CN110483499A - 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 - Google Patents

咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 Download PDF

Info

Publication number
CN110483499A
CN110483499A CN201910419228.7A CN201910419228A CN110483499A CN 110483499 A CN110483499 A CN 110483499A CN 201910419228 A CN201910419228 A CN 201910419228A CN 110483499 A CN110483499 A CN 110483499A
Authority
CN
China
Prior art keywords
compound
substituted
alkyl
imidazo
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910419228.7A
Other languages
English (en)
Chinese (zh)
Inventor
M·J·米勒
G·C·莫拉斯基
L·D·马克利
G·E·戴维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Notre Dame
Original Assignee
University Notre Dame
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Notre Dame filed Critical University Notre Dame
Publication of CN110483499A publication Critical patent/CN110483499A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201910419228.7A 2009-11-05 2010-11-05 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 Pending CN110483499A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25854909P 2009-11-05 2009-11-05
US61/258,549 2009-11-05
CN201080060716.0A CN102762556B (zh) 2009-11-05 2010-11-05 咪唑并[1,2‑a]吡啶类化合物及其合成及使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080060716.0A Division CN102762556B (zh) 2009-11-05 2010-11-05 咪唑并[1,2‑a]吡啶类化合物及其合成及使用方法

Publications (1)

Publication Number Publication Date
CN110483499A true CN110483499A (zh) 2019-11-22

Family

ID=43970798

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201910419228.7A Pending CN110483499A (zh) 2009-11-05 2010-11-05 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法
CN201710222577.0A Active CN106866667B (zh) 2009-11-05 2010-11-05 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法
CN201080060716.0A Active CN102762556B (zh) 2009-11-05 2010-11-05 咪唑并[1,2‑a]吡啶类化合物及其合成及使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201710222577.0A Active CN106866667B (zh) 2009-11-05 2010-11-05 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法
CN201080060716.0A Active CN102762556B (zh) 2009-11-05 2010-11-05 咪唑并[1,2‑a]吡啶类化合物及其合成及使用方法

Country Status (10)

