CN110475565A - 软骨归巢肽缀合物及其使用方法 - Google Patents

软骨归巢肽缀合物及其使用方法 Download PDF

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Publication number
CN110475565A
CN110475565A CN201880014833.XA CN201880014833A CN110475565A CN 110475565 A CN110475565 A CN 110475565A CN 201880014833 A CN201880014833 A CN 201880014833A CN 110475565 A CN110475565 A CN 110475565A
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peptide
seq
active agent
agent conjugate
peptides
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CN201880014833.XA
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Chinese (zh)
Inventor
J·E·诺瓦克
N·W·奈林
D·M·米勒
S·普利司内尔
C·约士海姆
M·斯陶德
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Blaze Bioscience Inc
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Blaze Bioscience Inc
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Insects & Arthropods (AREA)
  • Optics & Photonics (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
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CN201880014833.XA 2017-03-16 2018-03-16 软骨归巢肽缀合物及其使用方法 Pending CN110475565A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762472485P 2017-03-16 2017-03-16
US62/472,485 2017-03-16
PCT/US2018/023006 WO2018170480A1 (en) 2017-03-16 2018-03-16 Cartilage-homing peptide conjugates and methods of use thereof

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CN110475565A true CN110475565A (zh) 2019-11-19

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US (2) US11013814B2 (https=)
EP (1) EP3595699A4 (https=)
JP (2) JP7280193B2 (https=)
CN (1) CN110475565A (https=)
AU (1) AU2018236465A1 (https=)
CA (1) CA3056421A1 (https=)
WO (1) WO2018170480A1 (https=)

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US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US11090358B2 (en) 2015-09-09 2021-08-17 Fred Hutchinson Cancer Research Center Cartilage-homing peptides
AU2018210157B2 (en) 2017-01-18 2022-10-06 Fred Hutchinson Cancer Center Peptide compositions and methods of use thereof for disrupting TEAD interactions
EP3595699A4 (en) 2017-03-16 2020-12-23 Blaze Bioscience, Inc. PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE
AU2018283161A1 (en) 2017-06-15 2020-01-02 Blaze Bioscience, Inc. Renal-homing peptide conjugates and methods of use thereof
EP3727146A4 (en) 2017-12-19 2021-10-06 Blaze Bioscience, Inc. TUMOR HOMING AND CELL-PENETANT PEPTIDE IMMUNO-ONCOLOGY AGENT COMPLEX AND METHOD OF USE
WO2019178573A1 (en) * 2018-03-16 2019-09-19 Blaze Bioscience, Inc. Truncated cartilage-homing peptides and peptide complexes and methods of use thereof
WO2019209662A1 (en) * 2018-04-23 2019-10-31 Fred Hutchinson Cancer Research Center Conjugates of cartilage-homing peptides
US20200171051A1 (en) * 2018-11-30 2020-06-04 Renibus Therapeutics, Inc. Methods for treating renal injury by therapeutically upregulating p21
WO2020150679A1 (en) * 2019-01-18 2020-07-23 Memorial Sloan Kettering Cancer Center Proteins and fluorophore containing compounds selective for navl7
US12383547B2 (en) 2020-07-01 2025-08-12 Vanderbilt University Methods of treatment for a kidney disease
JP2024503480A (ja) * 2021-01-19 2024-01-25 ウィリアム マーシュ ライス ユニバーシティ ポリペプチドの骨特異的送達法
CN113577246B (zh) * 2021-08-02 2023-11-03 赛克赛斯生物科技股份有限公司 一种预防瘢痕粘连的组合物、术后防粘连材料及应用
WO2024173795A1 (en) * 2023-02-17 2024-08-22 California Institute Of Technology Activatable drug conjugates and therapeutic applications thereof

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