CN107412315A - Treat Chinese medicine composition of the proliferation of mammary gland and preparation method and application - Google Patents
Treat Chinese medicine composition of the proliferation of mammary gland and preparation method and application Download PDFInfo
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- CN107412315A CN107412315A CN201710698714.8A CN201710698714A CN107412315A CN 107412315 A CN107412315 A CN 107412315A CN 201710698714 A CN201710698714 A CN 201710698714A CN 107412315 A CN107412315 A CN 107412315A
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- 210000005075 mammary gland Anatomy 0.000 title claims abstract description 66
- 230000035755 proliferation Effects 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
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- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000002994 raw material Substances 0.000 claims abstract description 32
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating the proliferation of mammary gland and preparation method and application, the raw material components of Chinese medicine composition by weight, including：The parts by weight of dandelion 1~3, melon wither 1~3 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 1~3, the parts by weight of luffa 1~3 and the parts by weight of the seed of cowherb 1~3.The medicinal materials such as the present invention withers by using dandelion, melon, Radix Rhapontici seu Radix Echinopsis and luffa are as raw material, the Chinese medicine composition being refining to obtain has the effect of preventing and/or treating the proliferation of mammary gland, can reach treat both principal and secondary aspect of disease, the effect that As the medicine took effect, the symptoms lessened, and safe without toxic side effect, the use for the conventional medicament that side effect is larger and therapeutic effect is undesirable can be avoided；Easy to use, production cost is relatively low.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating the proliferation of mammary gland and its preparation
Method and application.
Background technology
The proliferation of mammary gland is the early symptom of breast cancer, is one of most common disease in gynaecological disease, and causes the sick disease
Because being mostly gastrointestinal disease.Gastrointestinal disease can cause pelvic fluid collection again, and then cause irregular menstruation, abnormal leucorrhea, long appearance
A series of gynecological diseases such as palace myomata, ovarian cyst.Therefore, it is also desirable to develop the medicine of the new treatment proliferation of mammary gland, make it
It can treat both principal and secondary aspect of disease, solve to endanger this physically and mentally healthy problem of women.
The content of the invention
For in the prior art the defects of, present invention aims at provide a kind of Chinese medicine composition for treating the proliferation of mammary gland
And preparation method and application, to be withered by using dandelion, melon, the medicinal material such as Radix Rhapontici seu Radix Echinopsis, luffa be used as raw material, extraction activity
Composition and the Chinese medicine composition being refining to obtain, there is the effect of preventing and/or treating the proliferation of mammary gland, safe without toxic side effect；Make
With conveniently, cost is relatively low, has good commercial promise.
To achieve the above object, technical scheme provided by the invention is：
In a first aspect, the invention provides a kind of Chinese medicine composition for treating the proliferation of mammary gland, the raw material group of Chinese medicine composition
Divide by weight, including：The parts by weight of dandelion 1~3, melon wither 1~3 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 1~3, luffa 1~3
Parts by weight and the parts by weight of the seed of cowherb 1~3.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The weight of rhizoma cyperi 1~3
Part.It should be noted that the Chinese medicine composition of the present invention is evident in efficacy for treating premenstrual swollen breasts.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The weight of cynanchum wilfordii 1~3
Part, the parts by weight of chingma abutilon seed 1~3, the parts by weight of rhizoma cyperi 1~3 and the parts by weight of rascal 1~3.It should be noted that the Chinese medicine of the present invention
Composition is evident in efficacy for treatment breast lump.
In the further embodiment of the present invention, the raw material components of Chinese medicine composition also include：The weight of radix semiaquilegiae 1~3
Part, the parts by weight of spina gleditsiae 1~3, the parts by weight of the root of Dahurain angelica 1~3, the parts by weight of frankincense 1~3, the parts by weight of myrrh 1~3, HERBA HEDYOTIS DIFFUSAE 1~3
Parts by weight, the parts by weight of Sculellaria barbata 1~3, the parts by weight of root of Chinese trichosanthes 1~3, the parts by weight of Radix Angelicae Sinensis 1~3, the parts by weight of Ligusticum wallichii 1~3, the radix paeoniae rubrathe 1
~3 parts by weight and the parts by weight of radix glycyrrhizae 1~3.It should be noted that the Chinese medicine composition of the present invention is treated for treatment relieving mammary gland gall
Effect is notable.
