CN110464917A - 便携式药物混合和递送系统及方法 - Google Patents
便携式药物混合和递送系统及方法 Download PDFInfo
- Publication number
- CN110464917A CN110464917A CN201910717491.4A CN201910717491A CN110464917A CN 110464917 A CN110464917 A CN 110464917A CN 201910717491 A CN201910717491 A CN 201910717491A CN 110464917 A CN110464917 A CN 110464917A
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- room
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- wet
- mixing system
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- Pending
Links
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- 229940079593 drug Drugs 0.000 title claims abstract description 66
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800014P | 2013-03-15 | 2013-03-15 | |
| US61/800,014 | 2013-03-15 | ||
| US201361917943P | 2013-12-19 | 2013-12-19 | |
| US61/917,943 | 2013-12-19 | ||
| CN201480025940.4A CN105407943B (zh) | 2013-03-15 | 2014-03-18 | 便携式药物混合和递送系统及方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480025940.4A Division CN105407943B (zh) | 2013-03-15 | 2014-03-18 | 便携式药物混合和递送系统及方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110464917A true CN110464917A (zh) | 2019-11-19 |
Family
ID=51530685
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910717491.4A Pending CN110464917A (zh) | 2013-03-15 | 2014-03-18 | 便携式药物混合和递送系统及方法 |
| CN201480025940.4A Active CN105407943B (zh) | 2013-03-15 | 2014-03-18 | 便携式药物混合和递送系统及方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480025940.4A Active CN105407943B (zh) | 2013-03-15 | 2014-03-18 | 便携式药物混合和递送系统及方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9199037B2 (enExample) |
| EP (1) | EP2968770B1 (enExample) |
| JP (2) | JP6560187B2 (enExample) |
| CN (2) | CN110464917A (enExample) |
| AU (1) | AU2014232211B2 (enExample) |
| CA (1) | CA2905207C (enExample) |
| WO (1) | WO2014146060A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114947774A (zh) * | 2022-05-31 | 2022-08-30 | 深圳大学 | 医用伤检系统、群体伤调度控制方法、救援调度控制装置 |
| US11771841B2 (en) | 2020-12-23 | 2023-10-03 | Tolmar International Limited | Systems and methods for mixing syringe valve assemblies |
| USD1029245S1 (en) | 2022-06-22 | 2024-05-28 | Tolmar International Limited | Syringe connector |
| CN119113353A (zh) * | 2024-08-21 | 2024-12-13 | 中国人民解放军军事科学院军事医学研究院 | 外伤止血敷料导入器械 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| CA2594627C (en) | 2005-02-01 | 2012-04-17 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| WO2008091838A2 (en) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
| USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
| US8021344B2 (en) | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
| US10350364B2 (en) | 2009-11-11 | 2019-07-16 | Windgap Medical, Inc. | Portable Drug Mixing and Delivery Device and Associated Methods |
| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| CA2896746A1 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
| WO2017062005A1 (en) * | 2015-10-08 | 2017-04-13 | Windgap Medical | Portable drug mixing and delivery device and associated methods |
| US12239822B2 (en) | 2013-03-15 | 2025-03-04 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| CN110464917A (zh) | 2013-03-15 | 2019-11-19 | 温德加普医疗股份有限公司 | 便携式药物混合和递送系统及方法 |
| US10569017B2 (en) | 2013-03-15 | 2020-02-25 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| US10391262B2 (en) | 2014-03-18 | 2019-08-27 | Windgap Medical, Inc. | Removable actuating cap for use with an auto-injector assembly |
