CN110446500B - 用于基质制备的方法和组合物 - Google Patents

用于基质制备的方法和组合物 Download PDF

Info

Publication number
CN110446500B
CN110446500B CN201880019401.8A CN201880019401A CN110446500B CN 110446500 B CN110446500 B CN 110446500B CN 201880019401 A CN201880019401 A CN 201880019401A CN 110446500 B CN110446500 B CN 110446500B
Authority
CN
China
Prior art keywords
collagen
solution
matrix
clauses
kit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880019401.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN110446500A (zh
Inventor
雪莉·L·沃伊提克-哈尔宾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genifis
Geniphys Inc
Original Assignee
Genifis
Geniphys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genifis, Geniphys Inc filed Critical Genifis
Publication of CN110446500A publication Critical patent/CN110446500A/zh
Application granted granted Critical
Publication of CN110446500B publication Critical patent/CN110446500B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0047—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
CN201880019401.8A 2017-01-31 2018-01-31 用于基质制备的方法和组合物 Active CN110446500B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762452564P 2017-01-31 2017-01-31
US62/452,564 2017-01-31
PCT/US2018/016069 WO2018144496A1 (en) 2017-01-31 2018-01-31 Methods and compositions for matrix preparation

Publications (2)

Publication Number Publication Date
CN110446500A CN110446500A (zh) 2019-11-12
CN110446500B true CN110446500B (zh) 2024-11-26

Family

ID=63041072

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880019401.8A Active CN110446500B (zh) 2017-01-31 2018-01-31 用于基质制备的方法和组合物

Country Status (7)

Country Link
US (1) US12280176B2 (enExample)
EP (1) EP3576775B1 (enExample)
JP (1) JP7242553B2 (enExample)
CN (1) CN110446500B (enExample)
CA (1) CA3052266A1 (enExample)
ES (1) ES3040675T3 (enExample)
WO (1) WO2018144496A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
EP3185922B1 (en) 2014-08-27 2025-04-02 Purdue Research Foundation Collagen-based therapeutic delivery systems
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
CN110446500B (zh) 2017-01-31 2024-11-26 格尼菲斯公司 用于基质制备的方法和组合物
WO2018200750A1 (en) 2017-04-25 2018-11-01 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
US11808760B1 (en) * 2019-02-14 2023-11-07 Curi Bio, Inc. System and methods for in vitro structural toxicity testing
WO2021154845A1 (en) * 2020-01-27 2021-08-05 Geniphys, Llc Biologic filler for restoring and regenerating tissue
CN116999619B (zh) * 2023-08-03 2024-03-19 浙江崇山生物制品有限公司 一种软骨用胶原凝胶及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5067961A (en) * 1988-02-18 1991-11-26 Autogenesis Technologies, Inc. Non-biodegradable two phase corneal implant and method for preparing same

