CN110433273A - It is a kind of for treating the external drug of psoriasis - Google Patents
It is a kind of for treating the external drug of psoriasis Download PDFInfo
- Publication number
- CN110433273A CN110433273A CN201910770953.9A CN201910770953A CN110433273A CN 110433273 A CN110433273 A CN 110433273A CN 201910770953 A CN201910770953 A CN 201910770953A CN 110433273 A CN110433273 A CN 110433273A
- Authority
- CN
- China
- Prior art keywords
- parts
- external drug
- psoriasis
- drug
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It is the present invention relates to drug field, in particular to a kind of for treating the field of the external drug of psoriasis；The invention discloses a kind of for treating the external drug of psoriasis, including the first external drug and the second external drug；First external drug is according to the number of parts by weight, comprising: 20~30 parts of almond, 10~40 parts of gypsum, 15~25 parts of ginger, 20~30 parts of loguat leaf, it is remaining be auxiliary material；Second external drug is according to the number of parts by weight, comprising: 10~40 parts of spina gleditsiae, 15~30 parts of the root of Dahurain angelica, 20~40 parts of radix angelicae sinensis, 10~20 parts of olibanum, it is remaining be auxiliary material.The present invention solves the problems, such as that existing Chinese and Western medicine effect is all inapparent to psoriasis, and the external drug for the treatment of psoriasis prepared by the present invention cracking can be absorbed by the skin utilization after smearing, active principle penetrates into blood circulation, therefore it can promote Rehabilitation, have the advantages that curative effect is obvious, easy to use.
Description
Technical field
It is the present invention relates to drug field, in particular to a kind of for treating the field of the external drug of psoriasis.
Background technique
Psoriasis is cured because being not easy, also known as " psoriasis ".It is a kind of inflammation based on erythema, papule, the silvery white scales of skin that peel off
Property, recurring skin disease, be more common in person between twenty and fifty, winter-spring season is easy to recur or aggravates, and summer improves or disappears.Modern medicine is thought
Psoriasis is neurodermatitis, is using paroxysmal pruitus and skin lichenification as the chronic skin inflammation of primary symptom.Mostly with essence
Godhead stimulation, physics sexual stimulus, solar radiation, scratching, abrasion etc. are related.Currently, the treatment of the disease is mainly traditional Chinese and western medicine drug
Treatment and external plaster etc., but effect is not significant, has greatly perplexed numerous psoriatics.
Summary of the invention
It is an object of the invention in view of the problems of the existing technology, provide a kind of curative effect to be significantly used to treat silver-colored bits
The external drug of disease.It is realized especially by following technical solution:
It is a kind of for treating the external drug of psoriasis, including the first external drug and the second external drug；
First external drug is according to the number of parts by weight, comprising: 20~30 parts of almond, 10~40 parts of gypsum, ginger
15~25 parts, 20~30 parts of loguat leaf, it is remaining be auxiliary material；
Second external drug is according to the number of parts by weight, comprising: 10~40 parts of spina gleditsiae, 15~30 parts of the root of Dahurain angelica, when
20~40 parts of angelica tail, 10~20 parts of olibanum, it is remaining be auxiliary material.
Preferably, first external drug is according to the number of parts by weight, comprising: 25~30 parts of almond, gypsum 20~30
Part, 20~25 parts of ginger, 25~30 parts of loguat leaf, it is remaining be auxiliary material；
Second external drug is according to the number of parts by weight, comprising: 10~20 parts of spina gleditsiae, 20~30 parts of the root of Dahurain angelica, when
20~30 parts of angelica tail, 10~15 parts of olibanum, it is remaining be auxiliary material.
It is highly preferred that first external drug is according to the number of parts by weight, comprising: 28 parts of almond, 25 parts of gypsum, ginger
22 parts, 28 parts of loguat leaf, it is remaining be auxiliary material；
Second external drug is according to the number of parts by weight, comprising: 15 parts of spina gleditsiae, 25 parts of the root of Dahurain angelica, 25 parts of radix angelicae sinensis,
13 parts of olibanum, it is remaining be auxiliary material.
The auxiliary material includes methyl p-hydroxybenzoate, gelling agent and glycerol.
The gelling agent includes one of carbomer 934, Acritamer 940, Carbopol 941 or a variety of.
