CN110478272A - Skin matrix and its preparation method and application - Google Patents
Skin matrix and its preparation method and application Download PDFInfo
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- CN110478272A CN110478272A CN201910878926.3A CN201910878926A CN110478272A CN 110478272 A CN110478272 A CN 110478272A CN 201910878926 A CN201910878926 A CN 201910878926A CN 110478272 A CN110478272 A CN 110478272A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The present invention provides a kind of skin matrixes and its preparation method and application, are related to cosmetic technical field.Above-mentioned skin matrix mainly is matched to obtain by Sodium Hyaluronate, niacinamide, allantoin, auxiliary agent and water through certain content, wherein Sodium Hyaluronate plays the role of lubricating and nourishing well to Skin Cell；Niacinamide can repair impaired Stratum corneum lipids barrier, effectively reduce the effect of the generation of acne；Allantoin can make skin keep moisture, moisten, soft and conditioning cutin；Water plays the role of carrier in skin matrix.Above-mentioned raw materials pass through the reasonable compatibility between each component, it can be realized synergistic effect, skin matrix obtained is while the generation for effectively reducing acne, also have and repairs damaged skin or enhancing skin barrier effect, it is uneven that people's hormone in vivo level has been effectively relieved, caused skin sensitivity, the problem of easily leading to dermatitis and acne.
Description
Technical field
The present invention relates to cosmetic technical fields, more particularly, to a kind of skin matrix and its preparation method and application.
Background technique
Acne is a kind of chronic inflammatory skin of pilosebaceous unit, and clinical manifestation is to be apt to occur in facial powder
With the characteristics of the pleomorphism skin lesion such as thorn, papule, warts, tubercle.Now due to the accelerating rhythm of life, diet work and rest it is irregular etc.
Reason often leads to human body internal hormone secretion level imbalance, and smegma grease is vigorous, so that people's skin is more
Sensitivity, skin barrier effect reduce.Therefore, acne species skin disease presents multiple trend in recent years.
Therefore, a kind of skin matrix with anti-acne (mitigating acne) is researched and developed, to alleviate human body internal hormone
The problem of level is uneven, caused skin sensitivity, easily leads to dermatitis and acne, becomes very necessary and urgent.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of skin matrix, and the skin matrix is in the generation for effectively reducing acne
While, also have and repair damaged skin or enhancing skin barrier effect, people's hormone in vivo level imbalance, institute has been effectively relieved
Caused skin sensitivity, the problem of easily leading to dermatitis and acne.
The second object of the present invention is to provide a kind of preparation method of skin matrix, which has preparation
Simple process, process facilitate controllable, are suitable for the advantage of industrialization large-scale production.
The third object of the present invention is to provide a kind of application of skin matrix, and party's skin matrix can answer extensively
For in anti-acne, the preparation process for the skin-protection product repaired damaged skin or enhance skin barrier.
A kind of skin matrix provided by the invention, by mass percentage, the component of the skin matrix are as follows: hyaluronic acid
Sodium 0.01~1%, niacinamide 1~10%, allantoin 0.01~2%, auxiliary agent 3~45%, surplus are water；In the skin matrix
The sum of mass percent of each component is 100%.
Further, by mass percentage, the component of the skin matrix are as follows: Sodium Hyaluronate 0.1~0.8%, cigarette
Amide 2~8%, allantoin 0.1~0.5%, auxiliary agent 9~30%, surplus are water；The quality hundred of each component in the skin matrix
The sum of score is 100%.
Further, by mass percentage, the component of the skin matrix are as follows: Sodium Hyaluronate 0.5%, niacinamide
5%, allantoin 0.25%, auxiliary agent 15%, surplus are water；The sum of the mass percent of each component is in the skin matrix
100%.
Further, the auxiliary agent includes at least one of glycerol, propylene glycol and 1,3-BDO.
Further, mass percent of the glycerol in skin matrix is 1~15%；
Preferably, mass percent of the glycerol in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the glycerol in skin matrix is 5%；
Preferably, mass percent of the propylene glycol in skin matrix is 1~15%；
Preferably, mass percent of the propylene glycol in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the propylene glycol in skin matrix is 5%；
Preferably, mass percent of the 1,3-BDO in skin matrix is 1~15%；
Preferably, mass percent of the 1,3-BDO in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the 1,3-BDO in skin matrix is 5%.