Second aspect, the invention provides the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland, including following step
Suddenly：S1：Dandelion, melon are withered to be put into water with Radix Rhapontici seu Radix Echinopsis and heated, is then filtered, collects the first filtrate； S2：Other are remaining former
Material component is added to the water immersion；Obtained mixture progress refluxing extraction will be soaked, filtered after extraction, collect the second filter
Liquid；S3：First filtrate and the second filtrate are well mixed, then concentrated, obtained concentrate is Chinese medicine composition.Need
Illustrate, the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland of the invention is not limited to cited method, any
The preparation method that raw material components can be extracted and can be used to treat the Chinese medicine composition of the proliferation of mammary gland is feasible；Such as：Will
All raw material components grind into powders, are then prepared into capsule or particle.
In the further embodiment of the present invention, in step S1, quality and dandelion, the melon of water wither total with Radix Rhapontici seu Radix Echinopsis
The ratio of quality is (6~10):1, the temperature of heating is 80~90 DEG C, and the time of heating is 60~80min.
In the further embodiment of the present invention, in step S2, the quality of water is the gross mass of other remaining ingredients
12~15 times.
In the further embodiment of the present invention, in step S2, the temperature of immersion is 35~45 DEG C, the time of immersion
For 30~40min；The time of refluxing extraction is 4~5h.
In the further embodiment of the present invention, in step S3, concentrate is 1.15 in the relative density of 25 DEG C of measure
~1.2.
The third aspect, the invention provides application of the above-mentioned Chinese medicine composition in the medicine for preparing the treatment proliferation of mammary gland.
It should be noted that the application method of the Chinese medicine composition for the treatment proliferation of mammary gland that the present invention is prepared is preferred
For：Each oral 20~30g, oral 1 time of every morning；It can be orally adjusted according to the state of an illness total time.The present invention provides
Chinese medicine composition it is rapid-action, general once effective by two days, patient can feel that the state of an illness mitigates；There is provided using the present invention
Chinese medicine composition when, to analyze the related taste state of an illness, stool abnormity, thick greasy fur symptom such as occur, simultaneous effect a permanent cure of being sure to
Disease；Further it is necessary to aviod certain food, including capsicum, leek, bamboo shoots, mushroom, pumpkin, salted vegetables, sea-tangle, wine, animal head and pin
Food is taboo food.
Chinese medicine composition prepared by the above method can be further prepared into pharmaceutically acceptable formulation as needed.This
Outside, protection scope of the present invention is fallen within by medicine made of active component of above-mentioned Chinese medicine composition.By by said medicine
Composition, prepared after directly preparing or adding pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable dose
Type.Include by taking external preparation as an example：Solution, patch, vina, tincture, gel, liniment, aerosol, spray, ointment
Agent, suppository and plastics.The medicine of above-mentioned various formulations can be prepared according to the conventional method of pharmaceutical field.
Technical scheme provided by the invention, there is following beneficial effect：(1) the treatment proliferation of mammary gland provided by the invention
Chinese medicine composition, what raw material components were selected is the Chinese medicinal material containing active skull cap components, prescription proportioning science, is not added
Any Western medicine hormonal components, safe without toxic side effect；(2) present invention is according to Chinese medicine meridian theoretical (breast category spleen, newborn core category
Liver), from liver and spleen two through medication, there is provided Chinese medicine composition there is excellent prevention and/or the treatment function such as the proliferation of mammary gland, clearly
Thermal detoxification, reducing phlegm and resolving masses, treat both principal and secondary aspect of disease, As the medicine took effect, the symptoms lessened, easy to use, and cost is relatively low, has good commercial promise；(3) adopt
, can be while each bulk drug active component be retained to greatest extent, each bulk drug with preparation method provided by the invention
Active ingredient in material fully discharges, so that the Chinese medicine composition being finally prepared not only has good drug effect,
And be easy to absorb, and then it is rapidly achieved the purpose of the treatment proliferation of mammary gland.