| US9907910B2 (en) | 2013-03-15 | 2018-03-06 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| WO2015057408A1 (en) * | 2013-10-03 | 2015-04-23 | Jeff Baker | Medicament delivery and training cartridge system and mechanisms of actuation |
| JP2017503017A (ja) | 2013-12-18 | 2017-01-26 | ウィンドギャップ メディカル， インコーポレイテッド | 薬物混合および送達システムならびに方法 |
| EP3183016B1 (en) | 2014-08-18 | 2020-01-29 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| US11116903B2 (en) | 2014-08-18 | 2021-09-14 | Windgap Medical, Inc | Compression seal for use with a liquid component storage vial of an auto-injector |
| HK1244450A1 (zh) * | 2014-12-18 | 2018-08-10 | 温德加普医疗股份有限公司 | 用於溶解或增溶治疗剂的方法和组合物 |
| EP3274021B1 (en) | 2015-03-24 | 2024-02-14 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
| CN108140332A (zh) * | 2015-06-19 | 2018-06-08 | 詹森药业有限公司 | 用于药物施用和混合的设备和方法及用于所述设备和方法的适当技术的训练 |
| US10220147B2 (en) | 2015-08-13 | 2019-03-05 | Windgap Medical, Inc. | Mixing and injection device with sterility features |
| US10532157B2 (en) * | 2016-04-08 | 2020-01-14 | University Of Washington | Ampule autoinjector systems and methods |
| US9636460B1 (en) | 2016-12-28 | 2017-05-02 | Creare Llc | Pneumatic autoinjector with automated mixing |
| WO2018136413A2 (en) | 2017-01-17 | 2018-07-26 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
| CN108404261B (zh) * | 2017-02-09 | 2021-06-04 | 温德加普医疗股份有限公司 | 药品混合装置以及混合药品的方法 |
| EP3727519A1 (en) * | 2017-12-21 | 2020-10-28 | Sanofi | Supplementary device for attachment to an injection device |
| WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
| WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
| CN109157417B (zh) * | 2018-09-30 | 2024-05-14 | 北京翰林航宇科技发展股份公司 | 一种装量调节装置 |
| JP2022519782A (ja) | 2019-02-07 | 2022-03-24 | ヴィヴェーク・ケー・シャルマ | 交番極性磁場によってがん細胞を治療するシステム、および方法 |
| US11642466B2 (en) | 2019-05-03 | 2023-05-09 | Carefusion 303, Inc. | Syringe with priming mechanism |
| EP4043864A4 (en) | 2019-10-28 | 2022-11-30 | FUJIFILM Corporation | METHOD FOR SORTING PLURIPOTENT STEM CELLS, METHOD FOR PREDICTING RESULTS OF INDUCTION OF DIFFERENTIATION, AND METHOD FOR MANUFACTURING CELLULAR PRODUCT |
| CN111110959B (zh) * | 2020-02-06 | 2021-08-13 | 周冬兵 | 一种医疗领域使用的注射器 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986006967A1 (en) * | 1985-05-20 | 1986-12-04 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| CN1244810A (zh) * | 1996-11-13 | 2000-02-16 | 阿斯特拉公司 | 药物输送装置的隔膜和室 |
| CN1270842A (zh) * | 1999-04-15 | 2000-10-25 | 费布尔南多·奥拉西奥·马克·克莱 | 一次性使用的注射器 |
| DE69725220D1 (de) * | 1996-06-28 | 2003-11-06 | Becton Dickinson Co | Kolbenvorrichtung mit Beipass zum Gebrauch im Zylinder einer Mehrkammerspritze |
| CN1541121A (zh) * | 2000-12-21 | 2004-10-27 | R・D・吉莱斯皮三世 | 自动混合和注射设备 |
| US6878338B2 (en) * | 2001-05-04 | 2005-04-12 | Prismedical Corporation | Dual chamber dissolution container with passive agitation |
| CN1684730A (zh) * | 2002-09-04 | 2005-10-19 | 梅里迪安医学技术公司 | 药品输送装置 |
| CA2412420C (en) * | 2000-06-08 | 2008-12-02 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| CN102458513A (zh) * | 2009-06-02 | 2012-05-16 | 赛诺菲-安万特德国有限公司 | 两种或更多种药物通过单一剂量选择和单一分配接口的输送 |
| CN102458519A (zh) * | 2009-06-02 | 2012-05-16 | 赛诺菲-安万特德国有限公司 | 具有预混药剂的加药模块 |
