CN101411857A - Pharmaceutical composition for treating cerebroma and cerebral concussion, and preparation method thereof - Google Patents
Pharmaceutical composition for treating cerebroma and cerebral concussion, and preparation method thereof Download PDFInfo
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- CN101411857A CN101411857A CNA2008101477120A CN200810147712A CN101411857A CN 101411857 A CN101411857 A CN 101411857A CN A2008101477120 A CNA2008101477120 A CN A2008101477120A CN 200810147712 A CN200810147712 A CN 200810147712A CN 101411857 A CN101411857 A CN 101411857A
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- zingiberis recens
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Abstract
The invention provides a medicine composition for treating encephaloma and cerebral concussion and a preparation method thereof, belongs to a medicine composition, and in particular relates to a medicine prepared by using plant traditional Chinese medicines as raw materials, and the preparation method thereof. Raw materials for preparing active ingredients of the medicine comprise ginger, realgar, hemlock parsley, rhizoma gastrodiae, leech and the like. The preparation method comprises the following steps: processing mixed materials into fine powder; and preparing the fine powder into capsules, watered pills, tablets or granules. The medicine can treat various headaches, dizziness, paralysis, numbness and the like caused by encephaloma, cerebral trauma, brain haemostasis, concussion of brain sequela, basilar papilledema and cerebral paralysis with high efficacy but without side effects.
Description
(1) technical field:
A kind of pharmaceutical composition for the treatment of cerebroma, cerebral concussion and preparation method thereof belongs to pharmaceutical composition, and especially relating to a kind of is the medicine that raw material is made with the botanical herbs, and its preparation method.
(2) background technology:
Intracranial tumor is meant the neoplasm that grows in the cranial cavity, is called for short cerebroma.It can betide the adnexa of meninges, cerebral tissue, cranial nerve, cerebrovascular and brain of intracranial such as choroid plexus, hypophysis, and pinus etc. are called the constitutional intracranial tumor.Also can betide its hetero-organization or the internal organs of health,, claim Secondary cases or transitivity intracranial tumor through spreading or blood running moves the intrusion intracranial.
Various countries' statistics is variant, and in per 100,000 populations, annual about 2--10 people is ill.With regard to the statistics in 1972 to 1977 in Shanghai Inst. of Tumor, average 1.9 people/100,000 populations account for the 1%--3% of the various tumors of whole body.Primary disease does not have tangible race difference, does not have tangible hotspot, and the various ages all can be ill, but falls ill higher with 20--50 year person.Except that meningioma, all with the male a little more than the women.
The definite cause of disease of cerebroma it be unclear that, and is likely the symphyogenetic result of multiple factor.As inherited genetic factors, physical factor, chemical factor, biological factor, congenital factors.
Cerebral concussion is that head has trauma history, often has giddy (swooning) dizzy, headache or coma, dysphoria, nausea and vomiting is easily forgotten when anything crops up, has to breathe deeply and slow, and pulse is slow, fluctuation of blood pressure is big, the time and when rising and descending, CT scan finds that the part has hematoma or density shade to increase etc.
The medicine of treatment cerebroma, cerebral concussion has the following disadvantages at present:
1, these medicines mostly are chemicals, cost an arm and a leg, and curative effect are not high, and side effect is big, bring very large economy burden and stress for patient and household thereof;
2, treatment cerebroma and treatment cerebral concussion are separated in these medicines, can not only treat cerebroma but also treat cerebral concussion.
(3) summary of the invention:
The problem to be solved in the present invention is exactly to provide a kind of Chinese medicine composition that cerebroma can be treated cerebral concussion of both can having treated at above deficiency, and this curative effect of medication height is free from side effects.Its technical scheme is as follows:
Prepare the raw material that its active component raw material comprises following weight portion:
Rhizoma Zingiberis Recens 40--60, Realgar 40--60, Rhizoma Chuanxiong 10--30, Rhizoma Gastrodiae 10--30, Hirudo 5--15, Radix Notoginseng 5--20, Rhizoma Acori Graminei 5--15.