As a further solution of the present invention, the production method for treating the external drug of leucoderma, step is such as
Under:
S1. raw material almond, gypsum, ginger, loguat leaf, spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum are ground into Chinese medicine respectively
Powder crosses 80~100 meshes, packs spare；
S2. herb powder almond, gypsum, ginger, loguat leaf are weighed according to quantity to be uniformly mixed, and are added 400~500mL75%'s
Ethyl alcohol is uniformly mixed, and 1~2h of ultrasound filters to take supernatant A, and supernatant A is concentrated under reduced pressure into 20~30mL, and addition 170~
180mL distilled water, stir 0.5~1h after be centrifuged, collect lower layer's solid B be dissolved in the dehydrated alcohol of 150~200mL, back spin
Turn to be evaporated to drying, collect solid C and the HCl solution of 100~150mL0.5% is added, 0.5~1h of ultrasound, centrifuging and taking lower layer consolidates
Solid D is washed to neutrality by body D, is dried under reduced pressure to get first group of Chinese medical extract, wherein mixing speed is 300~500r/
Min, centrifugal speed are 5000~8000r/min；
S3. spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum herb powder are weighed according to quantity to be uniformly mixed, and 400~500mL75% is added
Ethyl alcohol, be uniformly mixed, 1~2h of ultrasound filters to take supernatant E, supernatant E is concentrated under reduced pressure into 20~30mL, addition 170~
180mL distilled water, stir 0.5~1h after be centrifuged, collect lower layer's solid F be dissolved in the dehydrated alcohol of 150~200mL, back spin
Turn to be evaporated to drying, collect solid G and the HCl solution of 100~150mL0.5% is added, 0.5~1h of ultrasound, centrifuging and taking lower layer consolidates
Solid H is washed to neutrality by body H, is dried under reduced pressure to get second group of Chinese medical extract, wherein mixing speed is 300~500r/
Min, centrifugal speed are 5000~8000r/min；
S4. weigh 4~8g gelling agent, 3~9g methyl p-hydroxybenzoate is mixed with 5~10g glycerol, stir evenly, so
First group of Chinese medical extract is added thereto afterwards, after mixing evenly, decompression pumping bubble obtains the first external drug；Weigh 4~8g
Sodium Polyacrylate, 3~9g methyl p-hydroxybenzoate are mixed with 5~10g glycerol, stir evenly, second is then added thereto
Group Chinese medical extract, after mixing evenly, decompression pumping bubble obtains the second external drug.
The drug smearing method is the first external drug of the present invention to be uniformly first applied to affected part, massage is until medicine
After object is absorbed, then the second external drug of the present invention being uniformly applied to affected part, massage is until drug is absorbed, and daily three
Secondary, every minor tick 4 hours, smearing 1 month is 1 course for the treatment of.
The present invention provides a kind of for treating the external drug of psoriasis, and beneficial effect compared with the prior art is:
1. psoriasis is a kind of chronic relapsing disease, and the external drug of the present invention for treating psoriasis uses
" from phlegm opinion control " method, wherein almond, gypsum, ginger, loguat leaf have effects that " clearing heat and eliminating phlegm "；Spina gleditsiae, the root of Dahurain angelica, when
Angelica tail, olibanum have effects that " reducing phlegm and resolving masses " that the two can be effectively solved visceral dysfunction caused by phlegm heat after combining,
Play the role of tonic heart spleen, Shugan Qingre, and then promote immunity of organisms, the state of an illness also can be cured fundamentally.
2. as a kind of moisturizer and skin aquation occurs for glycerol in the present invention, promote the percutaneous absorbtion of drug；
In addition, being used cooperatively for glycerol and gelling agent in the present invention also achieves unexpected technical effect, it can be with epidermis
Ceramide in cuticula forms stable bilateral hydrogen bond, and then improves the skin targeting of drug, keeps more drugs stagnant
Skin is stayed in, to improve the bioavilability of drug.
3. the psoriasis preparation method that the present invention uses can be such that the effective component in Chinese herbal medicine mentions to the greatest extent
It takes out；Meanwhile the external drug for the treatment of psoriasis prepared by the present invention is first to smear the first topical agent, is absorbed to drug
Afterwards, then the second topical agent is smeared, not only contributes to the absorption of drug in this way, inhales the drug of same curative effect by skin rapidly
It receives, and has further agreed with the demonstration of Chinese medicine " controlling from phlegm opinion ", first " clearing heat and eliminating phlegm ", then " reducing phlegm and resolving masses ", accelerate the state of an illness
Restore.
4. drug of the invention cracking can be absorbed by the skin utilization after smearing, active principle penetrates into blood
Circulation, therefore Rehabilitation can be promoted, have the advantages that curative effect is obvious, easy to use.
Specific embodiment
In order to which technical characteristic of the invention, purpose and beneficial effect are more clearly understood, now to of the present invention
Content carry out it is described further below.