Further, the auxiliary agent includes glycerol, propylene glycol and 1,3-BDO.
Further, by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.01~1%,
Niacinamide 1~10%, allantoin 0.01~2%, glycerol 1~15%, propylene glycol 1~15%, 1,3-BDO 1~15%, it is remaining
Amount is water；The sum of mass percent of each component is 100% in the skin matrix；
Preferably, by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.1~0.8%,
Niacinamide 2~8%, allantoin 0.1~0.5%, glycerol 3~10%, propylene glycol 3~10%, 1,3-BDO 3~10%, it is remaining
Amount is water；The sum of mass percent of each component is 100% in the skin matrix；
It is furthermore preferred that by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.5%, nicotinoyl
Amine 5%, allantoin 0.25%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；It is each in the skin matrix
The sum of mass percent of component is 100%.
A kind of preparation method of above-mentioned skin matrix provided by the invention, the preparation method comprises the following steps:
Each component is uniformly mixed, skin matrix is made.
A kind of above-mentioned skin matrix provided by the invention is in preparation for anti-acne, reparation damaged skin or enhancing skin barrier
Skin-protection product in application.
Further, the skin-protection product includes one of lotion, cream, toner or Essence.
Compared with prior art, the invention has the benefit that
Skin matrix provided by the invention is mainly by Sodium Hyaluronate, niacinamide, allantoin, auxiliary agent and water through certain content
Proportion obtains, wherein Sodium Hyaluronate plays the role of lubricating and nourishing well to Skin Cell；Niacinamide can repair by
The Stratum corneum lipids barrier of damage improves skin resistance, effectively reduces the generation of acne, improves skin microgroove, provides for skin
Nutrition；Allantoin can make skin keep moisture, moisten and soft；Water plays the role of carrier in skin matrix.Above-mentioned raw materials
By the reasonable compatibility between each component, synergistic effect can be realized, skin matrix obtained is effectively reducing acne
Generation while, also have repair damaged skin and enhancing skin barrier effect, people's hormone in vivo level has been effectively relieved
Imbalance, caused skin sensitivity, the problem of easily leading to dermatitis and acne.
Shield is made by the way that each component to be uniformly mixed in the preparation method of skin matrix provided by the invention, the preparation method
Skin matrix.The preparation method has preparation process simple, and process facilitates controllable, is suitable for the advantage of industrialization large-scale production.
Skin matrix provided by the invention can be widely applied to anti-acne, repairs damaged skin and enhance skin barrier
In the preparation process of skin-protection product.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
Applying example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
According to an aspect of the present invention, a kind of skin matrix, by mass percentage, the component of the skin matrix
Are as follows: Sodium Hyaluronate 0.01~1%, niacinamide 1~10%, allantoin 0.01~2%, auxiliary agent 3~45%, surplus are water；Institute
Stating the sum of mass percent of each component in skin matrix is 100%.
Effect in skin matrix of the above-mentioned each component of the present invention are as follows:
Sodium Hyaluronate: it is a kind of intrinsic ingredient in human body, is a kind of glucan aldehydic acid, without species specificity.This
Sodium Hyaluronate is applied to play the role of lubricating and nourishing well to Skin Cell in skin matrix by invention.
Preferably, the typical but non-limiting content of Sodium Hyaluronate that embodiment of the present invention provides are as follows: 0.01%,
0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1%.
Niacinamide: niacinamide is a kind of derivative of vitamin B3, and niacinamide, which has, in the present invention repairs impaired cutin
Layer lipid barrier, improve the effect of skin resistance, while niacinamide is also equipped with deep layer water lock effect, have extremely strong water lock,
Moisture-keeping efficacy.The present invention, which is applied in skin matrix, can effectively reduce the generation of acne, improve skin microgroove, be skin
Nutrition is provided.
Preferably, embodiment of the present invention provide the typical but non-limiting content of niacinamide are as follows: 1%, 2%, 3%,
4%, 5%, 6%, 7%, 8%, 9% or 10%.