Country Link
US (3) US9309238B2 (cg-RX-API-DMAC7.html)
EP (2) EP2496578A4 (cg-RX-API-DMAC7.html)
CN (3) CN110483499A (cg-RX-API-DMAC7.html)
BR (1) BR112012010752B1 (cg-RX-API-DMAC7.html)
HK (1) HK1248676A1 (cg-RX-API-DMAC7.html)
IL (1) IL219564A (cg-RX-API-DMAC7.html)
IN (1) IN2012DN04917A (cg-RX-API-DMAC7.html)
RU (1) RU2608611C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011057145A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201204028B (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2012DN04917A (cg-RX-API-DMAC7.html) * 2009-11-05 2015-09-25 Univ Notre Dame Du Lac
RU2576662C2 (ru) * 2010-03-18 2016-03-10 Энститю Пастер Корея Противоинфекционные соединения
KR20140048079A (ko) 2011-02-01 2014-04-23 교와 핫꼬 기린 가부시키가이샤 축환 복소환 유도체
WO2012143796A2 (en) * 2011-04-21 2012-10-26 Institut Pasteur Korea Anti-inflammation compounds
CA2852615A1 (en) 2011-10-21 2013-04-25 Torrent Pharmaceuticals Limited Novel substituted imidazopyrimidines as gpbar1 receptor modulators
CN104619707A (zh) 2012-07-31 2015-05-13 协和发酵麒麟株式会社 稠环杂环化合物
WO2015014993A2 (en) * 2013-08-02 2015-02-05 Institut Pasteur Korea Anti-infective compounds
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
CN103965193B (zh) * 2014-05-30 2016-04-06 浙江司太立制药股份有限公司 N-(苯氧烷基)咪唑并[1,2-a]吡啶-3-酰胺类化合物及其制备方法
CN104628721A (zh) * 2015-01-22 2015-05-20 湖南华腾制药有限公司 一种咪唑并[1,2-a]吡啶衍生物的制备方法
MD3316969T2 (ro) 2015-07-02 2022-07-31 Janssen Sciences Ireland Unlimited Co Compuși antibacterieni
PE20181352A1 (es) * 2015-09-17 2018-08-22 Marvin J Miller Compuestos heterociclicos que contienen bencilamina y composiciones utiles contra infeccion por micobacterias
MA45377A (fr) 2016-06-16 2019-04-24 Janssen Sciences Ireland Unlimited Co Composés hétérocycliques en tant qu'agents antibacteriens
EP3472152A1 (en) * 2016-06-16 2019-04-24 Janssen Sciences Ireland Unlimited Company Heterocyclic compounds as antibacte rials
CN106588916A (zh) * 2016-11-21 2017-04-26 浙江司太立制药股份有限公司 N‑(苯氧乙基)咪唑并[1,2‑a]吡啶‑3‑酰胺类化合物及其制备方法
JP2020502110A (ja) * 2016-12-16 2020-01-23 バイエル・アクチエンゲゼルシヤフト 殺虫剤として使用するためのメソイオン性イミダゾピリジン類
MA47676A (fr) 2017-03-01 2021-06-02 Janssen Sciences Ireland Unlimited Co Polythérapie
CN108159049B (zh) * 2018-02-01 2021-01-05 中国科学院广州生物医药与健康研究院 一种吡啶类化合物的新用途
WO2019175737A1 (en) * 2018-03-12 2019-09-19 University Of Notre Dame Du Lac Deuterated imidazopyridines
CN110759913B (zh) * 2018-07-26 2022-01-28 南开大学 吲哚酰腙衍生物及其制备方法和在防治植物病毒、杀菌、杀虫方面的应用
CN111662283B (zh) * 2019-03-07 2021-11-16 湖南化工研究院有限公司 咪唑并吡啶类化合物及其中间体、制备方法与应用
KR20210150405A (ko) * 2019-04-08 2021-12-10 피아이 인더스트리스 엘티디. 식물병원성 진균을 방제 또는 예방하기 위한 신규한 옥사디아졸 화합물
TWI861208B (zh) 2019-09-10 2024-11-11 日商鹽野義製藥股份有限公司 對分枝桿菌感染有用之含苄胺的 5,6-雜芳族化合物
AU2021283568B2 (en) 2020-06-02 2023-12-14 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd 3,4-dihydroisoquinoline compound and use thereof
CN115073454B (zh) * 2022-08-09 2024-03-08 贵州大学 一种咪唑并吡啶-2-噁唑啉类化合物及其制备方法和应用
WO2024161423A1 (en) * 2023-02-02 2024-08-08 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Small molecules for the treatment of mycobacterial diseases
CN117964621A (zh) * 2024-03-01 2024-05-03 河北科技大学 一种咪唑并吡啶类衍生物及其制备方法和应用
CN117964622B (zh) * 2024-03-01 2026-08-07 河北科技大学 一种异噁唑类化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
WO2008082490A2 (en) * 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
US9309238B2 (en) * 2009-11-05 2016-04-12 University Of Notre Dame Du Lac Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
PT77844B (en) * 1982-12-27 1986-05-08 Lilly Co Eli Process for preparing substituted imidazopyrimidines -pyrazines and -triazines
FR2593818B1 (fr) * 1986-02-05 1988-04-29 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
DE4010797A1 (de) 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
DE4023215A1 (de) 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
JPH0539205A (ja) 1990-12-21 1993-02-19 Takeda Chem Ind Ltd 農園芸用混合組成物
JP3026845B2 (ja) 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
US5464843A (en) 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
