CN110461330A - 用于治疗亨廷顿氏病的PPARγ激动剂 - Google Patents

用于治疗亨廷顿氏病的PPARγ激动剂 Download PDF

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Publication number
CN110461330A
CN110461330A CN201880007571.4A CN201880007571A CN110461330A CN 110461330 A CN110461330 A CN 110461330A CN 201880007571 A CN201880007571 A CN 201880007571A CN 110461330 A CN110461330 A CN 110461330A
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CN
China
Prior art keywords
subject
disease
huntington
effective amount
therapeutically effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201880007571.4A
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English (en)
Chinese (zh)
Inventor
B·芬克
L·斯廷曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kohlros Biosciences Co Ltd
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Kohlros Biosciences Co Ltd
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Publication date
Application filed by Kohlros Biosciences Co Ltd filed Critical Kohlros Biosciences Co Ltd
Publication of CN110461330A publication Critical patent/CN110461330A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880007571.4A 2017-01-18 2018-01-18 用于治疗亨廷顿氏病的PPARγ激动剂 Pending CN110461330A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762447741P 2017-01-18 2017-01-18
US62/447,741 2017-01-18
PCT/US2018/014240 WO2018136635A1 (en) 2017-01-18 2018-01-18 Pparϒ agonist for the treatment of huntington's disease

Publications (1)

Publication Number Publication Date
CN110461330A true CN110461330A (zh) 2019-11-15

Family

ID=62908392

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880007571.4A Pending CN110461330A (zh) 2017-01-18 2018-01-18 用于治疗亨廷顿氏病的PPARγ激动剂

Country Status (13)

Country Link
US (1) US20190350918A1 (https=)
EP (1) EP3570841A4 (https=)
JP (1) JP2020505448A (https=)
KR (1) KR20190122664A (https=)
CN (1) CN110461330A (https=)
AU (1) AU2018210165A1 (https=)
BR (1) BR112019014529A2 (https=)
CA (1) CA3050104A1 (https=)
EA (1) EA201991716A1 (https=)
IL (1) IL268008A (https=)
MX (1) MX2019008535A (https=)
SG (1) SG11201906644YA (https=)
WO (1) WO2018136635A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201791982A1 (ru) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
AU2018249822A1 (en) 2017-04-03 2019-10-31 Coherus Biosciences Inc. PPArgamma agonist for treatment of progressive supranuclear palsy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224995A1 (en) * 2003-05-09 2004-11-11 University Of North Texas Health Science Center At Fort Worth Neuroprotective effects of PPARy agonists against cellular oxidative insults
US20050143416A1 (en) * 2003-10-03 2005-06-30 Kruk Henry T. Salts and polymorphs of a potent antidiabetic compound
CN1902185A (zh) * 2003-10-31 2007-01-24 舍林股份公司 噻唑烷酮类化合物、其制备方法以及作为药物的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895541B2 (en) * 2002-09-04 2014-11-25 James A. Carnazza Methods for inhibiting the development of huntington's disease
JP2008515978A (ja) * 2004-10-13 2008-05-15 ユニバーシティ オブ コネチカット カンナビネルジック脂質リガンド
WO2009097996A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Verwendung von substituierten phenylimidazolidinen zur herstellung von arzneimitteln zur behandlung des metabolischen syndroms
WO2010040055A2 (en) * 2008-10-03 2010-04-08 Intekrin Therapeutics, Inc. Oral pharmaceutical formulations for antidiabetic compounds
EP2448412B1 (en) * 2009-07-01 2019-05-01 JDS Therapeutics, LLC Chromium complexes as enhancers of brain glucose transporters
TW201609098A (zh) * 2013-12-20 2016-03-16 泰瓦藥品工業有限公司 拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）於延緩亨丁頓舞蹈症進展的用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224995A1 (en) * 2003-05-09 2004-11-11 University Of North Texas Health Science Center At Fort Worth Neuroprotective effects of PPARy agonists against cellular oxidative insults
US20050143416A1 (en) * 2003-10-03 2005-06-30 Kruk Henry T. Salts and polymorphs of a potent antidiabetic compound
CN1902185A (zh) * 2003-10-31 2007-01-24 舍林股份公司 噻唑烷酮类化合物、其制备方法以及作为药物的应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALEX M DEPAOLI等: "Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone?", 《DIABETES CARE》 *
JUAN CARLOS CORONA等: "PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease", 《FREE RADICAL BIOLOGY AND MEDICINE》 *
YANG YANG等: "The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases", 《BIOCHIMICA ET BIOPHYSICA ACTA》 *

Also Published As

Publication number Publication date
IL268008A (en) 2019-09-26
CA3050104A1 (en) 2018-07-26
BR112019014529A2 (pt) 2020-02-27
EA201991716A1 (ru) 2020-02-04
EP3570841A4 (en) 2020-08-19
KR20190122664A (ko) 2019-10-30
MX2019008535A (es) 2019-12-02
EP3570841A1 (en) 2019-11-27
WO2018136635A1 (en) 2018-07-26
JP2020505448A (ja) 2020-02-20
US20190350918A1 (en) 2019-11-21
AU2018210165A1 (en) 2019-08-01
SG11201906644YA (en) 2019-08-27

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