Allantoin: alias Allantoin, Allantoin, Allantion, Allantoin are a kind of second
Interior ureide derivative.Allantoin is applied to that skin high resilience can be made in skin matrix by the present invention, while promoting cell
Metabolism, cutin-softening layer albumen.
Preferably, embodiment of the present invention provide the typical but non-limiting content of allantoin are as follows: 0.01%, 0.1%,
0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%,
1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9% or 2%.
Auxiliary agent: those skilled in the art can add corresponding auxiliary agent according to the well-known technique of skin care industry, for example, above-mentioned
Auxiliary agent it is typical but non-limiting can be the auxiliary agent with figuration, moisturizing or lubricating action.
Preferably, embodiment of the present invention provide the typical but non-limiting content of auxiliary agent are as follows: 1%, 2%, 3%,
4%, 5%, 6%, 7%, 8%, 9% or 10%.
Skin matrix provided by the invention is mainly by Sodium Hyaluronate, niacinamide, allantoin, auxiliary agent and water through certain content
Proportion obtains, wherein Sodium Hyaluronate plays the role of lubricating and nourishing well to Skin Cell；Niacinamide can repair by
The Stratum corneum lipids barrier of damage improves skin resistance, effectively reduces the generation of acne, improves skin microgroove, provides for skin
Nutrition；Allantoin can make skin keep moisture, moisten and soft；Water plays the role of carrier in skin matrix.Above-mentioned raw materials
By the reasonable compatibility between each component, synergistic effect can be realized, skin matrix obtained is effectively reducing acne
Generation while, also have repair damaged skin and enhancing skin barrier effect, people's hormone in vivo level has been effectively relieved
Imbalance, caused skin sensitivity, the problem of easily leading to dermatitis and acne.
In the preferred embodiment of the present invention, by mass percentage, the component of the skin matrix are as follows: transparent
Matter acid sodium 0.1~0.8%, niacinamide 2~8%, allantoin 0.1~0.5%, auxiliary agent 9~30%, surplus are water；The skin care
The sum of mass percent of each component is 100% in matrix.
In above-mentioned preferred embodiment, by mass percentage, the component of the skin matrix are as follows: Sodium Hyaluronate
0.5%, niacinamide 5%, allantoin 0.25%, auxiliary agent 15%, surplus are water；The quality percentage of each component in the skin matrix
The sum of number is 100%.
In the present invention, by the further adjustment and optimization to each component raw material dosage ratio, to advanced optimize
The effect of skin matrix of the present invention.
In the preferred embodiment of the present invention, the auxiliary agent includes in glycerol, propylene glycol and 1,3-BDO
It is at least one.
As a preferred embodiment, above-mentioned auxiliary agent includes at least one in glycerol, propylene glycol and 1,3-BDO
Kind.Above-mentioned glycerol, propylene glycol and 1,3 butylene glycol, which are added in the application skin matrix, can form a stable solution body
System has good figuration effect, while above-mentioned glycerol, propylene glycol and 1,3-BDO all have good moisture-keeping function, have
Effect reduces the turnover rate of moisture in skin, enhances the barrier function of skin, highlights skin obviously, pore attenuates.
In above-mentioned preferred embodiment, mass percent of the glycerol in skin matrix is 1~15%；It is above-mentioned sweet
The typical but non-limiting preferred embodiment of mass percent of the oil in skin matrix are as follows: 1%, 2%, 3%, 4%, 5%,
6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% and 15%.
Preferably, mass percent of the glycerol in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the glycerol in skin matrix is 5%；
Preferably, mass percent of the propylene glycol in skin matrix is 1~15%；Above-mentioned propylene glycol is in skin care base
The typical but non-limiting preferred embodiment of mass percent in matter are as follows: 1%, 2%, 3%, 4%, 5%, 6%, 7%,
8%, 9%, 10%, 11%, 12%, 13%, 14% and 15%.
Preferably, mass percent of the propylene glycol in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the propylene glycol in skin matrix is 5%；
Preferably, mass percent of the 1,3-BDO in skin matrix is 1~15%；Above-mentioned 1,3 butylene glycol
The typical but non-limiting preferred embodiment of mass percent in skin matrix are as follows: 1%, 2%, 3%, 4%, 5%,
6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% and 15%.