US5721273A (en) * 1993-12-15 1998-02-24 Alcon Laboratories, Inc. Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
WO1995028389A1 (en) 1994-04-15 1995-10-26 Yamanouchi Pharmaceutical Co., Ltd. Spiro compound and medicinal composition thereof
EP0771319A1 (en) 1994-07-15 1997-05-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
US6323227B1 (en) 1996-01-02 2001-11-27 Aventis Pharmaceuticals Products Inc. Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
US6080767A (en) 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
JPH09249666A (ja) 1996-01-12 1997-09-22 Takeda Chem Ind Ltd 三環性化合物の製造法およびその中間体
SE9700661D0 (sv) * 1997-02-25 1997-02-25 Astra Ab New compounds
AUPP278498A0 (en) * 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
WO1999063929A2 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
GB2351081A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Pharmaceutically active imidazoline compounds and analogues thereof
AU781880B2 (en) 1999-09-17 2005-06-16 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
EP1277754B8 (en) 2000-04-27 2005-09-28 Astellas Pharma Inc. Imidazopyridine derivatives
US6403588B1 (en) * 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US6552037B2 (en) * 2000-06-30 2003-04-22 Neurogen Corporation 2-Substituted imidazo[1,2-A]pyridine derivatives
GB0021670D0 (en) 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
DE10247269A1 (de) * 2002-10-10 2004-04-22 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine
WO2004100868A2 (en) 2003-04-23 2004-11-25 Abbott Laboratories Method of treating transplant rejection
AP2006003619A0 (en) 2003-12-23 2006-06-30 Pfizer Novel quinoline derivatives
US7566781B2 (en) * 2004-05-10 2009-07-28 Banyu Pharmaceutical Co., Ltd. Imidazopyridine compound
US20060084806A1 (en) * 2004-07-21 2006-04-20 Ramasubramanian Sridharan Processes for the preparation of imidazo[1,2-a] pyridine derivatives
DE502005003491D1 (de) * 2004-08-02 2008-05-08 Sanol Arznei Schwarz Gmbh Carboxamide des indolizins und seiner aza- und diazaderivate
MX2007005611A (es) * 2004-11-11 2007-07-11 Ferrer Int Compuestos de imidazo[1,2-a]piridina, composiciones, usos y metodos relacionados.
UY29301A1 (es) * 2004-12-24 2006-07-31 Astrazeneca Ab Derivados amida
WO2007015866A2 (en) 2005-07-20 2007-02-08 Kalypsys, Inc. Inhibitors of p38 kinase and methods of treating inflammatory disorders
US20120135975A1 (en) 2006-05-18 2012-05-31 Merck & Co., Inc. Substituted Esters as Cannabinoid-1 Receptor Modulators
FR2903178B1 (fr) 2006-07-03 2008-10-03 Rech S De L Ecole Nationale Su Procede et dispositif de nettoyage des surfaces de ruissellement d'eau dans un echangeur thermique air/eau
CN101553224A (zh) * 2006-10-06 2009-10-07 艾博特公司 新型咪唑并噻唑和咪唑并唑
AU2008223348A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
EP1980251A1 (en) 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
CL2008001631A1 (es) 2007-06-06 2009-01-02 Smithkline Beecham Corp Compuestos derivados de heterociclos sustituidos, con la presencia de un grupo fenoxi, inhibidores de transcriptasa inversa; composicion farmaceutica; y uso en el tratamiento de infecciones virales por vih.
EP2200440B1 (en) * 2007-07-23 2017-07-19 Crestone, Inc. Antibacterial amide and sulfonamide substituted heterocyclic urea compounds
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
AU2009249186B2 (en) * 2008-05-19 2014-05-22 Sunovion Pharmaceuticals Inc. Imidazo [1, 2-a] pyridine compounds as GABA-A receptor modulators
US9066951B2 (en) 2008-05-29 2015-06-30 Wisconsin Alumni Research Foundation Drugs to treat HPV infection
CN102149384B (zh) 2008-08-14 2014-08-20 南京奥昭生物科技有限公司 作为ep4受体拮抗剂的杂环酰胺衍生物
US8198449B2 (en) * 2008-09-11 2012-06-12 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8293909B2 (en) 2008-09-11 2012-10-23 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
ES2403633T3 (es) * 2008-12-04 2013-05-20 Proximagen Limited Compuestos de imidazopiridina
WO2011050245A1 (en) 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
RU2576662C2 (ru) * 2010-03-18 2016-03-10 Энститю Пастер Корея Противоинфекционные соединения

