CN107496578A - Treat Chinese medicine composition of chronic cough and asthma and preparation method and application - Google Patents
Treat Chinese medicine composition of chronic cough and asthma and preparation method and application Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating chronic cough and asthma and preparation method and application, the raw material components of Chinese medicine composition by weight, including：The parts by weight of rhodiola root 1~3, the parts by weight of ephedra 1~3 and the parts by weight of the fruit of Chinese magnoliavine 1~3.The present invention considers in terms of phlegm matter and blood pressure two, by using medicinal materials such as ephedras as raw material, the Chinese medicine composition being refining to obtain has the effect for the treatment of chronic cough and asthma, can reach treat both principal and secondary aspect of disease, the effect that As the medicine took effect, the symptoms lessened, and safe without toxic side effect, the use for the conventional medicament that side effect is larger and therapeutic effect is undesirable can be avoided；Easy to use, production cost is relatively low.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic cough and asthma and its preparation side
Method and application.
Background technology
Chronic bronchial cough and asthma is the immediate cause of respiratory failure.Traditional Chinese and western medicine causes much to suffer from without effectively treatment at present
Person loses self care ability even death, and very big spirit and economic loss are caused to family and society.Treat at present chronic
The medicine of cough and asthma mainly has strength cough-relieving Yiganning capsule, only cough methoxyphenamini hydrochloridum syrup and Baihuadingchuan Pill etc., is mostly to cure the symptoms, not the disease,
Curative effect has much room for improvement, and certain side effect be present.Therefore, it is also desirable to develop new safely and effectively treatment chronic cough and asthma
Medicine, to avoid the deficiency of existing medicine.
The content of the invention
For in the prior art the defects of, present invention aims at provide a kind of Chinese medicine composition for treating chronic cough and asthma and
Its preparation method and application, as raw material, to extract active component and the Chinese medicine being refining to obtain by using medicinal materials such as ephedras
Composition, there is the effect for the treatment of chronic cough and asthma, safe without toxic side effect；Easy to use, cost is relatively low, has business well
Prospect.
To achieve the above object, technical scheme provided by the invention is：
In a first aspect, the invention provides a kind of Chinese medicine composition for treating chronic cough and asthma, the parts by weight of rhodiola root 1~3, process
The parts by weight of Chinese ephedra 1~3 and the parts by weight of the fruit of Chinese magnoliavine 1~3.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The weight of Inula britannica chinensis 1~3
Part, the parts by weight of raddle 1~3, the parts by weight of magnetite 1~3, the parts by weight of cymose buckwheat rhizome 1~3, the parts by weight of cassia twig 1~3, the weight of almond 1~3
Measure part, the parts by weight of perillaseed 1~3, the parts by weight of gingko 1~3 and the parts by weight of the root bark of white mulberry 1~3.It should be noted that the present invention provides
Chinese medicine composition for treatment cough breathe heavily less more high blood pressure types chronic cough and asthma it is evident in efficacy.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The weight of Inula britannica chinensis 1~3
Part, the parts by weight of almond 1~3, the parts by weight of perillaseed 1~3, the parts by weight of gingko 1~3, the parts by weight of the root bark of white mulberry 1~3, the weight of tussilago 1~3
Measure part, the parts by weight of radix scutellariae 1~3, the parts by weight of honey-fried licorice root 1~3, the parts by weight of the tuber of pinellia 1~3, the parts by weight of dried orange peel 1~3 and Poria cocos 1~3
Parts by weight.It should be noted that Chinese medicine composition provided by the invention breathes heavily the chronic of more blood pressure normal types less for treatment cough
Cough and asthma is evident in efficacy.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The parts by weight of red ginseng 1~3,
The parts by weight of the tuber of dwarf lilyturf 1~3, the parts by weight of cassia twig 1~3, the parts by weight of gekko 1~3, the parts by weight of honey-fried licorice root 1~3, the parts by weight of the Radix Astragali 1~3
With the parts by weight of the bighead atractylodes rhizome 1~3.It should be noted that Chinese medicine composition provided by the invention breathes heavily the low class of more blood pressures less for treatment cough
The chronic cough and asthma of type is evident in efficacy.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The parts by weight of cassia twig 1~3,
The parts by weight of rhizoma zingiberis 1~3, the parts by weight of asarum 1~3, the parts by weight of the tuber of pinellia 1~3, the parts by weight of the root of herbaceous peony 1~3, the parts by weight of honey-fried licorice root 1~3
With the parts by weight of stalactite 1~3.It should be noted that Chinese medicine composition provided by the invention breathes heavily type for treating dilute productive cough
Chronic cough and asthma is evident in efficacy.
