CN114869935A - Natural plant hair-nourishing and hair-growing liquid and preparation method thereof - Google Patents
Natural plant hair-nourishing and hair-growing liquid and preparation method thereof Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 29
- 241000196324 Embryophyta Species 0.000 claims abstract description 21
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 11
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 11
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 11
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 11
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 11
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 11
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 11
- 235000008434 ginseng Nutrition 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- 244000170916 Paeonia officinalis Species 0.000 claims abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 10
- 241000208340 Araliaceae Species 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 10
- 238000002137 ultrasound extraction Methods 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 230000003779 hair growth Effects 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 230000001737 promoting effect Effects 0.000 claims description 4
- 230000001256 tonic effect Effects 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 abstract description 22
- 231100000360 alopecia Toxicity 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 17
- 239000002453 shampoo Substances 0.000 abstract description 6
- 208000004631 alopecia areata Diseases 0.000 abstract description 5
- 230000007547 defect Effects 0.000 abstract description 4
- 230000002349 favourable effect Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract description 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 10
- 241001106477 Paeoniaceae Species 0.000 description 8
- 229940079593 drug Drugs 0.000 description 5
- 208000024963 hair loss Diseases 0.000 description 5
- 230000003676 hair loss Effects 0.000 description 5
- 229940126673 western medicines Drugs 0.000 description 5
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000006210 lotion Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 206010001766 Alopecia totalis Diseases 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a natural plant hair-growing and hair-growing liquid and a preparation method thereof, wherein the natural plant hair-growing and hair-growing liquid comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 1-25 parts of safflower, 1-25 parts of ginseng, 1-25 parts of salvia miltiorrhiza, 1-25 parts of ligusticum wallichii and 1-25 parts of red paeony root. The hair-blacking shampoo belongs to a natural plant formula, has no toxic or side effect and high safety, has the effects of growing hair, blacking hair and treating alopecia areata and seborrheic alopecia, has a good treatment effect, can be directly added into shampoo and other hair washing products for use in the application process, avoids the defect of inconvenient use, and is further favorable for popularization and application.
Description
Technical Field
The invention relates to the technical field of hair loss treatment of head, in particular to a natural plant hair-nourishing and hair-growing liquid and a preparation method thereof.
Background
According to the modern society, with the influence of factors such as life style, working pressure, learning pressure, environmental pollution and the like, the hair loss population is gradually expanded, the age distribution of the hair loss population is smaller and smaller, and researches show that the hair loss of men in 20-40 years is the most serious, which is 20 years ahead of the hair loss of the previous generation. Another network survey and follow-up study showed that six out of bald men began to lose hair from the age of 25, and even some students began to lose hair just before high school.
Nowadays, alopecia has become a common disease and frequently-occurring disease, and there are over ten types, such as seborrheic alopecia (also called alopecia areata and alopecia prematura), alopecia areata, alopecia totalis, pathologic alopecia, dystrophic alopecia, alopecia caused by medicines and certain diseases, and the like, wherein the most common alopecia is seborrheic and accounts for more than 95% of patients.
At present, the medical field has no specific medicine for treating alopecia, the medicines for treating alopecia are numerous and disorderly in the market, and western medicines are used, but although the western medicines have good effects in a short period, the western medicines have large side effects and high price, are easy to relapse, treat symptoms and not root causes, such as minoxidil solution, finasteride tablets and the like; compared with western medicines, the traditional Chinese medicine preparation has a better effect, but is inconvenient to take because most of the traditional Chinese medicine preparations are decoction medicines, and difficult to persist for a long time, while the traditional Chinese medicine preparation in the form of lotion and the like is relatively less, and the effect is not very obvious, so that the requirements of alopecia patients on the medicines can not be met.
Therefore, the prior hair growth promoting medicine has the following problems: 1. the western medicines have large side effects and high price and are easy to relapse; 2. most of the traditional Chinese medicines are decoction medicines, so that the traditional Chinese medicines are inconvenient to take and difficult to insist for a long time; the lotion has poor efficacy, so a natural plant hair-growing liquid and a preparation method thereof are provided.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a natural plant hair-growing and hair-growing liquid and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme: a natural plant hair-growing and hair-growing liquid comprises the following raw materials in parts by weight: 1-25 parts of safflower, 1-25 parts of ginseng, 1-25 parts of salvia miltiorrhiza, 1-25 parts of ligusticum wallichii and 1-25 parts of red paeony root.