| CN102753224A (zh) * | 2010-02-05 | 2012-10-24 | 赛诺菲-安万特德国有限公司 | 带有双安全护罩的载药模块 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3724460A (en) * | 1968-11-14 | 1973-04-03 | American Home Prod | Disposable cartridge for admixing two components of injectable medicament |
| US3680558A (en) | 1970-05-27 | 1972-08-01 | Robert F Kapelowitz | Syringe with multiple compartments |
| US3946732A (en) | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
| US4060082A (en) | 1976-08-16 | 1977-11-29 | Mpl, Inc. | Dual-ingredient medication dispenser |
| EP0072057B1 (en) | 1981-08-10 | 1988-02-10 | Duphar International Research B.V | Automatic injection syringe |
| FR2573310B1 (fr) | 1984-11-20 | 1988-12-30 | Poutrait Morin | Ampoule pour seringue hypodermique, en particulier seringue auto-injectante |
| US5114411A (en) | 1990-11-19 | 1992-05-19 | Habley Medical Technology Corporation | Multi-chamber vial |
| US5360410A (en) | 1991-01-16 | 1994-11-01 | Senetek Plc | Safety syringe for mixing two-component medicaments |
| EP0695555B1 (en) * | 1992-12-01 | 2001-06-20 | HIGASHIKAWA, Tetsuro | Syringe |
| WO1994013344A1 (fr) * | 1992-12-15 | 1994-06-23 | Gabriel Meyer | Dispositif pour la preparation d'une solution, d'une suspension ou d'une emulsion d'une substance medicinale |
| US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US5637087A (en) * | 1995-03-22 | 1997-06-10 | Abbott Laboratories | Prefilled, two-constituent syringe |
| US5569193A (en) | 1995-03-22 | 1996-10-29 | Abbott Laboratories | Syringe system accommodating separately storable prefilled containers for two constituents |
| JP3982855B2 (ja) * | 1995-10-06 | 2007-09-26 | 株式会社大協精工 | ２室を結合した注射器 |
| FR2741810B1 (fr) | 1995-11-30 | 1998-02-20 | Soc Et Et D Applic Tech Sedat | Seringue pour l'injection d'un melange extemporane |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6071270A (en) | 1997-12-04 | 2000-06-06 | Baxter International Inc. | Sliding reconstitution device with seal |
| US6149628A (en) | 1998-07-20 | 2000-11-21 | Szapiro; Jaime Luis | Syringe with two variable volume chambers for containing and administering mixtures of products provided separately |
| US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
| ES2251371T3 (es) | 1999-04-16 | 2006-05-01 | Becton Dickinson And Company | Inyector de tipo pluma con caracteristicas de combinacion de sustancias automatizada. |
| US6309372B1 (en) | 1999-07-16 | 2001-10-30 | Ultradent Products, Inc. | Integrated mixing and dispensing apparatus |
| US7621887B2 (en) | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| US6641561B1 (en) | 2000-10-10 | 2003-11-04 | Meridian Medical Technologies, Inc. | Drug delivery device |
| US7544189B2 (en) | 2000-10-10 | 2009-06-09 | Meridian Medical Technologies, Inc. | Needle and hub assembly for automatic injector |
| US6770052B2 (en) | 2000-10-10 | 2004-08-03 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| US6953445B2 (en) | 2000-10-10 | 2005-10-11 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| US6656150B2 (en) | 2000-10-10 | 2003-12-02 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| US7556614B2 (en) | 2000-10-10 | 2009-07-07 | Meridian Medical Technologies, Inc. | Separation assembly for drug delivery device |
| JP2002130103A (ja) | 2000-10-25 | 2002-05-09 | Honda Motor Co Ltd | リーンＮＯｘ触媒に捕捉したＮＯｘの還元時の点火時期を制御する電子制御装置 |
| US7947742B2 (en) | 2002-06-28 | 2011-05-24 | Civitas Therapeutics, Inc. | Inhalable epinephrine |