The present invention further embodiment in, the raw material components of Chinese medicine composition by weight, including：Ephedra
1~3 parts by weight, the parts by weight of cassia twig 1~3, the parts by weight of the root bark of white mulberry 1~3, the parts by weight of almond 1~3, the parts by weight of Tabasheer 1~3, Zhejiang
The parts by weight of shellfish 1~3, the parts by weight of gypsum 1~3, the parts by weight of the wind-weed 1~3, the parts by weight of Inula britannica chinensis 1~3, the parts by weight of raddle 1~3
With the parts by weight of ardisia japonica 1~3.It should be noted that Chinese medicine composition provided by the invention breathes heavily type for treating thick productive cough
Chronic cough and asthma is evident in efficacy.
Second aspect, the invention provides the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma, comprise the following steps：
S1：Ephedra is put into water and heated, is then filtered, collects the first filtrate；S2：Other surplus stock components are added to the water leaching
Bubble；Obtained mixture progress refluxing extraction will be soaked, filtered after extraction, collect the second filtrate；S3：By the first filtrate and
Second filtrate is well mixed, and then concentrates, and obtained concentrate is Chinese medicine composition.It should be noted that the present invention's controls
The preparation method for treating the Chinese medicine composition of chronic cough and asthma is not limited to cited method, any to extract raw material components and energy
The preparation method of Chinese medicine composition for treating chronic cough and asthma is feasible；Such as：All raw material components are pulverized
End, then it is prepared into capsule or particle.
In the further embodiment of the present invention, in step S1, the ratio of the quality of water and the quality of ephedra is (7
~9):1, the temperature of heating is 70~80 DEG C, and the time of heating is 80~90min.
In the further embodiment of the present invention, in step S2, the quality of water is the gross mass of other remaining ingredients
10~13 times；The temperature of immersion is 50~60 DEG C, and the time of immersion is 70~80min；The time of refluxing extraction is 1~2h；Step
In rapid S3, concentrate is 1.15~1.2 in the relative density of 25 DEG C of measure.
The third aspect, the invention provides application of the above-mentioned Chinese medicine composition in the medicine for preparing treatment chronic cough and asthma.
It should be noted that the application method of the Chinese medicine composition for the treatment chronic cough and asthma that the present invention is prepared is preferred
For：Each oral 15~25g, oral 1 time of every morning；It can be orally adjusted according to the state of an illness total time.In addition, medication period
Between must aviod certain food, the food including shrimp, crab, wine, capsicum, leek, animal head and pin is taboo food.
Chinese medicine composition prepared by the above method can be further prepared into pharmaceutically acceptable formulation as needed.This
Outside, protection scope of the present invention is fallen within by medicine made of active component of above-mentioned Chinese medicine composition.By by said medicine
Composition, prepared after directly preparing or adding pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable formulation.
Include by taking external preparation as an example：Solution, patch, vina, tincture, gel, liniment, aerosol, spray, ointment, bolt
Agent and plastics.The medicine of above-mentioned various formulations can be prepared according to the conventional method of pharmaceutical field.