A preparation method of a natural plant hair-growing liquid comprises the following steps:
s1: selecting certain weight parts of raw materials of safflower, ginseng, salvia miltiorrhiza, ligusticum wallichii and red paeony root, crushing the raw materials to 20-40 meshes by using a crusher, adding an ethanol solution which is 10-12 times of the weight of the raw materials, and extracting for 1-2 times under the ultrasonic condition to obtain an extracting solution;
s2, filtering impurities in the extracting solution by adopting a 100nm-10nm filter membrane aiming at the obtained extracting solution to obtain a filtrate;
s3: pouring the obtained filtrate into a rotary evaporator, and performing vacuum concentration at 60-80 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, and sterilizing at 90-100 deg.C for 20-30 min to obtain hair growth promoting solution.
Preferably, in step S1, the concentration of the ethanol solution is 50% to 70%.
Preferably, in the step S1, the single ultrasound extraction time lasts for 45-60 minutes.
Preferably, when the ultrasonic extraction is performed for 2 times in step S1, the extract is poured out after the first extraction is completed, an ethanol solution 10-12 times the weight of the raw material is added for the second extraction under the ultrasonic condition, and the two obtained extracts are combined before step S2 is started.
Preferably, in step S4, the 1, 2-hexanediol is added in an amount of 1% to 2% by volume of the concentrate.
The natural plant hair-growing and hair-growing liquid and the preparation method thereof have the beneficial effects that: according to the scheme, various raw materials are smooth plants, so that the obtained hair nourishing and growing liquid belongs to a natural plant formula, has no toxic or side effect and high safety, has the effects of growing hair, blackening hair and treating alopecia areata and seborrheic alopecia, is good in treatment effect, can be directly added into shampoo and other hair washing products for use in the application process, avoids the defect of inconvenience in use, and is further favorable for popularization and application.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A natural plant hair-growing and hair-growing liquid comprises the following raw materials in parts by weight: 5 parts of safflower, 5 parts of ginseng, 5 parts of salvia miltiorrhiza, 5 parts of ligusticum wallichii and 5 parts of red paeony root.
Aiming at the raw materials in parts by weight, the preparation of the natural plant hair-nourishing and hair-growing liquid is carried out by adopting the following steps:
s1: selecting the raw materials of safflower, ginseng, salvia miltiorrhiza, ligusticum wallichii and red paeony root in parts by weight, crushing the raw materials into 20 meshes by using a crusher, adding an ethanol solution which is 10 times of the weight of the raw materials, and extracting for 1 time under the ultrasonic condition to obtain an extracting solution;
s2, filtering impurities in the extracting solution by adopting a 100nm filter membrane aiming at the obtained extracting solution, and obtaining filtrate;
s3: pouring the obtained filtrate into a rotary evaporator, and performing vacuum concentration at 60 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, and sterilizing at 90 deg.C for 20 min to obtain hair growth promoting solution.
In step S1, the concentration of the ethanol solution is 50%.
In step S1, a single ultrasound extraction time lasts 45 minutes.
In step S4, 1, 2-hexanediol was added in an amount of 1% by volume based on the volume of the concentrate.
Example 2
A natural plant hair-growing and hair-growing liquid comprises the following raw materials in parts by weight: 5 parts of safflower, 5 parts of ginseng, 25 parts of salvia miltiorrhiza, 25 parts of ligusticum wallichii and 25 parts of red paeony root.
Aiming at the raw materials in parts by weight, the preparation of the natural plant hair-nourishing and hair-growing liquid is carried out by adopting the following steps:
s1: selecting the raw materials of safflower, ginseng, salvia miltiorrhiza, ligusticum wallichii and red paeony root in parts by weight, crushing the raw materials into 30 meshes by using a crusher, adding an ethanol solution which is 11 times of the weight of the raw materials, and extracting for 2 times under the ultrasonic condition to obtain an extracting solution;
s2, filtering impurities in the extracting solution by adopting a 50nm filter membrane aiming at the obtained extracting solution, and obtaining filtrate;
s3: pouring the obtained filtrate into a rotary evaporator, and performing vacuum concentration at 70 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, and sterilizing at 95 ℃ for 25 minutes to obtain the hair-nourishing and hair-growing liquid.
In step S1, the concentration of the ethanol solution is 60%.
In step S1, a single ultrasound extraction time lasts 55 minutes.
In the step S1, when the ultrasonic extraction is performed for 2 times, the extract is poured out after the first extraction is completed, an ethanol solution 11 times the weight of the raw materials is added for the second extraction under the ultrasonic condition, and the two obtained extracts are combined before the step S2 is started.
In step S4, 1, 2-hexanediol was added in an amount of 1.5% by volume based on the volume of the concentrate.