Its preparation method may further comprise the steps:
1) getting Rhizoma Zingiberis Recens, to be cut into granule standby;
2) Realgar is ground into fine powder, put into iron pan, fry to simply and not burnt with slow fire with the Rhizoma Zingiberis Recens granule;
3) Rhizoma Chuanxiong, Hirudo are fried the cool cold and above-mentioned medicine hybrid process in clear-cut back with 45--50 degree Chinese liquor slow fire respectively and become fine powder, or make capsule, or make water pill, or be pressed into tablet, or make granule.
Clinical drug of the present invention uses the result to show that its beneficial effect is:
1, curative effect of medication height of the present invention is 91.18% to cerebroma, cerebral concussion patient's cure rate, is free from side effects, and can alleviate patient's misery very soon.
2, composition of raw materials of the present invention belongs to pure natural plant Chinese medicine, and raw material sources are extensive, and production technology is simple, and preparation cost is low, alleviates patient's financial burden.
3, medicine of the present invention can be treated cerebroma and can be treated cerebral concussion again, has good social benefit and economic benefit.
Medicament sources:
Rhizoma Zingiberis Recens is the root stock of Zingiberaceae ginger Rhizoma Zingiberis Recens.
Realgar has another name called Realgar, gold stone, and orpiment is the Ore of arsenic sulfide.Remove the toxicity of arsenic sulfide in the Realgar, going property is taken.
Rhizoma Chuanxiong has another name called Rhizoma Chuanxiong.Be Umbelliferae, this platymiscium of punt-pole Rhizoma Chuanxiong is used as medicine with dry root.
Rhizoma Gastrodiae has another name called yellow moccasin flower, RHIZONA GASTRODIAE, the water Rhizoma Solani tuber osi, the winter Peng, rhizoma gastrodiae, SHENCAO etc.Tuber for orchid.
Hirudo has another name called Hirudo, leech, meat awl.Be length trematodiasis section animal whitmania, Folium Salicis Babylonicae Hirudo or Hirudo all are used as medicine with drying.
Radix Notoginseng has another name called Radix Notoginseng, Yunnan seven, Radix Notoginseng, Radix Notoginseng.Dried root for the araliaceae ginseng plant Radix Notoginseng.
Rhizoma Acori Graminei has another name called Folium Acori graminei, water Rhizoma Acori Graminei, white flag, medicine Rhizoma Acori Graminei.Dry root stock for Araeceae Acorus phytobezoar Rhizoma Acori Graminei.
Medicine of the present invention has following characteristics:
Character: yellowish-brown.
Abnormal smells from the patient: gas fragrance, bitter in the mouth, little peppery.
Nature and flavor: hot, bitter, little salty, warm.
Function: hard masses softening and resolving, removing blood stasis with potent drugs are invigorated blood circulation, damp eliminating eliminating phlegm, removing toxic substances and promoting subsidence of swelling, promoting the circulation of QI to relieve pain, wind dispelling spasmolytic, stopping nausea and vomiting by lowering the adverse flow of QI, warming YANG Fructus Alpiniae Oxyphyllae, inducing resuscitation etc.
Cure mainly: the headache due to various cerebromas, cerebral trauma, cerebral blood stasis, cerebral concussion sequela, brain papilla acustica basilaris edema, the apoplexy, dizziness, paralysis, numbness etc.
Usage and consumption: every day 3 times, each 4--6 grain (about 2--3 gram, other dosage form is also abided by this and taken) is swallowed with eliminating cold for resuscitation water.
The course of treatment: 20 days is a course of treatment.
For showing the therapeutic effect of medicine of the present invention to cerebroma, cerebral concussion, the inventor has done the clinical observation of system to 68 routine patients:
Physical data:
68 routine patients are out-patient treatment, and the shortest 2 courses of treatment, the longest 9 courses of treatment, wherein male's 62 examples are divided into: 25--35 one full year of life 31 example; 36--42 one full year of life 12 example; 43--48 one full year of life 10 example; 49--51 one full year of life 6 example; 52--60 one full year of life 3 example.Women's 6 examples are divided into: 26--31 one full year of life 3 example; 32--40 one full year of life 2 example: 41 one full year of life 1 examples.