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949073A (en) 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4233360A (en) 1975-10-22 1980-11-11 Collagen Corporation Non-antigenic collagen and articles of manufacture
US4439521A (en) 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4544516A (en) 1982-07-28 1985-10-01 Battelle Development Corporation Collagen orientation
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
CA1295796C (en) 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4789663A (en) 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US4743552A (en) 1984-09-26 1988-05-10 Sloan-Kettering Institute For Cancer Research Method for growth in tissue culture of normal colonic epithelial cells and method for determination of preneoplastic color cells
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US5863531A (en) 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
GB8618374D0 (en) 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
JPH0774239B2 (ja) 1986-09-04 1995-08-09 新田ゼラチン株式会社 細胞培養用高ゲル強度酸可溶性コラーゲンの製法
US5604106A (en) 1987-06-05 1997-02-18 Us Commerce Method for detecting carcinoma
JPH0728730B2 (ja) 1988-03-27 1995-04-05 新技術事業団 擬膵島および拡散チャンバー型人工膵臟
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4912057A (en) 1989-06-13 1990-03-27 Cancer Diagnostics, Inc. Cell chamber for chemotaxis assay
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5163955A (en) 1991-01-24 1992-11-17 Autogenics Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment
WO1992015676A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Somatic cell gene therapy
DE69232535T4 (de) 1991-06-24 2003-09-11 Hcell Technology, Inc. In langzeitkultur gehaltene hormon-absondernde pankreatische zellen
FR2678624A1 (fr) 1991-07-04 1993-01-08 Coletica Utilisation de la peau non pigmentee de poisson, en particulier de poisson plat comme nouvelle source industrielle de collagene, procede d'extraction, collagene et biomateriau ainsi obtenus.
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5204382A (en) 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5428022A (en) 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
US5478739A (en) 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5510263A (en) 1993-04-05 1996-04-23 Desmos, Inc. Growth of pancreatic islet-like cell clusters
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
JPH0789564B2 (ja) 1994-04-12 1995-09-27 株式会社東芝 半導体装置の製造方法
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US5709934A (en) 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5916790A (en) 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
AU736255B2 (en) 1995-10-25 2001-07-26 Shire Human Genetic Therapies, Inc. Hybrid matrix implants and explants
ATE258810T1 (de) 1995-11-09 2004-02-15 Univ Massachusetts Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen
US6497875B1 (en) 1996-04-26 2002-12-24 Case Western Reserve University Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
ATE237371T1 (de) 1996-08-16 2003-05-15 Childrens Medical Center Blasenmukosa mit zellen für die rekonstruktion von geweben
US6171344B1 (en) 1996-08-16 2001-01-09 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
BR9711166A (pt) 1996-08-23 1999-08-17 Cook Biotech Inc PrÄtese de enxerto materiais para sua prepara-Æo e m-todos para seu uso
CA2263898C (en) 1996-09-16 2009-12-08 Purdue Research Foundation Composition and method for repairing neurological tissue
WO1998025636A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Stomach submucosa derived tissue graft
AU743779B2 (en) 1996-12-10 2002-02-07 Cook Biotech, Inc. Tubular grafts from purified submucosa
US6375989B1 (en) 1996-12-10 2002-04-23 Purdue Research Foundation Submucosa extracts
CA2274033C (en) 1996-12-10 2010-05-11 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
WO1998052637A1 (en) 1997-05-23 1998-11-26 Biosense, Inc. Catheter with oblique lumen
CA2308146A1 (en) 1997-07-28 1999-02-04 Thomas B. Neff Collagen type i and type iii adhesive compositions