Psoriasis is also referred to as psoriasis, and doctor trained in Western medicine theory thinks by hereditary virus, bacterium infection, direct stimulation, hypoimmunity
It is caused；Theory of traditional Chinese medical science thinks wind, wet, hot invasion skin histology, reduces Abwehrkraft des Koepers, wind formation from blood deficiency, wet poison heat, skin
Caused by dystrophy.More acurrate fixed theory is still not clear so far.Psoriasis is mainly in incidence, four limbs, and is symmetric；It is clinical
It showing as initially being in syringe needle shape or rice-shaped papule, then be gradually increased, epidermis thickens, and it is dry and largely take off white bits, at skin lesion
Itch is unbearably.Modern medicine thinks that psoriasis is neurodermatitis, is using paroxysmal pruitus and skin lichenification as primary symptom
Chronic skin inflammation.It is mostly related with spiritual sexual stimulus, physics sexual stimulus, solar radiation, scratching, abrasion etc..Chinese medicine thinks: silver
Bits onset of disease is mostly that heresy of rheumatic fever blocks skin or neck hidrosis, is that a kind of disease and evil is smouldered in table caused by stiffened cloth friction etc.,
Numbness plug skin network, the pathological manifestations of turbid blood retention；Sick consumption impairment of yin liquid long, nutrient QI and blood being insufficient, wind formation from blood deficiency life is dry, and failure of skin and muscle to be nourished forms；
Blood deficiency and sthenic liver-energy, feelings will is unsuccessful, gloomy not relax, or nervous tired, flaring up of heart fire, so that QI-blood circulation is neglected one's duty, stagnate skin, accumulation
An important factor at " phlegm ", and the feelings recurrent exerbation that causes a disease.
Chinese medicine has " controlling from phlegm opinion " one to from the perspective of, it is believed that there are two types of connotations, the i.e. phlegm of the phlegm of narrow sense and broad sense for phlegm.The phlegm one of narrow sense
As refer to the secretion of lung's exudate and respiratory tract or cough cough up or evil of vomitting and go out, therefore someone be referred to as outer phlegm.Broad sense
Phlegm, be due to body depression and stagnation of QI or yang-energy is on the decline or feelings are unsmooth, cannot normally transporting body fluid, so that body fluid is stopped product
It is poly-, it gradually pents up, therefore someone is known as interior phlegm.Interior phlegm can go with gas, agglomerate with the stagnation of the circulation of vital energy, and the vital organs of the human body all have, thus
Generate miscellaneous illness, therefore Chinese medicine has saying for " all kinds of diseases and ailments and phlegm ", " phlegm is that all kinds of diseases and ailments are female " and " strange illness duty in phlegm ".Cause
This, the treatment thinkings of " being controlled from phlegm opinion " of the present invention from Chinese medicine, using with " clearing heat and eliminating phlegm " and " reducing phlegm and resolving masses "
Several Chinese medicines be combined with each other, complement each other, fundamentally to cure psoriasis, and achieve apparent curative effect.
Several Chinese medicines of the present invention are carried out below described further below.
Almond: good protein, fat and the other compositions being rich in almond have extremely important effect to human body, master
It wants function to show themselves in that expelling phlegm and arresting coughing, relievings asthma, ease constipation.Exogenous cough is controlled, asthma is full, sore throat, dry constipation of intestines.
Gypsum: it is its acrid flavour, sweet, it is slightly cold, it attaches to the lung and stomach meridians；There is clearing heat-fire, relieving restlessness is quenched the thirst, and convergence myogenic (uses calcined gypsum)
The effect of；Its both oral administration, can also be with external application.Cure mainly vigorous heat at qi-blood phase warm heat disease, high fever macular eruption, heat-clearing ecchymose removing, dyspnea and cough due to lung-heat, the heart
It is tired of thirsty；Stomach fire Kang Sheng, headache, dentalgia, swelling and aching of gum；Eczema, sore are not held back after bursting, the various cases of a physically strong patient running a high fever such as scald and external application
With heat-clearing sore, myogenic.
Ginger: Zingiber, zingiber herbaceos perennial fresh rhizome.Rhizome (rhizoma zingiberis), the cork (ginger peel), leaf of ginger
(ginger leaves) can be used as medicine.Ginger has disinfecting detoxifying in traditional Chinese medicine and pharmacy, and swelling and pain relieving has effects that clearing away heat-damp and expelling toxic material.
Loguat leaf: wind-dispelling disappears rash, resolving sputum；" herbal solutions " are described: " entering lung meridian, the heart channel of Hand-Shaoyin." have clearly
Lung cough-relieving, stomach function regulating diuresis, the effect of quenching the thirst.
Spina gleditsiae: for the drying quil of leguminous plant Chinese honey locust.With detumescence and poison retention, the effect of apocenosis, desinsection.It is usually used in carbuncle
Subcutaneous ulcer from the beginning of or purulence at not bursting；Castor is controlled outside.
