CN110559413A - 一种经典名方半夏泻心汤颗粒的制备方法 - Google Patents

一种经典名方半夏泻心汤颗粒的制备方法 Download PDF

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CN110559413A
CN110559413A CN201910861640.4A CN201910861640A CN110559413A CN 110559413 A CN110559413 A CN 110559413A CN 201910861640 A CN201910861640 A CN 201910861640A CN 110559413 A CN110559413 A CN 110559413A
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吴雪君
李震
王文智
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WANSUI PHARMACEUTICAL CO Ltd HEBEI PROV
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Abstract

本发明公开了一种经典名方半夏泻心汤颗粒的制备方法，包括炮制工序、提取浓缩工序和制粒工序；所述炮制工序、提取浓缩工序和制粒工序所得成品为6万袋，每袋10克。通过该方法制备的半夏泻心汤颗粒不需要现煎，服用量准确口感较好，携带方便，极大了推广了该方的广泛应用。

Description

一种经典名方半夏泻心汤颗粒的制备方法
技术领域
本发明属于半夏泻心汤制备技术领域，具体涉及一种经典名方半夏泻心汤颗粒的制备方法。
背景技术
半夏泻心汤，中医方剂名。为和解剂，具有调和肝脾，寒热平调，消痞散结之功效。主治寒热错杂之痞证。心下痞，但满而不痛，或呕吐，肠鸣下利，舌苔腻而微黄。临床常用于治疗急慢性胃肠炎，慢性结肠炎，慢性肝炎，早期肝硬化等属中气虚弱，寒热错杂者。
现有的目前临床仍采用汤剂的用药形式，然而汤剂需临用现煎，服用量大、口感差，携带不便极大影响了该方的广泛应用的问题，为此我们提出一种经典名方半夏泻心汤颗粒的制备方法。
发明内容
本发明的目的在于提供一种经典名方半夏泻心汤颗粒的制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：一种经典名方半夏泻心汤颗粒的制备方法，包括炮制工序、提取浓缩工序和制粒工序，所述炮制工序、提取浓缩工序和制粒工序所得成品为6万袋，每袋10克。
进一步的，优选的，所述炮制工序为将药材分别按各自炮制操作规程进行炮制。
进一步的，优选的，所述提取浓缩工序包括如下步骤：
步骤一：提取：将炮制好的药材分别投入提取罐中，加7.4倍量的水蒸汽加热至沸腾后，100℃煮提1.5小时，80目过滤，收集药液于储罐中，将所提取的滤液合并，静置6小时；
步骤二：浓缩收膏：开启浓缩器，滤取上清液打入浓缩器内，双效浓缩器一效真空度控制在-0.04Mpa—-0.06Mpa，温度70-80℃；二效真空度控制在-0.06Mpa—-0.08Mpa，温度60-70℃,浓缩过程中随时检查并记录浓缩温度、真空度，浓缩至适量转由单效浓缩器并液浓缩，待缩至标定液位后再转由球形浓缩器浓缩收膏，温度控制在70-80℃，浓缩过程中随时检查并记录温度。待浓缩至总药材饮片量的2.2倍药液时，转至收膏间，经200目筛网过滤收膏，取适量清膏测定干膏率，将合格的清膏装于密闭的容器中，称量贴好状态标识，入中间品库。
进一步的，优选的，所述制粒工序包括如下步骤：
步骤一：喷雾制粒：将领取的糊精和浸膏分别称量，将糊精放入喷雾制粒机内，调整流速和温度，喷入清膏制成颗粒，收集干燥颗粒粉；
步骤二：干法制粒：将领取的糊精和干燥颗粒粉分别称量，混合均匀后，将所有混合颗粒粉用干压制粒法制备颗粒剂，收集干燥颗粒于旋涡振荡筛中，用10目和40目筛网整粒，存入中转站，待验，内包装，外包装。
进一步的，优选的，所述药材分别为：清半夏552kg、黄芩414kg、干姜414kg、人参414kg、炙甘草414kg、黄连138kg、大枣360kg。
进一步的，优选的，所述标定液位为总药材饮片量的4.4倍，总药材饮片量的2.2倍药液。
与现有技术相比，本发明的有益效果是：通过该方法制备的半夏泻心汤颗粒不需要现煎，服用量准确口感较好，携带方便，极大了推广了该方的广泛应用。
具体实施方式
下面将本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明提供一种技术方案：一种经典名方半夏泻心汤颗粒的制备方法，包括炮制工序、提取浓缩工序和制粒工序，所述炮制工序、提取浓缩工序和制粒工序所得成品为6万袋，每袋10克。
本实施例中，优选的，炮制工序为将药材分别按各自炮制操作规程进行炮制。
本实施例中，优选的，提取浓缩工序包括如下步骤：
步骤一：提取：将炮制好的药材分别投入提取罐中，加7.4倍量的水蒸汽加热至沸腾后，100℃煮提1.5小时，80目过滤，收集药液于储罐中，将所提取的滤液合并，静置6小时；
步骤二：浓缩收膏：开启浓缩器，滤取上清液打入浓缩器内，双效浓缩器一效真空度控制在-0.04Mpa—-0.06Mpa，温度70-80℃；二效真空度控制在-0.06Mpa—-0.08Mpa，温度60-70℃,浓缩过程中随时检查并记录浓缩温度、真空度，浓缩至适量转由单效浓缩器并液浓缩，待缩至标定液位后再转由球形浓缩器浓缩收膏，温度控制在70-80℃，浓缩过程中随时检查并记录温度。待浓缩至总药材饮片量的2.2倍药液时，转至收膏间，经200目筛网过滤收膏，取适量清膏测定干膏率，将合格的清膏装于密闭的容器中，称量贴好状态标识，入中间品库。
本实施例中，优选的，制粒工序包括如下步骤：
步骤一：喷雾制粒：将领取的糊精和浸膏分别称量，将糊精放入喷雾制粒机内，调整流速和温度，喷入清膏制成颗粒，收集干燥颗粒粉；
步骤二：干法制粒：将领取的糊精和干燥颗粒粉分别称量，混合均匀后，将所有混合颗粒粉用干压制粒法制备颗粒剂，收集干燥颗粒于旋涡振荡筛中，用10目和40目筛网整粒。存入中转站，待验，内包装，外包装。
本实施例中，优选的，药材分别为：清半夏552kg、黄芩414kg、干姜414kg、人参414kg、炙甘草414kg、黄连138kg、大枣360kg。
本实施例中，优选的，标定液位为总药材饮片量的4.4倍，总药材饮片量的2.2倍药液。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (6)

