieve; (4) the 3-5 water logging doubly that adds its gross weight after the Radix Astragali, Radix Codonopsis, Radix Polygoni Multiflori, the Fructus Lycii mixing was steeped 24 hours, carry out under the normal temperature condition, after steaming and decocting made its boiling then, constant temperature 60 minutes carried out the screen plate filter and remove residue again, concentrated, and every milliliter reaches 0.6 and restrains crude drug; (5) with Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis alcohol extraction; (6) (4) are mixed the back reconcentration with (5), every milliliter reaches 1 gram crude drug; (7) packing.

4, the preparation method of Chinese medicine oral liquid according to claim 2, the processing step branch (1) that it is characterized in that it is got above-mentioned each composition Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Polygoni Multiflori, Fructus Lycii, Radix Angelicae Sinensis, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati, put, reject impurity respectively in order, and dried, make its water content reach 5-6%; (2) each composition is weighed to scale; (3) pulverize with pulverizer, 60 orders sieve; (4) the 3-5 water logging doubly that adds its gross weight after the Radix Astragali, Radix Codonopsis, Radix Polygoni Multiflori, Fructus Lycii, Fructus Jujubae, the Radix Et Caulis Acanthopanacis Senticosi mixing was steeped 24 hours, carry out under the normal temperature condition, after steaming and decocting makes its boiling then, constant temperature 60 minutes, carry out the screen plate filter and remove residue again, concentrate, every milliliter reaches 0.6 gram crude drug; (5) with Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Polygonati alcohol extraction; (6) (4) are mixed the back reconcentration with (5), every milliliter reaches 1 gram crude drug.