The root of Dahurain angelica: wind-cold-dispersing medicinal, acrid flavour is warm-natured, return lung, stomach, large intestine channel；Shennong's Herbal is taken in as middle product medicine
" ... long skin, moist to make face rouge ", the root of Dahurain angelica can promote the operating of Yangming Channel qi and blood, and Yangming Channel is reservoir of food and drink, Yangming Channel
Victory, then qi and blood is biochemical sufficient, therefore has long skin, moistens saying for face." general mood is dry, and wind is gone for " hundred kinds of Sheng Nong's herbal classic records " record
Then muscle is raw and moist ..., and the medicine of all wind dispellings does not have not withered consumption body fluid person, and the root of Dahurain angelica ... can be with sharp blood vessels without withered consumption ",
It follows that the root of Dahurain angelica has the characteristics that the fash of Runzao Zhiyang, wind-dispelling without consuming body fluid, suitable for blood-deficiency and wind-dry." card class sheet
Grass " " desolation scabies, analgesic, myogenic ", " Japan hanako materia medica " records " broken place blood, mend new blood ", it can thus be appreciated that for recession erythema,
Repairing skin has facilitation.
Radix angelicae sinensis: radix angelicae sinensis, that is, Radix Angelicae Sinensis tail portion, surface yellowish-brown to sepia have vertical wrinkle and horizontally long hole skin.Root head,
Have a ring grain, upper end round blunt, can promoting blood circulation, menostasis is obstructed and the illness of the stagnant swelling and pain of hemostasis for treatment.
Olibanum: property is pungent, bitter, warm-natured；Return heart, liver, the spleen channel；Promoting blood circulation, promoting the circulation of qi, analgesic.
In order to make it easy to understand, being carried out in detail to the present invention for treating the external drug of psoriasis below by specific embodiment
Thin description.It is important to note that specific embodiment is merely to explanation, it is clear that those skilled in the art can basis
Illustrate herein, carrying out various amendments or change, these modifications and variations to the present invention will also be included within the scope of the application.
Embodiment 1
It is a kind of for treating the external drug of psoriasis, according to the number of parts by weight, comprising:
28 parts of almond, 25 parts of gypsum, 22 parts of ginger, 28 parts of loguat leaf, 15 parts of spina gleditsiae, 25 parts of the root of Dahurain angelica, 25 parts of radix angelicae sinensis,
13 parts of olibanum, it is remaining be auxiliary material.
Auxiliary material includes Sodium Polyacrylate, glycerol and methyl p-hydroxybenzoate.
As a further solution of the present invention, the production method for treating the external drug of leucoderma, step is such as
Under:
S1. raw material almond, gypsum, ginger, loguat leaf, spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum are ground into Chinese medicine respectively
Powder sieves with 100 mesh sieve, and packs spare；
S2. herb powder almond, gypsum, ginger, loguat leaf are weighed according to quantity to be uniformly mixed, and the second of 500mL 75% is added
Alcohol is uniformly mixed, and ultrasonic 1h filters to take supernatant A, and supernatant A is concentrated under reduced pressure into 20mL, and 180mL distilled water, stirring is added
It is centrifuged after 0.5h, collects lower layer's solid B and be dissolved in the dehydrated alcohol of 200mL, later rotary evaporation, collected solid C and be added
Solid D is washed to neutrality, is dried under reduced pressure to get first by the HCl solution of 100mL0.5%, ultrasonic 0.5h, centrifuging and taking solid D
Group Chinese medical extract, wherein mixing speed is 500r/min, centrifugal speed 5000r/min；
S3. spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum herb powder are weighed according to quantity to be uniformly mixed, and the second of 500mL75% is added
Alcohol is uniformly mixed, and ultrasonic 1h filters to take supernatant E, and supernatant E is concentrated under reduced pressure into 20mL, and 180mL distilled water, stirring is added
It is centrifuged after 0.5h, collects lower layer's solid F and be dissolved in the dehydrated alcohol of 200mL, later rotary evaporation, collected solid G and be added
Solid H is washed to neutrality, is dried under reduced pressure to get second by the HCl solution of 100mL0.5%, ultrasonic 0.5h, centrifuging and taking solid H
Group Chinese medical extract, wherein mixing speed is 500r/min, centrifugal speed 5000r/min；
S4. weigh 6g gelling agent, 7g methyl p-hydroxybenzoate is mixed with 6g glycerol, stir evenly, then thereto plus
Enter first group of Chinese medical extract, after mixing evenly, decompression pumping bubble obtains the first external drug；Weigh 6g Sodium Polyacrylate, 7g
Methyl p-hydroxybenzoate is mixed with 6g glycerol, is stirred evenly, and second group of Chinese medical extract is then added thereto, stirs evenly
Afterwards, decompression pumping bubble, obtains the second external drug.
The drug smearing method is the first external drug of the present invention to be uniformly first applied to affected part, massage is until medicine
After object is absorbed, then the second external drug of the present invention being uniformly applied to affected part, massage is until drug is absorbed, and daily three
Secondary, every minor tick 4 hours, smearing 1 month is 1 course for the treatment of.