Preferably, mass percent of the 1,3-BDO in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the 1,3-BDO in skin matrix is 5%.
In above-mentioned preferred embodiment, the auxiliary agent includes glycerol, propylene glycol and 1,3-BDO.
As a preferred embodiment, above-mentioned auxiliary agent includes glycerol, propylene glycol and 1,3-BDO, i.e. present invention shield
When simultaneously including glycerol, propylene glycol and 1,3-BDO in skin matrix, better effect achieved by the skin matrix.
In the preferred embodiment of the present invention, by mass percentage, the skin matrix includes following components:
Sodium Hyaluronate 0.01~1%, niacinamide 1~10%, allantoin 0.01~2%, glycerol 1~15%, propylene glycol 1~15%,
1,3-BDO 1~15%, surplus are water；The sum of mass percent of each component is 100% in the skin matrix；
Preferably, by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.1~0.8%,
Niacinamide 2~8%, allantoin 0.1~0.5%, glycerol 3~10%, propylene glycol 3~10%, 1,3-BDO 3~10%, it is remaining
Amount is water；The sum of mass percent of each component is 100% in the skin matrix；
It is furthermore preferred that by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.5%, nicotinoyl
Amine 5%, allantoin 0.25%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；It is each in the skin matrix
The sum of mass percent of component is 100%.
In the present invention, by the further adjustment and optimization to each component raw material dosage ratio, to advanced optimize
The effect of skin matrix of the present invention.
According to an aspect of the present invention, a kind of preparation method of above-mentioned skin matrix, the preparation method includes following
Step:
Each component is uniformly mixed, skin matrix is made.
Shield is made by the way that each component to be uniformly mixed in the preparation method of skin matrix provided by the invention, the preparation method
Skin matrix.The preparation method has preparation process simple, and process facilitates controllable, is suitable for the advantage of industrialization large-scale production.
According to an aspect of the present invention, a kind of above-mentioned skin matrix is in preparation for anti-acne, reparation damaged skin or increasing
Application in the skin-protection product of strong skin barrier.
Skin matrix provided by the invention can be widely applied to anti-acne, repairs damaged skin and enhance skin barrier
In the preparation process of skin-protection product.
In the preferred embodiment of the present invention, the skin-protection product includes lotion, cream, toner or Essence
One of.
Technical solution of the present invention is described further below in conjunction with embodiment and comparative example.
Embodiment 1
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate
0.01%, niacinamide 1%, allantoin 0.01%, glycerol 15%, propylene glycol 1%, 1,3-BDO 15%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 2
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 1%, cigarette
Amide 10%, allantoin 2%, glycerol 1%, propylene glycol 15%, 1,3-BDO 1%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 3
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.8%,
Niacinamide 8%, allantoin 0.5%, glycerol 3%, propylene glycol 10%, 1,3-BDO 3%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 4
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.1%,
Niacinamide 2%, allantoin 1.5%, glycerol 10%, propylene glycol 3%, 1,3-BDO 10%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 5
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.5%,
Niacinamide 5%, allantoin 0.25%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 6
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.5%,
Niacinamide 5%, allantoin 0.25%, glycerol 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 7
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.5%,
Niacinamide 5%, allantoin 0.25%, propylene glycol 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Embodiment 8
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.5%,
Niacinamide 5%, allantoin 0.25%, glycerol 5%, 1,3-BDO 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Comparative example 1
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.5%,
Allantoin 0.25%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Comparative example 2
A kind of skin matrix, by mass percentage, the skin matrix include following components: Sodium Hyaluronate 0.5%,
Niacinamide 5%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Comparative example 3
A kind of skin matrix, by mass percentage, the skin matrix include following components: niacinamide 5%, allantoin
0.25%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix；
The preparation method of the skin matrix is the following steps are included: each component is uniformly mixed, obtained skin matrix.