Example 3
A natural plant hair-growing and hair-growing liquid comprises the following raw materials in parts by weight: 25 parts of safflower, 25 parts of ginseng, 25 parts of salvia miltiorrhiza, 5 parts of ligusticum wallichii and 5 parts of red paeony root.
Aiming at the raw materials in parts by weight, the preparation of the natural plant hair-nourishing and hair-growing liquid is carried out by adopting the following steps:
s1: selecting the raw materials of safflower, ginseng, salvia miltiorrhiza, ligusticum wallichii and red paeony root in parts by weight, crushing the raw materials into 40 meshes by using a crusher, adding an ethanol solution with the weight 12 times that of the raw materials, and extracting for 1 time under the ultrasonic condition to obtain an extracting solution;
s2, filtering impurities in the extracting solution by adopting a 10nm filter membrane aiming at the obtained extracting solution, and obtaining filtrate;
s3: pouring the obtained filtrate into a rotary evaporator, and performing vacuum concentration at 80 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, and sterilizing at 100 ℃ for 30 minutes to obtain the hair-nourishing and hair-growing liquid.
In step S1, the concentration of the ethanol solution is 70%.
In step S1, a single ultrasound extraction time lasts 60 minutes.
In step S4, 1, 2-hexanediol was added in an amount of 2% by volume based on the volume of the concentrate.
Comparative example:
the hair-nourishing and hair-growing liquid obtained in example 1, example 2 and example 3 is selected to be mixed with a common shampoo on the market and used for one group of alopecia patients, and then the shampoo for treating alopecia on the market is used for another group of alopecia patients, the application process is 1 time per day and lasts for 7 months, and the treatment effects (the treatment effects are classified into ineffectiveness, effectiveness and high efficiency) are counted in the following table 1:
according to the table 1, it can be seen that the hair growth and development liquid has an obvious treatment effect when being used for patients with alopecia, so that the hair growth and development liquid belongs to a natural plant formula, has no toxic or side effect and high safety when being used, has the effects of growing hair, blackening hair and treating alopecia areata and seborrheic alopecia, has a good treatment effect, can be directly added into shampoo and other hair washing products for use in the application process, avoids the defect of inconvenient use, and is further favorable for popularization and application.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is specific and detailed, but not construed as limiting the patent of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the spirit of the invention, which falls within the scope of the invention.
Claims (6)
1. The natural plant hair-growing and hair-growing liquid is characterized by comprising the following raw materials in parts by weight: 1-25 parts of safflower, 1-25 parts of ginseng, 1-25 parts of salvia miltiorrhiza, 1-25 parts of ligusticum wallichii and 1-25 parts of red paeony root.
2. The method for preparing a hair tonic and growing liquid of natural plants according to claim 1, comprising the steps of:
s1: selecting certain weight parts of raw materials of safflower, ginseng, salvia miltiorrhiza, ligusticum wallichii and red paeony root, crushing the raw materials to 20-40 meshes by using a crusher, adding an ethanol solution which is 10-12 times of the weight of the raw materials, and extracting for 1-2 times under the ultrasonic condition to obtain an extracting solution;
s2, filtering impurities in the extracting solution by adopting a 100nm-10nm filter membrane aiming at the obtained extracting solution to obtain a filtrate;
s3: pouring the obtained filtrate into a rotary evaporator, and performing vacuum concentration at 60-80 ℃ to recover the ethanol added in the step S1 to obtain a concentrated solution;
s4: adding 1, 2-hexanediol into the obtained concentrated solution, and sterilizing at 90-100 deg.C for 20-30 min to obtain hair growth promoting solution.
3. The method of claim 2, wherein the ethanol solution has a concentration of 50% to 70% in step S1.
4. The method of claim 2, wherein the ultrasonic extraction is performed for 45-60 minutes in step S1.
5. The method of claim 2, wherein in the step S1, when the ultrasonic extraction is performed 2 times, the extract is poured out after the first extraction is completed, an ethanol solution 10-12 times of the weight of the raw material is added to perform the second extraction under the ultrasonic condition, and the two extracts are combined before the step S2 is performed.
6. The method of claim 2, wherein the 1, 2-hexanediol is added in an amount of 1-2% by volume of the concentrate in step S4.
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CN104815013A (en) * | 2015-04-26 | 2015-08-05 | 肖付亮 | Medicine for treating premature alopecia and preparation method thereof |
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CN104800263A (en) * | 2015-04-15 | 2015-07-29 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating alopecia areata as well as preparation method and application of traditional Chinese medicine composition |
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