US6248587B1 (en) 1997-11-26 2001-06-19 University Of Southern Cailfornia Method for promoting mesenchymal stem and lineage-specific cell proliferation
WO1999043786A2 (en) 1998-02-27 1999-09-02 Purdue Research Foundation Submucosa gel compositions
DE19812713A1 (de) 1998-03-24 1999-09-30 Merck Patent Gmbh Verfahren zur Herstellung von mineralisierten Kollagenfibrillen und deren Verwendung als Knochenersatzwerkstoff
JP2002525043A (ja) 1998-09-11 2002-08-13 パーデュー・リサーチ・ファウンデーション 改良粘膜下組織グラフト構成物
ATE305967T1 (de) 1998-11-19 2005-10-15 Organogenesis Inc Biotechnisch konstruiertes gewebe und verfahren zu dessen produktion und benutzung
US6918396B1 (en) 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
ES2353728T3 (es) 1999-02-10 2011-03-04 Curis, Inc. Péptido yy (pyy) para tratar trastornos metabólicos de la glucosa.
US6592623B1 (en) 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
WO2000062833A1 (en) 1999-04-15 2000-10-26 The Research Foundation Of State University Of New York Cellular matrix system and use thereof
WO2001010355A1 (en) 1999-08-06 2001-02-15 Cook Biotech Incorporated Tubular graft construct
US6592794B1 (en) 1999-09-28 2003-07-15 Organogenesis Inc. Process of making bioengineered collagen fibrils
ATE428768T1 (de) 1999-09-28 2009-05-15 Organogenesis Inc Biotechnische kollagenfibrillen
US6482240B1 (en) 1999-12-07 2002-11-19 Ed. Geistlich Soehne Ag Fur Chemische Industrie Method of making a collagen membrane from porcine skin
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
CA2393468C (en) 1999-12-22 2012-03-20 Acell, Inc. Tissue regenerative composition
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US20020039788A1 (en) 2000-02-29 2002-04-04 Isseroff Roslyn R. Corneal epithelial graft composites
ES2288946T3 (es) 2000-04-14 2008-02-01 University Of Pittsburgh Aumento y abultamiento de tejido blando y hueso utilizando celulas progenitoras derivadas de musculo, sus composiciones y tratamientos.
US6893812B2 (en) 2000-05-30 2005-05-17 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Three-dimensional ex vivo angiogenesis system
CA2410956C (en) 2000-05-31 2012-12-04 Michaela Noll Three-dimensional skin model
DE20019809U1 (de) 2000-05-31 2001-07-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80636 München Knorpelersatz und Biomatrix zur Kultivierung von Zellen
CZ301649B6 (cs) 2000-06-28 2010-05-12 Ed. Geistlich Soehne Ag Fur Chemische Industrie Incorporated Under The Laws Of Switzerland Trubice pro regeneraci nervu a zpusob jejich výroby
DE10032610C2 (de) 2000-07-07 2003-05-15 Fischer W Mueller Blasformtech Verfahren zum Herstellen von Kunststoff-Blasformartikeln
HUP0300810A2 (hu) 2000-07-20 2003-08-28 M.G.V.S. Ltd. Mesterséges értranszplantátum, valamint ennek létrehozása és alkalmazása
AU2001284968B2 (en) 2000-08-16 2006-12-21 Duke University Decellularized tissue engineered constructs and tissues
AU2001291543A1 (en) 2000-09-06 2002-03-22 Germain, Lucie In vitro human angiogenesis model
US20020076816A1 (en) 2000-12-04 2002-06-20 Jianwu Dai Stem cells and signals developed for use in tissue and organ repair and replacement
US6586493B1 (en) 2001-03-07 2003-07-01 Arizona Board Of Regents Arizona State University Polysaccharide-based hydrogels and pre-gel blends for the same
US7029689B2 (en) 2001-05-10 2006-04-18 Georgia Tech Research Corporation Tubular construct for implantation
CA2388723C (en) 2001-06-06 2012-10-23 Becton, Dickinson & Company Method of providing a substrate with a ready-to-use, uniformly distributed extracellular matrix
US20030078653A1 (en) 2001-06-15 2003-04-24 Ivan Vesely Tissue engineered mitral valve chordae and methods of making and using same
EP1270672B1 (en) 2001-06-28 2007-11-14 PV Industries B.V. Process for recovering native collagen
US7087089B2 (en) 2001-06-28 2006-08-08 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
WO2003020955A2 (en) 2001-08-31 2003-03-13 Pacgen Cellco Llc Use of recipient endothelial cells for enhanced vascularization of tissue and tissue-engineered construct transplants