Technical scheme provided by the invention, there is following beneficial effect：(1) present invention avoids modern integrative therapy cough
The conventional thinking of asthma, the information for being easy to grasp from the presence or absence of phlegm, the change of phlegm matter, difference of blood pressure etc. are started with, efficiently solved
This problem for the treatment of chronic cough and asthma；(2) Chinese medicine composition provided by the invention for treating chronic cough and asthma, raw material components selection are
Chinese medicinal material containing active skull cap components, prescription proportioning science, any Western medicine hormonal components, safe and non-toxic secondary work is not added
With；(3) present invention consider in terms of phlegm matter and blood pressure two, there is provided Chinese medicine composition there is excellent treatment chronic cough and asthma
Etc. function, the crowd that is applicable includes cough and breathes heavily more high blood pressures, normal and low patient, dilute productive cough asthma patient and thick productive cough asthma patient less,
It can reach and treat both principal and secondary aspect of disease, the effect that As the medicine took effect, the symptoms lessened, easy to use, cost is relatively low, has good commercial promise；(4) using this
The preparation method provided is provided, can be while each bulk drug active component be retained to greatest extent, in each raw medicinal material
Active ingredient fully discharge so that the Chinese medicine composition being finally prepared not only has good drug effect, and easily
In absorption, and then it is rapidly achieved the purpose for the treatment of chronic cough and asthma.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme, therefore be intended only as example, and can not limit this hair with this
Bright protection domain.
Experimental method in following embodiments, it is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following examples, is respectively provided with three
Secondary to repeat to test, data are to repeat the average value or mean+SD of experiment three times.
Rhodiola root used, ephedra, the fruit of Chinese magnoliavine, Inula britannica chinensis, raddle, magnetite, cymose buckwheat rhizome, osmanthus in following embodiments
Branch, almond, perillaseed, gingko, the root bark of white mulberry, tussilago, radix scutellariae, honey-fried licorice root, the tuber of pinellia, dried orange peel, Poria cocos, red ginseng, the tuber of dwarf lilyturf, gekko, osmanthus
Branch, rhizoma zingiberis, asarum, the fruit of Chinese magnoliavine, the root of herbaceous peony, stalactite, Tabasheer, bulb of thunberg fritillary, gypsum, the wind-weed, raddle and ardisia japonica, in meeting
Pertinent regulations under each medicinal material item of text of state's pharmacopeia (version in 2015).Before feeding intake, by identification, ingredients material object and name
Title is consistent, and quality meets standard.
Embodiment one
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (dilute productive cough asthma), and raw material components are by weight
Meter, including：The parts by weight of ephedra 2, the parts by weight of cassia twig 2, the parts by weight of rhizoma zingiberis 2, the parts by weight of asarum 2, the parts by weight of the tuber of pinellia 2, the fruit of Chinese magnoliavine 2
Parts by weight, the parts by weight of the root of herbaceous peony 2, the parts by weight of honey-fried licorice root 2, the parts by weight of stalactite 2 and the parts by weight of rhodiola root 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 75 DEG C of heating 85min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 8:1；
S2：Other surplus stock components are added to the water, 55 DEG C of immersion 75min；The mixture that immersion obtains is returned
Stream extraction 1.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
12 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment two
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (dilute productive cough asthma), and raw material components are by weight
Meter, including：The parts by weight of ephedra 1, the parts by weight of cassia twig 3, the parts by weight of rhizoma zingiberis 1, the parts by weight of asarum 3, the parts by weight of the tuber of pinellia 1, the fruit of Chinese magnoliavine 3
Parts by weight, the parts by weight of the root of herbaceous peony 1, the parts by weight of honey-fried licorice root 3, the parts by weight of stalactite 1 and the parts by weight of rhodiola root 3.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 70 DEG C of heating 80min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 7:1；
S2：Other surplus stock components are added to the water, 50 DEG C of immersion 70min；The mixture that immersion obtains is returned
Stream extraction 1h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 10 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment three
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (dilute productive cough asthma), and raw material components are by weight
Meter, including：The parts by weight of ephedra 3, the parts by weight of cassia twig 1, the parts by weight of rhizoma zingiberis 3, the parts by weight of asarum 1, the parts by weight of the tuber of pinellia 3, the fruit of Chinese magnoliavine 1