Embodiment 2
It is a kind of for treating the external drug of psoriasis, according to the number of parts by weight, comprising:
20 parts of almond, 10 parts of gypsum, 15 parts of ginger, 20 parts of loguat leaf, 10 parts of spina gleditsiae, 15 parts of the root of Dahurain angelica, 20 parts of radix angelicae sinensis,
10 parts of olibanum, it is remaining be auxiliary material.
The auxiliary material includes Sodium Polyacrylate, glycerol and methyl p-hydroxybenzoate.
As a further solution of the present invention, the production method for treating the external drug of leucoderma, step is such as
Under:
S1. raw material almond, gypsum, ginger, loguat leaf, spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum are ground into Chinese medicine respectively
Powder crosses 80 meshes, packs spare；
S2. herb powder almond, gypsum, ginger, loguat leaf are weighed according to quantity to be uniformly mixed, and the second of 400mL 75% is added
Alcohol is uniformly mixed, and ultrasonic 2h filters to take supernatant A, and supernatant A is concentrated under reduced pressure into 30mL, and 170mL distilled water, stirring is added
It is centrifuged after 1h, collects lower layer's solid B and be dissolved in the dehydrated alcohol of 150mL, later rotary evaporation, collected solid C and be added
Solid D is washed to neutrality, is dried under reduced pressure to get first group by the HCl solution of 150mL0.5%, ultrasonic 1h, centrifuging and taking solid D
Chinese medical extract, wherein mixing speed is 300r/min, centrifugal speed 8000r/min；
S3. spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum herb powder are weighed according to quantity to be uniformly mixed, and the second of 400mL75% is added
Alcohol is uniformly mixed, and ultrasonic 2h filters to take supernatant E, and supernatant E is concentrated under reduced pressure into 30mL, and 170mL distilled water, stirring is added
It is centrifuged after 1h, collects lower layer's solid F and be dissolved in the dehydrated alcohol of 150mL, later rotary evaporation, collected solid G and be added
Solid H is washed to neutrality, is dried under reduced pressure to get second group by the HCl solution of 150mL0.5%, ultrasonic 1h, centrifuging and taking solid H
Chinese medical extract, wherein mixing speed is 300r/min, centrifugal speed 8000r/min；
S4. weigh 4g gelling agent, 3g methyl p-hydroxybenzoate is mixed with 5g glycerol, stir evenly, then thereto plus
Enter first group of Chinese medical extract, after mixing evenly, decompression pumping bubble obtains the first external drug；Weigh 4g Sodium Polyacrylate, 3g
Methyl p-hydroxybenzoate is mixed with 5g glycerol, is stirred evenly, and second group of Chinese medical extract is then added thereto, stirs evenly
Afterwards, decompression pumping bubble, obtains the second external drug.
The drug smearing method is the first external drug of the present invention to be uniformly first applied to affected part, massage is until medicine
After object is absorbed, then the second external drug of the present invention being uniformly applied to affected part, massage is until drug is absorbed, and daily three
Secondary, every minor tick 4 hours, smearing 1 month is 1 course for the treatment of.
Embodiment 3
It is a kind of for treating the external drug of psoriasis, according to the number of parts by weight, comprising:
30 parts of almond, 40 parts of gypsum, 25 parts of ginger, 30 parts of loguat leaf, 40 parts of spina gleditsiae, 30 parts of the root of Dahurain angelica, 40 parts of radix angelicae sinensis,
20 parts of olibanum, it is remaining be auxiliary material.
The auxiliary material includes Sodium Polyacrylate, glycerol and methyl p-hydroxybenzoate.
As a further solution of the present invention, the production method for treating the external drug of leucoderma, step is such as
Under:
S1. raw material almond, gypsum, ginger, loguat leaf, spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum are ground into Chinese medicine respectively
Powder sieves with 100 mesh sieve, and packs spare；
S2. herb powder almond, gypsum, ginger, loguat leaf are weighed according to quantity to be uniformly mixed, and the second of 500mL 75% is added
Alcohol is uniformly mixed, and ultrasonic 1h filters to take supernatant A, and supernatant A is concentrated under reduced pressure into 20mL, and 180mL distilled water, stirring is added
It is centrifuged after 0.5h, collects lower layer's solid B and be dissolved in the dehydrated alcohol of 200mL, later rotary evaporation, collected solid C and be added
Solid D is washed to neutrality, is dried under reduced pressure to get first by the HCl solution of 100mL0.5%, ultrasonic 0.5h, centrifuging and taking solid D
Group Chinese medical extract, wherein mixing speed is 500r/min, centrifugal speed 5000r/min；
S3. spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum herb powder are weighed according to quantity to be uniformly mixed, and the second of 500mL75% is added
Alcohol is uniformly mixed, and ultrasonic 1h filters to take supernatant E, and supernatant E is concentrated under reduced pressure into 20mL, and 180mL distilled water, stirring is added
It is centrifuged after 0.5h, collects lower layer's solid F and be dissolved in the dehydrated alcohol of 200mL, later rotary evaporation, collected solid G and be added
Solid H is washed to neutrality, is dried under reduced pressure to get second by the HCl solution of 100mL0.5%, ultrasonic 0.5h, centrifuging and taking solid H
Group Chinese medical extract, wherein mixing speed is 500r/min, centrifugal speed 5000r/min；
S4. weigh 8g gelling agent, 9g methyl p-hydroxybenzoate is mixed with 10g glycerol, stir evenly, then thereto plus
Enter first group of Chinese medical extract, after mixing evenly, decompression pumping bubble obtains the first external drug；Weigh 8g Sodium Polyacrylate, 9g
Methyl p-hydroxybenzoate is mixed with 10g glycerol, is stirred evenly, and second group of Chinese medical extract is then added thereto, and stirring is equal
After even, decompression pumping bubble obtains the second external drug.