The additional aspect and advantage of the present invention will be set forth in part in the description, partly will from the following description
Become obvious, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Following reality
Apply example to be only used for clearly illustrating technical scheme, therefore be intended only as example, and this can not be limited with this
The protection domain of invention.
Experimental method in following embodiments, it is conventional method unless otherwise specified.Used in following embodiments
Test material, it is to be commercially available from regular shops unless otherwise specified.Quantitative test in following examples, is respectively provided with
Repeat to test three times, data are to repeat the average value or mean+SD of experiment three times.
In following embodiments dandelion used, melon wither, Radix Rhapontici seu Radix Echinopsis, luffa, the seed of cowherb, rhizoma cyperi, cynanchum wilfordii, winter certain herbaceous plants with big flowers
Son, radix semiaquilegiae, spina gleditsiae, the root of Dahurain angelica, frankincense, myrrh, HERBA HEDYOTIS DIFFUSAE and Sculellaria barbata etc. meet Chinese Pharmacopoeia (version in 2015) one
Pertinent regulations under each medicinal material item of text.Before feeding intake, by identification, ingredients material object is consistent with title, and quality meets mark
It is accurate.
Embodiment one
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (premenstrual swollen breasts), and raw material components are by weight
Part meter is measured, including：The parts by weight of dandelion 2, melon wither 2 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 2, the parts by weight of luffa 2, the weight of the seed of cowherb 2
Measure part and the parts by weight of rhizoma cyperi 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 85 DEG C of heating 70min, then filters, collects the first filtrate；
Wherein, it is 8 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 40 DEG C of immersion 35min；The mixture that immersion obtains is returned
Stream extraction 4.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
13 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment two
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (premenstrual swollen breasts), and raw material components are by weight
Part meter is measured, including：The parts by weight of dandelion 1, melon wither 3 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 1, the parts by weight of luffa 3, the weight of the seed of cowherb 1
Measure part and the parts by weight of rhizoma cyperi 3.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 80 DEG C of heating 60min, then filters, collects the first filtrate；
Wherein, it is 6 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 35 DEG C of immersion 30min；The mixture that immersion obtains is returned
Stream extraction 4h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 12 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment three
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (premenstrual swollen breasts), and raw material components are by weight
Part meter is measured, including：The parts by weight of dandelion 3, melon wither 1 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 3, the parts by weight of luffa 1, the weight of the seed of cowherb 3
Measure part and the parts by weight of rhizoma cyperi 1.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 90 DEG C of heating 80min, then filters, collects the first filtrate；
Wherein, it is 10 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 45 DEG C of immersion 40min；The mixture that immersion obtains is returned
Stream extraction 5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 15 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
Example IV
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (breast lump), and raw material components are by weight
Meter, including：The parts by weight of dandelion 2, melon wither 2 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 2, the parts by weight of luffa 2, the parts by weight of the seed of cowherb 2,
The parts by weight of cynanchum wilfordii 2, the parts by weight of chingma abutilon seed 2, the parts by weight of rhizoma cyperi 2 and the parts by weight of rascal 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 85 DEG C of heating 70min, then filters, collects the first filtrate；
Wherein, it is 8 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 40 DEG C of immersion 35min；The mixture that immersion obtains is returned
Stream extraction 4.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
13 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment five
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (breast lump), and raw material components are by weight
Meter, including：The parts by weight of dandelion 1, melon wither 3 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 1, the parts by weight of luffa 3, the parts by weight of the seed of cowherb 1,
The parts by weight of cynanchum wilfordii 3, the parts by weight of chingma abutilon seed 2, the parts by weight of rhizoma cyperi 2 and the parts by weight of rascal 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 80 DEG C of heating 60min, then filters, collects the first filtrate；