Comparative example 4
A kind of skin care stoste, the raw material including following parts by weight: 2.5g propylene glycol, 2.5g butanediol, 0.05gEDTA bis-
Sodium, 0.1g allantoin, 0.1g hydroxyethyl cellulose, 0.1g xanthan gum, 2g glycine betaine, 0.03g hyaluronic acid, 1.2g trehalose,
0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g niacinamide, 0.3g hexapeptide -1,1.5g hydrolytic collagen, 0.1g are sweet
Oxalic acid dipotassium, 0.2g Phenoxyethanol and 88.02g water.
Preparation method includes the following steps:
Step 1, by propylene glycol, butanediol, EDETATE SODIUM, allantoin, hydroxyethyl cellulose, xanthan gum, glycine betaine, transparent
Matter acid, trehalose, carbomer, triethanolamine are added in water phase pot, and load weighted water is added, warming while stirring to 85
DEG C, constant temperature stirs 30min, until dissolution is without particle；
When opening cooling water temperature to 55 DEG C, panthenol, niacinamide is added, stirring is neutralized to fully transparent in step 2；
Step 3 when being cooled to 35 DEG C, is added hexapeptide -1, hydrolytic collagen, dipotassium glycyrrhizinate, Phenoxyethanol and stirs evenly, it
After sample inspection, it is filling after detection is qualified, obtain the compact essence stoste of the Argireline.Wherein, by packaging material sanitized,
Can be filling after detection is qualified, finished product inspection is obtained, detection microorganism is qualified.
Experimental example 1
Tested crowd: 60 young woman volunteers, the age is between 20~30 one full year of life；
Test method: 5 people of random every component, every group of people use embodiment 1-8 and comparative example 1-4 to prepare respectively in face
Skin matrix (dosage is about 1 yuan of coin-size)；It is detected, is assessed through the severe edema due to hypofunction of the spleen with percutaneous water loss instrument after being used continuously 4 weeks
Divide wastage.
Test result is as follows for it shown in table.
As seen from the above table, the above-mentioned percutaneous water loss rate of 60 volunteer faces has different degrees of reduction, barrier function
Can enhancing, wherein effect most preferably embodiment 5.
The experiment of 2 anti-acne effect of experimental example
To show that the application skin matrix has good anti-acne effect, now selected from 18 volunteer (age 20-30
Year, average age 25 years old), it is corresponding using skin matrix made from the embodiment of the present application 5 in face after daily morning and evening face cleaning, every time
The amount used is all the same, is detected after continuous use 4 weeks with VISIA instrument, assesses face's small pox quantity, long acne region area:
Specific experiment result is as shown in the table:
| Volunteer | Small pox quantity reduction/% | Long acne region area reduction/% |
| 1 | 68 | 78 |
| 2 | 56 | 66 |
| 3 | 70 | 80 |
| 4 | 66 | 76 |
| 5 | 43 | 63 |
| 6 | 80 | 90 |
| 7 | 58 | 78 |
| 8 | 48 | 68 |
| 9 | 66 | 76 |
| 10 | 70 | 80 |
| 11 | 69 | 79 |
| 12 | 43 | 63 |
| 13 | 70 | 80 |
| 14 | 58 | 68 |
| 15 | 72 | 82 |
| 16 | 63 | 73 |
| 17 | 83 | 93 |
| 18 | 92 | 98 |
As seen from the above table, above-mentioned 18 volunteer faces small pox quantity significantly reduces, and the skin in long acne region is clearly better,
Because the general red area of long acne is reduced, and period small pox recurrence rate is greatly reduced.
The experiment of 3 skin barrier of experimental example
To show that the application skin matrix has the effect of repairing damaged skin and enhancing skin barrier effect well,
It is now special to select 18 volunteers (age is 20-30 years old, average age 25 years old), it is corresponding using originally in face after daily morning and evening face cleaning
Apply for skin matrix made from embodiment 5, the amount used every time is all the same, is examined after continuous use 4 weeks with percutaneous water loss instrument
It surveys, assesses percutaneous water loss situation.
Specific experiment result is as shown in the table:
As seen from the above table, the percutaneous water loss rate of this 18 volunteer faces is reduced, barrier function enhancing.And skin is bright
Aobvious to highlight, pore attenuates.