The drug smearing method is the first external drug of the present invention to be uniformly first applied to affected part, massage is until medicine
After object is absorbed, then the second external drug of the present invention being uniformly applied to affected part, massage is until drug is absorbed, and daily three
Secondary, every minor tick 4 hours, smearing 1 month is 1 course for the treatment of.
For the contents of the present invention that illustrate being more clear, the present invention has carried out clinical trial, specific as follows:
One, clinical criteria:
The position of morbidity is most common with scalp, is secondly shank, ancon, back, upper arm, forearm knee, chest and abdomen
Portion and buttocks etc..
Clinically how much it is divided into generalized and two kinds of topical type by its site of pathological change, skin lesion.Topical type, skin lesion are detected in neck
The part such as item, for the clear moss sample plumpness patch of a small number of boundaries；It is generalized, it is distributed more widely general, it is apt to occur in head, four limbs, shoulder waist
Everywhere, skin lesion feature is identical as topical type for portion etc. or even general hair whole body.
Two, patient source
300 psoriatics are chosen in the major Dermatology of this city, wherein including topical type, two types generalized.
Patient includes male 187, women 113；Age, average age was 35 years old between 16-60 years old；Sick time is 1~10
Year, average sick time is 4.6 years.
Three, administrated method
Drug is prepared with preparation method used in the embodiment of the present invention 1, drug smearing method is, first by the first external drug
It is uniformly applied to affected part, massage is uniformly applied to affected part after drug is absorbed, then by the second external drug, and massage is until drug quilt
It absorbs, three times a day, every minor tick 4 hours, smearing 1 month is 1 course for the treatment of.
Four, curative effect determinate standard
(1) clinical observation:
It is effective: 70% or more skin lesion recession.
It is effective: between skin lesion recession 30-70%.
Invalid: skin lesion recession 30% or less or not controlled aggravates instead.
(2) curative effect judging standard:
Recurrence: expand or aggravate before the treatment of skin lesion area ratio.
Light recurrence: recurrence skin lesion is 50% or less former skin lesion.
Five, clinical treatment outcome
It is counted and is calculated according to above-mentioned curative effect determinate standard, treatment results are as shown in table 1:
Curative effect of 1 present invention of table to psoriatic
| Patient's number | Gender | It is effective | Effectively | In vain | Significant effect rate | It is efficient |
| 187 | Male | 118 | 56 | 13 | 63.1% | 93.0% |
| 113 | Female | 71 | 35 | 7 | 62.8% | 93.8% |
According to table 1, drug prepared by the embodiment of the present invention 1 to this city psoriatic it is efficient up to 93% with
On, thus, it can be known that being used to treat the drug of psoriasis prepared by the present invention is effective to most psoriatics；This
Drug prepared by inventive embodiments 1 reaches 62% or more to the significant effect rate of this city psoriatic, illustrates that this city silver is considered to be worth doing
Patient has 70% fell damage 70% or more recession completely, further demonstrates after according to subject treatment method use
For treating the external drug short treating period of psoriasis, quick and significant effect prepared by the present invention.
Wherein, some typical patients are as described below in above-mentioned patient:
Patient 1: Zhang, and male, 42 years old, back plumpness skin lesion 2 years, itch was serious, and fatigue aggravates, and color is light white, dry, examine for
Psoriasis.The outer drug for applying this treatment psoriasis, after two weeks, symptom mitigates, continuous treatment one month, and symptom eliminates recovery from illness is returned
It visits without recurrence.
Patient 2: Sun, female, and 28 years old.Make a definite diagnosis psoriasis 6 years.The year before discovery upper limb occur protrusion patch papule with
Large stretch of scales of skin that peel off.One yuan coin-size patch of head.Lower limb are to increase patch shape, and the surface scales of skin that peel off thickens, and are fallen off with blutpunkte.Out
Existing congestion and swelling pain occasionally has and feels run-down and the performance of anchylosis.Then it goes to local institute of traditional Chinese medicine medical, is diagnosed as psoriasis, gives
Intravenous drip is given, effect is good or bad, and is aggravated in the recent period, the outer drug for applying this treatment psoriasis, significant effect after two courses for the treatment of, and 1
It pays a return visit after year without recurrence.