1.一种经典名方半夏泻心汤颗粒的制备方法，其特征在于：包括炮制工序、提取浓缩工序和制粒工序，所述炮制工序、提取浓缩工序和制粒工序所得成品为6万袋，每袋10克。
2.根据权利要求1所述的一种经典名方半夏泻心汤颗粒的制备方法，其特征在于：所述炮制工序为将药材分别按各自炮制操作规程进行炮制。
3.根据权利要求1所述的一种经典名方半夏泻心汤颗粒的制备方法，其特征在于：所述提取浓缩工序包括如下步骤：
步骤一：提取：将炮制好的药材分别投入提取罐中，加7.4倍量的水蒸汽加热至沸腾后，100℃煮提1.5小时，80目过滤，收集药液于储罐中，将所提取的滤液合并，静置6小时；
步骤二：浓缩收膏：开启浓缩器，滤取上清液打入浓缩器内，双效浓缩器一效真空度控制在-0.04Mpa—-0.06Mpa，温度70-80℃；二效真空度控制在-0.06Mpa—-0.08Mpa，温度60-70℃,浓缩过程中随时检查并记录浓缩温度、真空度，浓缩至适量转由单效浓缩器并液浓缩，待缩至标定液位后再转由球形浓缩器浓缩收膏，温度控制在70-80℃，浓缩过程中随时检查并记录温度。待浓缩至总药材饮片量的2.2倍药液时，转至收膏间，经200目筛网过滤收膏，取适量清膏测定干膏率，将合格的清膏装于密闭的容器中，称量贴好状态标识，入中间品库。
4.根据权利要求1所述的一种经典名方半夏泻心汤颗粒的制备方法，其特征在于：所述制粒工序包括如下步骤：
步骤一：喷雾制粒：将领取的糊精和浸膏分别称量，将糊精放入喷雾制粒机内，调整流速和温度，喷入清膏制成颗粒，收集干燥颗粒粉；
步骤二：干法制粒：将领取的糊精和干燥颗粒粉分别称量，混合均匀后，将所有混合颗粒粉用干压制粒法制备颗粒剂，收集干燥颗粒于旋涡振荡筛中，用10目和40目筛网整粒。存入中转站，待验，内包装，外包装。
5.根据权利要求2所述的一种经典名方半夏泻心汤颗粒的制备方法，其特征在于：所述药材分别为：清半夏552kg、黄芩414kg、干姜414kg、人参414kg、炙甘草414kg、黄连138kg、大枣360kg。
6.根据权利要求3所述的一种经典名方半夏泻心汤颗粒的制备方法，其特征在于：所述标定液位为总药材饮片量的4.4倍，总药材饮片量的2.2倍药液。
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