In conclusion skin matrix provided by the invention is mainly by Sodium Hyaluronate, niacinamide, allantoin, auxiliary agent and water
It matches to obtain through certain content.Above-mentioned raw materials can be realized synergistic effect, system by the reasonable compatibility between each component
The skin matrix obtained also has while the generation for effectively reducing acne and repairs damaged skin and enhancing skin barrier work
With skin sensitivity uneven, caused due to people hormone in vivo level in recent years has been effectively relieved, has easily led to dermatitis and Cuo
The problem of sore.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of skin matrix, which is characterized in that by mass percentage, the component of the skin matrix are as follows: Sodium Hyaluronate
0.01~1%, niacinamide 1~10%, allantoin 0.01~2%, auxiliary agent 3~45%, surplus are water；It is each in the skin matrix
The sum of mass percent of component is 100%.
2. skin matrix according to claim 1, which is characterized in that by mass percentage, the group of the skin matrix
Be divided into: Sodium Hyaluronate 0.1~0.8%, niacinamide 2~8%, allantoin 0.1~0.5%, auxiliary agent 9~30%, surplus are water；
The sum of mass percent of each component is 100% in the skin matrix.
3. skin matrix according to claim 1, which is characterized in that by mass percentage, the group of the skin matrix
Be divided into: Sodium Hyaluronate 0.5%, niacinamide 5%, allantoin 0.25%, auxiliary agent 15%, surplus are water；In the skin matrix
The sum of mass percent of each component is 100%.
4. described in any item skin matrixes according to claim 1~3, which is characterized in that the auxiliary agent includes low-carbon polyol；
Preferably, the low-carbon polyol includes at least one of glycerol, propylene glycol and 1,3-BDO.
5. skin matrix according to claim 4, which is characterized in that mass percent of the glycerol in skin matrix
It is 1~15%；
Preferably, mass percent of the glycerol in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the glycerol in skin matrix is 5%；
Preferably, mass percent of the propylene glycol in skin matrix is 1~15%；
Preferably, mass percent of the propylene glycol in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the propylene glycol in skin matrix is 5%；
Preferably, mass percent of the 1,3-BDO in skin matrix is 1~15%；
Preferably, mass percent of the 1,3-BDO in skin matrix is 3~10%；
It is furthermore preferred that mass percent of the 1,3-BDO in skin matrix is 5%.
6. skin matrix according to claim 4, which is characterized in that the auxiliary agent includes glycerol, propylene glycol and 1,3- fourth
Glycol.
7. described in any item skin matrixes according to claim 1~3, which is characterized in that by mass percentage, the skin care
Matrix includes following components: Sodium Hyaluronate 0.01~1%, niacinamide 1~10%, allantoin 0.01~2%, glycerol 1~
15%, propylene glycol 1~15%, 1,3-BDO 1~15%, surplus are water；The quality percentage of each component in the skin matrix
The sum of number is 100%；
Preferably, by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.1~0.8%, nicotinoyl
Amine 2~8%, allantoin 0.1~0.5%, glycerol 3~10%, propylene glycol 3~10%, 1,3-BDO 3~10%, surplus are
Water；The sum of mass percent of each component is 100% in the skin matrix；
It is furthermore preferred that by mass percentage, the skin matrix includes following components: Sodium Hyaluronate 0.5%, niacinamide
5%, allantoin 0.25%, glycerol 5%, propylene glycol 5%, 1,3-BDO 5%, surplus are water；Each group in the skin matrix
The sum of mass percent divided is 100%.
8. a kind of preparation method of skin matrixes described in any item according to claim 1~7, which is characterized in that the preparation
Method the following steps are included:
Each component is uniformly mixed, skin matrix is made.
9. a kind of skin matrixes described in any item according to claim 1~7 are in preparation for anti-acne, reparation damaged skin or increasing
Application in the skin-protection product of strong skin barrier.
10. application according to claim 9, which is characterized in that the skin-protection product include lotion, cream, toner or
One of Essence.
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| CN201910878926.3A CN110478272A (en) | 2019-09-17 | 2019-09-17 | Skin matrix and its preparation method and application |
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| CN113081891A (en) * | 2021-03-30 | 2021-07-09 | 广东丸美生物技术股份有限公司 | Skin care composition and application thereof |
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