Finally, it should be noted that the invention is not limited in any way for above embodiments.Those skilled in the art are come
It says, on the basis of the present invention, some modification and improvement can be made to it.Therefore, it is all without departing from theon the basis of the spirit of the present invention
Done it is any modify or improve, fall within the scope of the claimed invention within.
Claims (6)
1. a kind of for treating the external drug of psoriasis, including the first external drug and the second external drug；
First external drug is according to the number of parts by weight, comprising: and 20~30 parts of almond, 10~40 parts of gypsum, ginger 15~
25 parts, 20~30 parts of loguat leaf, it is remaining be auxiliary material；
Second external drug is according to the number of parts by weight, comprising: 10~40 parts of spina gleditsiae, 15~30 parts of the root of Dahurain angelica, radix angelicae sinensis
20~40 parts, 10~20 parts of olibanum, it is remaining be auxiliary material.
2. according to claim 1 for treating the external drug of psoriasis, which is characterized in that first external drug
According to the number of parts by weight, comprising: 25~30 parts of almond, 20~30 parts of gypsum, 20~25 parts of ginger, 25~30 parts of loguat leaf,
Remaining is auxiliary material；
Second external drug is according to the number of parts by weight, comprising: 10~20 parts of spina gleditsiae, 20~30 parts of the root of Dahurain angelica, radix angelicae sinensis
20~30 parts, 10~15 parts of olibanum, it is remaining be auxiliary material.
3. according to claim 1 for treating the external drug of psoriasis, which is characterized in that first external drug
According to the number of parts by weight, comprising: 28 parts of almond, 25 parts of gypsum, 22 parts of ginger, 28 parts of loguat leaf, it is remaining be auxiliary material；
Second external drug is according to the number of parts by weight, comprising: 15 parts of spina gleditsiae, 25 parts of the root of Dahurain angelica, 25 parts of radix angelicae sinensis, olibanum
13 parts, it is remaining be auxiliary material.
4. according to claim 1 for treating the external drug of psoriasis, which is characterized in that the auxiliary material includes to hydroxyl
Yl benzoic acid methyl esters, gelling agent and glycerol.
5. according to claim 4 for treating the external drug of psoriasis, which is characterized in that the gelling agent includes card
One of wave nurse 934, Acritamer 940, Carbopol 941 are a variety of.
6. the production method of any external drug for treating psoriasis according to claim 1~6, including walk as follows
It is rapid:
S1. raw material almond, gypsum, ginger, loguat leaf, spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum are ground into herb powder respectively,
80~100 meshes are crossed, are packed spare；
S2. it weighs herb powder almond, gypsum, ginger, loguat leaf according to quantity to be uniformly mixed, 400~500mL mass fraction, which is added, is
75% ethyl alcohol is uniformly mixed, and 1~2h of ultrasound filters to take supernatant A；Supernatant A is concentrated under reduced pressure into 20~30mL, is added
170~180mL distilled water is centrifuged after stirring 0.5~1h, is collected lower layer's solid B and is dissolved in the dehydrated alcohol of 150~200mL, it
Rotary evaporated to dryness is dry afterwards, collects solid C and the HCl solution that 100~150mL mass fraction is 0.5% is added, and ultrasound 0.5~
1h, centrifuging and taking lower layer solid D；Solid D is washed to neutrality, is dried under reduced pressure to get first group of Chinese medical extract, wherein stirring speed
Degree is 300~500r/min, and centrifugal speed is 5000~8000r/min；
S3. spina gleditsiae, the root of Dahurain angelica, radix angelicae sinensis, olibanum herb powder are weighed according to quantity to be uniformly mixed, and 400~500mL mass fraction is added
For 75% ethyl alcohol, it is uniformly mixed, 1~2h of ultrasound filters to take supernatant E；Supernatant E is concentrated under reduced pressure into 20~30mL, is added
Enter 170~180mL distilled water, be centrifuged after stirring 0.5~1h, collects lower layer's solid F and be dissolved in the dehydrated alcohol of 150~200mL,
Rotary evaporated to dryness is dry later, collects solid G and the HCl solution that 100~150mL mass fraction is 0.5% is added, ultrasound 0.5
~1h, centrifuging and taking lower layer solid H；Solid H is washed to neutrality, is dried under reduced pressure to get second group of Chinese medical extract, wherein stirring
Speed is 300~500r/min, and centrifugal speed is 5000~8000r/min；
S4. weigh 4~8g gelling agent, 3~9g methyl p-hydroxybenzoate is mixed with 5~10g glycerol, stir evenly, then to
First group of Chinese medical extract is wherein added, after mixing evenly, decompression pumping bubble obtains the first external drug；Weigh 4~8g poly- third
