CA3057372A1 - Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling - Google Patents

Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling Download PDF

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Publication number
CA3057372A1
CA3057372A1 CA3057372A CA3057372A CA3057372A1 CA 3057372 A1 CA3057372 A1 CA 3057372A1 CA 3057372 A CA3057372 A CA 3057372A CA 3057372 A CA3057372 A CA 3057372A CA 3057372 A1 CA3057372 A1 CA 3057372A1
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car
domain
cell
cells
acid sequence
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English (en)
French (fr)
Inventor
Rachel LYNN
Crystal Mackall
Tom J. WANDLESS
Evan WEBER
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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CA3057372A 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling Pending CA3057372A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762479930P 2017-03-31 2017-03-31
US62/479,930 2017-03-31
PCT/US2018/025459 WO2018183888A2 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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CA3057372A1 true CA3057372A1 (en) 2018-10-04

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CA3057372A Pending CA3057372A1 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling
CA3057505A Pending CA3057505A1 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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CA3057505A Pending CA3057505A1 (en) 2017-03-31 2018-03-30 Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling

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US (3) US11938153B2 (cg-RX-API-DMAC7.html)
EP (2) EP3600323A4 (cg-RX-API-DMAC7.html)
JP (6) JP7278961B2 (cg-RX-API-DMAC7.html)
CN (3) CN110582280B (cg-RX-API-DMAC7.html)
AU (3) AU2018243571B2 (cg-RX-API-DMAC7.html)
CA (2) CA3057372A1 (cg-RX-API-DMAC7.html)
WO (2) WO2018183842A1 (cg-RX-API-DMAC7.html)

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JPWO2022210487A1 (cg-RX-API-DMAC7.html) * 2021-03-29 2022-10-06
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WO2022234063A1 (en) * 2021-05-07 2022-11-10 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Method for constitutive malt1 protease activation
CN113533729B (zh) * 2021-06-15 2024-09-06 北京大学人民医院 一种鉴定aml患者骨髓中nk细胞耗竭的研究方法及其应用
JP2024525727A (ja) 2021-07-14 2024-07-12 2セブンティ バイオ インコーポレイテッド 抗体由来の結合ドメインに融合した操作されたt細胞受容体
CN115677861A (zh) * 2021-07-29 2023-02-03 上海科技大学 一种泛素偶联修饰的嵌合抗原受体及免疫细胞
WO2023077026A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
WO2023077032A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing c-jun
KR20250008809A (ko) 2022-04-08 2025-01-15 리제너론 파마슈티칼스 인코포레이티드 다분할 수용체 및 신호전달 복합체
JP2025520384A (ja) * 2022-06-13 2025-07-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 改善されたグリカン依存性キメラ抗原受容体細胞
GB202218144D0 (en) * 2022-12-02 2023-01-18 Univ Oxford Innovation Ltd Product
CN116121196B (zh) * 2022-12-23 2025-07-22 广州安捷生物医学技术有限公司 一种调控car-t细胞的方法与应用

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