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
WO2008082490A2 (en) * 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
US9309238B2 (en) * 2009-11-05 2016-04-12 University Of Notre Dame Du Lac Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same
US9908876B2 (en) * 2009-11-05 2018-03-06 University Of Notre Dame Du Lac Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same
US10913737B2 (en) * 2009-11-05 2021-02-09 University Of Notre Dame Du Lac Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIRGUL OZDEN KASIMOGULLARI等: "Fused Heterocycles: Synthesis of Some New Imidazo[1,2-a]-pyridine Derivatives", 《MOLECULES》 *
LIXIN QIAO等: "Structure–activity relationship study of EphB3 receptor tyrosine kinase inhibitors", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
LUKE R. ODELL 等: "Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Also Published As

Publication number Publication date
US9309238B2 (en) 2016-04-12
EP3257854A1 (en) 2017-12-20
IN2012DN04917A (cg-RX-API-DMAC7.html) 2015-09-25
IL219564A0 (en) 2012-06-28
US20120220457A1 (en) 2012-08-30
CN102762556A (zh) 2012-10-31
CN106866667B (zh) 2019-11-15
US20160318925A1 (en) 2016-11-03
WO2011057145A3 (en) 2011-09-09
EP2496578A2 (en) 2012-09-12
IL219564A (en) 2017-01-31
ZA201204028B (en) 2013-11-27
RU2012122653A (ru) 2013-12-10
CN102762556B (zh) 2017-04-26
BR112012010752A2 (pt) 2020-09-15
WO2011057145A2 (en) 2011-05-12
US10913737B2 (en) 2021-02-09
CN106866667A (zh) 2017-06-20
RU2608611C2 (ru) 2017-01-23
US9908876B2 (en) 2018-03-06
HK1248676A1 (en) 2018-10-19
EP2496578A4 (en) 2013-08-21
US20180354944A1 (en) 2018-12-13
BR112012010752B1 (pt) 2021-07-20

Similar Documents

Publication Publication Date Title
CN106866667B (zh) 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法
JP6387401B2 (ja) 殺真菌組成物
AU2013226812B2 (en) Pest control composition including novel iminopyridine derivative
JP6247632B2 (ja) メタロ酵素阻害剤化合物
TWI282335B (en) A61k 31/437 200601 a i vhtw a61p 31/04 200601 a i vhtw
JP6223329B2 (ja) 金属酵素化合物
TWI623527B (zh) 抗真菌化合物、農業組成物、其用途及其合成方法
US20090192127A1 (en) Combination therapy comprising a diaryl urea compound and a p13, akt kinase or mtor inhibitors (rapamycins) for cancer treatment
ES2359187T3 (es) Derivados de 2-oxo-2-(2-fenil-5,6,7,8-tetrahidro-indolizin-3-il)-acetaminda y compuestos realcionados como agentes antifúngicos.
BR112019018238A2 (pt) Derivados de oxadiazol microbiocidas
JP2018522821A5 (cg-RX-API-DMAC7.html)
EP0556381A4 (cg-RX-API-DMAC7.html)
AU2006251429A1 (en) Combination therapy comprising a diaryl urea compound and a PI3, AKT kinase or mTOR inhibitors (rapamycins) for cancer treatment
JP2025503432A (ja) 殺微生物二環式複素環式誘導体
US20090306020A1 (en) Combination therapy comprising diaryl ureas for treating diseases
CN112592339A (zh) 1,3,4-恶二唑-2(3h)-硫酮-诺氟沙星杂合体及其制备方法和应用
BR112019024984A2 (pt) Derivados de oxadiazol microbicidas
CN102438993A (zh) 用于控制真菌的化合物和方法
JP2006516131A (ja) 殺真菌剤
BR112020004982A2 (pt) derivados microbiocidas de (tio)carboxamida de quinolina
JPH11269176A (ja) オキシム誘導体及びこれを含有する農薬
BR112019020739A2 (pt) derivados de oxadiazol microbiocidas
US20160152655A1 (en) 2', 3'- dideoxy-5-fluorouridine derivatives, a process for the manufacture thereof and application thereof
CN112020503A (zh) 杀微生物的噁二唑衍生物
CN117769551A (zh) 杀微生物的吡唑衍生物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20191122