Parts by weight, the parts by weight of the root of herbaceous peony 3, the parts by weight of honey-fried licorice root 1, the parts by weight of stalactite 3 and the parts by weight of rhodiola root 1.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 80 DEG C of heating 90min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 9:1；
S2：Other surplus stock components are added to the water, 60 DEG C of immersion 80min；The mixture that immersion obtains is returned
Stream extraction 2h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 13 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
Example IV
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (thick productive cough asthma), and raw material components are by weight
Meter, including：The parts by weight of ephedra 2, the parts by weight of cassia twig 2, the parts by weight of the root bark of white mulberry 2, the parts by weight of almond 2, the parts by weight of Tabasheer 2, Zhejiang
The parts by weight of shellfish 2, the parts by weight of gypsum 2, the parts by weight of the wind-weed 2, the parts by weight of Inula britannica chinensis 2, the parts by weight of raddle 2 and the parts by weight of ardisia japonica 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 75 DEG C of heating 85min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 8:1；
S2：Other surplus stock components are added to the water, 55 DEG C of immersion 75min；The mixture that immersion obtains is returned
Stream extraction 1.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
12 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment five
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (thick productive cough asthma), and raw material components are by weight
Meter, including：The parts by weight of ephedra 1, the parts by weight of cassia twig 3, the parts by weight of the root bark of white mulberry 1, the parts by weight of almond 3, the parts by weight of Tabasheer 1, Zhejiang
The parts by weight of shellfish 3, the parts by weight of gypsum 1, the parts by weight of the wind-weed 3, the parts by weight of Inula britannica chinensis 1, the parts by weight of raddle 3 and the parts by weight of ardisia japonica 1.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 70 DEG C of heating 80min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 7:1；
S2：Other surplus stock components are added to the water, 50 DEG C of immersion 70min；The mixture that immersion obtains is returned
Stream extraction 1h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 10 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment six
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (thick productive cough asthma), and raw material components are by weight
Meter, including：The parts by weight of ephedra 3, the parts by weight of cassia twig 1, the parts by weight of the root bark of white mulberry 3, the parts by weight of almond 1, the parts by weight of Tabasheer 3, Zhejiang
The parts by weight of shellfish 1, the parts by weight of gypsum 3, the parts by weight of the wind-weed 1, the parts by weight of Inula britannica chinensis 3, the parts by weight of raddle 1 and the parts by weight of ardisia japonica 3.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 80 DEG C of heating 90min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 9:1；
S2：Other surplus stock components are added to the water, 60 DEG C of immersion 80min；The mixture that immersion obtains is returned
Stream extraction 2h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 13 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
Embodiment seven
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (cough breathes heavily more high blood pressures less), and raw material components are by weight
Part meter is measured, including：The parts by weight of rhodiola root 2, the parts by weight of ephedra 2, the parts by weight of the fruit of Chinese magnoliavine 2, the parts by weight of Inula britannica chinensis 2, the weight of raddle 2
Measure part, the parts by weight of magnetite 2, the parts by weight of cymose buckwheat rhizome 2, the parts by weight of cassia twig 2, the parts by weight of almond 2, the parts by weight of perillaseed 2, the weight of gingko 2
Part and the parts by weight of the root bark of white mulberry 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 75 DEG C of heating 85min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 8:1；
S2：Other surplus stock components are added to the water, 55 DEG C of immersion 75min；The mixture that immersion obtains is returned
Stream extraction 1.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
12 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment eight
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (cough breathes heavily more high blood pressures less), and raw material components are by weight
Part meter is measured, including：The parts by weight of rhodiola root 1, the parts by weight of ephedra 3, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of Inula britannica chinensis 3, the weight of raddle 1
Measure part, the parts by weight of magnetite 3, the parts by weight of cymose buckwheat rhizome 1, the parts by weight of cassia twig 3, the parts by weight of almond 1, the parts by weight of perillaseed 3, the weight of gingko 1
