CN110582280B - 通过抑制或调节t细胞受体信号传导来治疗t细胞耗竭的方法 - Google Patents

通过抑制或调节t细胞受体信号传导来治疗t细胞耗竭的方法 Download PDF

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CN110582280B
CN110582280B CN201880028993.XA CN201880028993A CN110582280B CN 110582280 B CN110582280 B CN 110582280B CN 201880028993 A CN201880028993 A CN 201880028993A CN 110582280 B CN110582280 B CN 110582280B
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cells
cell
car
dasatinib
leu
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CN110582280A (zh
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瑞秋·琳恩
克里斯托·麦考尔
埃文·温伯
桑杰·马尔霍特拉
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Leland Stanford Junior University
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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CN201880028993.XA 2017-03-31 2018-03-30 通过抑制或调节t细胞受体信号传导来治疗t细胞耗竭的方法 Active CN110582280B (zh)

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US201762479930P 2017-03-31 2017-03-31
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PCT/US2018/025394 WO2018183842A1 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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CN202410272411.XA Pending CN118161496A (zh) 2017-03-31 2018-03-30 通过抑制或调节t细胞受体信号传导来治疗t细胞耗竭的方法
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US20210393628A1 (en) * 2018-10-30 2021-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating t cell exhaustion
EP3876958A1 (en) * 2018-11-08 2021-09-15 Juno Therapeutics, Inc. Methods and combinations for treatment and t cell modulation
AU2020231810B2 (en) * 2019-03-01 2025-12-18 National University Of Singapore Engineered immune cells
CN110157680A (zh) * 2019-05-08 2019-08-23 浙江大学 提高嵌合抗原受体t细胞疗效和作用持久性的细胞培养方法
WO2021020564A1 (ja) * 2019-08-01 2021-02-04 国立大学法人三重大学 Ｇｄ２結合性分子
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MX2022015764A (es) * 2020-06-19 2023-01-19 Chugai Pharmaceutical Co Ltd Molecula de union al antigeno anti-celulas t para usarse en combinacion con un inhibidor de angiogenesis.
KR20230074146A (ko) * 2020-09-24 2023-05-26 에프. 호프만-라 로슈 아게 T 세포 이중특이성 항체 관련 역효과의 예방 또는 완화
US20240108721A1 (en) * 2020-10-30 2024-04-04 The University Of North Carolina At Chapel Hill Dual targeting chimeric antigen receptors
JPWO2022210487A1 (cg-RX-API-DMAC7.html) * 2021-03-29 2022-10-06
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CN113533729B (zh) * 2021-06-15 2024-09-06 北京大学人民医院 一种鉴定aml患者骨髓中nk细胞耗竭的研究方法及其应用
JP2024525727A (ja) 2021-07-14 2024-07-12 ２セブンティ バイオ インコーポレイテッド 抗体由来の結合ドメインに融合した操作されたｔ細胞受容体
CN115677861A (zh) * 2021-07-29 2023-02-03 上海科技大学 一种泛素偶联修饰的嵌合抗原受体及免疫细胞
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