Wherein, it is 6 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 35 DEG C of immersion 30min；The mixture that immersion obtains is returned
Stream extraction 4h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 12 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment six
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (breast lump), and raw material components are by weight
Meter, including：The parts by weight of dandelion 3, melon wither 1 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 3, the parts by weight of luffa 1, the parts by weight of the seed of cowherb 3,
The parts by weight of cynanchum wilfordii 1, the parts by weight of chingma abutilon seed 3, the parts by weight of rhizoma cyperi 1 and the parts by weight of rascal 3.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 90 DEG C of heating 80min, then filters, collects the first filtrate；
Wherein, it is 10 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 45 DEG C of immersion 40min；The mixture that immersion obtains is returned
Stream extraction 5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 15 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
Embodiment seven
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (relieving mammary gland gall), and raw material components are by weight
Meter, including：The parts by weight of dandelion 2, melon wither 2 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 2, the parts by weight of luffa 2, the parts by weight of the seed of cowherb 2,
The parts by weight of cynanchum wilfordii 2, the parts by weight of chingma abutilon seed 2, the parts by weight of radix semiaquilegiae 2, the parts by weight of spina gleditsiae 2, the parts by weight of the root of Dahurain angelica 2, the weight of frankincense 2
Measure part, the parts by weight of myrrh 2, the parts by weight of HERBA HEDYOTIS DIFFUSAE 2, the parts by weight of Sculellaria barbata 2, the parts by weight of root of Chinese trichosanthes 2, the parts by weight of Radix Angelicae Sinensis 2, Ligusticum wallichii 2
Parts by weight, the parts by weight of the radix paeoniae rubrathe 2 and the parts by weight of radix glycyrrhizae 2..
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 85 DEG C of heating 70min, then filters, collects the first filtrate；
Wherein, it is 8 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 40 DEG C of immersion 35min；The mixture that immersion obtains is returned
Stream extraction 4.5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the gross mass of other remaining ingredients
13 times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.18 concentrate, as Chinese medicine composition.
Embodiment eight
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (relieving mammary gland gall), and raw material components are by weight
Meter, including：The parts by weight of dandelion 1, melon wither 3 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 1, the parts by weight of luffa 3, the parts by weight of the seed of cowherb 1,
The parts by weight of cynanchum wilfordii 3, the parts by weight of chingma abutilon seed 1, the parts by weight of radix semiaquilegiae 3, the parts by weight of spina gleditsiae 1, the parts by weight of the root of Dahurain angelica 3, the weight of frankincense 1
Measure part, the parts by weight of myrrh 3, the parts by weight of HERBA HEDYOTIS DIFFUSAE 1, the parts by weight of Sculellaria barbata 2, the parts by weight of root of Chinese trichosanthes 2, the parts by weight of Radix Angelicae Sinensis 2, Ligusticum wallichii 2
Parts by weight, the parts by weight of the radix paeoniae rubrathe 2 and the parts by weight of radix glycyrrhizae 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 80 DEG C of heating 60min, then filters, collects the first filtrate；
Wherein, it is 6 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 35 DEG C of immersion 30min；The mixture that immersion obtains is returned
Stream extraction 4h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 12 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.15 concentrate, as Chinese medicine composition.
Embodiment nine
The present embodiment provides the Chinese medicine composition that one kind treats the proliferation of mammary gland (relieving mammary gland gall), and raw material components are by weight
Meter, including：The parts by weight of dandelion 3, melon wither 1 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 3, the parts by weight of luffa 1, the parts by weight of the seed of cowherb 3,
The parts by weight of cynanchum wilfordii 1, the parts by weight of chingma abutilon seed 3, the parts by weight of radix semiaquilegiae 1, the parts by weight of spina gleditsiae 3, the parts by weight of the root of Dahurain angelica 1, the weight of frankincense 3
Measure part, the parts by weight of myrrh 1, the parts by weight of HERBA HEDYOTIS DIFFUSAE 3, the parts by weight of Sculellaria barbata 2, the parts by weight of root of Chinese trichosanthes 2, the parts by weight of Radix Angelicae Sinensis 2, Ligusticum wallichii 2
Parts by weight, the parts by weight of the radix paeoniae rubrathe 2 and the parts by weight of radix glycyrrhizae 2.