Part and the parts by weight of the root bark of white mulberry 3.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 70 DEG C of heating 80min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 7:1；
S2：Other surplus stock components are added to the water, 50 DEG C of immersion 70min；The mixture that immersion obtains is returned
Stream extraction 1h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 10 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment nine
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (cough breathes heavily more high blood pressures less), and raw material components are by weight
Part meter is measured, including：The parts by weight of rhodiola root 3, the parts by weight of ephedra 1, the parts by weight of the fruit of Chinese magnoliavine 3, the parts by weight of Inula britannica chinensis 1, the weight of raddle 3
Measure part, the parts by weight of magnetite 1, the parts by weight of cymose buckwheat rhizome 3, the parts by weight of cassia twig 1, the parts by weight of almond 3, the parts by weight of perillaseed 1, the weight of gingko 3
Part and the parts by weight of the root bark of white mulberry 1.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 80 DEG C of heating 90min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 9:1；
S2：Other surplus stock components are added to the water, 60 DEG C of immersion 80min；The mixture that immersion obtains is returned
Stream extraction 2h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 13 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
Embodiment ten
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (it is normal that cough breathes heavily more blood pressures less), and raw material components are pressed
Parts by weight meter, including：The parts by weight of rhodiola root 2, the parts by weight of ephedra 2, the parts by weight of the fruit of Chinese magnoliavine 2, the parts by weight of Inula britannica chinensis 2, the weight of almond 2
Measure part, the parts by weight of perillaseed 2, the parts by weight of gingko 2, the parts by weight of the root bark of white mulberry 2, the parts by weight of tussilago 2, the parts by weight of radix scutellariae 2, honey-fried licorice root 2
Parts by weight, the parts by weight of the tuber of pinellia 2, the parts by weight of dried orange peel 2 and the parts by weight of Poria cocos 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 75 DEG C of heating 85min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 8:1；
S2：Other surplus stock components are added to the water, 55 DEG C of immersion 75min；The mixture that immersion obtains is returned
Stream extraction 1.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
12 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment 11
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (it is normal that cough breathes heavily more blood pressures less), and raw material components are pressed
Parts by weight meter, including：The parts by weight of rhodiola root 1, the parts by weight of ephedra 3, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of Inula britannica chinensis 3, the weight of almond 1
Measure part, the parts by weight of perillaseed 3, the parts by weight of gingko 1, the parts by weight of the root bark of white mulberry 3, the parts by weight of tussilago 1, the parts by weight of radix scutellariae 3, honey-fried licorice root 1
Parts by weight, the parts by weight of the tuber of pinellia 3, the parts by weight of dried orange peel 1 and the parts by weight of Poria cocos 3.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 70 DEG C of heating 80min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 7:1；
S2：Other surplus stock components are added to the water, 50 DEG C of immersion 70min；The mixture that immersion obtains is returned
Stream extraction 1h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 10 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment 12
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (it is normal that cough breathes heavily more blood pressures less), and raw material components are pressed
Parts by weight meter, including：The parts by weight of rhodiola root 3, the parts by weight of ephedra 1, the parts by weight of the fruit of Chinese magnoliavine 3, the parts by weight of Inula britannica chinensis 1, the weight of almond 3
Measure part, the parts by weight of perillaseed 1, the parts by weight of gingko 3, the parts by weight of the root bark of white mulberry 1, the parts by weight of tussilago 3, the parts by weight of radix scutellariae 1, honey-fried licorice root 3
Parts by weight, the parts by weight of the tuber of pinellia 1, the parts by weight of dried orange peel 3 and the parts by weight of Poria cocos 1.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 80 DEG C of heating 90min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 9:1；
S2：Other surplus stock components are added to the water, 60 DEG C of immersion 80min；The mixture that immersion obtains is returned
Stream extraction 2h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 13 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
Embodiment 13
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (it is low that cough breathes heavily more blood pressures less), and raw material components are by weight