| CA2533887A1 (en) | 2003-09-30 | 2005-04-14 | Acusphere, Inc. | Injectable, oral, or topical sustained release pharmaceutical formulations |
| JP2007526023A (ja) | 2003-10-24 | 2007-09-13 | エム ディー シー インベストメント ホールディングス インコーポレイテッド | デュアルチャンバー混合シリンジおよびその使用方法 |
| US7635348B2 (en) | 2003-11-04 | 2009-12-22 | Meridian Medical Technologies, Inc. | Container for medicament automatic injector and automatic injector adapted therefor |
| US7449012B2 (en) | 2004-08-06 | 2008-11-11 | Meridian Medical Technologies, Inc. | Automatic injector |
| US7731678B2 (en) | 2004-10-13 | 2010-06-08 | Hyprotek, Inc. | Syringe devices and methods for mixing and administering medication |
| AT500930B1 (de) * | 2004-10-25 | 2007-03-15 | Pharma Consult Ges M B H & Co | Verfahren und vorrichtung zum lyophilisieren, rekonstituieren und verabreichen eines rekonstituierten wirkstoffes |
| WO2006058061A1 (en) | 2004-11-24 | 2006-06-01 | Becton Dickinson And Company | Automatic reconstitution injector device |
| CA2594627C (en) | 2005-02-01 | 2012-04-17 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| US20070202163A1 (en) | 2005-09-09 | 2007-08-30 | Mutasem Rawas-Qalaji | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| WO2011109340A1 (en) | 2010-03-01 | 2011-09-09 | Nova Southeastern University | Epinephrine nanop articles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| NZ570731A (en) * | 2006-03-29 | 2011-07-29 | Intelliject Inc | Device to deliver medication with circuit producing recorded speech output and movable structure to effectuate delivery and circuit |
| US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| TW200817049A (en) | 2006-06-05 | 2008-04-16 | Verus Pharmaceuticals Inc | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
| ES2704011T3 (es) | 2006-08-31 | 2019-03-13 | Meridian Medical Tech Inc | Dispositivo de vórtice para un sistema de administración de fármacos |
| KR100839969B1 (ko) | 2006-11-03 | 2008-06-19 | 중앙대학교 산학협력단 | 마이크로 공진기 센서 |
| US8190395B2 (en) | 2007-02-12 | 2012-05-29 | Locus Energy, Llc | Comparible diagnostics for renewable energy power systems |
| GB0705388D0 (en) | 2007-03-21 | 2007-04-25 | Medical House Plc The | Improved autoinjector |
| US8057427B2 (en) | 2007-05-09 | 2011-11-15 | Meridian Medical Technologies, Inc. | Drug delivery system with a small amount of a therapeutic agent |
| US20080306439A1 (en) | 2007-06-08 | 2008-12-11 | Nelson M Bud | Devices for mixing and applying a fluid composition |
| US20110097318A1 (en) * | 2007-08-31 | 2011-04-28 | Amgen Inc. | Solid-State Protein Formulation |
| AU2008345108A1 (en) * | 2007-12-28 | 2009-07-09 | Aktivpak, Inc. | Dispenser and therapeutic package suitable for administering a therapeutic substance to a subject |
| ES2752152T3 (es) | 2008-03-10 | 2020-04-03 | Antares Pharma Inc | Dispositivo de seguridad para inyector |
| WO2009118754A2 (en) | 2008-03-28 | 2009-10-01 | Astron Research Limited | A process for preparing a stable lyophilized composition |
| US8177758B2 (en) | 2008-04-08 | 2012-05-15 | Rochester Area Consulting Engineers (RACE) | Pneumatic injector |
| ES2660849T3 (es) | 2008-05-05 | 2018-03-26 | Becton, Dickinson And Company | Dispositivo de administración de medicamentos que tiene un cartucho con extremo distal agrandado |
| DE102008030270A1 (de) | 2008-06-19 | 2009-12-24 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Vorrichtung mit mindestens einer Kammer zur Aufnahme eines Medikaments oder eines Probenvolumens |