By above-mentioned raw material, using the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland provided by the invention, prepare
Treat the Chinese medicine composition of the proliferation of mammary gland：
S1：Dandelion, melon are withered and are put into Radix Rhapontici seu Radix Echinopsis in water, 90 DEG C of heating 80min, then filters, collects the first filtrate；
Wherein, it is 10 that the quality of water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with dandelion, melon:1；
S2：Other surplus stock components are added to the water, 45 DEG C of immersion 40min；The mixture that immersion obtains is returned
Stream extraction 5h, filters after extraction, collects the second filtrate；Wherein, the quality of water is the 15 of the gross mass of other remaining ingredients
Times；
S3：First filtrate and the second filtrate are well mixed, then concentrated, obtain 25 DEG C measure relative densities be
1.2 concentrate, as Chinese medicine composition.
The Chinese medicine composition for the treatment proliferation of mammary gland that the embodiment of the present invention one to embodiment nine is prepared, passes through work(
Experiment can be learned and carry out system evaluation its effect.
1st, to premenstrual swollen breasts the effect of
Recruitment is clinically diagnosed as premenstrual swollen breasts patient 150, is randomly divided into 3 groups, every group 50, takes respectively
The Chinese medicine composition that the embodiment of the present invention one is prepared to embodiment three, each oral 20g, every morning is edible 1 time, clothes
It was a course for the treatment of with 10 days；During medication, without using other drugs.
Diagnostic criteria：It is effective：Premenstrual swollen breasts related symptoms all disappear；Take a turn for the better：Premenstrual swollen breasts related symptoms
It is most of to disappear；It is invalid：Premenstrual swollen breasts related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 1 below.
The effect of table 1 is to premenstrual swollen breasts
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Embodiment one | 50 | 43 | 7 | 0 |
| Embodiment two | 50 | 40 | 10 | 0 |
| Embodiment three | 50 | 41 | 9 | 0 |
2nd, to breast lump the effect of
Recruitment is clinically diagnosed as patients with breast masses 150, is randomly divided into 3 groups, every group 50, takes this hair respectively
The Chinese medicine composition that bright example IV is prepared to embodiment six, each oral 20g, every morning is edible 1 time, takes 10
It is a course for the treatment of；During medication, without using other drugs.
Diagnostic criteria：It is effective：Breast lump related symptoms all disappear；Take a turn for the better：Breast lump related symptoms largely disappear
Lose；It is invalid：Breast lump related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 2 below.
The effect of table 2 is to breast lump
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Example IV | 50 | 35 | 14 | 1 |
| Embodiment five | 50 | 35 | 15 | 0 |
| Embodiment six | 50 | 33 | 16 | 1 |
3rd, to relieving mammary gland gall the effect of
Recruitment is clinically diagnosed as relieving mammary gland gall patient 150, is randomly divided into 3 groups, every group 50, takes this hair respectively
The Chinese medicine composition that bright embodiment seven is prepared to embodiment nine, each oral 20g, every morning is edible 1 time, takes 10
It is a course for the treatment of；During medication, without using other drugs.
Diagnostic criteria：It is effective：Relieving mammary gland gall related symptoms all disappear；Take a turn for the better：Relieving mammary gland gall related symptoms largely disappear
Lose；It is invalid：Relieving mammary gland gall related symptoms improve unobvious.
Result of the test：Concrete outcome is as shown in table 3 below.