Part meter is measured, including：The parts by weight of rhodiola root 2, the parts by weight of ephedra 2, the parts by weight of the fruit of Chinese magnoliavine 2, the parts by weight of red ginseng 2, the weight of the tuber of dwarf lilyturf 2
Part, the parts by weight of cassia twig 2, the parts by weight of gekko 2, the parts by weight of honey-fried licorice root 2, the parts by weight of the Radix Astragali 2 and the parts by weight of the bighead atractylodes rhizome 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 75 DEG C of heating 85min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 8:1；
S2：Other surplus stock components are added to the water, 55 DEG C of immersion 75min；The mixture that immersion obtains is returned
Stream extraction 1.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
12 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment 14
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (it is low that cough breathes heavily more blood pressures less), and raw material components are by weight
Part meter is measured, including：The parts by weight of rhodiola root 1, the parts by weight of ephedra 3, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of red ginseng 3, the weight of the tuber of dwarf lilyturf 1
Part, the parts by weight of cassia twig 3, the parts by weight of gekko 2, the parts by weight of honey-fried licorice root 2, the parts by weight of the Radix Astragali 2 and the parts by weight of the bighead atractylodes rhizome 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 70 DEG C of heating 80min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 7:1；
S2：Other surplus stock components are added to the water, 50 DEG C of immersion 70min；The mixture that immersion obtains is returned
Stream extraction 1h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 10 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment 15
The present embodiment provides the Chinese medicine composition that one kind treats chronic cough and asthma (it is low that cough breathes heavily more blood pressures less), and raw material components are by weight
Part meter is measured, including：The parts by weight of rhodiola root 3, the parts by weight of ephedra 1, the parts by weight of the fruit of Chinese magnoliavine 3, the parts by weight of red ginseng 1, the weight of the tuber of dwarf lilyturf 3
Part, the parts by weight of cassia twig 1, the parts by weight of gekko 2, the parts by weight of honey-fried licorice root 2, the parts by weight of the Radix Astragali 2 and the parts by weight of the bighead atractylodes rhizome 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma provided by the invention, prepare
Treat the Chinese medicine composition of chronic cough and asthma：
S1：Ephedra is put into water, 80 DEG C of heating 90min, then filters, collects the first filtrate；Wherein, the quality of water
Ratio with the quality of ephedra is 9:1；
S2：Other surplus stock components are added to the water, 60 DEG C of immersion 80min；The mixture that immersion obtains is returned
Stream extraction 2h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 13 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
The Chinese medicine composition for the treatment chronic cough and asthma that the embodiment of the present invention one to embodiment 15 is prepared, passes through work(
Experiment can be learned and carry out system evaluation its effect.
1st, to chronic cough and asthma (dilute productive cough asthma) patient the effect of
Recruitment is clinically diagnosed as chronic cough and asthma (dilute productive cough asthma) patient 150, is randomly divided into 3 groups, every group 50, distinguishes
The Chinese medicine composition that the embodiment of the present invention one is prepared to embodiment three is taken, each oral 20g, every morning is edible 1 time,
It is a course for the treatment of to take 15 days；During medication, without using other drugs.
Diagnostic criteria：It is effective：Chronic cough and asthma related symptoms all disappear；Take a turn for the better：Chronic cough and asthma related symptoms largely disappear
Lose；It is invalid：Chronic cough and asthma related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 1 below.
The effect of table 1 is to chronic cough and asthma (dilute productive cough asthma) patient
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Embodiment one | 50 | 48 | 2 | 0 |
| Embodiment two | 50 | 45 | 5 | 0 |
| Embodiment three | 50 | 46 | 4 | 0 |
2nd, to chronic cough and asthma (thick productive cough asthma) patient the effect of
Recruitment is clinically diagnosed as chronic cough and asthma (thick productive cough asthma) patient 150, is randomly divided into 3 groups, every group 50, distinguishes
The Chinese medicine composition that the embodiment of the present invention four is prepared to embodiment six is taken, each oral 20g, every morning is edible 1 time,
It is a course for the treatment of to take 15 days；During medication, without using other drugs.
Diagnostic criteria：It is effective：Chronic cough and asthma related symptoms all disappear；Take a turn for the better：Chronic cough and asthma related symptoms largely disappear
Lose；It is invalid：Chronic cough and asthma related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 2 below.