| GB2462811B (en) | 2008-08-18 | 2012-08-15 | Medical House Ltd | Improved autoinjector |
| ES2845352T3 (es) * | 2008-09-18 | 2021-07-26 | Becton Dickinson Co | Elemento de montaje de aguja para asegurar una secuencia de reconstitución apropiada |
| DK3545987T3 (da) * | 2008-09-18 | 2021-05-10 | Becton Dickinson Co | Medicinsk injektor med koblede legemsdele |
| GB0821492D0 (en) | 2008-11-25 | 2008-12-31 | Team Holdings Uk Ltd | Integrated auto-injector cartridge system |
| GB2467904B (en) | 2009-02-17 | 2013-06-12 | Oval Medical Technologies Ltd | Drug container and delivery mechanism |
| EP2405961A4 (en) | 2009-03-09 | 2012-08-08 | Purdue Research Foundation | COMPACT DEVICE FOR FAST MIXTURE AND ADMINISTRATION OF SUBSTANCES TO A PATIENT |
| EP2435112B1 (de) | 2009-05-29 | 2015-05-13 | Tecpharma Licensing AG | Injektionsvorrichtung, insbesondere autoinjektor mit stechschutz oder/und überlastsicherung für ein produktbehältnis |
| GB2471304B (en) | 2009-06-24 | 2013-12-11 | Oval Medical Technologies Ltd | A pre-filled syringe or autoinjector |
| CA2686433A1 (en) | 2009-11-20 | 2011-05-20 | Duoject Medical Systems Inc. | Double push injection device |
| WO2011095483A1 (en) | 2010-02-05 | 2011-08-11 | Sanofi-Aventis Deutschland Gmbh | Medicated module with time lock |
| CA2822582C (en) * | 2010-12-30 | 2016-07-12 | Meridian Medical Technologies, Inc. | Three-chambered autoinjector |
| WO2012099898A2 (en) | 2011-01-17 | 2012-07-26 | Aktivpak, Inc. | Aseptic cartridge and dispenser arrangement |
| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US9289562B2 (en) * | 2011-04-18 | 2016-03-22 | THORNE CONSULTING and INTELETUAL PROPERTY, LLC | Pressure actuated valve for multi-chamber syringe applications |
| MX346965B (es) | 2011-05-18 | 2017-04-07 | Becton Dickinson Co | Inyector de bajo costo para un solo uso. |
| DK2723426T3 (da) * | 2011-06-21 | 2019-11-04 | Brent Buchine | Automatisk blandeindretning og afgivelsessystem |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9821118B2 (en) | 2011-09-02 | 2017-11-21 | Unl Holdings Llc | Automatic reconstitution for dual chamber syringe |
| CH705692A2 (de) | 2011-11-03 | 2013-05-15 | Tecpharma Licensing Ag | Verabreichungsvorrichtung zum Abmischen eines Wirkstoffs mit einer Lösungsflüssigkeit. |
| GB2499612A (en) | 2012-02-22 | 2013-08-28 | Consort Medical Plc | Syringe assembly with a stopper |
| US9364610B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| EP2885028A4 (en) | 2012-08-14 | 2016-06-01 | Injector Aps | DISPOSABLE INJECTOR |
| EP3498322B1 (en) | 2012-10-17 | 2020-09-30 | Oval Medical Technologies Limited | Automatic drug delivery devices |
| WO2014066731A1 (en) | 2012-10-26 | 2014-05-01 | Massachusetts Institute Of Technology | Rapid reconstitution packages for mixing and delivery of drugs |
| US20140276413A1 (en) | 2013-03-15 | 2014-09-18 | Jeff Baker | Medicament delivery and simulation system with a removable disposable container for medicament and a rotatable actuation component |
| US10391262B2 (en) | 2014-03-18 | 2019-08-27 | Windgap Medical, Inc. | Removable actuating cap for use with an auto-injector assembly |
| CN110464917A (zh) | 2013-03-15 | 2019-11-19 | 温德加普医疗股份有限公司 | 便携式药物混合和递送系统及方法 |
| AT514484B1 (de) | 2013-06-24 | 2015-05-15 | Pharma Consult Gmbh | Aktivator für einen Autoinjektor |