DE20115753U1 (de) 2001-09-14 2002-01-10 Institut für Agrar- und Stadtökologische Projekte an der Humboldt-Universität zu Berlin, 10115 Berlin Lösliche Kollagene
AU2003202261A1 (en) 2002-01-11 2003-07-30 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
US8394371B2 (en) 2002-02-11 2013-03-12 Neocutis Sa Compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
US20060014284A1 (en) 2002-03-21 2006-01-19 Thomas Graeve Biomatrix and method for producting the same
AU2003241291A1 (en) 2002-04-12 2003-10-27 Yale University Vascularized human skin equivalent
CN1665527A (zh) 2002-05-02 2005-09-07 普渡研究基金会 血管化增强的移植构造物
CN1713861A (zh) 2002-05-02 2005-12-28 普渡研究基金会 血管化增强的移植构造物
NZ536563A (en) 2002-05-02 2008-03-28 Purdue Research Foundation Vascularization enhanced graft constructs
CA2484614A1 (en) 2002-05-02 2003-11-13 Cook Biotech Incorporated Cell-seeded extracellular matrix grafts
AUPS242702A0 (en) 2002-05-21 2002-06-13 Colltech Australia Limited Improved method for the extraction and purification of collagen
AU2003279730A1 (en) 2002-09-30 2004-04-19 Fibrogen, Inc. Dry tissue sealant compositions
US20040126405A1 (en) 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
EP1605862A4 (en) 2003-02-28 2008-09-03 Fibrogen Inc COLLAGEN COMPOSITIONS AND BIOMATERIALS
WO2005003300A2 (en) 2003-06-04 2005-01-13 University Of South Carolina Tissue scaffold having aligned fibrils, apparatus and method for producing same, and methods of using same
US20050014181A1 (en) 2003-06-18 2005-01-20 Galis Zorina S. Methods and compositions for the assessment of polymer assembly
US8741352B2 (en) 2003-08-25 2014-06-03 Cook Biotech Incorporated Graft materials containing ECM components, and methods for their manufacture
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US8337545B2 (en) 2004-02-09 2012-12-25 Cook Medical Technologies Llc Woven implantable device
CA2554094A1 (en) 2004-02-09 2005-08-25 Indiana University Research And Technology Corporation Isolation, expansion and use of clonogenic endothelial progenitor cells
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
US20050260748A1 (en) 2004-02-27 2005-11-24 Michigan State University Adult stem cells and uses thereof
GB0415080D0 (en) 2004-07-05 2004-08-04 Ucl Biomedica Plc Methods for preparing tissue equivalent implants and products thereof
WO2006030442A2 (en) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
US8337873B2 (en) 2004-10-22 2012-12-25 The Board Of Trustees Of The University Of Illinois Hollow and porous orthopaedic or dental implant that delivers a biological agent
WO2006060779A2 (en) 2004-12-03 2006-06-08 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization
US20060134072A1 (en) 2004-12-22 2006-06-22 Pedrozo Hugo A Self-assembling protein matrix prepared from natural extracellular matrices
US8728463B2 (en) 2005-03-11 2014-05-20 Wake Forest University Health Science Production of tissue engineered digits and limbs
CA2603116A1 (en) 2005-03-29 2006-10-05 The Regents Of The University Of California Controlling stem cell destiny with tunable network
CA2608422C (en) 2005-05-16 2014-10-28 Purdue Research Foundation Engineered extracellular matrices control stem cell behavior
CA2608708C (en) 2005-05-16 2014-04-22 Purdue Research Foundation Engineered extracellular matrix having a specified fibril area fraction
WO2007028079A2 (en) 2005-09-01 2007-03-08 Duke University Methods of stimulating expansion of hematopoietic stem cells
GB0524048D0 (en) 2005-11-25 2006-01-04 Ucl Biomedica Plc Bio-artificial materials with tuneable properties
US20070190646A1 (en) 2006-02-10 2007-08-16 The Trustees Of The University Of Pennsylvania Regulating stem cell differentiation by controlling matrix elasticity
US20070269476A1 (en) 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
WO2007136634A1 (en) 2006-05-16 2007-11-29 Purdue Research Foundation Three dimensional purified collagen matrices
US20080026032A1 (en) 2006-07-27 2008-01-31 Zubery Yuval Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use