Diagnostic criteria: be divided into 8 classes by NK of International Union of Counter Cancer in 1961, its cardinal symptom stationarity limitation headache, the outer tenderness of skull, dizzy, head ring, dizzy, hallucination, auditory hallucination, auditory dysesthesia, memory disorder, fidgety, vomiting, optical fundus nerve papilla edema, hydrocrania increased pressure, CT scan density occupy-place height, brain pond, brain stop up visible displacement, distortion, and the reinforcement in various degree of tumor body causes brain pressurized paralysis and numbness.Often check with (1) head ultrasonic investigation; (2) head X line is taken the photograph sheet; (3) electroencephalogram; (4) radioisotope scanning; (5) electronic computer x-ray tomography (CT detects); (6) nuclear magnetic resonance, NMR; (7) waist puncture isotope and hydrocrania are detected; (8) X line contrast examination etc.
Criterion of cure: the described clinical sign transference cure of above diagnostic criteria, various inspection indexs are normal.
Therapeutic outcome: medicine of the present invention is to cure 62 examples, wherein Patients with Brain Tumors 51 examples among 91.18%, the 68 routine patient to the cure rate of cerebroma, cerebral concussion; Cerebral concussion sequela patient 7 examples, cerebral blood stasis patient 4 examples.
Model case:
Draw horse xx, the man, 27 years old, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, He Bo township, Xide County cadre, examine on October 18th, 1998, the patient is self-induction cranium back stationarity distending pain before half a year, and with dizzy, head ring, dizzy, hallucination, auditory dysesthesia, dysmnesia, fidgety, vomiting, optical fundus nerve papilla edema, speed are gone to a doctor to Huaxi Medical Univ and are " intracranial vessel tumor ", tumor body 3.8-4.4cm.The doctor advises going home expectant treatment.All sxs of going up after the patient returns home, the household reaches and requires Chinese traditional treatment in person, and stupor companion numb hand and foot being arranged when next day, conditions of patients increased the weight of, and contacts iron bar, stone numbness.Take capsule of the present invention on October 19th, 1998, every day 3 times, each 6 (about 3 grams), and after 10 days, the patient brothers gradually have consciousness, and other symptom all take a favorable turn.Continue to take promptly 40 days two courses of treatment, all diseases of patient subtract greatly, and continuous clothes are after two courses of treatment, and check is made nuclear magnetic resonance check and accused more.The expert exclaims " this is the mystery of Chinese medicine ".Follow up a case by regular visits to and do not have discomfort in 10 years.
Yellow xx, the man, 56 years old, Han nationality, the two groups of peasants in source village, clarke township, Xide County, Sichuan Province examined in December in 2007 on the 6th.The patient is on the June 8th, 2005 of a certain iron mine underground work in the Shanxi Province, and self-induction is dizzy uncomfortable, and taking a favorable turn slightly aboveground doing odds and ends in the back, returns home subsequently rest a period of time.Go to the ferry to do manual work on April 9th, 2008 again with the partner, drank about 250 milliliter medicated beer during supper the same day, and 9 o'clock was felt distending pain in the head immediately, vomiting, and total numbness, speed send local hospital to rescue, and next day, all transference cures were returned home.The patient always feels that head has tenderness to expand and feels when being in, giddy, and actions such as walking can not be arranged, and memory falls sharply, feeling of fullness in the head, the unconnected phrase of speaking.Epilepsy is pressed by Xide County hospital, routine administration, disease does not subtract, after change the West China examination in hospital again for " neurogliocytoma ".The doctor advises and goes home in local hospitalize.Above-mentioned symptom increases the weight of after going home, and can not walk, and appetite subtracts greatly, gatism.Take capsule of the present invention after examining after 15 days, all symptoms that goes up subtract greatly, and continuous clothes 30 days patients can take care of oneself fully, and 2 courses of treatment are obeyed in the back consolidation, check and heal.