The effect of table 2 is to chronic cough and asthma (thick productive cough asthma) patient
3rd, to chronic cough and asthma (cough breathes heavily more high blood pressures less) patient the effect of
Recruitment is clinically diagnosed as chronic cough and asthma (cough breathes heavily more high blood pressures less) patient 150, is randomly divided into 3 groups, every group 50
Name, takes the Chinese medicine composition that the embodiment of the present invention seven is prepared to embodiment nine respectively, each oral 20g, every morning
Edible 1 time, it is a course for the treatment of to take 20 days；During medication, without using other drugs.
Diagnostic criteria：It is effective：Chronic cough and asthma related symptoms all disappear；Take a turn for the better：Chronic cough and asthma related symptoms largely disappear
Lose；It is invalid：Chronic cough and asthma related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 3 below.
The effect of table 3 is to chronic cough and asthma (cough breathes heavily more high blood pressures less) patient
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Embodiment seven | 50 | 39 | 9 | 2 |
| Embodiment eight | 50 | 37 | 10 | 3 |
| Embodiment nine | 50 | 38 | 10 | 2 |
4th, to chronic cough and asthma (it is normal that cough breathes heavily more blood pressures less) patient the effect of
Recruitment is clinically diagnosed as chronic cough and asthma (it is normal that cough breathes heavily more blood pressures less) patient 150, is randomly divided into 3 groups, every group
50, the Chinese medicine composition that the embodiment of the present invention ten is prepared to embodiment 12 is taken respectively, each oral 20g, daily
Morning is edible 1 time, and it is a course for the treatment of to take 20 days；During medication, without using other drugs.
Diagnostic criteria：It is effective：Chronic cough and asthma related symptoms all disappear；Take a turn for the better：Chronic cough and asthma related symptoms largely disappear
Lose；It is invalid：Newborn chronic cough and asthma related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 4 below.
The effect of table 4 is to chronic cough and asthma (it is normal that cough breathes heavily more blood pressures less) patient
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Embodiment ten | 50 | 46 | 4 | 0 |
| Embodiment 11 | 50 | 46 | 4 | 0 |
| Embodiment 12 | 50 | 45 | 5 | 0 |
5th, to chronic cough and asthma (it is low that cough breathes heavily more blood pressures less) patient the effect of
Recruitment is clinically diagnosed as chronic cough and asthma (it is low that cough breathes heavily more blood pressures less) patient 150, is randomly divided into 3 groups, every group 50
Name, takes the Chinese medicine composition that the embodiment of the present invention 13 is prepared to embodiment 15 respectively, each oral 20g, daily
Morning is edible 1 time, and it is a course for the treatment of to take 20 days；During medication, without using other drugs.
Diagnostic criteria：It is effective：Chronic cough and asthma related symptoms all disappear；Take a turn for the better：Chronic cough and asthma related symptoms largely disappear
Lose；It is invalid：Chronic cough and asthma related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 5 below.
The effect of table 5 is to chronic cough and asthma (it is low that cough breathes heavily more blood pressures less) patient
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Embodiment 13 | 50 | 43 | 7 | 0 |
| Embodiment 14 | 50 | 40 | 9 | 1 |
| Embodiment 15 | 50 | 41 | 9 | 0 |
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Thus, define " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating chronic cough and asthma, it is characterised in that the raw material components of the Chinese medicine composition are by weight
Part meter, including：
The parts by weight of rhodiola root 1~3, the parts by weight of ephedra 1~3 and the parts by weight of the fruit of Chinese magnoliavine 1~3.
2. the Chinese medicine composition for the treatment of chronic cough and asthma according to claim 1, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of Inula britannica chinensis 1~3, the parts by weight of raddle 1~3, the parts by weight of magnetite 1~3, the parts by weight of cymose buckwheat rhizome 1~3, cassia twig 1~
3 parts by weight, the parts by weight of almond 1~3, the parts by weight of perillaseed 1~3, the parts by weight of gingko 1~3 and the parts by weight of the root bark of white mulberry 1~3.