AU2007297611B2 (en) 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
EP2076279B1 (en) 2006-10-06 2014-08-27 Anthrogenesis Corporation Native (telopeptide) placental collagen compositions
EP2091335A4 (en) 2006-11-09 2012-07-04 Gamida Cell Ltd USE OF EX VIVO CULTIVATED HEMATOPOIETIC CELLS IN THE TREATMENT OF ACROSYNDROMES
US20100143476A1 (en) 2007-02-14 2010-06-10 March Keith L Composition for stimulating formation of vascular structures
US20100272697A1 (en) 2007-04-10 2010-10-28 Ali Naji Pancreatic islet cells composition and methods
WO2008131293A2 (en) 2007-04-19 2008-10-30 Collengin, Inc. Oriented collagen-based materials, films and methods of making same
WO2008154623A2 (en) * 2007-06-12 2008-12-18 Musculoskeletal Transplant Foundation Process for sterilizing acellular soft tissue with irradiation
GB0713079D0 (en) 2007-07-05 2007-08-15 Ucl Business Plc biomaterial scaffolds with defined stiffness
AU2008331099B2 (en) 2007-11-26 2013-10-24 Collplant Ltd. Compositions comprising fibrous polypeptides and polysaccharides
GB2468102B (en) 2007-12-10 2012-12-05 Purdue Research Foundation Collagen-based matrices with stem cells
CN102089425A (zh) 2008-05-07 2011-06-08 Ucl商业有限公司 仿生细胞支架
US20100119578A1 (en) 2008-11-07 2010-05-13 Specialized Vascular Technologies, Inc. Extracellular matrix modulating coatings for medical devices
WO2010123928A1 (en) 2009-04-20 2010-10-28 Purdue Research Foundation Collagen-based matrices for vessel density and size regulation
US9744123B2 (en) 2009-06-30 2017-08-29 Kensey Nash Corporation Biphasic implant device providing gradient
US20120115222A1 (en) 2009-07-16 2012-05-10 Purdue Research Foundation Composition and method for maintenance, differentiation, and proliferation of stem cells
GB0912399D0 (en) 2009-07-16 2009-08-26 Ucl Business Plc Polymeric collagen biomaterials
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
CN102131403B (zh) 2009-07-27 2014-06-04 成功大学 高纯度胶原蛋白的制备
WO2011019822A2 (en) 2009-08-11 2011-02-17 The Johns Hopkins University Compositions and methods for implantation of processed adipose tissue and processed adipose tissue products
WO2011064773A1 (en) 2009-11-24 2011-06-03 Collplant Ltd. Method of generating collagen fibers
US8475824B2 (en) 2010-01-26 2013-07-02 Warsaw Orthopedic, Inc. Resorbable matrix having elongated particles
ES2790628T3 (es) 2010-06-10 2020-10-28 Ucl Business Plc Aparatos, kits y métodos para la producción de construcciones biomiméticas
GB201011476D0 (en) 2010-07-07 2010-08-25 Ucl Business Plc Controlled production of biomaterial
US20120027732A1 (en) 2010-07-27 2012-02-02 Voytik-Harbin Sherry L Thermoreversible collagen
TW201247157A (en) 2011-05-27 2012-12-01 Hon Hai Prec Ind Co Ltd Object searching system and method, sweeper with the system
WO2012167249A2 (en) 2011-06-02 2012-12-06 Indiana University Research And Technology Corporation Materials and methods for controlling vasculogenesis from endothelial colony forming cells
FR2975922B1 (fr) 2011-06-06 2013-05-31 Arkema France Reacteur a plaques avec injection in situ
US20140056865A1 (en) 2012-08-17 2014-02-27 Allosource Adipose composition systems and methods
US20140193477A1 (en) 2012-10-11 2014-07-10 Emory University Collagen based materials and uses related thereto
EP3798226A1 (en) * 2013-02-01 2021-03-31 Children's Medical Center Corporation Collagen scaffolds
GB201314312D0 (en) 2013-08-09 2013-09-25 Regentec Ltd Composition and delivery system
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
AU2015301432B2 (en) 2014-08-15 2019-11-21 The Johns Hopkins University Composite material for tissue restoration
EP3185922B1 (en) 2014-08-27 2025-04-02 Purdue Research Foundation Collagen-based therapeutic delivery systems
EP4201413A1 (en) 2015-09-10 2023-06-28 Symbiocelltech, LLC Neo-islets comprising stem and islet cells and treatment of diabetes mellitus therewith
CN110446500B (zh) 2017-01-31 2024-11-26 格尼菲斯公司 用于基质制备的方法和组合物
WO2019023266A1 (en) 2017-07-25 2019-01-31 Purdue Research Foundation ENCAPSULATION OF COLLAGEN OF CELLS PRODUCING INSULIN