Liu xx, the man, 25 years old, Han nationality, Jiangjin, Sichuan Province people from city, examine on July 10th, 2002, the patient once fought with the people, was hit head by the human fragment of brick, once moved in Xide County hospital, is " cerebral concussion sequela " by being examined, the normal sense of a later climate change stationarity distending pain, giddy, fidgety, hypomnesis, tinnitus.Each tame hospital therapy is thrown: YUNNAN BAIYAO, NAOXINSHU, shake brain are peaceful, Radix Salviae Miltiorrhizae Tabellae etc. is similar still invalid.After take 2 courses of treatment of capsule of the present invention, and accuse recovery from illness, follow up a case by regular visits to not have in 6 years and recommit.
(4) specific embodiment:
Embodiment one:
Take by weighing Rhizoma Zingiberis Recens 40g, Realgar 60g, Rhizoma Chuanxiong 10g, Rhizoma Gastrodiae 30g, Hirudo 5g, Radix Notoginseng 20g, Rhizoma Acori Graminei 5g.
Its preparation method is as follows:
1) get Rhizoma Zingiberis Recens and remove sediment contamination, wash the after-filtration solid carbon dioxide, it is standby to be cut into the square size particles of 1cm;
2) Realgar being ground into 200 order fine powders does not have graininess, puts into iron pan with the Rhizoma Zingiberis Recens granule, fries to simply and not burnt with slow fire, is fine-powdered after pinching with hands, and no fiber gets final product;
3) Rhizoma Chuanxiong, Hirudo are fried the cool cold and above-mentioned medicine hybrid process in clear-cut back with 45--50 degree Chinese liquor slow fire respectively and become fine powder, make capsule.The consumption of Rhizoma Chuanxiong and Chinese liquor is a Rhizoma Chuanxiong: Chinese liquor=8.3:1; The consumption of Hirudo and Chinese liquor is a Hirudo: Chinese liquor=10:1.Concrete stir-fry method is Rhizoma Chuanxiong or Hirudo to be put into pot simultaneously with Chinese liquor fry, until stir-fry simply.
Embodiment two:
Take by weighing Rhizoma Zingiberis Recens 60g, Realgar 40g, Rhizoma Chuanxiong 30g, Rhizoma Gastrodiae 10g, Hirudo 15g, Radix Notoginseng 5g, Rhizoma Acori Graminei 15g.
Its preparation method is as follows:
1) get Rhizoma Zingiberis Recens and remove sediment contamination, wash the after-filtration solid carbon dioxide, it is standby to be cut into the square size particles of 1cm;
2) Realgar being ground into 200 order fine powders does not have graininess, puts into iron pan with the Rhizoma Zingiberis Recens granule, fries to simply and not burnt with slow fire, is fine-powdered after pinching with hands, and no fiber gets final product;
3) Rhizoma Chuanxiong, Hirudo are fried the cool cold and above-mentioned medicine hybrid process in clear-cut back with 45--50 degree Chinese liquor slow fire respectively and become fine powder,, behind sterilization, make water pill after 200 mesh sieves.
Embodiment three:
Rhizoma Zingiberis Recens 50g, Realgar 50g, Rhizoma Chuanxiong 20g, Rhizoma Gastrodiae 20g, Hirudo 10g, Radix Notoginseng 12g, Rhizoma Acori Graminei 9g.
Its preparation method is as follows:
1) get Rhizoma Zingiberis Recens and remove sediment contamination, wash the after-filtration solid carbon dioxide, it is standby to be cut into the square size particles of 1cm;
2) Realgar being ground into 200 order fine powders does not have graininess, puts into iron pan with the Rhizoma Zingiberis Recens granule, fries to simply and not burnt with slow fire, is fine-powdered after pinching with hands, and no fiber gets final product;
3) Rhizoma Chuanxiong, Hirudo are fried the cool cold and above-mentioned medicine hybrid process in clear-cut back with 45--50 degree Chinese liquor slow fire respectively and become fine powder,, behind sterilization, make capsule after 200 mesh sieves.