Olefin(e) acid sodium, 3~9g methyl p-hydroxybenzoate are mixed with 5~10g glycerol, are stirred evenly, and are then added in second group thereto
Medicament extract, after mixing evenly, decompression pumping bubble obtains the second external drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910770953.9A CN110433273A (en) | 2019-08-20 | 2019-08-20 | It is a kind of for treating the external drug of psoriasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910770953.9A CN110433273A (en) | 2019-08-20 | 2019-08-20 | It is a kind of for treating the external drug of psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110433273A true CN110433273A (en) | 2019-11-12 |
Family
ID=68436740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910770953.9A Pending CN110433273A (en) | 2019-08-20 | 2019-08-20 | It is a kind of for treating the external drug of psoriasis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110433273A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406658A (en) * | 2011-11-29 | 2012-04-11 | 丁荣松 | Paste plaster for treating psoriasis and preparation method thereof |
| CN102552824A (en) * | 2012-02-27 | 2012-07-11 | 王莲芬 | Traditional Chinese medicine patent prescription for treating psoriasis |
| CN103751290A (en) * | 2013-11-27 | 2014-04-30 | 青岛市市立医院 | Pharmaceutical composition for treating psoriasis |
| CN104800269A (en) * | 2015-05-19 | 2015-07-29 | 北京市中医研究所 | Traditional Chinese medicine external-use cream used for treating psoriasis and preparation method thereof |
-
2019
- 2019-08-20 CN CN201910770953.9A patent/CN110433273A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406658A (en) * | 2011-11-29 | 2012-04-11 | 丁荣松 | Paste plaster for treating psoriasis and preparation method thereof |
| CN102552824A (en) * | 2012-02-27 | 2012-07-11 | 王莲芬 | Traditional Chinese medicine patent prescription for treating psoriasis |
| CN103751290A (en) * | 2013-11-27 | 2014-04-30 | 青岛市市立医院 | Pharmaceutical composition for treating psoriasis |
| CN104800269A (en) * | 2015-05-19 | 2015-07-29 | 北京市中医研究所 | Traditional Chinese medicine external-use cream used for treating psoriasis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 谈依菱: "基于聚类分析和关联规则对寻常型银屑病中药内服用药规律的研究", 《中国博士学位论文全文数据库（电子期刊）》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN102091258B (en) | Chinese medicinal composition for dispelling scars and preparation method thereof | |
| CN101804166B (en) | Traditional Chinese medicine composition for treating dermatitis and eczema of infants | |
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| CN101979041A (en) | Chinese medicinal preparation for treating various dermatoses | |
| CN103272199A (en) | Frostbite treatment medicine | |
| CN101143171B (en) | Traditional Chinese medicine and its preparation method and its application | |
| CN107095905A (en) | A kind of healthful moxibustion bar and moxibustion cream | |
| CN104013919A (en) | Traditional Chinese medicine for treating angina pectoris | |
| CN110433273A (en) | It is a kind of for treating the external drug of psoriasis | |
| CN105343847A (en) | Traditional Chinese medicine composition for treating eczema containing folium artemisiae argyi and preparing method thereof | |
| CN111346145A (en) | Traditional Chinese medicine composition, preparation method thereof, external medicine and application | |
| CN107929492A (en) | A kind of strong doctor's external preparation for treating abscess and preparation method thereof | |
| CN115531503B (en) | External traditional Chinese medicine composition for novel coronavirus pneumonia recovery period, acupoint patch, preparation method and application | |
| CN104257813B (en) | A kind of Chinese medicine composition of QI and blood regulating and preparation method thereof | |
| CN103285300A (en) | Medicinal composition for treating stress incontinence | |
| CN1178681C (en) | Notoginseng and pangolin scales tinea curing pill | |
| CN107496567A (en) | A kind of Chinese medicine preparation for treating diabetic foot and preparation method thereof | |
| CN105106786A (en) | Traditional Chinese medicine composition capable of dredging collaterals and relaxing muscles as well as preparation and production method of composition | |
| CN103948804B (en) | A kind of Chinese medicine composition treating lung qi deficiency dermatitis aestivale | |
| CN104644973B (en) | A kind of Chinese medicine preparation and preparation method for the treatment of rheumatic heart disease | |
| CN103301303A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN103301372A (en) | Preparation method of umbilicus dressing agent for treating post-operation prostate stress urinary incontinence | |
| CN102688382B (en) | Gamene oral liquid for treating acute gastroenteritis and preparation method thereof | |
| CN103341108A (en) | Pharmaceutical composite for treating stress urinary incontinence after prostatectomy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191112 |