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5067961A (en) * 1988-02-18 1991-11-26 Autogenesis Technologies, Inc. Non-biodegradable two phase corneal implant and method for preparing same

Also Published As

Publication number Publication date
EP3576775A4 (en) 2020-11-25
EP3576775A1 (en) 2019-12-11
CA3052266A1 (en) 2018-08-09
US20200246507A1 (en) 2020-08-06
WO2018144496A1 (en) 2018-08-09
EP3576775B1 (en) 2025-06-25
JP2020505474A (ja) 2020-02-20
US12280176B2 (en) 2025-04-22
CN110446500A (zh) 2019-11-12
ES3040675T3 (en) 2025-11-04
JP7242553B2 (ja) 2023-03-20

Similar Documents

Publication Publication Date Title
CN110446500B (zh) 用于基质制备的方法和组合物
US20230190864A1 (en) Purified amphiphilic peptide compositions and uses thereof
Tomblyn et al. Keratin hydrogel carrier system for simultaneous delivery of exogenous growth factors and muscle progenitor cells
Nikkhah et al. Gelatin‐based biomaterials for tissue engineering and stem cell bioengineering
US11077226B2 (en) Scalable three-dimensional elastic construct manufacturing
CN102791301B (zh) 细胞支持体和骨再生材料
Monaco et al. Sterilization of collagen scaffolds designed for peripheral nerve regeneration: Effect on microstructure, degradation and cellular colonization
Lin et al. Novel nerve guidance material prepared from bovine aponeurosis
US20120114755A1 (en) Methods and materials for tissue repair
US11998658B2 (en) Injectable porous hydrogels
Yang et al. Using type III recombinant human collagen to construct a series of highly porous scaffolds for tissue regeneration
KR20080065973A (ko) 상호침투성 망상구조, 및 관련 방법 및 조성물
AU2017362105A1 (en) Construction of microRNA gene-mediated novel tissue engineered nerve and applications thereof in repairing nerve defect
Jarquín-Yáñez et al. Structural effect of different EDC crosslinker concentration in gelatin-hyaluronic acid scaffolds
CN108236739B (zh) 一种应用于软骨损伤修复的复合材料
JPH1147258A (ja) ゼラチンとコラーゲンとを含有する医用基材
JP7560886B2 (ja) 組換えバイオポリマーベース組成物及びバイオインクとしての使用
Betz et al. Tissue response and orbital floor regeneration using cyclic acetal hydrogels
Woo et al. Preparation of UV-curable gelatin derivatives for drug immobilization on polyurethane foam: development of wound dressing foam
Giretová et al. Effect of agarose/gelatin gel addition on the pro-angiogenic potential of polyhydroxybutyrate/chitosan scaffolds
RU2715715C1 (ru) Стерильный прозрачный концентрированный раствор биосовместимого коллагена, способ его получения и применения
CN106390206A (zh) 一种多肽水凝胶、其制备方法及应用
KR20230022392A (ko) 유무기 복합 하이드로겔 제조용 조성물 및 이를 포함하는 유무기 복합 하이드로겔 제조용 키트
Denkbas et al. EGF loaded chitosan sponges as wound dressing material
Schurig Tissue engineering for reconstructing the central dopaminergic nigro-striatal pathway in Parkinson’s disease: Cutting edge cell culture studies

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: Indiana, USA

Applicant after: Genifis

Address before: Indiana, USA

Applicant before: GENIPHYS, LLC

GR01 Patent grant
GR01 Patent grant
TG01 Patent term adjustment
TG01 Patent term adjustment