Embodiment four:
Rhizoma Zingiberis Recens 50g, Realgar 50g, Rhizoma Chuanxiong 20g, Rhizoma Gastrodiae 20g, Hirudo 10g, Radix Notoginseng 12g, Rhizoma Acori Graminei 9g.
Its preparation method is as follows:
1) get Rhizoma Zingiberis Recens and remove sediment contamination, wash the after-filtration solid carbon dioxide, it is standby to be cut into the square size particles of 1cm;
2) Realgar being ground into 200 order fine powders does not have graininess, puts into iron pan with the Rhizoma Zingiberis Recens granule, fries to simply and not burnt with slow fire, is fine-powdered after pinching with hands, and no fiber gets final product;
3) Rhizoma Chuanxiong, Hirudo are fried the cool cold and above-mentioned medicine hybrid process in clear-cut back with 45--50 degree Chinese liquor slow fire respectively and become fine powder,, behind sterilization, make granule after 200 mesh sieves.
More than the method for the various dosage forms of preparation is conventional preparation method.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of cerebroma, cerebral concussion is characterized in that preparing the raw material that its active component raw material comprises following weight portion:
Rhizoma Zingiberis Recens 40--60, Realgar 40--60, Rhizoma Chuanxiong 10--30, Rhizoma Gastrodiae 10--30, Hirudo 5--15, Radix Notoginseng 5--20, Rhizoma Acori Graminei 5--15.
2, the pharmaceutical composition of treatment cerebroma according to claim 1, cerebral concussion, the dosage form that it is characterized in that compositions is any peroral dosage form.
3, the pharmaceutical composition of treatment cerebroma according to claim 2, cerebral concussion, the dosage form that it is characterized in that compositions is capsule, water pill, tablet or granule.
4, the preparation of drug combination method of the described treatment cerebroma of claim 1, cerebral concussion is characterized in that may further comprise the steps:
1) get Rhizoma Zingiberis Recens 40--60, Realgar 40--60, Rhizoma Chuanxiong 10--30, Rhizoma Gastrodiae 10--30, Hirudo 5--15, Radix Notoginseng 5--20, Rhizoma Acori Graminei 5--15 part is standby;
2) getting Rhizoma Zingiberis Recens, to be cut into granule standby;
3) Realgar is ground into fine powder, put into iron pan, fry to simply and not burnt with slow fire with the Rhizoma Zingiberis Recens granule;
4) Rhizoma Chuanxiong, Hirudo are fried the cool cold and above-mentioned medicine hybrid process in clear-cut back with 45--50 degree Chinese liquor slow fire respectively and become fine powder, or make capsule, or make water pill, or be pressed into tablet, or make granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101477120A CN101411857A (en) | 2008-11-28 | 2008-11-28 | Pharmaceutical composition for treating cerebroma and cerebral concussion, and preparation method thereof |
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| CNA2008101477120A CN101411857A (en) | 2008-11-28 | 2008-11-28 | Pharmaceutical composition for treating cerebroma and cerebral concussion, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720961A (en) * | 2014-01-19 | 2014-04-16 | 王浦强 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN105288298A (en) * | 2015-11-27 | 2016-02-03 | 张传恩 | Traditional Chinese medicine preparation for treating cerebral aneurysm sequelae and preparation method of traditional Chinese medicine preparation |
-
2008
- 2008-11-28 CN CNA2008101477120A patent/CN101411857A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720961A (en) * | 2014-01-19 | 2014-04-16 | 王浦强 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN103720961B (en) * | 2014-01-19 | 2014-09-17 | 王浦强 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN105288298A (en) * | 2015-11-27 | 2016-02-03 | 张传恩 | Traditional Chinese medicine preparation for treating cerebral aneurysm sequelae and preparation method of traditional Chinese medicine preparation |
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Effective date of abandoning: 20090422 |
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