3. the Chinese medicine composition for the treatment of chronic cough and asthma according to claim 1, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of Inula britannica chinensis 1~3, the parts by weight of almond 1~3, the parts by weight of perillaseed 1~3, the parts by weight of gingko 1~3, the root bark of white mulberry 1~3
Parts by weight, the parts by weight of tussilago 1~3, the parts by weight of radix scutellariae 1~3, the parts by weight of honey-fried licorice root 1~3, the parts by weight of the tuber of pinellia 1~3, dried orange peel 1
~3 parts by weight and the parts by weight of Poria cocos 1~3.
4. the Chinese medicine composition for the treatment of chronic cough and asthma according to claim 1, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of red ginseng 1~3, the parts by weight of the tuber of dwarf lilyturf 1~3, the parts by weight of cassia twig 1~3, the parts by weight of gekko 1~3, the weight of honey-fried licorice root 1~3
Measure part, the parts by weight of the Radix Astragali 1~3 and the parts by weight of the bighead atractylodes rhizome 1~3.
5. the Chinese medicine composition for the treatment of chronic cough and asthma according to claim 1, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of cassia twig 1~3, the parts by weight of rhizoma zingiberis 1~3, the parts by weight of asarum 1~3, the parts by weight of the tuber of pinellia 1~3, the weight of the root of herbaceous peony 1~3
Part, the parts by weight of honey-fried licorice root 1~3 and the parts by weight of stalactite 1~3.
6. a kind of Chinese medicine composition for treating chronic cough and asthma, it is characterised in that the raw material components of the Chinese medicine composition are by weight
Part meter, including：
The parts by weight of ephedra 1~3, the parts by weight of cassia twig 1~3, the parts by weight of the root bark of white mulberry 1~3, the parts by weight of almond 1~3, Tabasheer 1~
3 parts by weight, the parts by weight of bulb of thunberg fritillary 1~3, the parts by weight of gypsum 1~3, the parts by weight of the wind-weed 1~3, the parts by weight of Inula britannica chinensis 1~3, raddle 1
~3 parts by weight and the parts by weight of ardisia japonica 1~3.
7. the preparation method of the Chinese medicine composition of the treatment chronic cough and asthma described in claim any one of 1-6, it is characterised in that bag
Include following steps：
S1：Ephedra is put into water and heated, is then filtered, collects the first filtrate；
S2：Other surplus stock components are added to the water immersion；By the mixture progress refluxing extraction soaked and obtained, extraction
After filter, collect the second filtrate；
S3：First filtrate and second filtrate are well mixed, then concentrated, obtained concentrate is the Chinese medicine
Composition.
8. the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma according to claim 7, it is characterised in that：
In step S1, the ratio of the quality of the water and the quality of the ephedra is (7~9):1, the temperature of the heating is
70~80 DEG C, the time of the heating is 80~90min.
9. the preparation method of the Chinese medicine composition for the treatment of chronic cough and asthma according to claim 7, it is characterised in that：
In step S2, the quality of the water is 10~13 times of the gross mass of other remaining ingredients；The temperature of the immersion is 50
~60 DEG C, the time of the immersion is 70~80min；The time of the refluxing extraction is 1~2h；
In step S3, the concentrate is 1.15~1.2 in the relative density of 25 DEG C of measure.
10. application of the Chinese medicine composition in the medicine for preparing treatment chronic cough and asthma described in claim any one of 1-5.
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| CN109512973A (en) * | 2018-12-14 | 2019-03-26 | 湖北荆江源制药股份有限公司 | A kind of medicine pill for treating chronic cough and asthma |
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| CN106491782A (en) * | 2016-12-29 | 2017-03-15 | 安徽中医药大学 | A kind of Chinese medicine preparation for treating asthma |
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2017
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| CN1296847A (en) * | 1999-11-18 | 2001-05-30 | 姜士兵 | Medicinal composition for treating asthma and tracheitis |
| CN102716372A (en) * | 2012-07-10 | 2012-10-10 | 李西秦 | Traditional Chinese medicine composition for curing chronic cough, and preparation method and usage thereof |
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| CN109512973A (en) * | 2018-12-14 | 2019-03-26 | 湖北荆江源制药股份有限公司 | A kind of medicine pill for treating chronic cough and asthma |
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