| EP3183016B1 (en) | 2014-08-18 | 2020-01-29 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
-
2014
- 2014-03-18 CN CN201910717491.4A patent/CN110464917A/zh active Pending
- 2014-03-18 CA CA2905207A patent/CA2905207C/en active Active
- 2014-03-18 CN CN201480025940.4A patent/CN105407943B/zh active Active
- 2014-03-18 EP EP14764198.9A patent/EP2968770B1/en active Active
- 2014-03-18 US US14/218,355 patent/US9199037B2/en active Active
- 2014-03-18 JP JP2016502592A patent/JP6560187B2/ja active Active
- 2014-03-18 WO PCT/US2014/030938 patent/WO2014146060A1/en not_active Ceased
- 2014-03-18 AU AU2014232211A patent/AU2014232211B2/en active Active
- 2014-04-17 US US14/255,909 patent/US10195361B2/en active Active
-
2019
- 2019-02-04 US US16/266,341 patent/US20190167910A1/en not_active Abandoned
- 2019-07-17 JP JP2019132125A patent/JP2019195670A/ja active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986006967A1 (en) * | 1985-05-20 | 1986-12-04 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| DE69725220D1 (de) * | 1996-06-28 | 2003-11-06 | Becton Dickinson Co | Kolbenvorrichtung mit Beipass zum Gebrauch im Zylinder einer Mehrkammerspritze |
| CN1244810A (zh) * | 1996-11-13 | 2000-02-16 | 阿斯特拉公司 | 药物输送装置的隔膜和室 |
| CN1270842A (zh) * | 1999-04-15 | 2000-10-25 | 费布尔南多·奥拉西奥·马克·克莱 | 一次性使用的注射器 |
| CA2412420C (en) * | 2000-06-08 | 2008-12-02 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| CN1541121A (zh) * | 2000-12-21 | 2004-10-27 | R・D・吉莱斯皮三世 | 自动混合和注射设备 |
| US6878338B2 (en) * | 2001-05-04 | 2005-04-12 | Prismedical Corporation | Dual chamber dissolution container with passive agitation |
| CN1684730A (zh) * | 2002-09-04 | 2005-10-19 | 梅里迪安医学技术公司 | 药品输送装置 |
| CN102458513A (zh) * | 2009-06-02 | 2012-05-16 | 赛诺菲-安万特德国有限公司 | 两种或更多种药物通过单一剂量选择和单一分配接口的输送 |
| CN102458519A (zh) * | 2009-06-02 | 2012-05-16 | 赛诺菲-安万特德国有限公司 | 具有预混药剂的加药模块 |
| CN102753224A (zh) * | 2010-02-05 | 2012-10-24 | 赛诺菲-安万特德国有限公司 | 带有双安全护罩的载药模块 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11771841B2 (en) | 2020-12-23 | 2023-10-03 | Tolmar International Limited | Systems and methods for mixing syringe valve assemblies |
| US11931559B2 (en) | 2020-12-23 | 2024-03-19 | Tolmar International Limited | Systems and methods for mixing syringe valve assemblies |
| CN114947774A (zh) * | 2022-05-31 | 2022-08-30 | 深圳大学 | 医用伤检系统、群体伤调度控制方法、救援调度控制装置 |
| CN114947774B (zh) * | 2022-05-31 | 2023-09-08 | 深圳大学 | 医用伤检系统、群体伤调度控制方法、救援调度控制装置 |
| USD1029245S1 (en) | 2022-06-22 | 2024-05-28 | Tolmar International Limited | Syringe connector |
| CN119113353A (zh) * | 2024-08-21 | 2024-12-13 | 中国人民解放军军事科学院军事医学研究院 | 外伤止血敷料导入器械 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150174336A1 (en) | 2015-06-25 |
| US10195361B2 (en) | 2019-02-05 |
| US9199037B2 (en) | 2015-12-01 |
| CA2905207A1 (en) | 2014-09-18 |
| CN105407943A (zh) | 2016-03-16 |
| EP2968770B1 (en) | 2020-12-30 |
| CN105407943B (zh) | 2019-08-20 |
| CA2905207C (en) | 2022-04-12 |
| WO2014146060A1 (en) | 2014-09-18 |
| AU2014232211B2 (en) | 2017-05-25 |
| JP2016512148A (ja) | 2016-04-25 |
| EP2968770A4 (en) | 2016-12-07 |
| US20190167910A1 (en) | 2019-06-06 |
| EP2968770A1 (en) | 2016-01-20 |
| AU2014232211A1 (en) | 2015-10-01 |
| JP2019195670A (ja) | 2019-11-14 |
| JP6560187B2 (ja) | 2019-08-14 |
| US20140276385A1 (en) | 2014-09-18 |
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