The effect of table 3 is to relieving mammary gland gall
| Group | Case number of cases | Effective (example) | Take a turn for the better (example) | Invalid (example) |
| Embodiment seven | 50 | 38 | 12 | 0 |
| Embodiment eight | 50 | 36 | 14 | 0 |
| Embodiment nine | 50 | 38 | 12 | 0 |
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Thus, define " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；
Although the present invention is described in detail with reference to foregoing embodiments, it will be understood by those within the art that：Its
The technical scheme described in foregoing embodiments can still be modified, it is either special to which part or whole technologies
Sign carries out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention
The scope of technical scheme, it all should cover among protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating the proliferation of mammary gland, it is characterised in that the raw material components of the Chinese medicine composition are by weight
Part meter, including：
The parts by weight of dandelion 1~3, melon wither 1~3 parts by weight, the parts by weight of Radix Rhapontici seu Radix Echinopsis 1~3, the parts by weight of luffa 1~3 and the seed of cowherb
1~3 parts by weight.
2. the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 1, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of rhizoma cyperi 1~3.
3. the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 1, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of cynanchum wilfordii 1~3, the parts by weight of chingma abutilon seed 1~3, the parts by weight of rhizoma cyperi 1~3 and the parts by weight of rascal 1~3.
4. the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 3, it is characterised in that the Chinese medicine composition
Raw material components also include：
The parts by weight of radix semiaquilegiae 1~3, the parts by weight of spina gleditsiae 1~3, the parts by weight of the root of Dahurain angelica 1~3, the parts by weight of frankincense 1~3, myrrh 1~3
Parts by weight, the parts by weight of HERBA HEDYOTIS DIFFUSAE 1~3, the parts by weight of Sculellaria barbata 1~3, the parts by weight of root of Chinese trichosanthes 1~3, the parts by weight of Radix Angelicae Sinensis 1~3, Ligusticum wallichii
1~3 parts by weight, the parts by weight of the radix paeoniae rubrathe 1~3 and the parts by weight of radix glycyrrhizae 1~3.
5. the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland described in claim any one of 1-4, it is characterised in that bag
Include following steps：
S1：Dandelion, melon are withered to be put into water with Radix Rhapontici seu Radix Echinopsis and heated, is then filtered, collects the first filtrate；
S2：Other surplus stock components are added to the water immersion；By the mixture progress refluxing extraction soaked and obtained, extraction
After filter, collect the second filtrate；
S3：First filtrate and second filtrate are well mixed, then concentrated, obtained concentrate is the Chinese medicine
Composition.
6. the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 5, it is characterised in that：
In step S1, it is (6~10) that the quality of the water is withered with the ratio of the gross mass of Radix Rhapontici seu Radix Echinopsis with the dandelion, melon:1, institute
The temperature for stating heating is 80~90 DEG C, and the time of the heating is 60~80min.
7. the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 5, it is characterised in that：
In step S2, the quality of the water is 12~15 times of the gross mass of other remaining ingredients.
8. the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 5, it is characterised in that：
In step S2, the temperature of the immersion is 35~45 DEG C, and the time of the immersion is 30~40min；The refluxing extraction
Time be 4~5h.
9. the preparation method of the Chinese medicine composition of the treatment proliferation of mammary gland according to claim 5, it is characterised in that：
In step S3, the concentrate is 1.15~1.2 in the relative density of 25 DEG C of measure.
10. application of the Chinese medicine composition in the medicine for preparing the treatment proliferation of mammary gland described in claim any one of 1-4.
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| CN102151325A (en) * | 2011-04-13 | 2011-08-17 | 苑学 | Traditional Chinese medicine for treating breast diseases |
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| CN102151325A (en) * | 2011-04-13 | 2011-08-17 | 苑学 | Traditional Chinese medicine for treating breast diseases |
Non-Patent Citations (3)
| Title |
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| 彭芷美: "逍遥散加减治疗乳腺增生病107例", 《江西中医药》 * |
| 阮诗兰等: "中医药治疗乳腺增生的研究进展", 《安徽医药》 * |
| 韩仲成等: "《中医方剂讲用》", 31 July 2017, 中国中医药出版社 * |
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